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The map label for this gene is gvrA [H]

Identifier: 170078543

GI number: 170078543

Start: 2020709

End: 2023246

Strand: Direct

Name: gvrA [H]

Synonym: SYNPCC7002_A1938

Alternate gene names: 170078543

Gene position: 2020709-2023246 (Clockwise)

Preceding gene: 170078541

Following gene: 170078545

Centisome position: 67.18

GC content: 52.29

Gene sequence:

>2538_bases
TTGTCCAATCAGCATAAATTCATGGCACAACAACTCGATCTGCTCCAGTCCGGTCACATTATCCCGACAGCGCTCCATGT
GGAAATGGAACAGTCCTATATGGAATATGCGATGAGTGTGATCGTCGGACGGGCATTGCCAGATGTGCGGGATGGTCTGA
AACCAGTGCATCGGCGGATTTTGTATGCGATGTATGAGTTGGGCTTAAGTCCGGATCGCCCTTACCGCAAATGTGCGCGG
GTGGTGGGGGATGTGTTGGGGAAGTATCACCCCCACGGCGATCAGTCCGTTTACGATGCGTTGGTGCGGTTGGTGCAGGA
TTTCTCAACGCGCTATCCGTTGTTGGCGGGACATGGGAATTTTGGTTCGATTGACAATGATCCGCCGGCGGCGATGCGGT
ATACGGAAACGCGGTTATCGCCCGTGAGTTTTGAGGCGATGTTGGCGCAGATTAGTGAGGATATTGTTGATTTTACGGAT
AATTTTGATGGGTCGCAGCAGGAGCCAGTGGTGCTGCCGGTACAGTTGCCGATCTTGCTGTTGAATGGTTCTTCGGGGAT
TGCGGTGGGGATGGCAACGAATATGCCGCCGCACAATTTGGGGGAAGTGGTGGATGGGTTGATCGCTTTGATTGATGATC
CAGAAATTGAGGATGAGAAGTTATGGGCAGTTATTCCTGCGCCGGATTTTCCGACAGGGGGAGAAATCGTTGATCTCGCT
GGGGTGCGCGACGCCTACCGGACGGGACGGGGCATTATTCCGATGCGGGGCATTGTCCATTTGGAAGTGCTGCAGGTGGG
GCGGAAACGGAAGCGGGATGTGAATGCATTGGTGGTGACGGAACTGCCCTATCAGGTGAATAAGGCGGCGTGGATTGAAA
AGATCGCGGATCTGGTGAATGATGGCAAGATTTCGGGAATTTCGGATATTCGGGATGAGAGCGATCGCCAAGGGATGCGG
GTGGTGATTGAACTGAAGCGGGATGCGGAGCCGGAGAAGGTTTTAAAGTTGCTGTATAAGAAAACGGCGTTGCAGTCCAA
TTTTGGGGCAATTTTACTGTCGTTGGTGAATAATCAGCCGCGCCAGTTGTCATTAAAGGCGATTTTGCAGGAATTTCTTG
AATTTCGGGAGGAAACGGTCACTCGGCAATATCGGTATGAGTTAGAGCAGAAGGAAACGCGGCAACATTCGGTGGAGGGG
TTATTGCTTGCGCTGAATAATTTGGATGCGGTGATCGAGATTTTGCGGAATGCGGCGGATGGCACGACGGCAAAACAGCA
GTTTCAGGCGGCATTGGGGTTTAGTGAGAGTCAGTCGGATGCGATCTTGGCGATGCCGATGCGACGGTTAACGGGCTTGG
AACGGCAAAAACTGGAACAGGAGTCTACGGAACTGGCGACGGAGATCGCCAAGTTAAATAAATTATTGAGCGATCGCCAC
GAATTACTCAAGGCACTAAAGCGGGAATTGCGCAGTTTAAAACGGAAATTTGCCGACCCGCGTCGCACCCGTTTACCGGA
TGTGCCATCCCCTGAACCGGAACCTGTCACAGTCGAGGCGGAGCCAGACACCCCCGCAGCGACCCCGAAGAAAAAACGCC
AATCCCGCAAAAAGGAGGAACCCGTGCTTGCCCTCCTGCCGCAATTGACGGAGACCTCCCATGTGGCGATCGCCGCGTCG
GGGGGCGTGTACTGGGGTAATGATGATGCGGGGCTATTGGATGAGGAACCGACCATTTTTAAGGCGCAGATCGGCACGCA
GAAAAAGTTAATCGTCTGCACCGATCAAGGAAAAGCCTTTCCGGTGGCGATCGCCGATTTACCCTACCAAGAACAGCGGG
ATAAACCCCAATTAATCGATTTATTACCAGATCATGCCCTACGGGATGACCATCAGCCGATCACTCAGTTTTTACTGCCC
GATAATTTAGCAGAGTACGATTTACTTTTACTTACAGCCCAAGGACGAATTAAACGTCTCCCGGCGATCGAACTCGAAAG
TTTCACCAGTCGCGGCTTGAGTTTGATCAAGCTCAAGGACAAGGACACCCTCAAATTCGCTTGTTTCGTGAAGGGGGGTG
AGCAGGTGGCGATCGCCGTCAGCAGTGGGCGGGTCTTACATTTGCCCGTCAACGATCACGAAATCCCCGTGATGGGCAGA
ACTTCCCAAGGGAACCAAGCCCTGCGCCTCCGCTTTAACGAGCAAATTGTCGCCTGTGTTCCCTGCCAACGGCACAACGA
ACTTTACTTAATCTCCGAGGAAGGCTACGGCAAGAAATTAGCCGCCAGCAGCTTACGGCTCGGTAAACGGGGTGATATGG
GCAACCATGTGATGCGCTTTGAATCAAAAACCGATCTGCTCCTCACACTTTTCGTTCCCGATCAACAGGAATCCCTGTTG
GTAAAAGATTCCCAAGAAAACCTCGATCTGTTGCCCTTCAGTAAATTCAACCTCACCGAAAAGGATAGCCCCGGACAAAA
ATTGGTGAAACTAAGCGGTGGCGATCGCCTCGTTAATTGTTATCTGAGTGGGTCGTAG

Upstream 100 bases:

>100_bases
TGCGACAGAGAGCCCTATGCCTTTATGGTGAAAAAGATGCAAACGCTTGTAAAGATTTAAGAATCAACAGTATATTCCTT
GAAAACAGCGTTCCCCATTA

Downstream 100 bases:

>100_bases
AAGCCATAAAAAAGAGGGGATTAATTTCCCCTCCGTGGTCATTGCCTTTGAGCTTGTTTTTGAGCATTTTATTGCGTTTT
TTTAGTTGCCGTTGACGGGC

Product: DNA topoisomerase chain A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 845; Mature: 844

Protein sequence:

>845_residues
MSNQHKFMAQQLDLLQSGHIIPTALHVEMEQSYMEYAMSVIVGRALPDVRDGLKPVHRRILYAMYELGLSPDRPYRKCAR
VVGDVLGKYHPHGDQSVYDALVRLVQDFSTRYPLLAGHGNFGSIDNDPPAAMRYTETRLSPVSFEAMLAQISEDIVDFTD
NFDGSQQEPVVLPVQLPILLLNGSSGIAVGMATNMPPHNLGEVVDGLIALIDDPEIEDEKLWAVIPAPDFPTGGEIVDLA
GVRDAYRTGRGIIPMRGIVHLEVLQVGRKRKRDVNALVVTELPYQVNKAAWIEKIADLVNDGKISGISDIRDESDRQGMR
VVIELKRDAEPEKVLKLLYKKTALQSNFGAILLSLVNNQPRQLSLKAILQEFLEFREETVTRQYRYELEQKETRQHSVEG
LLLALNNLDAVIEILRNAADGTTAKQQFQAALGFSESQSDAILAMPMRRLTGLERQKLEQESTELATEIAKLNKLLSDRH
ELLKALKRELRSLKRKFADPRRTRLPDVPSPEPEPVTVEAEPDTPAATPKKKRQSRKKEEPVLALLPQLTETSHVAIAAS
GGVYWGNDDAGLLDEEPTIFKAQIGTQKKLIVCTDQGKAFPVAIADLPYQEQRDKPQLIDLLPDHALRDDHQPITQFLLP
DNLAEYDLLLLTAQGRIKRLPAIELESFTSRGLSLIKLKDKDTLKFACFVKGGEQVAIAVSSGRVLHLPVNDHEIPVMGR
TSQGNQALRLRFNEQIVACVPCQRHNELYLISEEGYGKKLAASSLRLGKRGDMGNHVMRFESKTDLLLTLFVPDQQESLL
VKDSQENLDLLPFSKFNLTEKDSPGQKLVKLSGGDRLVNCYLSGS

Sequences:

>Translated_845_residues
MSNQHKFMAQQLDLLQSGHIIPTALHVEMEQSYMEYAMSVIVGRALPDVRDGLKPVHRRILYAMYELGLSPDRPYRKCAR
VVGDVLGKYHPHGDQSVYDALVRLVQDFSTRYPLLAGHGNFGSIDNDPPAAMRYTETRLSPVSFEAMLAQISEDIVDFTD
NFDGSQQEPVVLPVQLPILLLNGSSGIAVGMATNMPPHNLGEVVDGLIALIDDPEIEDEKLWAVIPAPDFPTGGEIVDLA
GVRDAYRTGRGIIPMRGIVHLEVLQVGRKRKRDVNALVVTELPYQVNKAAWIEKIADLVNDGKISGISDIRDESDRQGMR
VVIELKRDAEPEKVLKLLYKKTALQSNFGAILLSLVNNQPRQLSLKAILQEFLEFREETVTRQYRYELEQKETRQHSVEG
LLLALNNLDAVIEILRNAADGTTAKQQFQAALGFSESQSDAILAMPMRRLTGLERQKLEQESTELATEIAKLNKLLSDRH
ELLKALKRELRSLKRKFADPRRTRLPDVPSPEPEPVTVEAEPDTPAATPKKKRQSRKKEEPVLALLPQLTETSHVAIAAS
GGVYWGNDDAGLLDEEPTIFKAQIGTQKKLIVCTDQGKAFPVAIADLPYQEQRDKPQLIDLLPDHALRDDHQPITQFLLP
DNLAEYDLLLLTAQGRIKRLPAIELESFTSRGLSLIKLKDKDTLKFACFVKGGEQVAIAVSSGRVLHLPVNDHEIPVMGR
TSQGNQALRLRFNEQIVACVPCQRHNELYLISEEGYGKKLAASSLRLGKRGDMGNHVMRFESKTDLLLTLFVPDQQESLL
VKDSQENLDLLPFSKFNLTEKDSPGQKLVKLSGGDRLVNCYLSGS
>Mature_844_residues
SNQHKFMAQQLDLLQSGHIIPTALHVEMEQSYMEYAMSVIVGRALPDVRDGLKPVHRRILYAMYELGLSPDRPYRKCARV
VGDVLGKYHPHGDQSVYDALVRLVQDFSTRYPLLAGHGNFGSIDNDPPAAMRYTETRLSPVSFEAMLAQISEDIVDFTDN
FDGSQQEPVVLPVQLPILLLNGSSGIAVGMATNMPPHNLGEVVDGLIALIDDPEIEDEKLWAVIPAPDFPTGGEIVDLAG
VRDAYRTGRGIIPMRGIVHLEVLQVGRKRKRDVNALVVTELPYQVNKAAWIEKIADLVNDGKISGISDIRDESDRQGMRV
VIELKRDAEPEKVLKLLYKKTALQSNFGAILLSLVNNQPRQLSLKAILQEFLEFREETVTRQYRYELEQKETRQHSVEGL
LLALNNLDAVIEILRNAADGTTAKQQFQAALGFSESQSDAILAMPMRRLTGLERQKLEQESTELATEIAKLNKLLSDRHE
LLKALKRELRSLKRKFADPRRTRLPDVPSPEPEPVTVEAEPDTPAATPKKKRQSRKKEEPVLALLPQLTETSHVAIAASG
GVYWGNDDAGLLDEEPTIFKAQIGTQKKLIVCTDQGKAFPVAIADLPYQEQRDKPQLIDLLPDHALRDDHQPITQFLLPD
NLAEYDLLLLTAQGRIKRLPAIELESFTSRGLSLIKLKDKDTLKFACFVKGGEQVAIAVSSGRVLHLPVNDHEIPVMGRT
SQGNQALRLRFNEQIVACVPCQRHNELYLISEEGYGKKLAASSLRLGKRGDMGNHVMRFESKTDLLLTLFVPDQQESLLV
KDSQENLDLLPFSKFNLTEKDSPGQKLVKLSGGDRLVNCYLSGS

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=351, Percent_Identity=24.5014245014245, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI19913406, Length=353, Percent_Identity=25.4957507082153, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1788562, Length=858, Percent_Identity=36.1305361305361, Blast_Score=502, Evalue=1e-143,
Organism=Escherichia coli, GI1789396, Length=721, Percent_Identity=35.6449375866852, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI212645845, Length=474, Percent_Identity=24.8945147679325, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17535065, Length=397, Percent_Identity=26.7002518891688, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324241, Length=373, Percent_Identity=25.4691689008043, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17136538, Length=355, Percent_Identity=25.6338028169014, Blast_Score=76, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.3

Molecular weight: Translated: 94326; Mature: 94194

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQHKFMAQQLDLLQSGHIIPTALHVEMEQSYMEYAMSVIVGRALPDVRDGLKPVHRRI
CCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LYAMYELGLSPDRPYRKCARVVGDVLGKYHPHGDQSVYDALVRLVQDFSTRYPLLAGHGN
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCC
FGSIDNDPPAAMRYTETRLSPVSFEAMLAQISEDIVDFTDNFDGSQQEPVVLPVQLPILL
CCCCCCCCCCCEEEHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEE
LNGSSGIAVGMATNMPPHNLGEVVDGLIALIDDPEIEDEKLWAVIPAPDFPTGGEIVDLA
EECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCEEEEC
GVRDAYRTGRGIIPMRGIVHLEVLQVGRKRKRDVNALVVTELPYQVNKAAWIEKIADLVN
CCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHC
DGKISGISDIRDESDRQGMRVVIELKRDAEPEKVLKLLYKKTALQSNFGAILLSLVNNQP
CCCCCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
RQLSLKAILQEFLEFREETVTRQYRYELEQKETRQHSVEGLLLALNNLDAVIEILRNAAD
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GTTAKQQFQAALGFSESQSDAILAMPMRRLTGLERQKLEQESTELATEIAKLNKLLSDRH
CCHHHHHHHHHHCCCCCCCCEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLKALKRELRSLKRKFADPRRTRLPDVPSPEPEPVTVEAEPDTPAATPKKKRQSRKKEE
HHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCC
PVLALLPQLTETSHVAIAASGGVYWGNDDAGLLDEEPTIFKAQIGTQKKLIVCTDQGKAF
CHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCEE
PVAIADLPYQEQRDKPQLIDLLPDHALRDDHQPITQFLLPDNLAEYDLLLLTAQGRIKRL
EEEEECCCCHHHCCCCHHHHHCCCHHCCCCCHHHHHHHCCCCCCCCEEEEEECCCCHHCC
PAIELESFTSRGLSLIKLKDKDTLKFACFVKGGEQVAIAVSSGRVLHLPVNDHEIPVMGR
CCHHHHHHHHCCEEEEEECCCCCEEEEEEEECCCEEEEEEECCCEEEEECCCCCCCEEEC
TSQGNQALRLRFNEQIVACVPCQRHNELYLISEEGYGKKLAASSLRLGKRGDMGNHVMRF
CCCCCCEEEEEECCCEEEEECCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCEEEE
ESKTDLLLTLFVPDQQESLLVKDSQENLDLLPFSKFNLTEKDSPGQKLVKLSGGDRLVNC
CCCCCEEEEEEECCCCCCEEEECCCCCCEECCCCCCCCCCCCCCCCEEEEECCCCEEEEE
YLSGS
EEECC
>Mature Secondary Structure 
SNQHKFMAQQLDLLQSGHIIPTALHVEMEQSYMEYAMSVIVGRALPDVRDGLKPVHRRI
CCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LYAMYELGLSPDRPYRKCARVVGDVLGKYHPHGDQSVYDALVRLVQDFSTRYPLLAGHGN
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCC
FGSIDNDPPAAMRYTETRLSPVSFEAMLAQISEDIVDFTDNFDGSQQEPVVLPVQLPILL
CCCCCCCCCCCEEEHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEE
LNGSSGIAVGMATNMPPHNLGEVVDGLIALIDDPEIEDEKLWAVIPAPDFPTGGEIVDLA
EECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCEEEEC
GVRDAYRTGRGIIPMRGIVHLEVLQVGRKRKRDVNALVVTELPYQVNKAAWIEKIADLVN
CCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHC
DGKISGISDIRDESDRQGMRVVIELKRDAEPEKVLKLLYKKTALQSNFGAILLSLVNNQP
CCCCCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
RQLSLKAILQEFLEFREETVTRQYRYELEQKETRQHSVEGLLLALNNLDAVIEILRNAAD
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GTTAKQQFQAALGFSESQSDAILAMPMRRLTGLERQKLEQESTELATEIAKLNKLLSDRH
CCHHHHHHHHHHCCCCCCCCEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLKALKRELRSLKRKFADPRRTRLPDVPSPEPEPVTVEAEPDTPAATPKKKRQSRKKEE
HHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCC
PVLALLPQLTETSHVAIAASGGVYWGNDDAGLLDEEPTIFKAQIGTQKKLIVCTDQGKAF
CHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCEE
PVAIADLPYQEQRDKPQLIDLLPDHALRDDHQPITQFLLPDNLAEYDLLLLTAQGRIKRL
EEEEECCCCHHHCCCCHHHHHCCCHHCCCCCHHHHHHHCCCCCCCCEEEEEECCCCHHCC
PAIELESFTSRGLSLIKLKDKDTLKFACFVKGGEQVAIAVSSGRVLHLPVNDHEIPVMGR
CCHHHHHHHHCCEEEEEECCCCCEEEEEEEECCCEEEEEEECCCEEEEECCCCCCCEEEC
TSQGNQALRLRFNEQIVACVPCQRHNELYLISEEGYGKKLAASSLRLGKRGDMGNHVMRF
CCCCCCEEEEEECCCEEEEECCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCEEEE
ESKTDLLLTLFVPDQQESLLVKDSQENLDLLPFSKFNLTEKDSPGQKLVKLSGGDRLVNC
CCCCCEEEEEEECCCCCCEEEECCCCCCEECCCCCCCCCCCCCCCCEEEEECCCCEEEEE
YLSGS
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Isomerization [C]

Inhibitor: CJ-12, 371; CJ-12, 372; Coumermycin; Doxorubicin; Sitafloxacin [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]