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The map label for this gene is gloB

Identifier: 170078470

GI number: 170078470

Start: 1954591

End: 1955370

Strand: Direct

Name: gloB

Synonym: SYNPCC7002_A1864

Alternate gene names: 170078470

Gene position: 1954591-1955370 (Clockwise)

Preceding gene: 170078469

Following gene: 170078471

Centisome position: 64.98

GC content: 44.49

Gene sequence:

>780_bases
ATGGAAATTATTCGTTTACCAGCTTTTAACGATAACTATATTTTTCTCTTGGTTGATCGAGCTACAGGGGATTGTGCGGT
TGTTGATCCAGGCGACGCTAAGGTTGTTCTGGAGTATCTAAGTAAAGAAGATTTAACGCTTAAGACCATTCTGATTACGC
ACCATCATGCTGACCATGTGGGTGGCAATCGTCAACTATTAAGTCATTTTCCCGCAGCGGCTGTGTATGGTAGCGAGATA
GATTTACAAAAAAGACGTATTCCAGGCCAAACGGTGAGCCTTAAGGCTGGTAATCACTTAGATTTATTTAATCGCACCGT
CGAAATTTTGTTTGTGCCAGGCCATACCCAAGGTCACATCGCCTACTATTTCCCTCCCCTACAGCCCGAAGACAGTGGCG
ATTTATTTTGTGGCGATACGCTGTTTGCCAATGGCTGTGGTCGTCTTTTGGAAGGAACGCCTGCTCAACTTTTTGCCTCG
CTCCAACAAATTTGTGATTTGCCGGACAACACGAATATCTGGTGTGCCCATGAGTACACCCTGAAAAATATTAAATTTTC
CTTGACGGTTGATCCAGAAAATGAGGCTCTTCAGAGACGTTTTCAGCAAGTGCAGACCCAACGACAACGCCAGAAACCGA
CCATTCCAACGGTGTTAGCTTTAGAAAAACAGACAAATCCTTTTTTGCGCTGTAGCGATCGCCAACTGCAAGCTAACTTA
AAGACAACAGATCCCCTGCGAGTTTTTACAAAATTGCGCGGCAAACGGGATCTCTTTTGA

Upstream 100 bases:

>100_bases
GAGTGGGTTTATAAAATTTCCCTCGATTAATGACTCGTTTTTTCGTACAAAATCCCCCTTGTTATGATCAGCATCAGTGA
CTCATGGGGGACATTCCGGC

Downstream 100 bases:

>100_bases
AGTTTAAACTGGTGGCAGCGACTTCCATAAAAAAATTCAACCATACCCCAGGGGAACGATTGTGGATTTGCTAAAACCGT
TTACAGTGAGGATCAATCCC

Product: hydroxyacylglutathione hydrolase

Products: NA

Alternate protein names: Glyoxalase II; Glx II

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MEIIRLPAFNDNYIFLLVDRATGDCAVVDPGDAKVVLEYLSKEDLTLKTILITHHHADHVGGNRQLLSHFPAAAVYGSEI
DLQKRRIPGQTVSLKAGNHLDLFNRTVEILFVPGHTQGHIAYYFPPLQPEDSGDLFCGDTLFANGCGRLLEGTPAQLFAS
LQQICDLPDNTNIWCAHEYTLKNIKFSLTVDPENEALQRRFQQVQTQRQRQKPTIPTVLALEKQTNPFLRCSDRQLQANL
KTTDPLRVFTKLRGKRDLF

Sequences:

>Translated_259_residues
MEIIRLPAFNDNYIFLLVDRATGDCAVVDPGDAKVVLEYLSKEDLTLKTILITHHHADHVGGNRQLLSHFPAAAVYGSEI
DLQKRRIPGQTVSLKAGNHLDLFNRTVEILFVPGHTQGHIAYYFPPLQPEDSGDLFCGDTLFANGCGRLLEGTPAQLFAS
LQQICDLPDNTNIWCAHEYTLKNIKFSLTVDPENEALQRRFQQVQTQRQRQKPTIPTVLALEKQTNPFLRCSDRQLQANL
KTTDPLRVFTKLRGKRDLF
>Mature_259_residues
MEIIRLPAFNDNYIFLLVDRATGDCAVVDPGDAKVVLEYLSKEDLTLKTILITHHHADHVGGNRQLLSHFPAAAVYGSEI
DLQKRRIPGQTVSLKAGNHLDLFNRTVEILFVPGHTQGHIAYYFPPLQPEDSGDLFCGDTLFANGCGRLLEGTPAQLFAS
LQQICDLPDNTNIWCAHEYTLKNIKFSLTVDPENEALQRRFQQVQTQRQRQKPTIPTVLALEKQTNPFLRCSDRQLQANL
KTTDPLRVFTKLRGKRDLF

Specific function: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family

Homologues:

Organism=Homo sapiens, GI94538320, Length=260, Percent_Identity=34.6153846153846, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI94538322, Length=260, Percent_Identity=34.6153846153846, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI116642887, Length=240, Percent_Identity=38.3333333333333, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI21703352, Length=240, Percent_Identity=38.3333333333333, Blast_Score=163, Evalue=1e-40,
Organism=Homo sapiens, GI14150041, Length=259, Percent_Identity=33.2046332046332, Blast_Score=161, Evalue=7e-40,
Organism=Homo sapiens, GI46361987, Length=207, Percent_Identity=34.2995169082126, Blast_Score=137, Evalue=7e-33,
Organism=Escherichia coli, GI1786406, Length=263, Percent_Identity=41.06463878327, Blast_Score=187, Evalue=6e-49,
Organism=Escherichia coli, GI1787158, Length=179, Percent_Identity=30.1675977653631, Blast_Score=69, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536925, Length=254, Percent_Identity=33.8582677165354, Blast_Score=154, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17538952, Length=177, Percent_Identity=28.8135593220339, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320478, Length=272, Percent_Identity=28.3088235294118, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324614, Length=236, Percent_Identity=30.0847457627119, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356335, Length=262, Percent_Identity=39.3129770992366, Blast_Score=204, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24667711, Length=262, Percent_Identity=39.3129770992366, Blast_Score=204, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24667703, Length=262, Percent_Identity=39.3129770992366, Blast_Score=203, Evalue=9e-53,
Organism=Drosophila melanogaster, GI221330176, Length=175, Percent_Identity=30.8571428571429, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLO2_SYNP2 (B1XQ70)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001735108.1
- ProteinModelPortal:   B1XQ70
- SMR:   B1XQ70
- GeneID:   6056270
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A1864
- HOGENOM:   HBG753931
- OMA:   WCAHEYT
- HAMAP:   MF_01374
- InterPro:   IPR001279
- InterPro:   IPR017782
- SMART:   SM00849
- TIGRFAMs:   TIGR03413

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.2.6

Molecular weight: Translated: 29278; Mature: 29278

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIRLPAFNDNYIFLLVDRATGDCAVVDPGDAKVVLEYLSKEDLTLKTILITHHHADHV
CCEEECCCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHHCCCCCEEEEEEEEECCHHHC
GGNRQLLSHFPAAAVYGSEIDLQKRRIPGQTVSLKAGNHLDLFNRTVEILFVPGHTQGHI
CCCHHHHHHCCHHHCCCCCCCHHHHCCCCCEEEEECCCCHHHCCCEEEEEEECCCCCCEE
AYYFPPLQPEDSGDLFCGDTLFANGCGRLLEGTPAQLFASLQQICDLPDNTNIWCAHEYT
EEEECCCCCCCCCCEEECCHHHHCCCCHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEE
LKNIKFSLTVDPENEALQRRFQQVQTQRQRQKPTIPTVLALEKQTNPFLRCSDRQLQANL
EEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEECCCEEEECC
KTTDPLRVFTKLRGKRDLF
CCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEIIRLPAFNDNYIFLLVDRATGDCAVVDPGDAKVVLEYLSKEDLTLKTILITHHHADHV
CCEEECCCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHHCCCCCEEEEEEEEECCHHHC
GGNRQLLSHFPAAAVYGSEIDLQKRRIPGQTVSLKAGNHLDLFNRTVEILFVPGHTQGHI
CCCHHHHHHCCHHHCCCCCCCHHHHCCCCCEEEEECCCCHHHCCCEEEEEEECCCCCCEE
AYYFPPLQPEDSGDLFCGDTLFANGCGRLLEGTPAQLFASLQQICDLPDNTNIWCAHEYT
EEEECCCCCCCCCCEEECCHHHHCCCCHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEE
LKNIKFSLTVDPENEALQRRFQQVQTQRQRQKPTIPTVLALEKQTNPFLRCSDRQLQANL
EEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEECCCEEEECC
KTTDPLRVFTKLRGKRDLF
CCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA