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The map label for this gene is clpP [H]

Identifier: 170078453

GI number: 170078453

Start: 1936507

End: 1937103

Strand: Direct

Name: clpP [H]

Synonym: SYNPCC7002_A1847

Alternate gene names: 170078453

Gene position: 1936507-1937103 (Clockwise)

Preceding gene: 170078452

Following gene: 170078455

Centisome position: 64.38

GC content: 50.75

Gene sequence:

>597_bases
ATGATTCCAACCGTTATCGAAAGTTCTGGTCGGGGCGAACGTGCCTTTGATATTTACTCTCGTCTACTCCGGGAGCGCAT
TGTGTTCCTCGGCACCCAAGTCAACGACGAAATTGCCAATCTCATCGTGGCACAGTTGTTATTCCTCGAAGCCGATGATC
CCGAAAAGGATATTTACCTCTACATCAATTCTCCGGGGGGTTCTGTCTCAGCCGGCATGGGGATCTTCGATACGATGAAC
CAAGTGCGTCCGGATGTTTGTACGATCTGTATTGGTCTAGCGGCCAGTATGGGGGCGTTTCTGCTGAGTGCTGGGGCCAA
AGGGAAGCGCATGAGCTTACCCAACTCCCGGATTATGATCCACCAACCCCTAGGCGGTGCCCAGGGCCAGGCGACGGATA
TTGAAATTCAAGCCAAAGAAATTCTTTATCTCAAAGGCAAGCTCAACCAACACCTGGCTGACCACACAGGCCAACCTTTA
GAAAAGATTGAGATTGATACAGACCGCGATTTCTTCATGTCTGCAGCGGAGGCGAAGGATTATGGCCTCATTGATCAGGT
CATTGAGAGAAGTCCTTCGGCCACAAATCCAGCTTAG

Upstream 100 bases:

>100_bases
CGAAAAAGTGATTTTCAGCTAGCCGAAACGCCACCGCTGCCAACTGAATCCATTACAATCAAACAAATAAGACATAAACA
ACAACGAGCTTACAGACCCC

Downstream 100 bases:

>100_bases
ATTTTTTTCTGTTGTGAATGATTGATCGTCCTCCTATTCCTAGGGGGATTTTTTTATGGTTGAGGCTTGCAACCTGTGGC
GCGATAAATGGTCAGGGTAA

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MIPTVIESSGRGERAFDIYSRLLRERIVFLGTQVNDEIANLIVAQLLFLEADDPEKDIYLYINSPGGSVSAGMGIFDTMN
QVRPDVCTICIGLAASMGAFLLSAGAKGKRMSLPNSRIMIHQPLGGAQGQATDIEIQAKEILYLKGKLNQHLADHTGQPL
EKIEIDTDRDFFMSAAEAKDYGLIDQVIERSPSATNPA

Sequences:

>Translated_198_residues
MIPTVIESSGRGERAFDIYSRLLRERIVFLGTQVNDEIANLIVAQLLFLEADDPEKDIYLYINSPGGSVSAGMGIFDTMN
QVRPDVCTICIGLAASMGAFLLSAGAKGKRMSLPNSRIMIHQPLGGAQGQATDIEIQAKEILYLKGKLNQHLADHTGQPL
EKIEIDTDRDFFMSAAEAKDYGLIDQVIERSPSATNPA
>Mature_198_residues
MIPTVIESSGRGERAFDIYSRLLRERIVFLGTQVNDEIANLIVAQLLFLEADDPEKDIYLYINSPGGSVSAGMGIFDTMN
QVRPDVCTICIGLAASMGAFLLSAGAKGKRMSLPNSRIMIHQPLGGAQGQATDIEIQAKEILYLKGKLNQHLADHTGQPL
EKIEIDTDRDFFMSAAEAKDYGLIDQVIERSPSATNPA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=56.25, Blast_Score=230, Evalue=5e-61,
Organism=Escherichia coli, GI1786641, Length=188, Percent_Identity=69.1489361702128, Blast_Score=283, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=56.4516129032258, Blast_Score=214, Evalue=3e-56,
Organism=Drosophila melanogaster, GI20129427, Length=201, Percent_Identity=53.7313432835821, Blast_Score=223, Evalue=7e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21570; Mature: 21570

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPTVIESSGRGERAFDIYSRLLRERIVFLGTQVNDEIANLIVAQLLFLEADDPEKDIYL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEE
YINSPGGSVSAGMGIFDTMNQVRPDVCTICIGLAASMGAFLLSAGAKGKRMSLPNSRIMI
EEECCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEE
HQPLGGAQGQATDIEIQAKEILYLKGKLNQHLADHTGQPLEKIEIDTDRDFFMSAAEAKD
ECCCCCCCCCCCEEEEEHEEEEEEECHHHHHHHHCCCCCHHEEECCCCHHHHHHHHCCCC
YGLIDQVIERSPSATNPA
CHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIPTVIESSGRGERAFDIYSRLLRERIVFLGTQVNDEIANLIVAQLLFLEADDPEKDIYL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEE
YINSPGGSVSAGMGIFDTMNQVRPDVCTICIGLAASMGAFLLSAGAKGKRMSLPNSRIMI
EEECCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEE
HQPLGGAQGQATDIEIQAKEILYLKGKLNQHLADHTGQPLEKIEIDTDRDFFMSAAEAKD
ECCCCCCCCCCCEEEEEHEEEEEEECHHHHHHHHCCCCCHHEEECCCCHHHHHHHHCCCC
YGLIDQVIERSPSATNPA
CHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]