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The map label for this gene is mutM [H]

Identifier: 170078422

GI number: 170078422

Start: 1904620

End: 1905453

Strand: Reverse

Name: mutM [H]

Synonym: SYNPCC7002_A1816

Alternate gene names: 170078422

Gene position: 1905453-1904620 (Counterclockwise)

Preceding gene: 170078423

Following gene: 170078420

Centisome position: 63.35

GC content: 49.64

Gene sequence:

>834_bases
ATGCCAGAACTACCAGAGGTGGAAACCGTTCGTCGCGGTTTAATGCAAATTAGTCTAAATCAGCAGTTTACAGGAGCAGA
AATTCTCCTCCGGAAGACCCTGGCCTATCCCACAGATCCCGATCACTTTTTAGGGATGATCCAAGGCCTGTTCATTCAAG
ATTGGCAGCGACGCGGCAAGTACTTACTCGGAAAATTATCGGATGGCTCAACCCTTGGGATTCACCTGCGGATGACAGGG
AAATTTCTCTGGACAACCCCGGATGTGCCTGTGCAAAAACATACTCGGATACGCTTTTTCATAGAAGGCGATCGCGAACT
GAGATTTGTTGACCTGCGCACCTTTGGACAAATTTGGTGGGTACCAGCGGGAACCATTGTGAAATCTGTAATTACGGGAT
TGACACGCTTGGGTGTGGAACCGCTTTCCCCAGATTTTACGGCTGATCTGTTGGCCAATTTCTGCGAAAAGCGCCAGCGG
CCAATGAAAACGTTTTTGCTTGACCAAAGCATTATCACTGGCTTGGGAAATATCTATGCTGACGAAGCACTGTTTAAATC
GGGCATCCATCCCACCCGCAAGGCCAGCAGTTTAAAGATGTCAGAAATCGAGAAGCTCCATAAAGCAATTGTCGAAGTGC
TGGAAACTTCTATTGCCCAAGGCGGCACCACCTTTAGCGATTTTGTCAGCACCACGGGCACCAACGGTAACTATGGCGGC
ATGGCTCTCACCTACGGGCGCACAGGTGAACCTTGTCGTGTTTGCAGTCATCCCATCGAACGGATCAAACTCGGCGGACG
ATCAACCCATTTCTGTCCCCAATGCCAGAGCTAA

Upstream 100 bases:

>100_bases
AGAATTAATTCTTCATTCAGTAACGCGAGGCTCGTCCAAGTTGCTCCATCCCTGAAAAACTGCTTCAATCTGCAAAGGCG
ATAGTAAGTTAGGGGAATCC

Downstream 100 bases:

>100_bases
TATTTTTGTTTGGTTAATCTTTGGCTTGGATGATGTAGCCGCACTGGTGTTCCCCTTCGTTGATCCACTGGGTGCGAGTC
ACAGTGCAGTCGGGCAAAAC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MPELPEVETVRRGLMQISLNQQFTGAEILLRKTLAYPTDPDHFLGMIQGLFIQDWQRRGKYLLGKLSDGSTLGIHLRMTG
KFLWTTPDVPVQKHTRIRFFIEGDRELRFVDLRTFGQIWWVPAGTIVKSVITGLTRLGVEPLSPDFTADLLANFCEKRQR
PMKTFLLDQSIITGLGNIYADEALFKSGIHPTRKASSLKMSEIEKLHKAIVEVLETSIAQGGTTFSDFVSTTGTNGNYGG
MALTYGRTGEPCRVCSHPIERIKLGGRSTHFCPQCQS

Sequences:

>Translated_277_residues
MPELPEVETVRRGLMQISLNQQFTGAEILLRKTLAYPTDPDHFLGMIQGLFIQDWQRRGKYLLGKLSDGSTLGIHLRMTG
KFLWTTPDVPVQKHTRIRFFIEGDRELRFVDLRTFGQIWWVPAGTIVKSVITGLTRLGVEPLSPDFTADLLANFCEKRQR
PMKTFLLDQSIITGLGNIYADEALFKSGIHPTRKASSLKMSEIEKLHKAIVEVLETSIAQGGTTFSDFVSTTGTNGNYGG
MALTYGRTGEPCRVCSHPIERIKLGGRSTHFCPQCQS
>Mature_276_residues
PELPEVETVRRGLMQISLNQQFTGAEILLRKTLAYPTDPDHFLGMIQGLFIQDWQRRGKYLLGKLSDGSTLGIHLRMTGK
FLWTTPDVPVQKHTRIRFFIEGDRELRFVDLRTFGQIWWVPAGTIVKSVITGLTRLGVEPLSPDFTADLLANFCEKRQRP
MKTFLLDQSIITGLGNIYADEALFKSGIHPTRKASSLKMSEIEKLHKAIVEVLETSIAQGGTTFSDFVSTTGTNGNYGGM
ALTYGRTGEPCRVCSHPIERIKLGGRSTHFCPQCQS

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=280, Percent_Identity=41.0714285714286, Blast_Score=190, Evalue=9e-50,
Organism=Escherichia coli, GI1786932, Length=288, Percent_Identity=25, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 31034; Mature: 30903

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRGLMQISLNQQFTGAEILLRKTLAYPTDPDHFLGMIQGLFIQDWQRRGK
CCCCCCHHHHHHHHHEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
YLLGKLSDGSTLGIHLRMTGKFLWTTPDVPVQKHTRIRFFIEGDRELRFVDLRTFGQIWW
EEEEECCCCCEEEEEEEEECEEEEECCCCCCCCCCEEEEEEECCCEEEEEEEECCCCEEE
VPAGTIVKSVITGLTRLGVEPLSPDFTADLLANFCEKRQRPMKTFLLDQSIITGLGNIYA
CCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
DEALFKSGIHPTRKASSLKMSEIEKLHKAIVEVLETSIAQGGTTFSDFVSTTGTNGNYGG
HHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC
MALTYGRTGEPCRVCSHPIERIKLGGRSTHFCPQCQS
EEEEECCCCCCHHHHHCHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVRRGLMQISLNQQFTGAEILLRKTLAYPTDPDHFLGMIQGLFIQDWQRRGK
CCCCCHHHHHHHHHEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
YLLGKLSDGSTLGIHLRMTGKFLWTTPDVPVQKHTRIRFFIEGDRELRFVDLRTFGQIWW
EEEEECCCCCEEEEEEEEECEEEEECCCCCCCCCCEEEEEEECCCEEEEEEEECCCCEEE
VPAGTIVKSVITGLTRLGVEPLSPDFTADLLANFCEKRQRPMKTFLLDQSIITGLGNIYA
CCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
DEALFKSGIHPTRKASSLKMSEIEKLHKAIVEVLETSIAQGGTTFSDFVSTTGTNGNYGG
HHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC
MALTYGRTGEPCRVCSHPIERIKLGGRSTHFCPQCQS
EEEEECCCCCCHHHHHCHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]