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The map label for this gene is hemB [H]

Identifier: 170078360

GI number: 170078360

Start: 1838504

End: 1839487

Strand: Reverse

Name: hemB [H]

Synonym: SYNPCC7002_A1753

Alternate gene names: 170078360

Gene position: 1839487-1838504 (Counterclockwise)

Preceding gene: 170078362

Following gene: 170078357

Centisome position: 61.15

GC content: 52.85

Gene sequence:

>984_bases
ATGTTCCCTTCTAGCCGCCCCCGTCGCCTTCGCCAAAGTGAGTCGCTTCGCCGCATGGTGCGGGAAAATACCTTTACGGC
CAATGATTTGATCTATCCCCTCTTTGCAGTGCCCGGAGAGGCGATCGCCAATGAAGTAAAGTCGATGCCCGGTGTTTATC
AACTGTCCATCGATAAGATCGTCACCGAGGCCAAGGAAGTTTGGGAACTGGGCATTCCGGCGGTGATTTTGTTTGGCATT
CCCCCCGAAAAAGATAACGATGCAACCGGAGCCTGGCACGATTGCGGCATTGTCCAAAAGGCAACCACGGCGATCAAGGA
AGCAATTCCTGAAATGACAGTCATTAATGACACTTGTCTGTGTGAATATACGCCCCACGGTCACTGCGGTTACCTGCAAA
CCGGAGACTTAACCGGACGCGTCTTAAATGATCCCACCCTTGAACTGCTGAAAAAAACCGCTGTATCCCAGGCCAAAGCT
GGCGCGGATATTATCGCGCCTTCGGGGATGATGGATGGTTTCGTCGCCGCGATTCGTGAAGGTTTAGATGAAGCTGGTTT
TACGAATATTCCGATCATGGGCTATTCCGCAAAATATGCCTCGGCTTACTATGGCCCCTTTCGGGATGTGGCCGAATCTG
CTCCCCAATTTGGCGATCGCCGCACCTACCAAATGGATCCGGGTAATGGCCGCGAAGCCCTCAAGGAAGTGGAACTCGAC
ATCCTCGAAGGGGTAGATTTCGTCATGGTCAAACCGGCCCTCGCCTACATGGACATCATTTGGCGGGTCAAGGAAATGAC
CAACCTGCCCGTCGCCGCCTACAACGTGTCTGGAGAATATTCCATGGTCAAAGCCGCCGCCTTAAACGGTTGGATTGACG
AGAAAAAAGTCGTCCTCGAAACCCTCACGAGCTTTAAACGGGCGGGCGCAGATTTGATTCTCACCTACCACGCTAAAGAC
GCTGTGCGCTGGTTAGCAGAGTAA

Upstream 100 bases:

>100_bases
TGCTAATCATTGAGGACTGTTACGTTTCAGTAAAGGAAAGGGAGCGATCGCCTAAACTATTCAGAAGCAATTTTTCATCT
GGATTTTATTTTTGCCAACT

Downstream 100 bases:

>100_bases
ATTTTGGCCTGGGACATATTTCCCCGAACCAACAAATGAATGAATCATGGGGACGCTTGTGAGTTGTCCCCTTTTTTGTG
ATCAAAGAAAGCCCCGTACA

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MFPSSRPRRLRQSESLRRMVRENTFTANDLIYPLFAVPGEAIANEVKSMPGVYQLSIDKIVTEAKEVWELGIPAVILFGI
PPEKDNDATGAWHDCGIVQKATTAIKEAIPEMTVINDTCLCEYTPHGHCGYLQTGDLTGRVLNDPTLELLKKTAVSQAKA
GADIIAPSGMMDGFVAAIREGLDEAGFTNIPIMGYSAKYASAYYGPFRDVAESAPQFGDRRTYQMDPGNGREALKEVELD
ILEGVDFVMVKPALAYMDIIWRVKEMTNLPVAAYNVSGEYSMVKAAALNGWIDEKKVVLETLTSFKRAGADLILTYHAKD
AVRWLAE

Sequences:

>Translated_327_residues
MFPSSRPRRLRQSESLRRMVRENTFTANDLIYPLFAVPGEAIANEVKSMPGVYQLSIDKIVTEAKEVWELGIPAVILFGI
PPEKDNDATGAWHDCGIVQKATTAIKEAIPEMTVINDTCLCEYTPHGHCGYLQTGDLTGRVLNDPTLELLKKTAVSQAKA
GADIIAPSGMMDGFVAAIREGLDEAGFTNIPIMGYSAKYASAYYGPFRDVAESAPQFGDRRTYQMDPGNGREALKEVELD
ILEGVDFVMVKPALAYMDIIWRVKEMTNLPVAAYNVSGEYSMVKAAALNGWIDEKKVVLETLTSFKRAGADLILTYHAKD
AVRWLAE
>Mature_327_residues
MFPSSRPRRLRQSESLRRMVRENTFTANDLIYPLFAVPGEAIANEVKSMPGVYQLSIDKIVTEAKEVWELGIPAVILFGI
PPEKDNDATGAWHDCGIVQKATTAIKEAIPEMTVINDTCLCEYTPHGHCGYLQTGDLTGRVLNDPTLELLKKTAVSQAKA
GADIIAPSGMMDGFVAAIREGLDEAGFTNIPIMGYSAKYASAYYGPFRDVAESAPQFGDRRTYQMDPGNGREALKEVELD
ILEGVDFVMVKPALAYMDIIWRVKEMTNLPVAAYNVSGEYSMVKAAALNGWIDEKKVVLETLTSFKRAGADLILTYHAKD
AVRWLAE

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=309, Percent_Identity=40.7766990291262, Blast_Score=243, Evalue=1e-64,
Organism=Escherichia coli, GI87081728, Length=315, Percent_Identity=51.1111111111111, Blast_Score=302, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6321398, Length=317, Percent_Identity=40.0630914826498, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI21358291, Length=310, Percent_Identity=38.0645161290323, Blast_Score=223, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36022; Mature: 36022

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPSSRPRRLRQSESLRRMVRENTFTANDLIYPLFAVPGEAIANEVKSMPGVYQLSIDKI
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHCCCEEEEHHHHH
VTEAKEVWELGIPAVILFGIPPEKDNDATGAWHDCGIVQKATTAIKEAIPEMTVINDTCL
HHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHCCHHHHHHHHHHHHCCCEEEECCCEE
CEYTPHGHCGYLQTGDLTGRVLNDPTLELLKKTAVSQAKAGADIIAPSGMMDGFVAAIRE
EEECCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHH
GLDEAGFTNIPIMGYSAKYASAYYGPFRDVAESAPQFGDRRTYQMDPGNGREALKEVELD
HHHHCCCCCCCEECCCCHHHHHHCCHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHH
ILEGVDFVMVKPALAYMDIIWRVKEMTNLPVAAYNVSGEYSMVKAAALNGWIDEKKVVLE
HHCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHH
TLTSFKRAGADLILTYHAKDAVRWLAE
HHHHHHHCCCCEEEEECHHHHHHHHCC
>Mature Secondary Structure
MFPSSRPRRLRQSESLRRMVRENTFTANDLIYPLFAVPGEAIANEVKSMPGVYQLSIDKI
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHCCCEEEEHHHHH
VTEAKEVWELGIPAVILFGIPPEKDNDATGAWHDCGIVQKATTAIKEAIPEMTVINDTCL
HHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHCCHHHHHHHHHHHHCCCEEEECCCEE
CEYTPHGHCGYLQTGDLTGRVLNDPTLELLKKTAVSQAKAGADIIAPSGMMDGFVAAIRE
EEECCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHH
GLDEAGFTNIPIMGYSAKYASAYYGPFRDVAESAPQFGDRRTYQMDPGNGREALKEVELD
HHHHCCCCCCCEECCCCHHHHHHCCHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHH
ILEGVDFVMVKPALAYMDIIWRVKEMTNLPVAAYNVSGEYSMVKAAALNGWIDEKKVVLE
HHCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHH
TLTSFKRAGADLILTYHAKDAVRWLAE
HHHHHHHCCCCEEEEECHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]