| Definition | Synechococcus sp. PCC 7002 chromosome, complete genome. |
|---|---|
| Accession | NC_010475 |
| Length | 3,008,047 |
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The map label for this gene is purH [H]
Identifier: 170078298
GI number: 170078298
Start: 1774136
End: 1775686
Strand: Direct
Name: purH [H]
Synonym: SYNPCC7002_A1691
Alternate gene names: 170078298
Gene position: 1774136-1775686 (Clockwise)
Preceding gene: 170078297
Following gene: 170078300
Centisome position: 58.98
GC content: 53.84
Gene sequence:
>1551_bases ATGGCACGTCGTTTAGCACTATTGAGCGTCTCAGACAAAACTGGCATCGTCGAATTTGCCCGACAACTCGTAGAAGAATT TGAATTTGACATCATCAGTAGCGGCGGCACCGCCAAAGCCCTCAAGGATGCAGGCGTCCCCGTCACCAAAGTCAGCGATT ACACCGGTTCCCCAGAAATCCTCGGTGGCCGTGTGAAAACTCTCCATCCCAAGATCCACGGGGGCATCCTCGCTCGTCAG GACTTCCCCGAACATTTACAAGACTTAGACGACAATAATATTCGGCCCCTCAGCCTCGTCGCGGTTAACCTTTATCCCTT CGAGCAGACCATTGCCAAAGCGGGTGTAACTGTTCCCGAAGCCGTTGAACAAATTGATATCGGTGGCCCCGCAATGCTCC GGGCAGCGGCGAAAAACTTTGGGAGCCTTACGGTCATTTCTAATCCCCGCTATTACGACGAATATTTAACGGAACTGCGC AATAACAGCGGCACTGCCACGATTGAATTTCGGCAACGCATGGCCGGGGAAACCTTTGCCCTCACCTGTGCCTATGACCA GGCCATTTCCAGTTATTTTGCTAGCACGGTGAATGCTGAAGCTGACTTACCCCAACGCTTAGGGCTCAGCGGGGAAGCCG TCCAAACCCTCCGTTACGGCGAAAACCCCCACCAAAAGGCCACTTGGTACAAGACCGGCACCCAAGTTAGTGGTTGGGCC GCCGCTGAAAAACTCCAGGGCAAGGAACTTAGTTACAACAACCTCGTGGATCTCGAAGCGGCACGACGGATCATTGCCGA ATTTCCCGATGGGGATCCTGCTGTGGCCATTCTCAAGCACACCAATCCCTGTGGTGTCGCCCTGGGTTCAACGTTACAAG AAGCTTACGAAAAAGCCTTTGCCGCCGATTCTGTGTCTGCCTTTGGCGGTATTGTCGCCCTAAATAAACCCCTTGATGGC CCCACCGCTGAAGCCATGGGGAAAGTCTTTTTAGAATGTGTGGTTGCCCCCGACTGTACCCCCGAAGCCAGGGAAATCAT TGCGAAGAAGAAAAATCTGCGGGTTTTAACCCTCTCCGATCTGCTCACTGGCCCGACCCAAACCCTAAAGGCGATCGCCG GGGGTTTTTTGGCCCAGGATGCCGATACCCAGATTGAAGACCCCAAGGATTGGCAGTGCGTCACGGAGAAGCAACCCAGT GAAGCGGATCTTGCGGAATTATTCTTCGCCTGGAAGCTCTGCAAGCACGTTAAATCCAACGCAATTCTCGTTTCCAAGGA TCGGGCCACCGTCGGTGTGGGTGCTGGTCAGATGAACCGAGTCGGTGCCGCAAAAATTGCCTTTGAACAGGCGGGAGAAA AAGCCCAAGGAGCATATCTTGCGAGTGATGCCTTCTTCCCCTTCGATGACTCTGTGCGCAGTGCGGCCGCAGCAGGGATT AAGGCGATCGTTCAACCGGGTGGTTCCATTCGGGACGAAGATTCGATCAAGGCAGCCAATGAATTGGGCCTAATCATGAT GTTCACGGGTTCCCGCCATTTCCTCCACTAG
Upstream 100 bases:
>100_bases GGCTGTTAATCCTTCCTGACAGATGCCCCCGTAATCGTTTGAAGAAAGTTTAGGCGATCGCGTATGATGGGACGCTGGTT CACATAAGGAAATCGCGGAT
Downstream 100 bases:
>100_bases GATTTCTTTTTGAAATGAAGCGAGAAGGTGTGTTGTAGAAATTGCGATGCACCTTTTTTGCTGTCTATTTGATCAGTTCT ACGGCATCACGGCCATCCAA
Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
Products: NA
Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]
Number of amino acids: Translated: 516; Mature: 515
Protein sequence:
>516_residues MARRLALLSVSDKTGIVEFARQLVEEFEFDIISSGGTAKALKDAGVPVTKVSDYTGSPEILGGRVKTLHPKIHGGILARQ DFPEHLQDLDDNNIRPLSLVAVNLYPFEQTIAKAGVTVPEAVEQIDIGGPAMLRAAAKNFGSLTVISNPRYYDEYLTELR NNSGTATIEFRQRMAGETFALTCAYDQAISSYFASTVNAEADLPQRLGLSGEAVQTLRYGENPHQKATWYKTGTQVSGWA AAEKLQGKELSYNNLVDLEAARRIIAEFPDGDPAVAILKHTNPCGVALGSTLQEAYEKAFAADSVSAFGGIVALNKPLDG PTAEAMGKVFLECVVAPDCTPEAREIIAKKKNLRVLTLSDLLTGPTQTLKAIAGGFLAQDADTQIEDPKDWQCVTEKQPS EADLAELFFAWKLCKHVKSNAILVSKDRATVGVGAGQMNRVGAAKIAFEQAGEKAQGAYLASDAFFPFDDSVRSAAAAGI KAIVQPGGSIRDEDSIKAANELGLIMMFTGSRHFLH
Sequences:
>Translated_516_residues MARRLALLSVSDKTGIVEFARQLVEEFEFDIISSGGTAKALKDAGVPVTKVSDYTGSPEILGGRVKTLHPKIHGGILARQ DFPEHLQDLDDNNIRPLSLVAVNLYPFEQTIAKAGVTVPEAVEQIDIGGPAMLRAAAKNFGSLTVISNPRYYDEYLTELR NNSGTATIEFRQRMAGETFALTCAYDQAISSYFASTVNAEADLPQRLGLSGEAVQTLRYGENPHQKATWYKTGTQVSGWA AAEKLQGKELSYNNLVDLEAARRIIAEFPDGDPAVAILKHTNPCGVALGSTLQEAYEKAFAADSVSAFGGIVALNKPLDG PTAEAMGKVFLECVVAPDCTPEAREIIAKKKNLRVLTLSDLLTGPTQTLKAIAGGFLAQDADTQIEDPKDWQCVTEKQPS EADLAELFFAWKLCKHVKSNAILVSKDRATVGVGAGQMNRVGAAKIAFEQAGEKAQGAYLASDAFFPFDDSVRSAAAAGI KAIVQPGGSIRDEDSIKAANELGLIMMFTGSRHFLH >Mature_515_residues ARRLALLSVSDKTGIVEFARQLVEEFEFDIISSGGTAKALKDAGVPVTKVSDYTGSPEILGGRVKTLHPKIHGGILARQD FPEHLQDLDDNNIRPLSLVAVNLYPFEQTIAKAGVTVPEAVEQIDIGGPAMLRAAAKNFGSLTVISNPRYYDEYLTELRN NSGTATIEFRQRMAGETFALTCAYDQAISSYFASTVNAEADLPQRLGLSGEAVQTLRYGENPHQKATWYKTGTQVSGWAA AEKLQGKELSYNNLVDLEAARRIIAEFPDGDPAVAILKHTNPCGVALGSTLQEAYEKAFAADSVSAFGGIVALNKPLDGP TAEAMGKVFLECVVAPDCTPEAREIIAKKKNLRVLTLSDLLTGPTQTLKAIAGGFLAQDADTQIEDPKDWQCVTEKQPSE ADLAELFFAWKLCKHVKSNAILVSKDRATVGVGAGQMNRVGAAKIAFEQAGEKAQGAYLASDAFFPFDDSVRSAAAAGIK AIVQPGGSIRDEDSIKAANELGLIMMFTGSRHFLH
Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]
COG id: COG0138
COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the purH family [H]
Homologues:
Organism=Homo sapiens, GI20127454, Length=488, Percent_Identity=37.5, Blast_Score=270, Evalue=3e-72, Organism=Escherichia coli, GI1790439, Length=527, Percent_Identity=45.9203036053131, Blast_Score=457, Evalue=1e-129, Organism=Caenorhabditis elegans, GI71985564, Length=490, Percent_Identity=35.1020408163265, Blast_Score=241, Evalue=4e-64, Organism=Caenorhabditis elegans, GI71985574, Length=317, Percent_Identity=26.1829652996845, Blast_Score=84, Evalue=2e-16, Organism=Saccharomyces cerevisiae, GI6323768, Length=473, Percent_Identity=36.7864693446089, Blast_Score=270, Evalue=3e-73, Organism=Saccharomyces cerevisiae, GI6323056, Length=487, Percent_Identity=35.7289527720739, Blast_Score=251, Evalue=2e-67, Organism=Drosophila melanogaster, GI24649832, Length=484, Percent_Identity=36.5702479338843, Blast_Score=249, Evalue=4e-66,
Paralogues:
None
Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002695 - InterPro: IPR013982 - InterPro: IPR016193 - InterPro: IPR011607 [H]
Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]
EC number: =2.1.2.3; =3.5.4.10 [H]
Molecular weight: Translated: 55398; Mature: 55267
Theoretical pI: Translated: 5.16; Mature: 5.16
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MARRLALLSVSDKTGIVEFARQLVEEFEFDIISSGGTAKALKDAGVPVTKVSDYTGSPEI CCCEEEEEEECCCCCHHHHHHHHHHHHCCEEECCCCCHHHHHHCCCCEEEECCCCCCCHH LGGRVKTLHPKIHGGILARQDFPEHLQDLDDNNIRPLSLVAVNLYPFEQTIAKAGVTVPE CCCCEEEECCHHHCCEEECCCCHHHHHCCCCCCCCEEEEEEEEECCHHHHHHHCCCCHHH AVEQIDIGGPAMLRAAAKNFGSLTVISNPRYYDEYLTELRNNSGTATIEFRQRMAGETFA HHHHHCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEEHHHHCCCEEE LTCAYDQAISSYFASTVNAEADLPQRLGLSGEAVQTLRYGENPHQKATWYKTGTQVSGWA EEEHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCHH AAEKLQGKELSYNNLVDLEAARRIIAEFPDGDPAVAILKHTNPCGVALGSTLQEAYEKAF HHHHHCCCCCCCCCEECHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH AADSVSAFGGIVALNKPLDGPTAEAMGKVFLECVVAPDCTPEAREIIAKKKNLRVLTLSD HHCCHHHHCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEHHH LLTGPTQTLKAIAGGFLAQDADTQIEDPKDWQCVTEKQPSEADLAELFFAWKLCKHVKSN HHCCHHHHHHHHHCCHHCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCC AILVSKDRATVGVGAGQMNRVGAAKIAFEQAGEKAQGAYLASDAFFPFDDSVRSAAAAGI EEEEECCCCEEEECCCCCCCCCHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHH KAIVQPGGSIRDEDSIKAANELGLIMMFTGSRHFLH HHHHCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCC >Mature Secondary Structure ARRLALLSVSDKTGIVEFARQLVEEFEFDIISSGGTAKALKDAGVPVTKVSDYTGSPEI CCEEEEEEECCCCCHHHHHHHHHHHHCCEEECCCCCHHHHHHCCCCEEEECCCCCCCHH LGGRVKTLHPKIHGGILARQDFPEHLQDLDDNNIRPLSLVAVNLYPFEQTIAKAGVTVPE CCCCEEEECCHHHCCEEECCCCHHHHHCCCCCCCCEEEEEEEEECCHHHHHHHCCCCHHH AVEQIDIGGPAMLRAAAKNFGSLTVISNPRYYDEYLTELRNNSGTATIEFRQRMAGETFA HHHHHCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEEHHHHCCCEEE LTCAYDQAISSYFASTVNAEADLPQRLGLSGEAVQTLRYGENPHQKATWYKTGTQVSGWA EEEHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCHH AAEKLQGKELSYNNLVDLEAARRIIAEFPDGDPAVAILKHTNPCGVALGSTLQEAYEKAF HHHHHCCCCCCCCCEECHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH AADSVSAFGGIVALNKPLDGPTAEAMGKVFLECVVAPDCTPEAREIIAKKKNLRVLTLSD HHCCHHHHCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEHHH LLTGPTQTLKAIAGGFLAQDADTQIEDPKDWQCVTEKQPSEADLAELFFAWKLCKHVKSN HHCCHHHHHHHHHCCHHCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCC AILVSKDRATVGVGAGQMNRVGAAKIAFEQAGEKAQGAYLASDAFFPFDDSVRSAAAAGI EEEEECCCCEEEECCCCCCCCCHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHH KAIVQPGGSIRDEDSIKAANELGLIMMFTGSRHFLH HHHHCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA