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The map label for this gene is hemC [H]

Identifier: 170078218

GI number: 170078218

Start: 1690751

End: 1691716

Strand: Direct

Name: hemC [H]

Synonym: SYNPCC7002_A1610

Alternate gene names: 170078218

Gene position: 1690751-1691716 (Clockwise)

Preceding gene: 170078217

Following gene: 170078219

Centisome position: 56.21

GC content: 53.52

Gene sequence:

>966_bases
ATGACCGCTGAGACCCCTTCGAAACGCACTGTGCGGATTGGCTCCCGCAAAAGCCAACTTGCTTTAGTCCAAACCTATTG
GGTACGGGATGAGCTCCAAAAGGCTTACCCAGAGATCACCTTTGAAGTCCAAACCATGGAAACCCAAGGGGATAAGGTGC
TGGATGTGGCCCTCTCGAAAATTGGCGATAAGGGGCTATTTACCCAAGAACTCGAAGACGGCATGCTCAAGGGAGAGACA
GATTTTGCGGTGCATTCCCTGAAGGATTTGCCCACGAATTTGCCTGAGGGGTTGATGCTCGGCTGTGTCACGGAACGGGT
TGACCCGGCGGATGCCCTGGTGGTTAACGAAAAGCATCGGGATAAAAAGCTAGAAACCCTCCCAAGCGGTTCGGTGATTG
GCACTTCTTCGCTACGGCGTCTGGCTCAACTGCGGCACCACTTCCCCCATTTGGAATTTAAAGATATTCGCGGCAATGTG
AATACGCGCCTAGCGAAGTTAGACCGGGGTGAGTATGATGCGATTATTTTGGCGGCGGCGGGTCTGCAACGGCTTGATTT
TGGCGATCGCATCCACCAGATTATTTCCAGCGATATTTCCCTCCATGCCGTGGGCCAAGGGGCCTTGGGTATCGAATGCC
GGGATGGGGATGAAGAGATTTTGGGTCTGTTACGGCCTGTACTCGAACACGCCGAGAGCCGCGATCGCTGTTATGCAGAA
CGCTCTTTCCTGCGTCAGTTAGAGGGGGGCTGCCAAGTACCGATTGGGGTCAACACAACCATTGAAGGTGATCGCCTAAC
CTTAGTGGGGATGGTTGCGAGCCTTGATGGCCAAACCTTAATCCGCGATGAGGTCAGTGGTAGCCGTGCCGATGCCGAGA
AATTGGGCATTGAATTAGCCCAAAAGGCGATCGCCCAGGGAGCAGACAAGATTTTGGCTGAAATTAATGAGGCGAACCGC
GCCTAA

Upstream 100 bases:

>100_bases
TCCGGTTGTTCTCAGAAAAAATTCTGCGATTAGGGACGGACAACGCGATACCCTAGTTTGAGTCAAAATTTTAAGATCAT
TTTTATAAATCCGAATTGAT

Downstream 100 bases:

>100_bases
TTCCGTAGTTGAGTGATCAATTGCCCCCTCCTCCAGGCGAGGGGGGATTTTTATTACAGCTTTATAACTGGGGTTCTGGT
CGATCGGCGGGAATTTCTGG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MTAETPSKRTVRIGSRKSQLALVQTYWVRDELQKAYPEITFEVQTMETQGDKVLDVALSKIGDKGLFTQELEDGMLKGET
DFAVHSLKDLPTNLPEGLMLGCVTERVDPADALVVNEKHRDKKLETLPSGSVIGTSSLRRLAQLRHHFPHLEFKDIRGNV
NTRLAKLDRGEYDAIILAAAGLQRLDFGDRIHQIISSDISLHAVGQGALGIECRDGDEEILGLLRPVLEHAESRDRCYAE
RSFLRQLEGGCQVPIGVNTTIEGDRLTLVGMVASLDGQTLIRDEVSGSRADAEKLGIELAQKAIAQGADKILAEINEANR
A

Sequences:

>Translated_321_residues
MTAETPSKRTVRIGSRKSQLALVQTYWVRDELQKAYPEITFEVQTMETQGDKVLDVALSKIGDKGLFTQELEDGMLKGET
DFAVHSLKDLPTNLPEGLMLGCVTERVDPADALVVNEKHRDKKLETLPSGSVIGTSSLRRLAQLRHHFPHLEFKDIRGNV
NTRLAKLDRGEYDAIILAAAGLQRLDFGDRIHQIISSDISLHAVGQGALGIECRDGDEEILGLLRPVLEHAESRDRCYAE
RSFLRQLEGGCQVPIGVNTTIEGDRLTLVGMVASLDGQTLIRDEVSGSRADAEKLGIELAQKAIAQGADKILAEINEANR
A
>Mature_320_residues
TAETPSKRTVRIGSRKSQLALVQTYWVRDELQKAYPEITFEVQTMETQGDKVLDVALSKIGDKGLFTQELEDGMLKGETD
FAVHSLKDLPTNLPEGLMLGCVTERVDPADALVVNEKHRDKKLETLPSGSVIGTSSLRRLAQLRHHFPHLEFKDIRGNVN
TRLAKLDRGEYDAIILAAAGLQRLDFGDRIHQIISSDISLHAVGQGALGIECRDGDEEILGLLRPVLEHAESRDRCYAER
SFLRQLEGGCQVPIGVNTTIEGDRLTLVGMVASLDGQTLIRDEVSGSRADAEKLGIELAQKAIAQGADKILAEINEANRA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=352, Percent_Identity=47.7272727272727, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI66933009, Length=343, Percent_Identity=47.8134110787172, Blast_Score=295, Evalue=4e-80,
Organism=Escherichia coli, GI48994974, Length=306, Percent_Identity=48.0392156862745, Blast_Score=270, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6319996, Length=319, Percent_Identity=43.8871473354232, Blast_Score=249, Evalue=6e-67,
Organism=Drosophila melanogaster, GI20130425, Length=290, Percent_Identity=49.6551724137931, Blast_Score=275, Evalue=3e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35285; Mature: 35153

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAETPSKRTVRIGSRKSQLALVQTYWVRDELQKAYPEITFEVQTMETQGDKVLDVALSK
CCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHH
IGDKGLFTQELEDGMLKGETDFAVHSLKDLPTNLPEGLMLGCVTERVDPADALVVNEKHR
HCCCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEECCHHH
DKKLETLPSGSVIGTSSLRRLAQLRHHFPHLEFKDIRGNVNTRLAKLDRGEYDAIILAAA
CCHHHHCCCCCEECHHHHHHHHHHHHHCCCCEEHHCCCCHHHHHHHCCCCCCCEEEEEEC
GLQRLDFGDRIHQIISSDISLHAVGQGALGIECRDGDEEILGLLRPVLEHAESRDRCYAE
CCHHCCHHHHHHHHHHCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
RSFLRQLEGGCQVPIGVNTTIEGDRLTLVGMVASLDGQTLIRDEVSGSRADAEKLGIELA
HHHHHHHCCCCCCCCCCCCEECCCCEEEEEHHHHCCCCEEEHHHCCCCCCCHHHHHHHHH
QKAIAQGADKILAEINEANRA
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TAETPSKRTVRIGSRKSQLALVQTYWVRDELQKAYPEITFEVQTMETQGDKVLDVALSK
CCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHH
IGDKGLFTQELEDGMLKGETDFAVHSLKDLPTNLPEGLMLGCVTERVDPADALVVNEKHR
HCCCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEECCHHH
DKKLETLPSGSVIGTSSLRRLAQLRHHFPHLEFKDIRGNVNTRLAKLDRGEYDAIILAAA
CCHHHHCCCCCEECHHHHHHHHHHHHHCCCCEEHHCCCCHHHHHHHCCCCCCCEEEEEEC
GLQRLDFGDRIHQIISSDISLHAVGQGALGIECRDGDEEILGLLRPVLEHAESRDRCYAE
CCHHCCHHHHHHHHHHCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
RSFLRQLEGGCQVPIGVNTTIEGDRLTLVGMVASLDGQTLIRDEVSGSRADAEKLGIELA
HHHHHHHCCCCCCCCCCCCEECCCCEEEEEHHHHCCCCEEEHHHCCCCCCCHHHHHHHHH
QKAIAQGADKILAEINEANRA
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]