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The map label for this gene is xth [H]

Identifier: 170077908

GI number: 170077908

Start: 1344169

End: 1344843

Strand: Direct

Name: xth [H]

Synonym: SYNPCC7002_A1293

Alternate gene names: 170077908

Gene position: 1344169-1344843 (Clockwise)

Preceding gene: 170077904

Following gene: 170077909

Centisome position: 44.69

GC content: 51.41

Gene sequence:

>675_bases
GTGGTAGATCCGGACTTTCCCCGGCAGCCCTTTGAAGCCCTGGGGTATCACACCTCGATCTCTGGCCAAAAATCCTACAA
TGGCGTTGCTCTCCTCAGTCGGGAACCGCTCCAGGACGTGATTATTGGTTTTACGCCTGTGGTCGGGGCGGCGATCGCCC
AGGATTTTGACGCGCAGAAACGGGTGATTTCTGGGGTGATTGGCGATGTGCGGGTGGTGAATCTCTATGTGCCCAATGGT
TCCGCCGTCGGTAGCGAAAAATATGACTACAAGCTGGGCTGGTTTGAGGTTCTCAAGGCCTATTTAAAAGAATTGTGCAA
AGACGATCGAGAGATTTTAATGTGCGGCGATTTTAATATTGCCCTCGAAGACCGGGATATTTATATGCCGAAAAAACCGG
ATCACATTATGGCTTCCCCCGCAGAAAGAGAGACTTTAACGGCGATCCTGGACTTCGGCTTTCAGGATGTATTCCGCAAA
TTTAACCAAGAGGCAGATCAATTTAGCTGGTGGGATTATCGGACGCGGGGTTTTAGTCGGAATCGCGGCTGGCGCATTGA
CCACATTTATCTGACGGAAAAGCTTTACGGCCAGGCAAAACGCTGTTGGATCGACCGGGAGCCGCGCGGTTGGGAAAAAC
CCAGTGACCATACCCCTGTAATTGTGGAGCTTTAG

Upstream 100 bases:

>100_bases
CGCAACCTGGAACGTGAACTCGGTGCGTTCTCGCCAAACCCACATCTGCCAATGGTTAGAACAAACGGGGGTTGATCTGC
TCTGTCTCCAAGAAACAAAG

Downstream 100 bases:

>100_bases
ACCGATGGAACCGCTTACCCTCCGGAATCAAACTTTTACCTGGGGCGATCGCACCTATGTGATGGGGATTCTCAATGTCA
CCCCCGACAGTTTTAGTGAT

Product: exodeoxyribonuclease III

Products: NA

Alternate protein names: EXO III; Exonuclease III [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MVDPDFPRQPFEALGYHTSISGQKSYNGVALLSREPLQDVIIGFTPVVGAAIAQDFDAQKRVISGVIGDVRVVNLYVPNG
SAVGSEKYDYKLGWFEVLKAYLKELCKDDREILMCGDFNIALEDRDIYMPKKPDHIMASPAERETLTAILDFGFQDVFRK
FNQEADQFSWWDYRTRGFSRNRGWRIDHIYLTEKLYGQAKRCWIDREPRGWEKPSDHTPVIVEL

Sequences:

>Translated_224_residues
MVDPDFPRQPFEALGYHTSISGQKSYNGVALLSREPLQDVIIGFTPVVGAAIAQDFDAQKRVISGVIGDVRVVNLYVPNG
SAVGSEKYDYKLGWFEVLKAYLKELCKDDREILMCGDFNIALEDRDIYMPKKPDHIMASPAERETLTAILDFGFQDVFRK
FNQEADQFSWWDYRTRGFSRNRGWRIDHIYLTEKLYGQAKRCWIDREPRGWEKPSDHTPVIVEL
>Mature_224_residues
MVDPDFPRQPFEALGYHTSISGQKSYNGVALLSREPLQDVIIGFTPVVGAAIAQDFDAQKRVISGVIGDVRVVNLYVPNG
SAVGSEKYDYKLGWFEVLKAYLKELCKDDREILMCGDFNIALEDRDIYMPKKPDHIMASPAERETLTAILDFGFQDVFRK
FNQEADQFSWWDYRTRGFSRNRGWRIDHIYLTEKLYGQAKRCWIDREPRGWEKPSDHTPVIVEL

Specific function: Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction [H]

COG id: COG0708

COG function: function code L; Exonuclease III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA repair enzymes AP/ExoA family [H]

Homologues:

Organism=Homo sapiens, GI18375505, Length=212, Percent_Identity=28.3018867924528, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI18375503, Length=212, Percent_Identity=28.3018867924528, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI18375501, Length=212, Percent_Identity=28.3018867924528, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1788046, Length=231, Percent_Identity=36.3636363636364, Blast_Score=125, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71989536, Length=210, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330655, Length=171, Percent_Identity=26.9005847953216, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17136678, Length=171, Percent_Identity=26.9005847953216, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000097
- InterPro:   IPR020847
- InterPro:   IPR020848
- InterPro:   IPR005135
- InterPro:   IPR004808 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.11.2 [H]

Molecular weight: Translated: 25862; Mature: 25862

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDPDFPRQPFEALGYHTSISGQKSYNGVALLSREPLQDVIIGFTPVVGAAIAQDFDAQK
CCCCCCCCCCHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCHHHHH
RVISGVIGDVRVVNLYVPNGSAVGSEKYDYKLGWFEVLKAYLKELCKDDREILMCGDFNI
HHHHHHCCCEEEEEEEECCCCCCCCCCCCEECCHHHHHHHHHHHHHCCCCEEEEECCCEE
ALEDRDIYMPKKPDHIMASPAERETLTAILDFGFQDVFRKFNQEADQFSWWDYRTRGFSR
EEECCEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHCCCCC
NRGWRIDHIYLTEKLYGQAKRCWIDREPRGWEKPSDHTPVIVEL
CCCEEEEEEEECHHHHCCHHHEEECCCCCCCCCCCCCCCEEEEC
>Mature Secondary Structure
MVDPDFPRQPFEALGYHTSISGQKSYNGVALLSREPLQDVIIGFTPVVGAAIAQDFDAQK
CCCCCCCCCCHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCHHHHH
RVISGVIGDVRVVNLYVPNGSAVGSEKYDYKLGWFEVLKAYLKELCKDDREILMCGDFNI
HHHHHHCCCEEEEEEEECCCCCCCCCCCCEECCHHHHHHHHHHHHHCCCCEEEEECCCEE
ALEDRDIYMPKKPDHIMASPAERETLTAILDFGFQDVFRKFNQEADQFSWWDYRTRGFSR
EEECCEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHCCCCC
NRGWRIDHIYLTEKLYGQAKRCWIDREPRGWEKPSDHTPVIVEL
CCCEEEEEEEECHHHHCCHHHEEECCCCCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]