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The map label for this gene is adk [H]

Identifier: 170077666

GI number: 170077666

Start: 1079126

End: 1079689

Strand: Reverse

Name: adk [H]

Synonym: SYNPCC7002_A1046

Alternate gene names: 170077666

Gene position: 1079689-1079126 (Counterclockwise)

Preceding gene: 170077667

Following gene: 170077665

Centisome position: 35.89

GC content: 50.89

Gene sequence:

>564_bases
ATGGCTCAGGGAGTAAGGTTGATTTTTTTGGGGCCCCCAGGGGCTGGAAAGGGCACTCAAGCTCAGGTTTTGGCAGAATC
TTGTGGAATCCCCCACATTTCTACTGGCGAAATTCTCCGGGCGGCGATCGCCAACCAAACAGAACTTGGCCAACAGGCCC
AGGGGTTTGTGGATCGTGGTGAATTAGTGCCCGATAGTCTGATTCTGAATTTAATTCGCGAAAGACTACAGGAGCAAGAT
GCCCAGCAAGGCTGGATTTTGGATGGTTTTCCGCGCAATGTGAGCCAAGCCGAGTTCCTCAACACCTTACTCACTGAGCT
GAAGCAGCAATGTGATGTTGCCCTTAACTTGGAAGTTCCCGATGCCACATTGGTAGAACGCTTACTAAGTCGTGGCAGAA
AAGATGACAACCAGGAGACCATTCGGCGTCGTTTAGAAGTTTACCGGGAGCAAACAGCCCCAGTTATTGACTTCTACCAA
AAACAGGGTTCTCTGAAATCCGTCGATGGCGATCGCTCCCTTGAAGAAGTTACCGCCGCCCTAGAGCAGGCGATCGCTTC
ATAA

Upstream 100 bases:

>100_bases
ATGGTTAAACAATAGTGTTTTTAGCAGGGTTTAGATATTAGCTGGAATATCTAAACTCTTTGTTGATTTAGTAAGCAATT
TGGATGGGAATAGAGGCGTT

Downstream 100 bases:

>100_bases
CTCCTGGTTAGAATTCGATGCCGATTGATGAAATTTATTAGGAGATCTATTTGTTTTGTCTAAACAAGATCTAATTGAAA
TGGAAGGTACCGTCACCGAG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MAQGVRLIFLGPPGAGKGTQAQVLAESCGIPHISTGEILRAAIANQTELGQQAQGFVDRGELVPDSLILNLIRERLQEQD
AQQGWILDGFPRNVSQAEFLNTLLTELKQQCDVALNLEVPDATLVERLLSRGRKDDNQETIRRRLEVYREQTAPVIDFYQ
KQGSLKSVDGDRSLEEVTAALEQAIAS

Sequences:

>Translated_187_residues
MAQGVRLIFLGPPGAGKGTQAQVLAESCGIPHISTGEILRAAIANQTELGQQAQGFVDRGELVPDSLILNLIRERLQEQD
AQQGWILDGFPRNVSQAEFLNTLLTELKQQCDVALNLEVPDATLVERLLSRGRKDDNQETIRRRLEVYREQTAPVIDFYQ
KQGSLKSVDGDRSLEEVTAALEQAIAS
>Mature_186_residues
AQGVRLIFLGPPGAGKGTQAQVLAESCGIPHISTGEILRAAIANQTELGQQAQGFVDRGELVPDSLILNLIRERLQEQDA
QQGWILDGFPRNVSQAEFLNTLLTELKQQCDVALNLEVPDATLVERLLSRGRKDDNQETIRRRLEVYREQTAPVIDFYQK
QGSLKSVDGDRSLEEVTAALEQAIAS

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=215, Percent_Identity=33.953488372093, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI7524346, Length=215, Percent_Identity=33.953488372093, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI4502011, Length=178, Percent_Identity=34.8314606741573, Blast_Score=121, Evalue=3e-28,
Organism=Homo sapiens, GI19923437, Length=200, Percent_Identity=32.5, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI310110345, Length=197, Percent_Identity=32.994923857868, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI53832003, Length=197, Percent_Identity=32.994923857868, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI8051579, Length=197, Percent_Identity=32.994923857868, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI53832001, Length=197, Percent_Identity=32.994923857868, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI28144899, Length=189, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI28144897, Length=189, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI7706497, Length=180, Percent_Identity=31.6666666666667, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI22749187, Length=210, Percent_Identity=28.0952380952381, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI209915597, Length=97, Percent_Identity=32.9896907216495, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=38.9908256880734, Blast_Score=154, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17552384, Length=217, Percent_Identity=34.5622119815668, Blast_Score=149, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17567503, Length=187, Percent_Identity=33.6898395721925, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17533833, Length=182, Percent_Identity=31.8681318681319, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17550688, Length=185, Percent_Identity=31.3513513513514, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17537943, Length=204, Percent_Identity=31.8627450980392, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25147457, Length=187, Percent_Identity=25.1336898395722, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=210, Percent_Identity=35.7142857142857, Blast_Score=136, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322828, Length=189, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=32.3232323232323, Blast_Score=108, Evalue=5e-25,
Organism=Drosophila melanogaster, GI22026816, Length=210, Percent_Identity=34.7619047619048, Blast_Score=140, Evalue=5e-34,
Organism=Drosophila melanogaster, GI17737899, Length=201, Percent_Identity=32.3383084577114, Blast_Score=123, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24645822, Length=201, Percent_Identity=32.3383084577114, Blast_Score=123, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24663208, Length=185, Percent_Identity=30.2702702702703, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI17647141, Length=185, Percent_Identity=30.2702702702703, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI221459597, Length=189, Percent_Identity=28.5714285714286, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21356893, Length=189, Percent_Identity=28.5714285714286, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24582962, Length=184, Percent_Identity=30.4347826086957, Blast_Score=73, Evalue=9e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 20608; Mature: 20476

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQGVRLIFLGPPGAGKGTQAQVLAESCGIPHISTGEILRAAIANQTELGQQAQGFVDRG
CCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCC
ELVPDSLILNLIRERLQEQDAQQGWILDGFPRNVSQAEFLNTLLTELKQQCDVALNLEVP
CCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCC
DATLVERLLSRGRKDDNQETIRRRLEVYREQTAPVIDFYQKQGSLKSVDGDRSLEEVTAA
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHH
LEQAIAS
HHHHHCC
>Mature Secondary Structure 
AQGVRLIFLGPPGAGKGTQAQVLAESCGIPHISTGEILRAAIANQTELGQQAQGFVDRG
CCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCC
ELVPDSLILNLIRERLQEQDAQQGWILDGFPRNVSQAEFLNTLLTELKQQCDVALNLEVP
CCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCC
DATLVERLLSRGRKDDNQETIRRRLEVYREQTAPVIDFYQKQGSLKSVDGDRSLEEVTAA
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHH
LEQAIAS
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA