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The map label for this gene is hemE

Identifier: 170077445

GI number: 170077445

Start: 848300

End: 849352

Strand: Direct

Name: hemE

Synonym: SYNPCC7002_A0823

Alternate gene names: 170077445

Gene position: 848300-849352 (Clockwise)

Preceding gene: 170077440

Following gene: 170077446

Centisome position: 28.2

GC content: 50.81

Gene sequence:

>1053_bases
ATGTCGGAAAGCAATAATACACCTCTTTTATTGAGGGCTGCACGGGGGGAAAAAGTTGAGCGGACACCGGTTTGGATGAT
GCGTCAAGCCGGACGTTACATGAAAATTTATCGCGACCTGCGGGAGAAGTACCCGAGCTTCCGGGAACGTTCTGAAAATC
CTGATCTCGCTATCGAAATTTCGCTCCAACCTTGGCATGCATTCCAGCCTGACGGTGTAATTATGTTTTCGGATATTCTC
ACTCCCCTACCAGGGATGGGGATTCCCTTCGACATCATCGAAAGCAAAGGGCCAATCATTGAAAACCCGATCCGCACCCA
GGCCCAGGTCGATGCTATGACCCCCTTTGATCCGGCAGAATCCTTGCCTTTTATCAAAACAATCCTTGGCACCCTCCGCC
AGGAAGTGGGCAATGCCTCAACGGTACTGGGATTTGTCGGTGCCCCCTGGACGCTAGCGGCCTATGCCATTGAAGGTAAG
AGTTCAAAGAACTACGCCATCATCAAAAATATGGCCTTTTCTGAGCCTGCTGTGTTGCACAGTTTCCTTGGAAAAATTGC
CGATGCGATCGCCGATTATGTTTGCTACCAGATCGAATGTGGGGCCCAGGTGATCCAAATGTTCGACTCTTGGGCGGGCC
AACTCAGTCCCCAAGACTACGATATGTTTGCCTTGCCATATCAAAAACGGGTCGTGGACAAAGTCAAAGCAAAATACCCA
GACTTCCCGCTGATTCTGTACATCAGTGGCAGTGCCGGTGTTCTAGAGCGCATGGGTAAATCTGGTGTCGATATCGTCAG
CGTCGATTGGACGGTGGATATGGCCGATGCCCGCCAGCGCCTTGGTAAAGACATGAAAGTCCAAGGCAATATTGATCCTG
GTGTGCTGTTTGGTTCCCAGGACTTCATCAAAGCGCGGATCATTGACACCGTGCGTAAAGCGGGCAATTGGGGACATATT
CTCAATCTCGGCCACGGTGTTCTCGTCGGTACCCCCGAAGATAATGTCCGCTTCTTCTTTGAAACCTGTAAGAACGTCCA
GAGTTTCCTCTAG

Upstream 100 bases:

>100_bases
GTTTCTTAATAATTGTTAACTGCTTACGATAGTGCCTCAAGTTTATTTCACAAACCGAGATGATAAGCTTACAAATGCAC
AAAAATTATTTTAATAAATC

Downstream 100 bases:

>100_bases
GTTTTAAAGCCATTCCTTCATTCAGAAAAAGCGTTTTAGGAGAGTCAAATCCTAGGGCGCTTTTTTTGGGGAATTGGGCT
GATACCGTAGGCAGGGCCGA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSESNNTPLLLRAARGEKVERTPVWMMRQAGRYMKIYRDLREKYPSFRERSENPDLAIEISLQPWHAFQPDGVIMFSDIL
TPLPGMGIPFDIIESKGPIIENPIRTQAQVDAMTPFDPAESLPFIKTILGTLRQEVGNASTVLGFVGAPWTLAAYAIEGK
SSKNYAIIKNMAFSEPAVLHSFLGKIADAIADYVCYQIECGAQVIQMFDSWAGQLSPQDYDMFALPYQKRVVDKVKAKYP
DFPLILYISGSAGVLERMGKSGVDIVSVDWTVDMADARQRLGKDMKVQGNIDPGVLFGSQDFIKARIIDTVRKAGNWGHI
LNLGHGVLVGTPEDNVRFFFETCKNVQSFL

Sequences:

>Translated_350_residues
MSESNNTPLLLRAARGEKVERTPVWMMRQAGRYMKIYRDLREKYPSFRERSENPDLAIEISLQPWHAFQPDGVIMFSDIL
TPLPGMGIPFDIIESKGPIIENPIRTQAQVDAMTPFDPAESLPFIKTILGTLRQEVGNASTVLGFVGAPWTLAAYAIEGK
SSKNYAIIKNMAFSEPAVLHSFLGKIADAIADYVCYQIECGAQVIQMFDSWAGQLSPQDYDMFALPYQKRVVDKVKAKYP
DFPLILYISGSAGVLERMGKSGVDIVSVDWTVDMADARQRLGKDMKVQGNIDPGVLFGSQDFIKARIIDTVRKAGNWGHI
LNLGHGVLVGTPEDNVRFFFETCKNVQSFL
>Mature_349_residues
SESNNTPLLLRAARGEKVERTPVWMMRQAGRYMKIYRDLREKYPSFRERSENPDLAIEISLQPWHAFQPDGVIMFSDILT
PLPGMGIPFDIIESKGPIIENPIRTQAQVDAMTPFDPAESLPFIKTILGTLRQEVGNASTVLGFVGAPWTLAAYAIEGKS
SKNYAIIKNMAFSEPAVLHSFLGKIADAIADYVCYQIECGAQVIQMFDSWAGQLSPQDYDMFALPYQKRVVDKVKAKYPD
FPLILYISGSAGVLERMGKSGVDIVSVDWTVDMADARQRLGKDMKVQGNIDPGVLFGSQDFIKARIIDTVRKAGNWGHIL
NLGHGVLVGTPEDNVRFFFETCKNVQSFL

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=355, Percent_Identity=33.8028169014084, Blast_Score=213, Evalue=2e-55,
Organism=Escherichia coli, GI2367337, Length=349, Percent_Identity=36.676217765043, Blast_Score=251, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6320252, Length=352, Percent_Identity=33.2386363636364, Blast_Score=219, Evalue=5e-58,
Organism=Drosophila melanogaster, GI221330099, Length=337, Percent_Identity=35.3115727002967, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI19921920, Length=341, Percent_Identity=34.8973607038123, Blast_Score=224, Evalue=9e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_SYNP2 (B1XIF6)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001734083.1
- ProteinModelPortal:   B1XIF6
- SMR:   B1XIF6
- GeneID:   6057538
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A0823
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39050; Mature: 38919

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 78-78 BINDING 155-155 BINDING 210-210 BINDING 325-325

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESNNTPLLLRAARGEKVERTPVWMMRQAGRYMKIYRDLREKYPSFRERSENPDLAIEI
CCCCCCCCEEEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCHHHCCCCCCEEEEE
SLQPWHAFQPDGVIMFSDILTPLPGMGIPFDIIESKGPIIENPIRTQAQVDAMTPFDPAE
EECCCCCCCCCCEEEEHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCHHCCCCCCCCCCC
SLPFIKTILGTLRQEVGNASTVLGFVGAPWTLAAYAIEGKSSKNYAIIKNMAFSEPAVLH
CCHHHHHHHHHHHHHHCCHHEEEEECCCCCEEEEEEEECCCCCCEEEEECCCCCCHHHHH
SFLGKIADAIADYVCYQIECGAQVIQMFDSWAGQLSPQDYDMFALPYQKRVVDKVKAKYP
HHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHCCC
DFPLILYISGSAGVLERMGKSGVDIVSVDWTVDMADARQRLGKDMKVQGNIDPGVLFGSQ
CCCEEEEECCCCHHHHHCCCCCCEEEEEEEEEEHHHHHHHCCCCCEEECCCCCCEEECCH
DFIKARIIDTVRKAGNWGHILNLGHGVLVGTPEDNVRFFFETCKNVQSFL
HHHHHHHHHHHHHCCCCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SESNNTPLLLRAARGEKVERTPVWMMRQAGRYMKIYRDLREKYPSFRERSENPDLAIEI
CCCCCCCEEEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCHHHCCCCCCEEEEE
SLQPWHAFQPDGVIMFSDILTPLPGMGIPFDIIESKGPIIENPIRTQAQVDAMTPFDPAE
EECCCCCCCCCCEEEEHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCHHCCCCCCCCCCC
SLPFIKTILGTLRQEVGNASTVLGFVGAPWTLAAYAIEGKSSKNYAIIKNMAFSEPAVLH
CCHHHHHHHHHHHHHHCCHHEEEEECCCCCEEEEEEEECCCCCCEEEEECCCCCCHHHHH
SFLGKIADAIADYVCYQIECGAQVIQMFDSWAGQLSPQDYDMFALPYQKRVVDKVKAKYP
HHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHCCC
DFPLILYISGSAGVLERMGKSGVDIVSVDWTVDMADARQRLGKDMKVQGNIDPGVLFGSQ
CCCEEEEECCCCHHHHHCCCCCCEEEEEEEEEEHHHHHHHCCCCCEEECCCCCCEEECCH
DFIKARIIDTVRKAGNWGHILNLGHGVLVGTPEDNVRFFFETCKNVQSFL
HHHHHHHHHHHHHCCCCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA