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The map label for this gene is mdmC [H]

Identifier: 170077388

GI number: 170077388

Start: 796425

End: 797087

Strand: Direct

Name: mdmC [H]

Synonym: SYNPCC7002_A0765

Alternate gene names: 170077388

Gene position: 796425-797087 (Clockwise)

Preceding gene: 170077385

Following gene: 170077396

Centisome position: 26.48

GC content: 52.79

Gene sequence:

>663_bases
ATGACCCGTAGTAGCCTCTCCCTGGACGCCCCTTTATATGATTACCTCCTGCGCATTTCCCTCAAAGAGCATCCCGTCCT
CAAAGAATTACGGGAAATCACGGCCCAACACCCAGCAGCCCGGATGCAGATCGCTCCGGAACAGGGTCAGTTGATGGCCT
GGCTCGTGCAACTGCTGGGGGCGCAGAAAACCTTAGATATCGGCGTTTTTACGGGTTACAGTGCTCTCGTTGTCGCCTTA
GCGCTGCCGAAAAACGGAAAAGTCATTGCTTGCGATCGCGACCCAAGGCCAACGGCGATCGCCCAAACCTATTGGGAAAA
AGCAGGGGTCGCCGAAAAAATTGAACTCCACCTTGCCCCAGCCCTTGAAACCCTAGATTCTCTACTGGCAGATGGCCAAG
CGGGCACCTTTGATTTTGCCTTCATTGATGCGGACAAAGGCAACTACCTAAACTATTTTGAGCGGTCTCTCAAATTACTG
CGGGTCGGCGGCGTGATTGCCGTTGATAATGTGTTGTGGTCGGGACGCGTGGCTGATCCAGCGGATCAAGACAAACGTAC
GGTCAAAATTCGCGCTTTCAATGAAGCTTTGTATAATGACCCACGCATTAGTTTAACGGTATTGCCCGTGGCTGATGGTC
TGACCCTCGCCCGCAAACTTTAG

Upstream 100 bases:

>100_bases
TTTGCGGATGTGCTCAAGTCTTAACATCGGGAAAAACTCCTGGTTGGGATCAGCATCAGTCTATAACAAATTGTAAACTT
TTTTCGTTCACTCCTTTGCC

Downstream 100 bases:

>100_bases
AAAAATCTGGCTAAAGTACTTCGTCAAAGCCCGCCGCTTTTTTAACGGTGTAGAGGGGACGCTGTTTCACCTCGTCGTAA
ATGCGGCCAATGTATTCACC

Product: O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MTRSSLSLDAPLYDYLLRISLKEHPVLKELREITAQHPAARMQIAPEQGQLMAWLVQLLGAQKTLDIGVFTGYSALVVAL
ALPKNGKVIACDRDPRPTAIAQTYWEKAGVAEKIELHLAPALETLDSLLADGQAGTFDFAFIDADKGNYLNYFERSLKLL
RVGGVIAVDNVLWSGRVADPADQDKRTVKIRAFNEALYNDPRISLTVLPVADGLTLARKL

Sequences:

>Translated_220_residues
MTRSSLSLDAPLYDYLLRISLKEHPVLKELREITAQHPAARMQIAPEQGQLMAWLVQLLGAQKTLDIGVFTGYSALVVAL
ALPKNGKVIACDRDPRPTAIAQTYWEKAGVAEKIELHLAPALETLDSLLADGQAGTFDFAFIDADKGNYLNYFERSLKLL
RVGGVIAVDNVLWSGRVADPADQDKRTVKIRAFNEALYNDPRISLTVLPVADGLTLARKL
>Mature_219_residues
TRSSLSLDAPLYDYLLRISLKEHPVLKELREITAQHPAARMQIAPEQGQLMAWLVQLLGAQKTLDIGVFTGYSALVVALA
LPKNGKVIACDRDPRPTAIAQTYWEKAGVAEKIELHLAPALETLDSLLADGQAGTFDFAFIDADKGNYLNYFERSLKLLR
VGGVIAVDNVLWSGRVADPADQDKRTVKIRAFNEALYNDPRISLTVLPVADGLTLARKL

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=212, Percent_Identity=48.5849056603774, Blast_Score=194, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17565612, Length=220, Percent_Identity=41.8181818181818, Blast_Score=157, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI72001127, Length=220, Percent_Identity=39.0909090909091, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI72001028, Length=221, Percent_Identity=39.8190045248869, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI25148771, Length=220, Percent_Identity=39.0909090909091, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71991493, Length=198, Percent_Identity=30.8080808080808, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24211; Mature: 24080

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSSLSLDAPLYDYLLRISLKEHPVLKELREITAQHPAARMQIAPEQGQLMAWLVQLLG
CCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHEEECCCCCHHHHHHHHHHC
AQKTLDIGVFTGYSALVVALALPKNGKVIACDRDPRPTAIAQTYWEKAGVAEKIELHLAP
CCCEEEEEEECCHHHHHEEEECCCCCCEEEECCCCCCCHHHHHHHHHCCCHHHEEEEHHH
ALETLDSLLADGQAGTFDFAFIDADKGNYLNYFERSLKLLRVGGVIAVDNVLWSGRVADP
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEECCEEECCCCCCC
ADQDKRTVKIRAFNEALYNDPRISLTVLPVADGLTLARKL
CCCCCEEEEEEEECHHHCCCCCEEEEEEECCCCCHHHHCC
>Mature Secondary Structure 
TRSSLSLDAPLYDYLLRISLKEHPVLKELREITAQHPAARMQIAPEQGQLMAWLVQLLG
CCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHEEECCCCCHHHHHHHHHHC
AQKTLDIGVFTGYSALVVALALPKNGKVIACDRDPRPTAIAQTYWEKAGVAEKIELHLAP
CCCEEEEEEECCHHHHHEEEECCCCCCEEEECCCCCCCHHHHHHHHHCCCHHHEEEEHHH
ALETLDSLLADGQAGTFDFAFIDADKGNYLNYFERSLKLLRVGGVIAVDNVLWSGRVADP
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEECCEEECCCCCCC
ADQDKRTVKIRAFNEALYNDPRISLTVLPVADGLTLARKL
CCCCCEEEEEEEECHHHCCCCCEEEEEEECCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]