Click here to switch to the map view.

The map label for this gene is pyrF/pyrE [H]

Identifier: 170077235

GI number: 170077235

Start: 638393

End: 639841

Strand: Direct

Name: pyrF/pyrE [H]

Synonym: SYNPCC7002_A0610

Alternate gene names: 170077235

Gene position: 638393-639841 (Clockwise)

Preceding gene: 170077234

Following gene: 170077236

Centisome position: 21.22

GC content: 53.49

Gene sequence:

>1449_bases
TTGGAGCTAGCACCCGCAACTTTCACCGAAAAACTCACTGGGGCGATCGCCGCCCAAAAGACCCTCCTCGTGGCGGGCCT
CGATCCGAACCCGGAAATGCTGCCGGATTCTTTGCGCACCGGAGATTTAATTCAGAACCTGAAAACGTGGCTTTTGGGGA
TTATTGACCAGACCCAGGATCTCGTCTGTGCCTACAAACCAACCCTCGGTTTTTATCAAGCCTTGGGTGTACCGGGGTTG
CAACTGTTAGAAACAGTTTTAGCCCATATTCCGCCTGATATCCCCATTATTCTCGATGCGAAACACGCCGATCTCAATAC
CAGCAGCCTTTTCGCCCAGGCGATTTTTGAGGCGTGGCAAGTGGATGCAGTCACCCTCAGCGCCTACCCGGGCCAAGACC
ACGTTGCCCCTTTTTTGCTCTATCCCGACAAAGGCGTTTTCTTGCAATGCCGCACCTCGAACCCCGGCGCCTTTCCCCTG
CAAAATTACCCCGACCCGCAACGGCCTTTTTATCTGCACCTGATCCAAGAAATCAAACAGTGGGGCACCCCGGAACAACT
TTTCCTAGAAATTGGGGGCGATCGCCCGGCGGTTTTTCGCCAAGTACGTGCCATTGCCCCGGAACGGTGGATTCTCGCCC
GCAGTATCTGGCAACGGAGTGAAAACCTCGAAGAAATTGTGCACCAGGGTTTAAATTCCAATGGGTCTGGCCTCTTAATT
CCCATTCCCAACGATGACCTGAGTCAAACGGATTGTCGGCAACCCGTCGCCCAGCTACGGCAAAAGATTGAAGACATCCG
CCAGCGTTATACCCCCAGCAATGCCCGGTGTGATTTGCTCCAAGTACCGACAAATTTCCCCGCAGCGCACCCCCAGGCGG
AGTTGATTGTGCAGTTGTTTGACCTGGGCTGTCTGCTCTTTGGGGAATATGTCCAGGCCTCCGGAGCGACGTTTTCCTAT
TACATTGATCTGCGCAAAATTATTTCTAACCCCCAGGTTTTTAACCAGGTGCTCAATGCCTACGGGGCGATCGCCAAAAA
CCTGAAATTTGACCGTATCGCCGGGATTCCCTATGGTTCGCTCCCGACGGCAACGGGGTTGGCTCTGAAATTAAATTACC
CGATGATTTTCCCCCGTAAGGAAGTCAAGGCCCACGGGACGAGGCGGGTGATTGAGGGCCATTTTGAGCCAGGGGAAACG
ATTTTGGTCGTCGATGACGTGCTGATTACGGGCAAAAGTATCGTTGAGGGGGCGAAAAAACTGGAGTCGGCGGGCCTCAC
CGTGCAGGAGATGGTAGTTCTCATAGACCACGAAGCGGGCGTTAAGGATCGGCTCCAGGCCCAAGGATATCAAGCCCACG
CCATTTTAACCATTTCTGAAATCACCGAAACCCTTTTCCAAGCGGGTCGCATTAACCAGAGTCAGTATGATTGCCTCGTG
AGCCATTGA

Upstream 100 bases:

>100_bases
AGTGGGGCCTGACGGAGGACGTTTTATTCGCTAAAACAAGGGAAATCCATGCGGCCGGGCGGGCCTACAAACATCTACGC
CATGGCGAGGAGCAACAGGA

Downstream 100 bases:

>100_bases
GCTTTTTTCGGACAAAATTCTGCCAGGGCTTGGGTCTTTTGCGTACAGTAGAGAAGAAGCACCTTTATCGACGACGGCCC
CATGGGATTACATCTGTTTG

Product: bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein

Products: NA

Alternate protein names: Orotidine 5'-phosphate decarboxylase; OMP decarboxylase; OMPDCase; OMPdecase; Orotate phosphoribosyltransferase; OPRT; OPRTase [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MELAPATFTEKLTGAIAAQKTLLVAGLDPNPEMLPDSLRTGDLIQNLKTWLLGIIDQTQDLVCAYKPTLGFYQALGVPGL
QLLETVLAHIPPDIPIILDAKHADLNTSSLFAQAIFEAWQVDAVTLSAYPGQDHVAPFLLYPDKGVFLQCRTSNPGAFPL
QNYPDPQRPFYLHLIQEIKQWGTPEQLFLEIGGDRPAVFRQVRAIAPERWILARSIWQRSENLEEIVHQGLNSNGSGLLI
PIPNDDLSQTDCRQPVAQLRQKIEDIRQRYTPSNARCDLLQVPTNFPAAHPQAELIVQLFDLGCLLFGEYVQASGATFSY
YIDLRKIISNPQVFNQVLNAYGAIAKNLKFDRIAGIPYGSLPTATGLALKLNYPMIFPRKEVKAHGTRRVIEGHFEPGET
ILVVDDVLITGKSIVEGAKKLESAGLTVQEMVVLIDHEAGVKDRLQAQGYQAHAILTISEITETLFQAGRINQSQYDCLV
SH

Sequences:

>Translated_482_residues
MELAPATFTEKLTGAIAAQKTLLVAGLDPNPEMLPDSLRTGDLIQNLKTWLLGIIDQTQDLVCAYKPTLGFYQALGVPGL
QLLETVLAHIPPDIPIILDAKHADLNTSSLFAQAIFEAWQVDAVTLSAYPGQDHVAPFLLYPDKGVFLQCRTSNPGAFPL
QNYPDPQRPFYLHLIQEIKQWGTPEQLFLEIGGDRPAVFRQVRAIAPERWILARSIWQRSENLEEIVHQGLNSNGSGLLI
PIPNDDLSQTDCRQPVAQLRQKIEDIRQRYTPSNARCDLLQVPTNFPAAHPQAELIVQLFDLGCLLFGEYVQASGATFSY
YIDLRKIISNPQVFNQVLNAYGAIAKNLKFDRIAGIPYGSLPTATGLALKLNYPMIFPRKEVKAHGTRRVIEGHFEPGET
ILVVDDVLITGKSIVEGAKKLESAGLTVQEMVVLIDHEAGVKDRLQAQGYQAHAILTISEITETLFQAGRINQSQYDCLV
SH
>Mature_482_residues
MELAPATFTEKLTGAIAAQKTLLVAGLDPNPEMLPDSLRTGDLIQNLKTWLLGIIDQTQDLVCAYKPTLGFYQALGVPGL
QLLETVLAHIPPDIPIILDAKHADLNTSSLFAQAIFEAWQVDAVTLSAYPGQDHVAPFLLYPDKGVFLQCRTSNPGAFPL
QNYPDPQRPFYLHLIQEIKQWGTPEQLFLEIGGDRPAVFRQVRAIAPERWILARSIWQRSENLEEIVHQGLNSNGSGLLI
PIPNDDLSQTDCRQPVAQLRQKIEDIRQRYTPSNARCDLLQVPTNFPAAHPQAELIVQLFDLGCLLFGEYVQASGATFSY
YIDLRKIISNPQVFNQVLNAYGAIAKNLKFDRIAGIPYGSLPTATGLALKLNYPMIFPRKEVKAHGTRRVIEGHFEPGET
ILVVDDVLITGKSIVEGAKKLESAGLTVQEMVVLIDHEAGVKDRLQAQGYQAHAILTISEITETLFQAGRINQSQYDCLV
SH

Specific function: Catalyzes the decarboxylation of orotidine monophosphate (OMP) to uridine monophosphate (UMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=180, Percent_Identity=39.4444444444444, Blast_Score=147, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17508631, Length=199, Percent_Identity=34.1708542713568, Blast_Score=131, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17554964, Length=189, Percent_Identity=29.6296296296296, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17933654, Length=190, Percent_Identity=34.2105263157895, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011995
- InterPro:   IPR001754
- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase; PF00156 Pribosyltran [H]

EC number: =4.1.1.23; =2.4.2.10 [H]

Molecular weight: Translated: 53415; Mature: 53415

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELAPATFTEKLTGAIAAQKTLLVAGLDPNPEMLPDSLRTGDLIQNLKTWLLGIIDQTQD
CCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
LVCAYKPTLGFYQALGVPGLQLLETVLAHIPPDIPIILDAKHADLNTSSLFAQAIFEAWQ
EEEEECCCHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHC
VDAVTLSAYPGQDHVAPFLLYPDKGVFLQCRTSNPGAFPLQNYPDPQRPFYLHLIQEIKQ
CCEEEEEECCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHH
WGTPEQLFLEIGGDRPAVFRQVRAIAPERWILARSIWQRSENLEEIVHQGLNSNGSGLLI
CCCCHHEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEE
PIPNDDLSQTDCRQPVAQLRQKIEDIRQRYTPSNARCDLLQVPTNFPAAHPQAELIVQLF
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
DLGCLLFGEYVQASGATFSYYIDLRKIISNPQVFNQVLNAYGAIAKNLKFDRIAGIPYGS
HHHHHHHHHHHHCCCCEEEEHEEHHHHHCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
LPTATGLALKLNYPMIFPRKEVKAHGTRRVIEGHFEPGETILVVDDVLITGKSIVEGAKK
CCCCCCEEEEECCCEECCCHHHHHCCCHHHHCCCCCCCCEEEEECCHHHCCHHHHHHHHH
LESAGLTVQEMVVLIDHEAGVKDRLQAQGYQAHAILTISEITETLFQAGRINQSQYDCLV
HHHCCCCHHHEEEEEECCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCCCCHHHHCC
SH
CC
>Mature Secondary Structure
MELAPATFTEKLTGAIAAQKTLLVAGLDPNPEMLPDSLRTGDLIQNLKTWLLGIIDQTQD
CCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
LVCAYKPTLGFYQALGVPGLQLLETVLAHIPPDIPIILDAKHADLNTSSLFAQAIFEAWQ
EEEEECCCHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHC
VDAVTLSAYPGQDHVAPFLLYPDKGVFLQCRTSNPGAFPLQNYPDPQRPFYLHLIQEIKQ
CCEEEEEECCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHH
WGTPEQLFLEIGGDRPAVFRQVRAIAPERWILARSIWQRSENLEEIVHQGLNSNGSGLLI
CCCCHHEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEE
PIPNDDLSQTDCRQPVAQLRQKIEDIRQRYTPSNARCDLLQVPTNFPAAHPQAELIVQLF
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
DLGCLLFGEYVQASGATFSYYIDLRKIISNPQVFNQVLNAYGAIAKNLKFDRIAGIPYGS
HHHHHHHHHHHHCCCCEEEEHEEHHHHHCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
LPTATGLALKLNYPMIFPRKEVKAHGTRRVIEGHFEPGETILVVDDVLITGKSIVEGAKK
CCCCCCEEEEECCCEECCCHHHHHCCCHHHHCCCCCCCCEEEEECCHHHCCHHHHHHHHH
LESAGLTVQEMVVLIDHEAGVKDRLQAQGYQAHAILTISEITETLFQAGRINQSQYDCLV
HHHCCCCHHHEEEEEECCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHCCCCCCHHHHCC
SH
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]