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The map label for this gene is tpiA

Identifier: 170077220

GI number: 170077220

Start: 624033

End: 624758

Strand: Direct

Name: tpiA

Synonym: SYNPCC7002_A0595

Alternate gene names: 170077220

Gene position: 624033-624758 (Clockwise)

Preceding gene: 170077219

Following gene: 170077221

Centisome position: 20.75

GC content: 48.07

Gene sequence:

>726_bases
GTGCGAAAGATCATTATTGCGGGTAATTGGAAAATGTATAAGACTCAAGCCGAGTCTTTAGACTTTCTCAAAGCATTACT
GCCCAAAATCGCCGATGACCATGAAGAACGAGAAGTGGTACTCTGTACGCCCTTTACCGATTTAGGCTTAATGTCCAAGA
GTCTCCACGGAACGCGGGTACGTCTAGGAGCACAAAATATCCACTGGGCTGACGAAGGTGCCTTTACTGGGGAAATCTCC
GGGTCAATGCTGACGGAAATGGGCGTCCGTTATGTCATTGTGGGCCATAGCGAAAGACGGCAATATTTTGGTGAAACCGA
TGAAACCGTAAATCAACGCCTTAAAGCGGCCCAACGCCACGGTCTAACGCCGATTCTCTGTGTTGGTGAAAGCAAAGCCC
AACGGGATGCTGGCGAAACGGAAGCGGTGATTTTTGCCCAGTTAGAGCAAGATTTAGTCGATATTGATCAAAATAACTTG
GTTGTTGCCTACGAACCCATTTGGGCCATTGGCACAGGTGACACTTGTGATGCCACCGAAGCAAACCGAGTCATTGGTCT
GATCCGCGAAAAACTCACCAATAAAAATGTCACCATTCAATATGGTGGTTCCGTCAAGCCGAATAACGTTGATGAGATTA
TGGCCCAGCCCGAAATTGATGGAGCCTTGGTAGGTGGTGCGAGCCTAGAGGCAGAGAGTTTTGCCCGCTTGGTGAACTAT
GTGTAA

Upstream 100 bases:

>100_bases
ACTCTCTTTCCCGGAGAAGCCGACCCCCCATTAGCACCGCTTCGGCAATGGGGTAAACTGGATCCCTGTGCATTGTAAGG
AAAGCATTAGTAGGAAAGCC

Downstream 100 bases:

>100_bases
GTTCTAATCAATTTTTCATTGGGTGGGGGTTTACCATGGTAAACCCCTACGTTTTAATCATCTTTTCATTTCCACATTGC
CAAACTTTTATTTTTATAAA

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MRKIIIAGNWKMYKTQAESLDFLKALLPKIADDHEEREVVLCTPFTDLGLMSKSLHGTRVRLGAQNIHWADEGAFTGEIS
GSMLTEMGVRYVIVGHSERRQYFGETDETVNQRLKAAQRHGLTPILCVGESKAQRDAGETEAVIFAQLEQDLVDIDQNNL
VVAYEPIWAIGTGDTCDATEANRVIGLIREKLTNKNVTIQYGGSVKPNNVDEIMAQPEIDGALVGGASLEAESFARLVNY
V

Sequences:

>Translated_241_residues
MRKIIIAGNWKMYKTQAESLDFLKALLPKIADDHEEREVVLCTPFTDLGLMSKSLHGTRVRLGAQNIHWADEGAFTGEIS
GSMLTEMGVRYVIVGHSERRQYFGETDETVNQRLKAAQRHGLTPILCVGESKAQRDAGETEAVIFAQLEQDLVDIDQNNL
VVAYEPIWAIGTGDTCDATEANRVIGLIREKLTNKNVTIQYGGSVKPNNVDEIMAQPEIDGALVGGASLEAESFARLVNY
V
>Mature_241_residues
MRKIIIAGNWKMYKTQAESLDFLKALLPKIADDHEEREVVLCTPFTDLGLMSKSLHGTRVRLGAQNIHWADEGAFTGEIS
GSMLTEMGVRYVIVGHSERRQYFGETDETVNQRLKAAQRHGLTPILCVGESKAQRDAGETEAVIFAQLEQDLVDIDQNNL
VVAYEPIWAIGTGDTCDATEANRVIGLIREKLTNKNVTIQYGGSVKPNNVDEIMAQPEIDGALVGGASLEAESFARLVNY
V

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family

Homologues:

Organism=Homo sapiens, GI226529917, Length=248, Percent_Identity=39.1129032258064, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI4507645, Length=248, Percent_Identity=39.1129032258064, Blast_Score=158, Evalue=3e-39,
Organism=Escherichia coli, GI1790353, Length=248, Percent_Identity=39.1129032258064, Blast_Score=183, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17536593, Length=247, Percent_Identity=40.8906882591093, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320255, Length=246, Percent_Identity=36.9918699186992, Blast_Score=147, Evalue=2e-36,
Organism=Drosophila melanogaster, GI28572008, Length=246, Percent_Identity=40.2439024390244, Blast_Score=167, Evalue=6e-42,
Organism=Drosophila melanogaster, GI28572006, Length=246, Percent_Identity=40.2439024390244, Blast_Score=167, Evalue=6e-42,
Organism=Drosophila melanogaster, GI28572004, Length=246, Percent_Identity=40.2439024390244, Blast_Score=166, Evalue=9e-42,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): TPIS_SYNP2 (B1XPX4)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001733858.1
- ProteinModelPortal:   B1XPX4
- SMR:   B1XPX4
- GeneID:   6055718
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A0595
- HOGENOM:   HBG708281
- OMA:   DIRSVQT
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00147_B
- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21139
- TIGRFAMs:   TIGR00419

Pfam domain/function: PF00121 TIM; SSF51351 Triophos_ismrse

EC number: =5.3.1.1

Molecular weight: Translated: 26564; Mature: 26564

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00171 TIM_1; PS51440 TIM_2

Important sites: ACT_SITE 96-96 ACT_SITE 165-165 BINDING 9-9 BINDING 11-11

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIIIAGNWKMYKTQAESLDFLKALLPKIADDHEEREVVLCTPFTDLGLMSKSLHGTRV
CCEEEEECCCEEEECHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCEE
RLGAQNIHWADEGAFTGEISGSMLTEMGVRYVIVGHSERRQYFGETDETVNQRLKAAQRH
EECCCCCEECCCCCEEECCCCHHHHHCCEEEEEEECHHHHHHCCCCHHHHHHHHHHHHHC
GLTPILCVGESKAQRDAGETEAVIFAQLEQDLVDIDQNNLVVAYEPIWAIGTGDTCDATE
CCCEEEEECCCHHHCCCCCCCEEEEHHHHHHHHCCCCCCEEEEECCEEEECCCCCCCCCH
ANRVIGLIREKLTNKNVTIQYGGSVKPNNVDEIMAQPEIDGALVGGASLEAESFARLVNY
HHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCCCCEEECCCCCCHHHHHHHHHC
V
C
>Mature Secondary Structure
MRKIIIAGNWKMYKTQAESLDFLKALLPKIADDHEEREVVLCTPFTDLGLMSKSLHGTRV
CCEEEEECCCEEEECHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCEE
RLGAQNIHWADEGAFTGEISGSMLTEMGVRYVIVGHSERRQYFGETDETVNQRLKAAQRH
EECCCCCEECCCCCEEECCCCHHHHHCCEEEEEEECHHHHHHCCCCHHHHHHHHHHHHHC
GLTPILCVGESKAQRDAGETEAVIFAQLEQDLVDIDQNNLVVAYEPIWAIGTGDTCDATE
CCCEEEEECCCHHHCCCCCCCEEEEHHHHHHHHCCCCCCEEEEECCEEEECCCCCCCCCH
ANRVIGLIREKLTNKNVTIQYGGSVKPNNVDEIMAQPEIDGALVGGASLEAESFARLVNY
HHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCCCCEEECCCCCCHHHHHHHHHC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA