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The map label for this gene is mprA [H]

Identifier: 170076849

GI number: 170076849

Start: 229891

End: 230616

Strand: Direct

Name: mprA [H]

Synonym: SYNPCC7002_A0218

Alternate gene names: 170076849

Gene position: 229891-230616 (Clockwise)

Preceding gene: 170076848

Following gene: 170076850

Centisome position: 7.64

GC content: 48.9

Gene sequence:

>726_bases
ATGCCCCAAAGCCAATATGCCGCCGATGGTTTAGCCTATGTTCTCCTCGTTGGGACGGATCAAGAGTTTACACAACGGGC
CACCCTAGATCTTGCTGATCTCGGCTATCAAACCATTACCGTTGAAACGGTAGAACAAGCCCAACAACGCCTCCAACAGT
TACCAGCAGGCATGGTAATTGTGGACTATCCCCTCCTGGGACAACGGGGGATCGACTTTTGTCGCAGTCTCCGCAAAGCG
CAATTTGTGCGGCCCATTTTATTTCTGGTGACCCAGGATCGCGTTGAGGAACGGGTGATCTGCCTGGAAGCGGGTGCCGA
TGATTATGTGCTGCAACCCTACCAACAGGAACGCTTTTTACGACTCCTCGAAATTTATCTCCAGCCCCAAACAGGCCAAC
GGGAGCAACTTTTTTTTGGGGATTTAATCTTAGATCTCAATACCCGCCAGGTGTGGCGATCGCCAGGCCAAAGTAGCGAC
TCGCCCCGTCCCATTGAACTAACGGTCAAAGAATTTGAACTGTTGAAATATTTGATGTCCCATCCCCAACAGGTCTTAAC
ACGGGAGCAAATCCTTGAAAATGTCTGGGGCAACGAATTTCAAGGGGAATCCAACGTGATTGAAGTCTATATTCGTTATT
TACGCCTTAAAATTGAAGCAAAAGGCCAGAAACGCCTAATTCAAACTGTGCGGGGAGTCGGTTATGTCCTCAAAAAAGAT
CCCTAG

Upstream 100 bases:

>100_bases
CCCCAAATTGAGCCTTTCTAGAATCAAAAAGATTACCCCTTGAGCTTTTTTATTTAGCCACATTTACTTTTCTTTGTTCG
GAAGATTTCGATAGCTTGAT

Downstream 100 bases:

>100_bases
GTTTTAAAATGCGTTCCAAATGCCTCCCTTCGATCTCCACCATTTAACTAAGCACCATGTCTTTTACTTCCCGTCTTTGT
CTGGCTCTCTGTGGCACCGT

Product: two-component response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MPQSQYAADGLAYVLLVGTDQEFTQRATLDLADLGYQTITVETVEQAQQRLQQLPAGMVIVDYPLLGQRGIDFCRSLRKA
QFVRPILFLVTQDRVEERVICLEAGADDYVLQPYQQERFLRLLEIYLQPQTGQREQLFFGDLILDLNTRQVWRSPGQSSD
SPRPIELTVKEFELLKYLMSHPQQVLTREQILENVWGNEFQGESNVIEVYIRYLRLKIEAKGQKRLIQTVRGVGYVLKKD
P

Sequences:

>Translated_241_residues
MPQSQYAADGLAYVLLVGTDQEFTQRATLDLADLGYQTITVETVEQAQQRLQQLPAGMVIVDYPLLGQRGIDFCRSLRKA
QFVRPILFLVTQDRVEERVICLEAGADDYVLQPYQQERFLRLLEIYLQPQTGQREQLFFGDLILDLNTRQVWRSPGQSSD
SPRPIELTVKEFELLKYLMSHPQQVLTREQILENVWGNEFQGESNVIEVYIRYLRLKIEAKGQKRLIQTVRGVGYVLKKD
P
>Mature_240_residues
PQSQYAADGLAYVLLVGTDQEFTQRATLDLADLGYQTITVETVEQAQQRLQQLPAGMVIVDYPLLGQRGIDFCRSLRKAQ
FVRPILFLVTQDRVEERVICLEAGADDYVLQPYQQERFLRLLEIYLQPQTGQREQLFFGDLILDLNTRQVWRSPGQSSDS
PRPIELTVKEFELLKYLMSHPQQVLTREQILENVWGNEFQGESNVIEVYIRYLRLKIEAKGQKRLIQTVRGVGYVLKKDP

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=30.0884955752212, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1786784, Length=183, Percent_Identity=37.7049180327869, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1789809, Length=239, Percent_Identity=32.6359832635983, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=30.2222222222222, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=30.3964757709251, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=28.8288288288288, Blast_Score=94, Evalue=5e-21,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=26.6666666666667, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1788394, Length=211, Percent_Identity=28.9099526066351, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=27.5109170305677, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790860, Length=195, Percent_Identity=30.7692307692308, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI145693140, Length=211, Percent_Identity=28.9099526066351, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=25.9574468085106, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787229, Length=215, Percent_Identity=26.9767441860465, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=27.7056277056277, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27908; Mature: 27777

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQSQYAADGLAYVLLVGTDQEFTQRATLDLADLGYQTITVETVEQAQQRLQQLPAGMVI
CCCCHHCCCCEEEEEEEECCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCEEE
VDYPLLGQRGIDFCRSLRKAQFVRPILFLVTQDRVEERVICLEAGADDYVLQPYQQERFL
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEECCHHHHHHH
RLLEIYLQPQTGQREQLFFGDLILDLNTRQVWRSPGQSSDSPRPIELTVKEFELLKYLMS
HHHHHHHCCCCCCCCCEEEHHEEEECCHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHH
HPQQVLTREQILENVWGNEFQGESNVIEVYIRYLRLKIEAKGQKRLIQTVRGVGYVLKKD
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEECCCHHHHHHHHHHCCEEEECC
P
C
>Mature Secondary Structure 
PQSQYAADGLAYVLLVGTDQEFTQRATLDLADLGYQTITVETVEQAQQRLQQLPAGMVI
CCCHHCCCCEEEEEEEECCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCEEE
VDYPLLGQRGIDFCRSLRKAQFVRPILFLVTQDRVEERVICLEAGADDYVLQPYQQERFL
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEECCHHHHHHH
RLLEIYLQPQTGQREQLFFGDLILDLNTRQVWRSPGQSSDSPRPIELTVKEFELLKYLMS
HHHHHHHCCCCCCCCCEEEHHEEEECCHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHH
HPQQVLTREQILENVWGNEFQGESNVIEVYIRYLRLKIEAKGQKRLIQTVRGVGYVLKKD
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEECCCHHHHHHHHHHCCEEEECC
P
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA