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The map label for this gene is dut

Identifier: 170076787

GI number: 170076787

Start: 160274

End: 160702

Strand: Direct

Name: dut

Synonym: SYNPCC7002_A0155

Alternate gene names: 170076787

Gene position: 160274-160702 (Clockwise)

Preceding gene: 170076786

Following gene: 170076788

Centisome position: 5.33

GC content: 53.38

Gene sequence:

>429_bases
ATGCACCTCCGTCTCCTCAAACTCCACCCCAACGCGATTATTCCCAAATACCAACATGAAGGAGATTCTGGCGTTGATCT
CCATGCCATTGAACCCGTGGCGATCGCCCCCCACAAAACCGCCTTGATCAAAACGGGCCTCGCGGCGGAAATTCCCATTG
GCACCGAACTTCAAATTCGTCCCCGCAGTGGTTTGGCCCTCAAACAAAGCGTCACCGTTCTCAATAGCCCTGGCACCATC
GACGCCAACTATCGCGGCGAAATCGGCGTGATTTTAATCAACCATAGCGATACAGTTTTTGAGGTCAAAGCCGGGATGCG
CATTGCCCAAATGGTGATGGTTCCCGTGATGCATTTGGATATTACGGTGGTTGACAAAGTCAGCGACACAAGCCGAGGTA
CGGGCGGGTTCGGCTCTACGGGCACTTAA

Upstream 100 bases:

>100_bases
TTGTGATGGGGCCTTCCTCTTGGAAAATGGCCGAGTCGTTGACCAAGGCGATCCTCAAACCCTTAAACATCGTCTACAAA
CCACCACCGTCTAGCTTTCT

Downstream 100 bases:

>100_bases
ATCCAAAGTGCCTTACGCTAAATTGGAAGAAAGGTAACTACGGTAGGCAACATTTGCGGCTATGGACTTTTCTTTTTTTT
GGGGCTTAGGGTTAGGGGGA

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase)

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase

Number of amino acids: Translated: 142; Mature: 142

Protein sequence:

>142_residues
MHLRLLKLHPNAIIPKYQHEGDSGVDLHAIEPVAIAPHKTALIKTGLAAEIPIGTELQIRPRSGLALKQSVTVLNSPGTI
DANYRGEIGVILINHSDTVFEVKAGMRIAQMVMVPVMHLDITVVDKVSDTSRGTGGFGSTGT

Sequences:

>Translated_142_residues
MHLRLLKLHPNAIIPKYQHEGDSGVDLHAIEPVAIAPHKTALIKTGLAAEIPIGTELQIRPRSGLALKQSVTVLNSPGTI
DANYRGEIGVILINHSDTVFEVKAGMRIAQMVMVPVMHLDITVVDKVSDTSRGTGGFGSTGT
>Mature_142_residues
MHLRLLKLHPNAIIPKYQHEGDSGVDLHAIEPVAIAPHKTALIKTGLAAEIPIGTELQIRPRSGLALKQSVTVLNSPGTI
DANYRGEIGVILINHSDTVFEVKAGMRIAQMVMVPVMHLDITVVDKVSDTSRGTGGFGSTGT

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family

Homologues:

Organism=Homo sapiens, GI70906444, Length=141, Percent_Identity=39.7163120567376, Blast_Score=106, Evalue=5e-24,
Organism=Homo sapiens, GI4503423, Length=141, Percent_Identity=39.7163120567376, Blast_Score=106, Evalue=7e-24,
Organism=Homo sapiens, GI70906441, Length=141, Percent_Identity=39.7163120567376, Blast_Score=105, Evalue=2e-23,
Organism=Escherichia coli, GI1790071, Length=131, Percent_Identity=37.4045801526718, Blast_Score=89, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71988561, Length=139, Percent_Identity=40.2877697841727, Blast_Score=117, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319729, Length=142, Percent_Identity=34.5070422535211, Blast_Score=94, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24583610, Length=139, Percent_Identity=43.1654676258993, Blast_Score=116, Evalue=6e-27,
Organism=Drosophila melanogaster, GI19921126, Length=139, Percent_Identity=43.1654676258993, Blast_Score=115, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DUT_SYNP2 (B1XM22)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001733425.1
- ProteinModelPortal:   B1XM22
- SMR:   B1XM22
- GeneID:   6056952
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A0155
- HOGENOM:   HBG436079
- OMA:   GTIDEGY
- HAMAP:   MF_00116
- InterPro:   IPR008180
- InterPro:   IPR008181
- TIGRFAMs:   TIGR00576

Pfam domain/function: PF00692 dUTPase

EC number: =3.6.1.23

Molecular weight: Translated: 15149; Mature: 15149

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: NA

Important sites: BINDING 75-75

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLRLLKLHPNAIIPKYQHEGDSGVDLHAIEPVAIAPHKTALIKTGLAAEIPIGTELQIR
CCEEEEEECCCEECCCCCCCCCCCCEEEEECCEEECCCCEEEEECCCEEECCCCCEEEEE
PRSGLALKQSVTVLNSPGTIDANYRGEIGVILINHSDTVFEVKAGMRIAQMVMVPVMHLD
CCCCCEEEEEEEEEECCCEECCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCE
ITVVDKVSDTSRGTGGFGSTGT
EEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHLRLLKLHPNAIIPKYQHEGDSGVDLHAIEPVAIAPHKTALIKTGLAAEIPIGTELQIR
CCEEEEEECCCEECCCCCCCCCCCCEEEEECCEEECCCCEEEEECCCEEECCCCCEEEEE
PRSGLALKQSVTVLNSPGTIDANYRGEIGVILINHSDTVFEVKAGMRIAQMVMVPVMHLD
CCCCCEEEEEEEEEECCCEECCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHCCE
ITVVDKVSDTSRGTGGFGSTGT
EEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA