Click here to switch to the map view.

The map label for this gene is metF [H]

Identifier: 170076673

GI number: 170076673

Start: 35772

End: 36683

Strand: Direct

Name: metF [H]

Synonym: SYNPCC7002_A0038

Alternate gene names: 170076673

Gene position: 35772-36683 (Clockwise)

Preceding gene: 170076672

Following gene: 170076674

Centisome position: 1.19

GC content: 50.88

Gene sequence:

>912_bases
ATGACCACCCGTCTGCGTCGTGCCATCGAAAATCGAGACTTTGTCGTTACGGCTGAGGTTGCGCCTCCAAAGGGGGGTGA
CCCGACAAAAATGCTGCGGATGGCAAAATTGCTTGGCGATCGCGTCCATGGGGTGAATGTGACCGATGGGAGCCGGGCCG
TGATGCGCATGTCGTCCATTGCCGCCTCAACTTTACTCTTGCAAAACGGTATCGACCCAATTTTTCAGGTGGCCTGCCGC
GATCGCAATGTCATTGGTCTCCAAGCAGATTTAATGGGCGCCCATGCCCTGGGTTTACGGAATGTGTTGGCCCTCACGGG
GGATCCCGTCAAAGCGGGCGATCACCCCAAAGCCAAGGCAGTTTTCGATCTCGAATCGGTGCGTCTATTAAAACTGATCA
CCAAATTAAATAACGGCCAAGACTTTAACGACAAAAAAATGCCCGATGGCCCCCTGGATTTGTTCCCTGGGGGCGCGGTG
GATCCCCAGCTTAAGAGTTGGTACACCATTGAATCTCGCTTTGCCCGCAAAGTAGAAGCCGGGGCGCAGTTTTTCCAGTC
GCAAATGATTACGGATTTCCAGCGACTCGAAGAATTTATGAACCGGGTGGCTAGTCAATATGATGTGCCCGTATTTGCGG
GAATTTTTCTGTTGAAATCGGCAAAAAATGCTCAATTTATCAACCGCTGTGTACCAGGGGCGCAAATTCCCGATGCGATT
ATTGAGCGCCTAGCCCAAGCTGAAAATCCCCTCGAAGAGGGTCTCAAAATTGCGGCGGAGCAGGTAAAAATTGCCAAAAA
TCTCTGCCACGGTGTCCATATGATGGCCGTCAAAAAAGAAGATCTGATTCCGCAAATTCTTGATTTAGCAGACGTTTCCA
TTCAAATCTCCACGGCACCGGCCTTAGTTTAA

Upstream 100 bases:

>100_bases
GCAAATGCAACCCTCAAGCAGGTGAAAGACGCCCTTGGTTTTCTGCCGTCCCTGTAGAATGGTTCATTACCTGTGATTTT
TTAACCCTAAAACTGCTTCC

Downstream 100 bases:

>100_bases
GTTTATTTTTAACCTATATGTCACAAACCTATACTTTTCATACCCTCGATGTGTTTACAGAGCAAATTTTCGGGGGTAAT
CCCCTGGCGGTGTTCCCCCA

Product: 5,10-methylenetetrahydrofolate reductase

Products: NA

Alternate protein names: Homocysteine S-methyltransferase; S-methylmethionine:homocysteine methyltransferase; 5,10-methylenetetrahydrofolate reductase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MTTRLRRAIENRDFVVTAEVAPPKGGDPTKMLRMAKLLGDRVHGVNVTDGSRAVMRMSSIAASTLLLQNGIDPIFQVACR
DRNVIGLQADLMGAHALGLRNVLALTGDPVKAGDHPKAKAVFDLESVRLLKLITKLNNGQDFNDKKMPDGPLDLFPGGAV
DPQLKSWYTIESRFARKVEAGAQFFQSQMITDFQRLEEFMNRVASQYDVPVFAGIFLLKSAKNAQFINRCVPGAQIPDAI
IERLAQAENPLEEGLKIAAEQVKIAKNLCHGVHMMAVKKEDLIPQILDLADVSIQISTAPALV

Sequences:

>Translated_303_residues
MTTRLRRAIENRDFVVTAEVAPPKGGDPTKMLRMAKLLGDRVHGVNVTDGSRAVMRMSSIAASTLLLQNGIDPIFQVACR
DRNVIGLQADLMGAHALGLRNVLALTGDPVKAGDHPKAKAVFDLESVRLLKLITKLNNGQDFNDKKMPDGPLDLFPGGAV
DPQLKSWYTIESRFARKVEAGAQFFQSQMITDFQRLEEFMNRVASQYDVPVFAGIFLLKSAKNAQFINRCVPGAQIPDAI
IERLAQAENPLEEGLKIAAEQVKIAKNLCHGVHMMAVKKEDLIPQILDLADVSIQISTAPALV
>Mature_302_residues
TTRLRRAIENRDFVVTAEVAPPKGGDPTKMLRMAKLLGDRVHGVNVTDGSRAVMRMSSIAASTLLLQNGIDPIFQVACRD
RNVIGLQADLMGAHALGLRNVLALTGDPVKAGDHPKAKAVFDLESVRLLKLITKLNNGQDFNDKKMPDGPLDLFPGGAVD
PQLKSWYTIESRFARKVEAGAQFFQSQMITDFQRLEEFMNRVASQYDVPVFAGIFLLKSAKNAQFINRCVPGAQIPDAII
ERLAQAENPLEEGLKIAAEQVKIAKNLCHGVHMMAVKKEDLIPQILDLADVSIQISTAPALV

Specific function: Unknown

COG id: COG0685

COG function: function code E; 5,10-methylenetetrahydrofolate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003171
- InterPro:   IPR003726 [H]

Pfam domain/function: PF02219 MTHFR; PF02574 S-methyl_trans [H]

EC number: =2.1.1.10; =1.5.1.20 [H]

Molecular weight: Translated: 33177; Mature: 33046

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRLRRAIENRDFVVTAEVAPPKGGDPTKMLRMAKLLGDRVHGVNVTDGSRAVMRMSSI
CCHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
AASTLLLQNGIDPIFQVACRDRNVIGLQADLMGAHALGLRNVLALTGDPVKAGDHPKAKA
HHHHHHHHHCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHE
VFDLESVRLLKLITKLNNGQDFNDKKMPDGPLDLFPGGAVDPQLKSWYTIESRFARKVEA
EHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
GAQFFQSQMITDFQRLEEFMNRVASQYDVPVFAGIFLLKSAKNAQFINRCVPGAQIPDAI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHH
IERLAQAENPLEEGLKIAAEQVKIAKNLCHGVHMMAVKKEDLIPQILDLADVSIQISTAP
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
ALV
CCC
>Mature Secondary Structure 
TTRLRRAIENRDFVVTAEVAPPKGGDPTKMLRMAKLLGDRVHGVNVTDGSRAVMRMSSI
CHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH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CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]