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The map label for this gene is cpdB [H]

Identifier: 170025991

GI number: 170025991

Start: 4165808

End: 4167766

Strand: Direct

Name: cpdB [H]

Synonym: YPK_3776

Alternate gene names: 170025991

Gene position: 4165808-4167766 (Clockwise)

Preceding gene: 170025989

Following gene: 170025992

Centisome position: 88.83

GC content: 48.65

Gene sequence:

>1959_bases
ATGTTCAAGCGTCCGCTGACGTTATCCCTCCTTGCCAGCCTGATTGCTGTCGCGACATCACTGTCTGCTGCCACTGTTGA
TTTACGAGTATTGGAAACCACCGACCTACACAGCAACATGATGGATTTTGATTACTACAAAGATAAACCCACGGAAAAAT
TCGGGCTGGTACGCACTGCCAGCTTGATTATCGCAGCCCGGCAACAAGCCACTAACAGCGTGCTGGTGGATAACGGTGAC
GTGATCCAGGGGAGTCCGCTTGGTGATTATATCGCGGCTAAAGGGTTAAACGACGGAGAGATTCACCCAGTCTATAAAGC
GATGAACACGCTGGATTATGCGGTCGGCAATATCGGTAACCATGAGTTTAACTATGGGCTGGACTACCTGAAGAAATCAC
TGGCAGGGGCGAAATTCCCGTATGTTAACGCCAACGTGATTGATGTTAAAACAGGTAAACCCTTGTTCCAGCCTTACCTG
ATCATCGATACCCCAGTGAAAGATCGTGACGGAAAGAGCCATAACCTGCGGATCGGGTACATTGGTTTTGTACCGCCTCA
AGTGATGATCTGGGATAAAGCGAATCTGAGTGGCAAAGTCACGGTGAACGATATCACTGAAACCGCCAAGAAGTGGGTAC
CGGAGATGCGTGAGCAAGGGGCTGATCTGGTTGTTGCTATCCCGCACTCTGGTCTTTCCAGCGATCCTTATAAAACCATG
GCTGAAAATTCGGTTTATTACCTCAGTCAAGTTCCAGGTATCGATACCATCATGTTCGGCCACGCACATGGTGTGTTCCC
CAGCAAAGATTTTGCCGCCATCAAAGGCGCGGATATCACTCAAGGTACCTTAAACGGTATTCCGGCAGTGATGCCTGGCC
AATGGGGTGACCATTTAGGCGTAGTCGATTTTGTCCTGAATAATGATCAGGGGAAATGGCAAGTTATCGATGCCAAGGCT
GAAGCCCGTCCTATCTACGATAAAACAGCACAAAAATCACTGGCGGCAGAAAATGCCAAACTGGTGGAAGTACTGGCAGT
TGATCACCAGAGCACCCGTGATTTTGTCAGCCAACCGATTGGTGAAGCATCAGATAACATGTACAGCTATCTGGCACTGA
TCCAAGATGACCCCACCGTGCAGATTGTGAATAACGCCCAGCGCGCGTATACCGAACATTTTATTCAGGGCGATCCTGAT
TTAGCTGACCTCCCGGTACTGTCTGCCGCTGCACCGTTTAAAGCCGGTGGCCGCAAAAATGATCCCACCAGTTTTGTTGA
GGTGGAAAAAGGGAAGCTGACCTTCCGTAACGCCGCGGATTTGTACCTTTATCCAAATACGCTCGTCGTCGTGAAAGCCA
GTGGGGCGGAGGTTAAGCAGTGGCTGGAGTGTTCCGCCGCACAGTTTAATCAAATCGATATTAACAGCAGCAAACCGCAA
TCGTTGATTAATTGGGATGGTTTTCGTACTTATAATTTCGATGTCATCGATGGTGTAGAGTATGAAATTGATGTCAGCCA
GCCTGCCCGTTACGATGGCGAATGTACGCTAATCAACGACCAAGCTGAACGTATCAAAAACCTGACGTTTAACGGTAAGC
CTATCGATCCGAAAGCCACATTCCTGATTGCCACCAATAACTACCGCGCTTACAGCGGTAAGTTTGCCGGTACCGGTGAC
AGCCATATCGCATTCGCTTCGCCCGACGAAAATCGAGCGGTCCTGTCTGCATATATCAGTGCTGAAACCAAGAAAAAGGG
TCAGGTCATCCCGCGAGCCGACAACAATTGGCGTCTGGCAACCCTTGATAGCAAGCAACCTTTGGATGTTCGTTTTGAAA
CCTCTCCAACTGCTAAGGCCGCTGATTTTATTAAACAAAAAGCGCAATACCCAATGAAAGTACAGGGTACTGATGAGGTT
GGCTTCGCCGTTTATCAAATCGATTTACAGAGAAAGTAA

Upstream 100 bases:

>100_bases
AGCAATTAATTAAAATTACATATTCTTTTGCGATACATATCGAATATACACCAAGTACGAAGGGTAGCGTTTTTAATGGA
AACCCACGATGGAGAAAGCC

Downstream 100 bases:

>100_bases
TCTCTGGCGGCGGCGCCTTACTGTGCGCTGCCGTTACCCCATAATACCCACTTGGAGTTATATCACAATCTATAACATGT
ATTTATCATGCATGTTATAG

Product: bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 652; Mature: 652

Protein sequence:

>652_residues
MFKRPLTLSLLASLIAVATSLSAATVDLRVLETTDLHSNMMDFDYYKDKPTEKFGLVRTASLIIAARQQATNSVLVDNGD
VIQGSPLGDYIAAKGLNDGEIHPVYKAMNTLDYAVGNIGNHEFNYGLDYLKKSLAGAKFPYVNANVIDVKTGKPLFQPYL
IIDTPVKDRDGKSHNLRIGYIGFVPPQVMIWDKANLSGKVTVNDITETAKKWVPEMREQGADLVVAIPHSGLSSDPYKTM
AENSVYYLSQVPGIDTIMFGHAHGVFPSKDFAAIKGADITQGTLNGIPAVMPGQWGDHLGVVDFVLNNDQGKWQVIDAKA
EARPIYDKTAQKSLAAENAKLVEVLAVDHQSTRDFVSQPIGEASDNMYSYLALIQDDPTVQIVNNAQRAYTEHFIQGDPD
LADLPVLSAAAPFKAGGRKNDPTSFVEVEKGKLTFRNAADLYLYPNTLVVVKASGAEVKQWLECSAAQFNQIDINSSKPQ
SLINWDGFRTYNFDVIDGVEYEIDVSQPARYDGECTLINDQAERIKNLTFNGKPIDPKATFLIATNNYRAYSGKFAGTGD
SHIAFASPDENRAVLSAYISAETKKKGQVIPRADNNWRLATLDSKQPLDVRFETSPTAKAADFIKQKAQYPMKVQGTDEV
GFAVYQIDLQRK

Sequences:

>Translated_652_residues
MFKRPLTLSLLASLIAVATSLSAATVDLRVLETTDLHSNMMDFDYYKDKPTEKFGLVRTASLIIAARQQATNSVLVDNGD
VIQGSPLGDYIAAKGLNDGEIHPVYKAMNTLDYAVGNIGNHEFNYGLDYLKKSLAGAKFPYVNANVIDVKTGKPLFQPYL
IIDTPVKDRDGKSHNLRIGYIGFVPPQVMIWDKANLSGKVTVNDITETAKKWVPEMREQGADLVVAIPHSGLSSDPYKTM
AENSVYYLSQVPGIDTIMFGHAHGVFPSKDFAAIKGADITQGTLNGIPAVMPGQWGDHLGVVDFVLNNDQGKWQVIDAKA
EARPIYDKTAQKSLAAENAKLVEVLAVDHQSTRDFVSQPIGEASDNMYSYLALIQDDPTVQIVNNAQRAYTEHFIQGDPD
LADLPVLSAAAPFKAGGRKNDPTSFVEVEKGKLTFRNAADLYLYPNTLVVVKASGAEVKQWLECSAAQFNQIDINSSKPQ
SLINWDGFRTYNFDVIDGVEYEIDVSQPARYDGECTLINDQAERIKNLTFNGKPIDPKATFLIATNNYRAYSGKFAGTGD
SHIAFASPDENRAVLSAYISAETKKKGQVIPRADNNWRLATLDSKQPLDVRFETSPTAKAADFIKQKAQYPMKVQGTDEV
GFAVYQIDLQRK
>Mature_652_residues
MFKRPLTLSLLASLIAVATSLSAATVDLRVLETTDLHSNMMDFDYYKDKPTEKFGLVRTASLIIAARQQATNSVLVDNGD
VIQGSPLGDYIAAKGLNDGEIHPVYKAMNTLDYAVGNIGNHEFNYGLDYLKKSLAGAKFPYVNANVIDVKTGKPLFQPYL
IIDTPVKDRDGKSHNLRIGYIGFVPPQVMIWDKANLSGKVTVNDITETAKKWVPEMREQGADLVVAIPHSGLSSDPYKTM
AENSVYYLSQVPGIDTIMFGHAHGVFPSKDFAAIKGADITQGTLNGIPAVMPGQWGDHLGVVDFVLNNDQGKWQVIDAKA
EARPIYDKTAQKSLAAENAKLVEVLAVDHQSTRDFVSQPIGEASDNMYSYLALIQDDPTVQIVNNAQRAYTEHFIQGDPD
LADLPVLSAAAPFKAGGRKNDPTSFVEVEKGKLTFRNAADLYLYPNTLVVVKASGAEVKQWLECSAAQFNQIDINSSKPQ
SLINWDGFRTYNFDVIDGVEYEIDVSQPARYDGECTLINDQAERIKNLTFNGKPIDPKATFLIATNNYRAYSGKFAGTGD
SHIAFASPDENRAVLSAYISAETKKKGQVIPRADNNWRLATLDSKQPLDVRFETSPTAKAADFIKQKAQYPMKVQGTDEV
GFAVYQIDLQRK

Specific function: This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'- cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate [H]

COG id: COG0737

COG function: function code F; 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5'-nucleotidase family [H]

Homologues:

Organism=Escherichia coli, GI1790658, Length=646, Percent_Identity=75.6965944272446, Blast_Score=1049, Evalue=0.0,
Organism=Escherichia coli, GI1786687, Length=580, Percent_Identity=23.1034482758621, Blast_Score=102, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24652512, Length=196, Percent_Identity=28.0612244897959, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI161076508, Length=196, Percent_Identity=28.0612244897959, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19921980, Length=196, Percent_Identity=28.0612244897959, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008334
- InterPro:   IPR006146
- InterPro:   IPR006179
- InterPro:   IPR006294
- InterPro:   IPR004843 [H]

Pfam domain/function: PF02872 5_nucleotid_C; PF00149 Metallophos [H]

EC number: =3.1.3.6; =3.1.4.16 [H]

Molecular weight: Translated: 71688; Mature: 71688

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00785 5_NUCLEOTIDASE_1 ; PS00786 5_NUCLEOTIDASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKRPLTLSLLASLIAVATSLSAATVDLRVLETTDLHSNMMDFDYYKDKPTEKFGLVRTA
CCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
SLIIAARQQATNSVLVDNGDVIQGSPLGDYIAAKGLNDGEIHPVYKAMNTLDYAVGNIGN
HHHHEEHHHCCCEEEECCCCEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC
HEFNYGLDYLKKSLAGAKFPYVNANVIDVKTGKPLFQPYLIIDTPVKDRDGKSHNLRIGY
CCCCCCHHHHHHHHCCCCCCEECCEEEEEECCCCCCCCEEEEECCCCCCCCCCCEEEEEE
IGFVPPQVMIWDKANLSGKVTVNDITETAKKWVPEMREQGADLVVAIPHSGLSSDPYKTM
EECCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHH
AENSVYYLSQVPGIDTIMFGHAHGVFPSKDFAAIKGADITQGTLNGIPAVMPGQWGDHLG
HCCCEEEEECCCCCCEEEEECCCCCCCCCCCCEECCCCCCCCHHCCCCCCCCCCCCCCCC
VVDFVLNNDQGKWQVIDAKAEARPIYDKTAQKSLAAENAKLVEVLAVDHQSTRDFVSQPI
EEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHCCC
GEASDNMYSYLALIQDDPTVQIVNNAQRAYTEHFIQGDPDLADLPVLSAAAPFKAGGRKN
CCCCCCCEEEEEEECCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCC
DPTSFVEVEKGKLTFRNAADLYLYPNTLVVVKASGAEVKQWLECSAAQFNQIDINSSKPQ
CCCCEEEEECCEEEEECCCEEEECCCEEEEEEECCHHHHHHHHHCCCCCCEEECCCCCCC
SLINWDGFRTYNFDVIDGVEYEIDVSQPARYDGECTLINDQAERIKNLTFNGKPIDPKAT
HHCCCCCEEEEEEEEECCEEEEEECCCCCCCCCEEEEECCHHHHHHCCCCCCCCCCCCEE
FLIATNNYRAYSGKFAGTGDSHIAFASPDENRAVLSAYISAETKKKGQVIPRADNNWRLA
EEEEECCCEEECCCCCCCCCCEEEEECCCCCCEEEEEEHHHCCCCCCCCCCCCCCCEEEE
TLDSKQPLDVRFETSPTAKAADFIKQKAQYPMKVQGTDEVGFAVYQIDLQRK
EECCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEEEEEECC
>Mature Secondary Structure
MFKRPLTLSLLASLIAVATSLSAATVDLRVLETTDLHSNMMDFDYYKDKPTEKFGLVRTA
CCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
SLIIAARQQATNSVLVDNGDVIQGSPLGDYIAAKGLNDGEIHPVYKAMNTLDYAVGNIGN
HHHHEEHHHCCCEEEECCCCEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC
HEFNYGLDYLKKSLAGAKFPYVNANVIDVKTGKPLFQPYLIIDTPVKDRDGKSHNLRIGY
CCCCCCHHHHHHHHCCCCCCEECCEEEEEECCCCCCCCEEEEECCCCCCCCCCCEEEEEE
IGFVPPQVMIWDKANLSGKVTVNDITETAKKWVPEMREQGADLVVAIPHSGLSSDPYKTM
EECCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHH
AENSVYYLSQVPGIDTIMFGHAHGVFPSKDFAAIKGADITQGTLNGIPAVMPGQWGDHLG
HCCCEEEEECCCCCCEEEEECCCCCCCCCCCCEECCCCCCCCHHCCCCCCCCCCCCCCCC
VVDFVLNNDQGKWQVIDAKAEARPIYDKTAQKSLAAENAKLVEVLAVDHQSTRDFVSQPI
EEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHCCC
GEASDNMYSYLALIQDDPTVQIVNNAQRAYTEHFIQGDPDLADLPVLSAAAPFKAGGRKN
CCCCCCCEEEEEEECCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCC
DPTSFVEVEKGKLTFRNAADLYLYPNTLVVVKASGAEVKQWLECSAAQFNQIDINSSKPQ
CCCCEEEEECCEEEEECCCEEEECCCEEEEEEECCHHHHHHHHHCCCCCCEEECCCCCCC
SLINWDGFRTYNFDVIDGVEYEIDVSQPARYDGECTLINDQAERIKNLTFNGKPIDPKAT
HHCCCCCEEEEEEEEECCEEEEEECCCCCCCCCEEEEECCHHHHHHCCCCCCCCCCCCEE
FLIATNNYRAYSGKFAGTGDSHIAFASPDENRAVLSAYISAETKKKGQVIPRADNNWRLA
EEEEECCCEEECCCCCCCCCCEEEEECCCCCCEEEEEEHHHCCCCCCCCCCCCCCCEEEE
TLDSKQPLDVRFETSPTAKAADFIKQKAQYPMKVQGTDEVGFAVYQIDLQRK
EECCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA