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The map label for this gene is pheA [H]

Identifier: 170025570

GI number: 170025570

Start: 3680436

End: 3681593

Strand: Direct

Name: pheA [H]

Synonym: YPK_3355

Alternate gene names: 170025570

Gene position: 3680436-3681593 (Clockwise)

Preceding gene: 170025568

Following gene: 170025573

Centisome position: 78.48

GC content: 47.75

Gene sequence:

>1158_bases
ATGACCGATAATCCATTACTGGTGCTGCGTGAACGTATCAGTGCATTAGATTTAAAACTGCTGGCTTTGCTGGCAGAACG
GCGTGAACTGGCAGTGGATGTGGCCAAAGCCAAGCAGCTCCATCATCGCCCAATTCGCGATAAAGAACGTGAGCGTGACT
TATTAGACGCACTGATCGATGCCGCTAAGCCTTATAATCTTGATGGATTCTATGTCACACGCCTGTTTCAGCTGATTATT
GAAGATTCCGTATTGACCCAGCAGGCTTTATTGCAACATCAGCTTAACCAAACCGCCCTGCTCTCTGCCCGTATCGCCTT
CCTTGGCCCTAAGGGCTCCTATTCACATCTGGCAGCTCGCCAATATGCAGCACGTCATTTTGAGCAATTAATTGAATGCG
GTTGCCTGAAATTCCAAGACATTTTTACCCAGGTTGAGACCGGGCAAGCGGATTACGCCGTACTGCCGATCGAGAATACC
AGTTCAGGTTCTATTAATGATGTGTATGACTTACTCCAACACACCAGCTTGTCTATTGTGGGCGAAATAACCAACCCTAT
CGAGCACTGCGTACTCATTGCCACAGAAACAGATTTGAACAAAATTGAGACTGTATACAGCCATCCTCAGCCTTTCCAGC
AATGCAGCCAGTTCATTAACCGTTTCCCACATTGGAAAATTGAGTATTGTGAGAGTACGGCTGCCGCGATGGAAAAAGTT
GCAGGAATGAAATCACCAACGGCGGCTGCATTAGGTAGCGAAGCGGGCGGTGCGCTCTATAATCTGCAAGTGCTGGAGCA
CAATCTGGCAAATCAGCAACAAAATATTACTCGATTCATTGTCCTTGCTCGCAAACCCATTGATGTATCTGAGCAAATTC
CGGCCAAAACCACCTTAATTATGGCGACCGGGCAGCAATCCGGGGCATTGGTAGAGGCTTTGCTGGTACTCAGAGAGCAT
GGCATTATCATGACGAAACTGGAGTCCCGGCCAATTAATGGCAACCCGTGGGAAGAGATGTTTTATATTGATGTGCAGGC
CAATATACGTTCAGAAGCGATGCAAAAAGCATTGGCCGATCTAACACCGATTACCCGTTCCTTAAAAGTGTTGGGCTGCT
ACCCAAGTGAGAACGTCGTTCCCGTCGAGCCTTGGTAA

Upstream 100 bases:

>100_bases
TATGCCCGTCATACTTCAAGCTGCATGTGCGTTAGTCGCTTTCATGCAACTCGAATTATTGAAAGTGTAATCATTCATAA
AAATTATAAGGCAAAAGTCT

Downstream 100 bases:

>100_bases
CGCCCTTTATTCAGGCTCATTTTATGCGCCCACACCATAAAAAAAGTCATCCCGGCAGGCTGTGCTGGGATGACCTATAA
AAATCTATCACTTGCTGATG

Product: bifunctional chorismate mutase/prephenate dehydratase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTDNPLLVLRERISALDLKLLALLAERRELAVDVAKAKQLHHRPIRDKERERDLLDALIDAAKPYNLDGFYVTRLFQLII
EDSVLTQQALLQHQLNQTALLSARIAFLGPKGSYSHLAARQYAARHFEQLIECGCLKFQDIFTQVETGQADYAVLPIENT
SSGSINDVYDLLQHTSLSIVGEITNPIEHCVLIATETDLNKIETVYSHPQPFQQCSQFINRFPHWKIEYCESTAAAMEKV
AGMKSPTAAALGSEAGGALYNLQVLEHNLANQQQNITRFIVLARKPIDVSEQIPAKTTLIMATGQQSGALVEALLVLREH
GIIMTKLESRPINGNPWEEMFYIDVQANIRSEAMQKALADLTPITRSLKVLGCYPSENVVPVEPW

Sequences:

>Translated_385_residues
MTDNPLLVLRERISALDLKLLALLAERRELAVDVAKAKQLHHRPIRDKERERDLLDALIDAAKPYNLDGFYVTRLFQLII
EDSVLTQQALLQHQLNQTALLSARIAFLGPKGSYSHLAARQYAARHFEQLIECGCLKFQDIFTQVETGQADYAVLPIENT
SSGSINDVYDLLQHTSLSIVGEITNPIEHCVLIATETDLNKIETVYSHPQPFQQCSQFINRFPHWKIEYCESTAAAMEKV
AGMKSPTAAALGSEAGGALYNLQVLEHNLANQQQNITRFIVLARKPIDVSEQIPAKTTLIMATGQQSGALVEALLVLREH
GIIMTKLESRPINGNPWEEMFYIDVQANIRSEAMQKALADLTPITRSLKVLGCYPSENVVPVEPW
>Mature_384_residues
TDNPLLVLRERISALDLKLLALLAERRELAVDVAKAKQLHHRPIRDKERERDLLDALIDAAKPYNLDGFYVTRLFQLIIE
DSVLTQQALLQHQLNQTALLSARIAFLGPKGSYSHLAARQYAARHFEQLIECGCLKFQDIFTQVETGQADYAVLPIENTS
SGSINDVYDLLQHTSLSIVGEITNPIEHCVLIATETDLNKIETVYSHPQPFQQCSQFINRFPHWKIEYCESTAAAMEKVA
GMKSPTAAALGSEAGGALYNLQVLEHNLANQQQNITRFIVLARKPIDVSEQIPAKTTLIMATGQQSGALVEALLVLREHG
IIMTKLESRPINGNPWEEMFYIDVQANIRSEAMQKALADLTPITRSLKVLGCYPSENVVPVEPW

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=383, Percent_Identity=76.7624020887728, Blast_Score=613, Evalue=1e-177,
Organism=Saccharomyces cerevisiae, GI6324013, Length=329, Percent_Identity=25.531914893617, Blast_Score=97, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010952
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 43063; Mature: 42932

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00857 PREPHENATE_DEHYDR_1 ; PS00858 PREPHENATE_DEHYDR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDNPLLVLRERISALDLKLLALLAERRELAVDVAKAKQLHHRPIRDKERERDLLDALID
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
AAKPYNLDGFYVTRLFQLIIEDSVLTQQALLQHQLNQTALLSARIAFLGPKGSYSHLAAR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHEEECCCCCHHHHHHH
QYAARHFEQLIECGCLKFQDIFTQVETGQADYAVLPIENTSSGSINDVYDLLQHTSLSIV
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCHHHH
GEITNPIEHCVLIATETDLNKIETVYSHPQPFQQCSQFINRFPHWKIEYCESTAAAMEKV
HHHHCCHHHEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHH
AGMKSPTAAALGSEAGGALYNLQVLEHNLANQQQNITRFIVLARKPIDVSEQIPAKTTLI
HCCCCCCHHHHCCCCCCCEEEHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCEEEE
MATGQQSGALVEALLVLREHGIIMTKLESRPINGNPWEEMFYIDVQANIRSEAMQKALAD
EEECCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHH
LTPITRSLKVLGCYPSENVVPVEPW
HHHHHHCCEEEEECCCCCEEECCCC
>Mature Secondary Structure 
TDNPLLVLRERISALDLKLLALLAERRELAVDVAKAKQLHHRPIRDKERERDLLDALID
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
AAKPYNLDGFYVTRLFQLIIEDSVLTQQALLQHQLNQTALLSARIAFLGPKGSYSHLAAR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHEEECCCCCHHHHHHH
QYAARHFEQLIECGCLKFQDIFTQVETGQADYAVLPIENTSSGSINDVYDLLQHTSLSIV
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCHHHH
GEITNPIEHCVLIATETDLNKIETVYSHPQPFQQCSQFINRFPHWKIEYCESTAAAMEKV
HHHHCCHHHEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHH
AGMKSPTAAALGSEAGGALYNLQVLEHNLANQQQNITRFIVLARKPIDVSEQIPAKTTLI
HCCCCCCHHHHCCCCCCCEEEHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCEEEE
MATGQQSGALVEALLVLREHGIIMTKLESRPINGNPWEEMFYIDVQANIRSEAMQKALAD
EEECCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHH
LTPITRSLKVLGCYPSENVVPVEPW
HHHHHHCCEEEEECCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]