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The map label for this gene is ddc [H]

Identifier: 170025091

GI number: 170025091

Start: 3164245

End: 3165660

Strand: Reverse

Name: ddc [H]

Synonym: YPK_2867

Alternate gene names: 170025091

Gene position: 3165660-3164245 (Counterclockwise)

Preceding gene: 170025092

Following gene: 170025089

Centisome position: 67.51

GC content: 47.95

Gene sequence:

>1416_bases
ATGACTCCTGAAGAGTTTCGCCGCCATGGCTATGCCATGATCGACCTGATTGCTGATTACCGACAAAATATCGAATTGCG
TGGCGTTAATCCCACGACAGCACCCGGTGAGATTAAATCTCGTCTGTCGTTAAATGCACCTGAAAAAGCAGAACCTTTCG
AACACATTATTTCTGACATAGAAGAGCTCATCATGCCAGGGCTATTGCATTGGCAACATCCTGACTTTTTTGGTTATTTT
CCTTCTAATGTAGAGTTATCCTCCGTTCTTGGGGATTGCTTGAGTACTGGGCTGGGGGTGATAGGTCTGTCTTGGCAATC
CAGCCCGGCCCTGACAGAAATTGAAGAGGTGGCCACCAATTGGTTGCTAAAAATGCTTGGTCTTAGCGTTGCCTGGAGTG
GCGTGATTCAGGATTCCGCCTCAACCGCCACGTTAGTGGCGCTGATCAGCGGCCGAGAGCGAACATCTAACTATGCATTA
ATGAATAAAGGGATGCAAAACAGTGATGCACCTTTGATTGTCTACACTTCATCAGAAGCCCATAGCGGAGTGAATAAAGC
CGCTCTGCTCGCTGGGTTTGGTCATAATAATATCCGTTTAGTGCCCACCGATGAGCACAATGCCATGTCACCCTTGGCAT
TAGAAAAGATCATTCAACAGGATTTGGTGAAGGGAAACCGGCCTTGTATCGTTGTTGCTACGACAGGTACTACCGCTGCG
ACAGCGATGGATCCCCTTGATGCGATTGGTGATATTACTCAGCGTTATGGTTTATGGCTGCATGTGGATTCTGCTATGGC
TGGTTCAGCGATGATTTTGCCAGAATGCCGTCATCTGTGGTGCGGTATAGAAAAGGCTGATTCTGTGGTGATAAATCCGC
ATAAATGGCTGGGTGCTGCTTTTGATTGTTCGGTTTATTGTGTACAAGATTCAGAGCATTTGATTCGTATCATGAGTACT
AACCCCAGTTTCTTACAATCCGATGCCGATGGGAAAGTGAGAAATTACCGCGATTGGGGGATCCCCCTGGGTCGTCGTTT
TCGTGCGCTTAAGCTATGGTTTCTAATCCGTGAGCAAGGGGTGGAAGGGCTGCAGGCGCGTTTGCGTCGTGATATTGCCA
ATGCTAATTGGTTAGCAGAACAAATTAAAAACAGCGATGATTGGAAACTGGTCGCACCTGTAGTGTTGCAAACCTTGTGT
ATTCGTCATGAACCGGGTGGGCTGATGGGCGACGCGTTGGATAATTATACCCGCAGTTGGGCCGAGAAACTCAATCAATC
TGGTAAGGGTTATGTTACACCAGCCACGCTTGGTGGCCGCTGGATGGTGCGGGTTTCCATCGGCACTTTGGGTACGGAAC
GTCATCACGTTGAGAAGTTGTGGTTGTTGTTGCAGTCTTTGGTTAAGGAGAGATAA

Upstream 100 bases:

>100_bases
TTGATTCAGGCAAACGAATCAGCATGCAGTCATTTATAGGTTACAACACGAACCAGCCGTTCTATTTCTGGTGTTAATGA
CTTCAAAATGAGAGCTTTTT

Downstream 100 bases:

>100_bases
AAGGGCCTTACCATATTAAGAATTGAACAATGAGCAATGAGCAATGAGCAATGAGCAATGAGCAATGAGCAATGAACAAT
GAACAATGAACAATGAACAA

Product: aromatic-L-amino-acid decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTPEEFRRHGYAMIDLIADYRQNIELRGVNPTTAPGEIKSRLSLNAPEKAEPFEHIISDIEELIMPGLLHWQHPDFFGYF
PSNVELSSVLGDCLSTGLGVIGLSWQSSPALTEIEEVATNWLLKMLGLSVAWSGVIQDSASTATLVALISGRERTSNYAL
MNKGMQNSDAPLIVYTSSEAHSGVNKAALLAGFGHNNIRLVPTDEHNAMSPLALEKIIQQDLVKGNRPCIVVATTGTTAA
TAMDPLDAIGDITQRYGLWLHVDSAMAGSAMILPECRHLWCGIEKADSVVINPHKWLGAAFDCSVYCVQDSEHLIRIMST
NPSFLQSDADGKVRNYRDWGIPLGRRFRALKLWFLIREQGVEGLQARLRRDIANANWLAEQIKNSDDWKLVAPVVLQTLC
IRHEPGGLMGDALDNYTRSWAEKLNQSGKGYVTPATLGGRWMVRVSIGTLGTERHHVEKLWLLLQSLVKER

Sequences:

>Translated_471_residues
MTPEEFRRHGYAMIDLIADYRQNIELRGVNPTTAPGEIKSRLSLNAPEKAEPFEHIISDIEELIMPGLLHWQHPDFFGYF
PSNVELSSVLGDCLSTGLGVIGLSWQSSPALTEIEEVATNWLLKMLGLSVAWSGVIQDSASTATLVALISGRERTSNYAL
MNKGMQNSDAPLIVYTSSEAHSGVNKAALLAGFGHNNIRLVPTDEHNAMSPLALEKIIQQDLVKGNRPCIVVATTGTTAA
TAMDPLDAIGDITQRYGLWLHVDSAMAGSAMILPECRHLWCGIEKADSVVINPHKWLGAAFDCSVYCVQDSEHLIRIMST
NPSFLQSDADGKVRNYRDWGIPLGRRFRALKLWFLIREQGVEGLQARLRRDIANANWLAEQIKNSDDWKLVAPVVLQTLC
IRHEPGGLMGDALDNYTRSWAEKLNQSGKGYVTPATLGGRWMVRVSIGTLGTERHHVEKLWLLLQSLVKER
>Mature_470_residues
TPEEFRRHGYAMIDLIADYRQNIELRGVNPTTAPGEIKSRLSLNAPEKAEPFEHIISDIEELIMPGLLHWQHPDFFGYFP
SNVELSSVLGDCLSTGLGVIGLSWQSSPALTEIEEVATNWLLKMLGLSVAWSGVIQDSASTATLVALISGRERTSNYALM
NKGMQNSDAPLIVYTSSEAHSGVNKAALLAGFGHNNIRLVPTDEHNAMSPLALEKIIQQDLVKGNRPCIVVATTGTTAAT
AMDPLDAIGDITQRYGLWLHVDSAMAGSAMILPECRHLWCGIEKADSVVINPHKWLGAAFDCSVYCVQDSEHLIRIMSTN
PSFLQSDADGKVRNYRDWGIPLGRRFRALKLWFLIREQGVEGLQARLRRDIANANWLAEQIKNSDDWKLVAPVVLQTLCI
RHEPGGLMGDALDNYTRSWAEKLNQSGKGYVTPATLGGRWMVRVSIGTLGTERHHVEKLWLLLQSLVKER

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI4503281, Length=491, Percent_Identity=37.2708757637475, Blast_Score=334, Evalue=8e-92,
Organism=Homo sapiens, GI132814448, Length=491, Percent_Identity=37.2708757637475, Blast_Score=334, Evalue=8e-92,
Organism=Homo sapiens, GI92110055, Length=480, Percent_Identity=35.2083333333333, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI194294551, Length=379, Percent_Identity=31.9261213720317, Blast_Score=185, Evalue=9e-47,
Organism=Homo sapiens, GI197383062, Length=424, Percent_Identity=30.8962264150943, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI58331246, Length=357, Percent_Identity=27.4509803921569, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI197276620, Length=324, Percent_Identity=28.0864197530864, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI4503875, Length=324, Percent_Identity=28.0864197530864, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17534817, Length=461, Percent_Identity=38.6117136659436, Blast_Score=324, Evalue=6e-89,
Organism=Caenorhabditis elegans, GI17534819, Length=461, Percent_Identity=38.6117136659436, Blast_Score=324, Evalue=6e-89,
Organism=Caenorhabditis elegans, GI71981211, Length=499, Percent_Identity=28.2565130260521, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI71981217, Length=508, Percent_Identity=28.1496062992126, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI17551992, Length=500, Percent_Identity=28.8, Blast_Score=224, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI133931025, Length=479, Percent_Identity=27.9749478079332, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71993058, Length=394, Percent_Identity=26.6497461928934, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17555682, Length=394, Percent_Identity=26.6497461928934, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71993062, Length=323, Percent_Identity=27.8637770897833, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI193205882, Length=389, Percent_Identity=23.1362467866324, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI28573972, Length=482, Percent_Identity=38.7966804979253, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24652373, Length=479, Percent_Identity=37.3695198329854, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI221476190, Length=480, Percent_Identity=37.0833333333333, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24585143, Length=480, Percent_Identity=37.0833333333333, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24585139, Length=480, Percent_Identity=37.0833333333333, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24586044, Length=485, Percent_Identity=35.0515463917526, Blast_Score=305, Evalue=5e-83,
Organism=Drosophila melanogaster, GI17136190, Length=480, Percent_Identity=35.2083333333333, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24585135, Length=480, Percent_Identity=34.375, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI17136594, Length=361, Percent_Identity=30.4709141274238, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24657193, Length=396, Percent_Identity=28.2828282828283, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24657185, Length=396, Percent_Identity=28.2828282828283, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24657188, Length=396, Percent_Identity=28.2828282828283, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI21356415, Length=380, Percent_Identity=26.5789473684211, Blast_Score=133, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 52170; Mature: 52039

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00123 ALKALINE_PHOSPHATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPEEFRRHGYAMIDLIADYRQNIELRGVNPTTAPGEIKSRLSLNAPEKAEPFEHIISDI
CCCHHHHHCCHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHH
EELIMPGLLHWQHPDFFGYFPSNVELSSVLGDCLSTGLGVIGLSWQSSPALTEIEEVATN
HHHHCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHH
WLLKMLGLSVAWSGVIQDSASTATLVALISGRERTSNYALMNKGMQNSDAPLIVYTSSEA
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHCCCCCCCCCEEEEECCHH
HSGVNKAALLAGFGHNNIRLVPTDEHNAMSPLALEKIIQQDLVKGNRPCIVVATTGTTAA
HCCCCHHHEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHH
TAMDPLDAIGDITQRYGLWLHVDSAMAGSAMILPECRHLWCGIEKADSVVINPHKWLGAA
HHCCHHHHHHHHHHHCCEEEEECCCCCCCEEECHHHHHHHCCCCCCCEEEECCHHHHCCE
FDCSVYCVQDSEHLIRIMSTNPSFLQSDADGKVRNYRDWGIPLGRRFRALKLWFLIREQG
ECCEEEEEECCCEEEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
VEGLQARLRRDIANANWLAEQIKNSDDWKLVAPVVLQTLCIRHEPGGLMGDALDNYTRSW
HHHHHHHHHHHHCCHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
AEKLNQSGKGYVTPATLGGRWMVRVSIGTLGTERHHVEKLWLLLQSLVKER
HHHHCCCCCCEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPEEFRRHGYAMIDLIADYRQNIELRGVNPTTAPGEIKSRLSLNAPEKAEPFEHIISDI
CCHHHHHCCHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHH
EELIMPGLLHWQHPDFFGYFPSNVELSSVLGDCLSTGLGVIGLSWQSSPALTEIEEVATN
HHHHCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHH
WLLKMLGLSVAWSGVIQDSASTATLVALISGRERTSNYALMNKGMQNSDAPLIVYTSSEA
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHCCCCCCCCCEEEEECCHH
HSGVNKAALLAGFGHNNIRLVPTDEHNAMSPLALEKIIQQDLVKGNRPCIVVATTGTTAA
HCCCCHHHEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHH
TAMDPLDAIGDITQRYGLWLHVDSAMAGSAMILPECRHLWCGIEKADSVVINPHKWLGAA
HHCCHHHHHHHHHHHCCEEEEECCCCCCCEEECHHHHHHHCCCCCCCEEEECCHHHHCCE
FDCSVYCVQDSEHLIRIMSTNPSFLQSDADGKVRNYRDWGIPLGRRFRALKLWFLIREQG
ECCEEEEEECCCEEEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
VEGLQARLRRDIANANWLAEQIKNSDDWKLVAPVVLQTLCIRHEPGGLMGDALDNYTRSW
HHHHHHHHHHHHCCHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
AEKLNQSGKGYVTPATLGGRWMVRVSIGTLGTERHHVEKLWLLLQSLVKER
HHHHCCCCCCEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]