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The map label for this gene is mcl1 [H]

Identifier: 170024493

GI number: 170024493

Start: 2515994

End: 2516836

Strand: Direct

Name: mcl1 [H]

Synonym: YPK_2266

Alternate gene names: 170024493

Gene position: 2515994-2516836 (Clockwise)

Preceding gene: 170024491

Following gene: 170024494

Centisome position: 53.65

GC content: 53.5

Gene sequence:

>843_bases
ATGTCTAATCTTGATACTTACCAAACCCGCAGTTGGCTCTTTACGCCAGCCACTCGCTCGGATCGCTTTGCTAAAGCGGC
TGAAAACGGTGCAGATGTCGCCATTATTGATCTTGAAGATTCGGTCTCTCAAGCGGATAAGGAGCAGGCCCGACAAAAAG
CCATCTCTTATCTCTCTTCACGTCCGGCTACATCACTACCGCTGGCACTACGGATCAACGGACTGGATACTCGTGCCGGT
ATTGAGGATATTCACGCCTTGCTCGAATGTGGCAGCCTTCCCGATTACCTAGTCCTTCCTAAAACGGAGTCAGCGGCTCA
TCTGCAGATTCTGGAACGCCTAATGATGTTCGCAGGCTCTGATACACGCCTTATCGGCATCATTGAATCTGTACGTGGCC
TCAACGCTGTTGAGTCTATTGCTGCTGCCACCCCAAAATTGGCCGGATTGATATTTGGTGCTGCGGATATGGCCGCCGAT
ATTGGCGCAGCATCCACCTGGGAACCGCTAGCGCTGGCGCGTGCCCGGTTAGTCTCCGCCTGTGCGATGAATGGCATTCC
CGCTATTGATGCCCCTTTTTTTGATGTCCACGATGTTTCAGGCCTACAGTCTGAGACCCTTCGCGCATCTGATTTCGGCT
TTTCTGCAAAAGCGGCCATTCATCCCGCACAAATCAGCACAATCAATACCTTATTTACCCCCACTGCAGCAGAGATACGC
CATGCCCGCGCAGTGCTCGCCGAGAATACCAAAGGGGTCGGGACCGTCAACGGAATGATGATCGATGAGGCTGTTGCACG
TCAGGCCCGCCGGGTACTTACCCGAGCGGGTATCTCTGCCTGA

Upstream 100 bases:

>100_bases
CTCCATCTTCATATCCAAAAGCAATTAAACACACCGGTATCATATATTGGATAAATGATAACGGCGACCATAGACTAAGC
GAAGTTGGAGGAGGAACATC

Downstream 100 bases:

>100_bases
TATCACTTTATCTATTGATTTAACGGTGTTTTACACTTCACTGTCGCTGATGGAGGATAGTGCTATGGATTCTTTATTGT
CTGCTTATAAAACAGTTGGT

Product: HpcH/HpaI aldolase

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MSNLDTYQTRSWLFTPATRSDRFAKAAENGADVAIIDLEDSVSQADKEQARQKAISYLSSRPATSLPLALRINGLDTRAG
IEDIHALLECGSLPDYLVLPKTESAAHLQILERLMMFAGSDTRLIGIIESVRGLNAVESIAAATPKLAGLIFGAADMAAD
IGAASTWEPLALARARLVSACAMNGIPAIDAPFFDVHDVSGLQSETLRASDFGFSAKAAIHPAQISTINTLFTPTAAEIR
HARAVLAENTKGVGTVNGMMIDEAVARQARRVLTRAGISA

Sequences:

>Translated_280_residues
MSNLDTYQTRSWLFTPATRSDRFAKAAENGADVAIIDLEDSVSQADKEQARQKAISYLSSRPATSLPLALRINGLDTRAG
IEDIHALLECGSLPDYLVLPKTESAAHLQILERLMMFAGSDTRLIGIIESVRGLNAVESIAAATPKLAGLIFGAADMAAD
IGAASTWEPLALARARLVSACAMNGIPAIDAPFFDVHDVSGLQSETLRASDFGFSAKAAIHPAQISTINTLFTPTAAEIR
HARAVLAENTKGVGTVNGMMIDEAVARQARRVLTRAGISA
>Mature_279_residues
SNLDTYQTRSWLFTPATRSDRFAKAAENGADVAIIDLEDSVSQADKEQARQKAISYLSSRPATSLPLALRINGLDTRAGI
EDIHALLECGSLPDYLVLPKTESAAHLQILERLMMFAGSDTRLIGIIESVRGLNAVESIAAATPKLAGLIFGAADMAADI
GAASTWEPLALARARLVSACAMNGIPAIDAPFFDVHDVSGLQSETLRASDFGFSAKAAIHPAQISTINTLFTPTAAEIRH
ARAVLAENTKGVGTVNGMMIDEAVARQARRVLTRAGISA

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=289, Percent_Identity=28.719723183391, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI87081764, Length=290, Percent_Identity=31.0344827586207, Blast_Score=116, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17557458, Length=291, Percent_Identity=28.8659793814433, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 29672; Mature: 29541

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLDTYQTRSWLFTPATRSDRFAKAAENGADVAIIDLEDSVSQADKEQARQKAISYLSS
CCCCCCCCCCCEEECCCCCCHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHC
RPATSLPLALRINGLDTRAGIEDIHALLECGSLPDYLVLPKTESAAHLQILERLMMFAGS
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCC
DTRLIGIIESVRGLNAVESIAAATPKLAGLIFGAADMAADIGAASTWEPLALARARLVSA
CCHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
CAMNGIPAIDAPFFDVHDVSGLQSETLRASDFGFSAKAAIHPAQISTINTLFTPTAAEIR
HHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCEECCHHHHHHHHHCCCCHHHHH
HARAVLAENTKGVGTVNGMMIDEAVARQARRVLTRAGISA
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SNLDTYQTRSWLFTPATRSDRFAKAAENGADVAIIDLEDSVSQADKEQARQKAISYLSS
CCCCCCCCCCEEECCCCCCHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHC
RPATSLPLALRINGLDTRAGIEDIHALLECGSLPDYLVLPKTESAAHLQILERLMMFAGS
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCC
DTRLIGIIESVRGLNAVESIAAATPKLAGLIFGAADMAADIGAASTWEPLALARARLVSA
CCHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
CAMNGIPAIDAPFFDVHDVSGLQSETLRASDFGFSAKAAIHPAQISTINTLFTPTAAEIR
HHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCEECCHHHHHHHHHCCCCHHHHH
HARAVLAENTKGVGTVNGMMIDEAVARQARRVLTRAGISA
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA