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The map label for this gene is ipk

Identifier: 170024413

GI number: 170024413

Start: 2421027

End: 2421959

Strand: Direct

Name: ipk

Synonym: YPK_2182

Alternate gene names: 170024413

Gene position: 2421027-2421959 (Clockwise)

Preceding gene: 170024412

Following gene: 170024414

Centisome position: 51.63

GC content: 48.87

Gene sequence:

>933_bases
ATGACTACCGCGAATCAACCTATATGTCCGTCACCAGCAAAATGGCCGTCACCGGCAAAATTGAATTTGTTTCTTTATAT
CACCGGGCAACGCGCCGACGGCTATCATCAGTTACAAACGCTGTTTCAATTTCTTGATTATGGTGATCAACTGACGATTG
AACCGCGCGATGACAACCAAATTCGCTTATTAACCCCCATAGCAGGGGTGGAAAATGAGCAAAACCTGATCGTCCGCGCG
GCAAAAATGCTGCAAAAACACCCTGGCAATACCCCCGTGCCACGCGGTGCTGATATCAGCATTGATAAATGTTTACCGAT
GGGCGGTGGATTGGGGGGCGGTTCGTCTAATGCAGCCACAGTCTTGGTGGCACTCAACCTACTGTGGCAATGTGGTTTAA
CTGATGAACAATTAGCCGATCTCGGACTAACATTAGGGGCTGATGTCCCGGTATTTGTTCGGGGCCATGCCGCCTTCGCA
GAGGGTATTGGTGAAAAATTACAGCCAGCAGAGCCTGTAGAGAAGTGGTATTTGGTCATACACCCCGGTGTAAACATCCC
AACACCGATTATTTTTTCTGATCCTGAATTAAAAAGAAATACGCCAATCCGCCCACTGGCGGCGCTTTTAAGCACTCCAT
ACGCAAATGATTGCGAACCGATCGCAAGAAAACGTTTTCGCGAGGTTGAACAGGCTCTTTCATGGCTGTTAGAATACGCC
CCGTCACGCCTTACCGGTACCGGCGCTTGTGTGTTTGCAGAATTCGACACGGAGTCATCGGCCCGGCAGGTGTTAAGTAT
TGCCCCTGAGTGGTTACATGGTTTTGTCGCCCGTGGTGTAAATGTTTCACCACTGCATCGTGTACGCTCAGGGAAAAAAT
TGAAAGCAGTGAGCGCAGATAACGATTTACAGCGTTATGTAAGGTCGAAGTAA

Upstream 100 bases:

>100_bases
TACAACACGCAGGTCACGCCCCCCTTACCCAGCCGCCTGGAGCTGAATCAAGATGGGCAACGGATTAAACTGAAAATGGA
TAGCTGGACGATCAAATAAC

Downstream 100 bases:

>100_bases
TGGCCTCACTGACCTTGGGTTCTGAAAATACCTGTCTCACTTGATTGAAAGCCGGTTCATAATGCTGTTTTGTACCTAAT
ATATTTCAAGATGCAGGAAG

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTTANQPICPSPAKWPSPAKLNLFLYITGQRADGYHQLQTLFQFLDYGDQLTIEPRDDNQIRLLTPIAGVENEQNLIVRA
AKMLQKHPGNTPVPRGADISIDKCLPMGGGLGGGSSNAATVLVALNLLWQCGLTDEQLADLGLTLGADVPVFVRGHAAFA
EGIGEKLQPAEPVEKWYLVIHPGVNIPTPIIFSDPELKRNTPIRPLAALLSTPYANDCEPIARKRFREVEQALSWLLEYA
PSRLTGTGACVFAEFDTESSARQVLSIAPEWLHGFVARGVNVSPLHRVRSGKKLKAVSADNDLQRYVRSK

Sequences:

>Translated_310_residues
MTTANQPICPSPAKWPSPAKLNLFLYITGQRADGYHQLQTLFQFLDYGDQLTIEPRDDNQIRLLTPIAGVENEQNLIVRA
AKMLQKHPGNTPVPRGADISIDKCLPMGGGLGGGSSNAATVLVALNLLWQCGLTDEQLADLGLTLGADVPVFVRGHAAFA
EGIGEKLQPAEPVEKWYLVIHPGVNIPTPIIFSDPELKRNTPIRPLAALLSTPYANDCEPIARKRFREVEQALSWLLEYA
PSRLTGTGACVFAEFDTESSARQVLSIAPEWLHGFVARGVNVSPLHRVRSGKKLKAVSADNDLQRYVRSK
>Mature_309_residues
TTANQPICPSPAKWPSPAKLNLFLYITGQRADGYHQLQTLFQFLDYGDQLTIEPRDDNQIRLLTPIAGVENEQNLIVRAA
KMLQKHPGNTPVPRGADISIDKCLPMGGGLGGGSSNAATVLVALNLLWQCGLTDEQLADLGLTLGADVPVFVRGHAAFAE
GIGEKLQPAEPVEKWYLVIHPGVNIPTPIIFSDPELKRNTPIRPLAALLSTPYANDCEPIARKRFREVEQALSWLLEYAP
SRLTGTGACVFAEFDTESSARQVLSIAPEWLHGFVARGVNVSPLHRVRSGKKLKAVSADNDLQRYVRSK

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily

Homologues:

Organism=Escherichia coli, GI1787459, Length=277, Percent_Identity=76.1732851985559, Blast_Score=418, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPE_YERPY (B1JM88)

Other databases:

- EMBL:   CP000950
- RefSeq:   YP_001720918.1
- ProteinModelPortal:   B1JM88
- SMR:   B1JM88
- GeneID:   6088014
- GenomeReviews:   CP000950_GR
- KEGG:   ypy:YPK_2182
- HOGENOM:   HBG734593
- OMA:   LNLFLHV
- ProtClustDB:   PRK00343
- HAMAP:   MF_00061
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR20861:SF2
- PIRSF:   PIRSF010376
- TIGRFAMs:   TIGR00154

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.148

Molecular weight: Translated: 33891; Mature: 33760

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: ACT_SITE 20-20 ACT_SITE 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTANQPICPSPAKWPSPAKLNLFLYITGQRADGYHQLQTLFQFLDYGDQLTIEPRDDNQ
CCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCCC
IRLLTPIAGVENEQNLIVRAAKMLQKHPGNTPVPRGADISIDKCLPMGGGLGGGSSNAAT
EEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHH
VLVALNLLWQCGLTDEQLADLGLTLGADVPVFVRGHAAFAEGIGEKLQPAEPVEKWYLVI
HHHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCCCCEEEEEE
HPGVNIPTPIIFSDPELKRNTPIRPLAALLSTPYANDCEPIARKRFREVEQALSWLLEYA
ECCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
PSRLTGTGACVFAEFDTESSARQVLSIAPEWLHGFVARGVNVSPLHRVRSGKKLKAVSAD
CCCCCCCCEEEEEECCCCHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHCCCEEEEECCC
NDLQRYVRSK
HHHHHHHHCC
>Mature Secondary Structure 
TTANQPICPSPAKWPSPAKLNLFLYITGQRADGYHQLQTLFQFLDYGDQLTIEPRDDNQ
CCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCCC
IRLLTPIAGVENEQNLIVRAAKMLQKHPGNTPVPRGADISIDKCLPMGGGLGGGSSNAAT
EEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHH
VLVALNLLWQCGLTDEQLADLGLTLGADVPVFVRGHAAFAEGIGEKLQPAEPVEKWYLVI
HHHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCCCCEEEEEE
HPGVNIPTPIIFSDPELKRNTPIRPLAALLSTPYANDCEPIARKRFREVEQALSWLLEYA
ECCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
PSRLTGTGACVFAEFDTESSARQVLSIAPEWLHGFVARGVNVSPLHRVRSGKKLKAVSAD
CCCCCCCCEEEEEECCCCHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHCCCEEEEECCC
NDLQRYVRSK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA