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The map label for this gene is mdtH [H]

Identifier: 170024394

GI number: 170024394

Start: 2399696

End: 2400901

Strand: Direct

Name: mdtH [H]

Synonym: YPK_2162

Alternate gene names: 170024394

Gene position: 2399696-2400901 (Clockwise)

Preceding gene: 170024389

Following gene: 170024395

Centisome position: 51.17

GC content: 52.57

Gene sequence:

>1206_bases
ATGGCTTTGGTATCGCAAGCTCGAAGCTTGGGTAAGTATTTTTTATTGTTTGATAATTTATTAGTTGTGTTGGGATTTTT
TGTCGTATTCCCGCTCATTTCTATCCGATTTGTCGATCAATTAGGTTGGGCTGCGTTGGTCGTGGGCCTTGCTTTAGGCC
TAAGGCAATTGGTTCAACAGGGATTGGGGATCTTTGGCGGGGCCATTGCCGACCGGTTCGGTGCCAAACCGATGATTGTC
ACCGGGATGCTAATGCGAGCCGCGGGTTTTGCCTTGATGGCCATGGCGGATGAACCTTGGATACTTTGGCTGGCCTGTGC
GCTGTCAGGGCTGGGCGGCACCCTGTTTGATCCACCACGCACAGCGTTGGTCATCAAGTTGACCCGCCCCCATGAACGAG
GCCGTTTTTATTCGCTGCTAATGATGCAGGATAGCGCCGGAGCGGTAATTGGTGCGTTGATTGGCAGTTGGCTGCTGCAA
TATGACTTCCACTTCGTCTGTTGGACCGGTGCGGCTATTTTTGTGCTGGCAGCCGGTTGGAACGCCTGGTTACTCCCCGC
TTACCGTATCTCGACCGTTCGCGCCCCGATGAAAGAGGGCCTGATGCGAGTGTTGCGTGATCGCCGTTTTGTGACCTATG
TGCTGACGCTCACTGGCTATTATATGCTCGCCGTACAGGTCATGCTGATGCTGCCGATCGTGGTGAATGAACTTGCTGGC
TCACCGGCCGCAGTTAAATGGATGTATGCCATTGAAGCCGCACTTTCTCTGACGCTGCTTTATCCGCTGGCCCGTTGGAG
TGAAAAGCGTTTTAGCCTTGAGCAACGCTTAATGGCCGGCTTACTGATCATGACGCTCAGTTTGTTCCCCATCGGGATGA
TCACTCATCTACAAACACTGTTCATGTTTATCTGTTTCTTCTATATGGGATCAATCCTCGCTGAACCCGCCCGTGAAACA
CTGGGAGCATCGCTGGCTGACTCCCGCGCCCGTGGTAGCTATATGGGCTTTAGTCGCCTTGGATTAGCGCTGGGGGGGGC
ATTAGGTTATACCGGCGGTGGCTGGATGTACGATACCGGCAAAACCCTTGATATGCCTGAGCTACCCTGGTTCTTGCTGG
GTATTATTGGACTCATTACATTGGCAGGGCTTTACTGGCAATTCAATCGACGGCGGATTGAATCTGCCATGTTGAGCAGC
AGCTAA

Upstream 100 bases:

>100_bases
AATATTATCCCGGTAACCCCTATCGTTTATATCAATTTGGGTACAAACTATAAGCCTATTTATTTTATTCCCTCCTATTT
TTAAGTTCTGACGGTGAAGC

Downstream 100 bases:

>100_bases
CGTTATGTCCCTTATCAACCGGAGACGTTTTGCCTTTCCGGTTGATAAGCACATTCCTCGCGCATACGGCGCGGTCTTCA
GGGTTATCTGATTGGCAGAT

Product: multidrug resistance protein MdtH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MALVSQARSLGKYFLLFDNLLVVLGFFVVFPLISIRFVDQLGWAALVVGLALGLRQLVQQGLGIFGGAIADRFGAKPMIV
TGMLMRAAGFALMAMADEPWILWLACALSGLGGTLFDPPRTALVIKLTRPHERGRFYSLLMMQDSAGAVIGALIGSWLLQ
YDFHFVCWTGAAIFVLAAGWNAWLLPAYRISTVRAPMKEGLMRVLRDRRFVTYVLTLTGYYMLAVQVMLMLPIVVNELAG
SPAAVKWMYAIEAALSLTLLYPLARWSEKRFSLEQRLMAGLLIMTLSLFPIGMITHLQTLFMFICFFYMGSILAEPARET
LGASLADSRARGSYMGFSRLGLALGGALGYTGGGWMYDTGKTLDMPELPWFLLGIIGLITLAGLYWQFNRRRIESAMLSS
S

Sequences:

>Translated_401_residues
MALVSQARSLGKYFLLFDNLLVVLGFFVVFPLISIRFVDQLGWAALVVGLALGLRQLVQQGLGIFGGAIADRFGAKPMIV
TGMLMRAAGFALMAMADEPWILWLACALSGLGGTLFDPPRTALVIKLTRPHERGRFYSLLMMQDSAGAVIGALIGSWLLQ
YDFHFVCWTGAAIFVLAAGWNAWLLPAYRISTVRAPMKEGLMRVLRDRRFVTYVLTLTGYYMLAVQVMLMLPIVVNELAG
SPAAVKWMYAIEAALSLTLLYPLARWSEKRFSLEQRLMAGLLIMTLSLFPIGMITHLQTLFMFICFFYMGSILAEPARET
LGASLADSRARGSYMGFSRLGLALGGALGYTGGGWMYDTGKTLDMPELPWFLLGIIGLITLAGLYWQFNRRRIESAMLSS
S
>Mature_400_residues
ALVSQARSLGKYFLLFDNLLVVLGFFVVFPLISIRFVDQLGWAALVVGLALGLRQLVQQGLGIFGGAIADRFGAKPMIVT
GMLMRAAGFALMAMADEPWILWLACALSGLGGTLFDPPRTALVIKLTRPHERGRFYSLLMMQDSAGAVIGALIGSWLLQY
DFHFVCWTGAAIFVLAAGWNAWLLPAYRISTVRAPMKEGLMRVLRDRRFVTYVLTLTGYYMLAVQVMLMLPIVVNELAGS
PAAVKWMYAIEAALSLTLLYPLARWSEKRFSLEQRLMAGLLIMTLSLFPIGMITHLQTLFMFICFFYMGSILAEPARETL
GASLADSRARGSYMGFSRLGLALGGALGYTGGGWMYDTGKTLDMPELPWFLLGIIGLITLAGLYWQFNRRRIESAMLSSS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081828, Length=401, Percent_Identity=75.3117206982544, Blast_Score=604, Evalue=1e-174,
Organism=Escherichia coli, GI87081738, Length=347, Percent_Identity=23.9193083573487, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR022855
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44286; Mature: 44154

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVSQARSLGKYFLLFDNLLVVLGFFVVFPLISIRFVDQLGWAALVVGLALGLRQLVQQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGIFGGAIADRFGAKPMIVTGMLMRAAGFALMAMADEPWILWLACALSGLGGTLFDPPR
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCCCCCC
TALVIKLTRPHERGRFYSLLMMQDSAGAVIGALIGSWLLQYDFHFVCWTGAAIFVLAAGW
CEEEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
NAWLLPAYRISTVRAPMKEGLMRVLRDRRFVTYVLTLTGYYMLAVQVMLMLPIVVNELAG
CHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SPAAVKWMYAIEAALSLTLLYPLARWSEKRFSLEQRLMAGLLIMTLSLFPIGMITHLQTL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FMFICFFYMGSILAEPARETLGASLADSRARGSYMGFSRLGLALGGALGYTGGGWMYDTG
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEECCC
KTLDMPELPWFLLGIIGLITLAGLYWQFNRRRIESAMLSSS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALVSQARSLGKYFLLFDNLLVVLGFFVVFPLISIRFVDQLGWAALVVGLALGLRQLVQQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGIFGGAIADRFGAKPMIVTGMLMRAAGFALMAMADEPWILWLACALSGLGGTLFDPPR
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCCCCCC
TALVIKLTRPHERGRFYSLLMMQDSAGAVIGALIGSWLLQYDFHFVCWTGAAIFVLAAGW
CEEEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
NAWLLPAYRISTVRAPMKEGLMRVLRDRRFVTYVLTLTGYYMLAVQVMLMLPIVVNELAG
CHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SPAAVKWMYAIEAALSLTLLYPLARWSEKRFSLEQRLMAGLLIMTLSLFPIGMITHLQTL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FMFICFFYMGSILAEPARETLGASLADSRARGSYMGFSRLGLALGGALGYTGGGWMYDTG
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEECCC
KTLDMPELPWFLLGIIGLITLAGLYWQFNRRRIESAMLSSS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA