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The map label for this gene is ribA [H]

Identifier: 170024264

GI number: 170024264

Start: 2257514

End: 2258116

Strand: Direct

Name: ribA [H]

Synonym: YPK_2029

Alternate gene names: 170024264

Gene position: 2257514-2258116 (Clockwise)

Preceding gene: 170024260

Following gene: 170024270

Centisome position: 48.14

GC content: 46.43

Gene sequence:

>603_bases
ATGAACAATGATATGCAGCTAAAACGTGTAGCAGAAGCAAAGTTACCCACTCCTTGGGGTGACTTTTTAATGGTCGGTTT
TGAAGAATTGGCCACCGGGCATGACCACCTGGCCTTGATATTCGGTGATATCTCCGGTGATAAACCGGTTCTGTCCCGTG
TACATTCTGAATGCCTGACTGGTGATGCTTTATTTAGCCTGCGTTGTGACTGTGGTTTTCAGTTAGAGGTTGCACTGACG
CGTATCGCGGAAGAAGGCCGTGGTGTGCTGATTTATCATCGTCAGGAGGGCCGTAATATTGGCTTGCTGAATAAAATTCG
TGCTTATGCATTGCAGGATTTAGGGGCTGATACGGTAGAAGCCAATCATCAGCTTGGTTTTGCTGCGGATGAACGTGATT
TCACACTCTGTTCTGATATGTATAAATTATTAGGCATCAAAGCGGTTCGTCTGCTGACCAACAACCCTAAAAAGGTCGAG
ATCCTCACCCAAGCGGGGATCAATATCGTCGAACGTGTGCCACTGATCGTGGGCGAAAACCCAAAAAACGAACATTATCT
GGCAACCAAAGCGGCCAAAATGGGGCATTTACTCACCAAATAA

Upstream 100 bases:

>100_bases
CTGCACTGCAACTCTCCAAGTAGAAAGGTCTATATCTGGTTAAAACGGACATCCGGCAGTAGGATGCGCCACAACATACT
CTAAGAGCCTAAGTCATAAT

Downstream 100 bases:

>100_bases
TCAGTACGGGTGAGTCGCGAAATAAGAATAAGGGTAGGTTCAATAATTATACCTACCCTTTAGAGGCTGATAACCTCGGT
GGCTCAATCCAAATGACACT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MNNDMQLKRVAEAKLPTPWGDFLMVGFEELATGHDHLALIFGDISGDKPVLSRVHSECLTGDALFSLRCDCGFQLEVALT
RIAEEGRGVLIYHRQEGRNIGLLNKIRAYALQDLGADTVEANHQLGFAADERDFTLCSDMYKLLGIKAVRLLTNNPKKVE
ILTQAGINIVERVPLIVGENPKNEHYLATKAAKMGHLLTK

Sequences:

>Translated_200_residues
MNNDMQLKRVAEAKLPTPWGDFLMVGFEELATGHDHLALIFGDISGDKPVLSRVHSECLTGDALFSLRCDCGFQLEVALT
RIAEEGRGVLIYHRQEGRNIGLLNKIRAYALQDLGADTVEANHQLGFAADERDFTLCSDMYKLLGIKAVRLLTNNPKKVE
ILTQAGINIVERVPLIVGENPKNEHYLATKAAKMGHLLTK
>Mature_200_residues
MNNDMQLKRVAEAKLPTPWGDFLMVGFEELATGHDHLALIFGDISGDKPVLSRVHSECLTGDALFSLRCDCGFQLEVALT
RIAEEGRGVLIYHRQEGRNIGLLNKIRAYALQDLGADTVEANHQLGFAADERDFTLCSDMYKLLGIKAVRLLTNNPKKVE
ILTQAGINIVERVPLIVGENPKNEHYLATKAAKMGHLLTK

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=196, Percent_Identity=88.265306122449, Blast_Score=365, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319438, Length=197, Percent_Identity=44.1624365482233, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 22152; Mature: 22152

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNDMQLKRVAEAKLPTPWGDFLMVGFEELATGHDHLALIFGDISGDKPVLSRVHSECLT
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCC
GDALFSLRCDCGFQLEVALTRIAEEGRGVLIYHRQEGRNIGLLNKIRAYALQDLGADTVE
CCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCC
ANHQLGFAADERDFTLCSDMYKLLGIKAVRLLTNNPKKVEILTQAGINIVERVPLIVGEN
CCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCHHHHCCEEECCC
PKNEHYLATKAAKMGHLLTK
CCCCCEEEHHHHHHHHHCCC
>Mature Secondary Structure
MNNDMQLKRVAEAKLPTPWGDFLMVGFEELATGHDHLALIFGDISGDKPVLSRVHSECLT
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCC
GDALFSLRCDCGFQLEVALTRIAEEGRGVLIYHRQEGRNIGLLNKIRAYALQDLGADTVE
CCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCC
ANHQLGFAADERDFTLCSDMYKLLGIKAVRLLTNNPKKVEILTQAGINIVERVPLIVGEN
CCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCHHHHCCEEECCC
PKNEHYLATKAAKMGHLLTK
CCCCCEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]