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The map label for this gene is proC [H]

Identifier: 170023080

GI number: 170023080

Start: 954042

End: 954863

Strand: Reverse

Name: proC [H]

Synonym: YPK_0831

Alternate gene names: 170023080

Gene position: 954863-954042 (Counterclockwise)

Preceding gene: 170023081

Following gene: 170023079

Centisome position: 20.36

GC content: 50.73

Gene sequence:

>822_bases
ATGCAGCATCGCAATATTACATTCATTGGTGCTGGCAATATGGCCCGCGCTATTATCGCTGGTTTGGTTGCCGGGGGATA
TCCGGCCAAAATGATCAGCGTTTGCGCCCCTTCTGCCAAAAACCGTGATGCACTAGCCACTGAATTTGGTGTTATCAGCA
GTGATGATAATATCCGCGAGTCACAAAAAGCGGAGGTTGTGGTGTTAGCGGTAAAGCCCCAGTTAATGGCCGATGTATGC
CAGCAATTGCAAAAACAGGTCGATTTTAGCGATAAGTTGGTGCTGTCGATTGCGGCAGGTGTCCAGGTTGCACGTTTCTA
CGCGCTTTTGGGGAATAAACTGAATCTGGTTCGTATTATGCCGAATACCCCCTCTCTGGTGGGAAAAGGAATGAGTGGTC
TCTACGCCCCCGAGCAGGTTTCAGCCGCAGATCGTGATTTCACCACTGAACTAATGAGTGCAATTGGCAAAGTATGCTGG
GTGGACAATGAGGATGGCATTAATAGCATTATTGCCGCTGCGGGGAGTTCACCTGCCTATTTCTTCTTATTTATGGAAGC
GATGCAGCAAGAGACTGAACGCTTAGGGTTTGACAGTGAAACCGCCCGTCAGTTAGTGCAGCAAGCCGCTTCCGGGGCTT
GTGCGCTGGTCGAGGCTAACCCACATGTGCCACTTTCGGCCTTGCGGGAGCAGGTTACGTCGAAAGGGGGGACCACTGCC
GAGGCAATCCGGGTGTTCAATGAACAGCACTTACCTGAAATGGTTGCCCATGCCATGCAAGCCGCTATTACTCGCGCAAA
AGAGATGGAAAAACTGTTCTAA

Upstream 100 bases:

>100_bases
ACATAACTCTCTGTTGAACGTAATTATTTGTTGAACATCAGTTCCTGTTGAACATAAGTCCTCGTTGAACATAAAGACTG
TGCACGCTTAGGAGAATTCG

Downstream 100 bases:

>100_bases
TTAGCGGCAAAATTTACAAAAACCGACACCGCCCTTGGCACTTTCTCGTTAAAATAGGGGCCGTTAAAGTATGTGAATAG
ATTTTTTATTTGTACCTAAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MQHRNITFIGAGNMARAIIAGLVAGGYPAKMISVCAPSAKNRDALATEFGVISSDDNIRESQKAEVVVLAVKPQLMADVC
QQLQKQVDFSDKLVLSIAAGVQVARFYALLGNKLNLVRIMPNTPSLVGKGMSGLYAPEQVSAADRDFTTELMSAIGKVCW
VDNEDGINSIIAAAGSSPAYFFLFMEAMQQETERLGFDSETARQLVQQAASGACALVEANPHVPLSALREQVTSKGGTTA
EAIRVFNEQHLPEMVAHAMQAAITRAKEMEKLF

Sequences:

>Translated_273_residues
MQHRNITFIGAGNMARAIIAGLVAGGYPAKMISVCAPSAKNRDALATEFGVISSDDNIRESQKAEVVVLAVKPQLMADVC
QQLQKQVDFSDKLVLSIAAGVQVARFYALLGNKLNLVRIMPNTPSLVGKGMSGLYAPEQVSAADRDFTTELMSAIGKVCW
VDNEDGINSIIAAAGSSPAYFFLFMEAMQQETERLGFDSETARQLVQQAASGACALVEANPHVPLSALREQVTSKGGTTA
EAIRVFNEQHLPEMVAHAMQAAITRAKEMEKLF
>Mature_273_residues
MQHRNITFIGAGNMARAIIAGLVAGGYPAKMISVCAPSAKNRDALATEFGVISSDDNIRESQKAEVVVLAVKPQLMADVC
QQLQKQVDFSDKLVLSIAAGVQVARFYALLGNKLNLVRIMPNTPSLVGKGMSGLYAPEQVSAADRDFTTELMSAIGKVCW
VDNEDGINSIIAAAGSSPAYFFLFMEAMQQETERLGFDSETARQLVQQAASGACALVEANPHVPLSALREQVTSKGGTTA
EAIRVFNEQHLPEMVAHAMQAAITRAKEMEKLF

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=274, Percent_Identity=27.007299270073, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI24797095, Length=278, Percent_Identity=27.6978417266187, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI24797097, Length=278, Percent_Identity=27.6978417266187, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI21361454, Length=273, Percent_Identity=26.007326007326, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1786585, Length=271, Percent_Identity=33.9483394833948, Blast_Score=140, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17569021, Length=269, Percent_Identity=29.7397769516729, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17540664, Length=281, Percent_Identity=29.1814946619217, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320861, Length=287, Percent_Identity=25.0871080139373, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=30.2238805970149, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24648116, Length=276, Percent_Identity=28.9855072463768, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=28.0701754385965, Blast_Score=77, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29306; Mature: 29306

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00521 P5CR ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHRNITFIGAGNMARAIIAGLVAGGYPAKMISVCAPSAKNRDALATEFGVISSDDNIRE
CCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCC
SQKAEVVVLAVKPQLMADVCQQLQKQVDFSDKLVLSIAAGVQVARFYALLGNKLNLVRIM
CCCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PNTPSLVGKGMSGLYAPEQVSAADRDFTTELMSAIGKVCWVDNEDGINSIIAAAGSSPAY
CCCHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHCCCCCHH
FFLFMEAMQQETERLGFDSETARQLVQQAASGACALVEANPHVPLSALREQVTSKGGTTA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCHH
EAIRVFNEQHLPEMVAHAMQAAITRAKEMEKLF
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQHRNITFIGAGNMARAIIAGLVAGGYPAKMISVCAPSAKNRDALATEFGVISSDDNIRE
CCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCC
SQKAEVVVLAVKPQLMADVCQQLQKQVDFSDKLVLSIAAGVQVARFYALLGNKLNLVRIM
CCCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PNTPSLVGKGMSGLYAPEQVSAADRDFTTELMSAIGKVCWVDNEDGINSIIAAAGSSPAY
CCCHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHCCCCCHH
FFLFMEAMQQETERLGFDSETARQLVQQAASGACALVEANPHVPLSALREQVTSKGGTTA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCHH
EAIRVFNEQHLPEMVAHAMQAAITRAKEMEKLF
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8982386 [H]