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The map label for this gene is mltC [H]

Identifier: 170023067

GI number: 170023067

Start: 934906

End: 935994

Strand: Reverse

Name: mltC [H]

Synonym: YPK_0818

Alternate gene names: 170023067

Gene position: 935994-934906 (Counterclockwise)

Preceding gene: 170023068

Following gene: 170023066

Centisome position: 19.96

GC content: 46.19

Gene sequence:

>1089_bases
ATGGCTTGTAAGATGAAGAAAATTTTAGCTTTGCTGGTAATCGCCCCCTTATTAGTGTCTTGTTCGGGCAACAAAAATCA
GGTTGAAAACGAAGTTTTTGTCAAAGACACCAATGGTTTTGAGATTTTAATGGGCCAATTTGCCCATAACATTGAAAATA
TTTGGGGCTTAAAAGAAGTCTTAATCGCTGGTCCAAAAGATTACGTTAAGTACACGGATCAATATCAAACCCGCAGCCAT
ATCAATTTTGATGCTGGTACCATTACGATAGAGACGATCGCCACGACCAATCCGGCGGCACATTTACGTCAGGCGATCAT
CACAACGCTACTGATGGGTGATGATCCAGGCTCGATCGACCTCTATTCTGATGTAAACGATATTCAGATCAGTAAAGAGC
CGTTCCTCTATGGCCAGGTGCTGGACAACAATGGCGAACCAATCCGTTGGGAATGGCGGGCAGCCCATTTTGCTGATTAT
TTGCTACAAAACAAAATGCAAACACGGACTTCCGGTTTGCATGTGATCTCGTTCGTTACCATACAGTTAGTGCCAAACCA
TCTGGACAAACGGGCGCATAAATACCTGCCATTGGTACGGAAATCAGCAGCACGTTACGGCGTGGAAGAGTCTTTGATTC
TCGCCATTATGCAAACCGAATCGAGCTTCAACCCCTATGCCGTCAGCCGTTCTGATGCGCTCGGTCTGATGCAGGTGGTT
CAACATACTGCAGGAAAAGATGTATTCAAACTGAAAGGCAAAAGTGGCCAACCAAGCCGCAGCTATCTGTTTGATCCTGA
AAATAATATCGACGCAGGCACCGCATATTTATCTATTCTGCAAAATACCTATTTGGGGGGGATTCAAAATGCCACCTCAC
GGCGTTATGCCGTGATCACCTCCTACAACGGCGGCGCAGGTAGCGTATTGCGCGTGTTCCACAGCGATAAAAATAAGGCA
GTGGGTATCATTAACACGATGTCACCAGGGGATGTGTTCCAAACACTCACGACCAAGCATCCATCAGGTGAATCCCGCCG
TTATCTGGTGAAAGTGAACAGCGCACAGAAGAACTATCGCCGCTATTAG

Upstream 100 bases:

>100_bases
GTAAATCCCCAGGAGCTTACATCAGTAAGTGACTGGGGTGAGCGAAGGCAGCCAACGCACTGGTAGCTTGAAATATGACG
GGTAAATTCCTCATCAAGAT

Downstream 100 bases:

>100_bases
TGGTTAATAAGTAAATAGTGGTTAATAAGTAAATAGTGGTTAATAAGTAAATAGTGGTTAATAGGCAAATAGTGGTTAGC
AGGCAAATAATGGTTAGCAA

Product: murein transglycosylase C

Products: N-Acetylmuramic Acid Residues; N-Acetylglucosamine Residues [C]

Alternate protein names: Murein hydrolase C [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MACKMKKILALLVIAPLLVSCSGNKNQVENEVFVKDTNGFEILMGQFAHNIENIWGLKEVLIAGPKDYVKYTDQYQTRSH
INFDAGTITIETIATTNPAAHLRQAIITTLLMGDDPGSIDLYSDVNDIQISKEPFLYGQVLDNNGEPIRWEWRAAHFADY
LLQNKMQTRTSGLHVISFVTIQLVPNHLDKRAHKYLPLVRKSAARYGVEESLILAIMQTESSFNPYAVSRSDALGLMQVV
QHTAGKDVFKLKGKSGQPSRSYLFDPENNIDAGTAYLSILQNTYLGGIQNATSRRYAVITSYNGGAGSVLRVFHSDKNKA
VGIINTMSPGDVFQTLTTKHPSGESRRYLVKVNSAQKNYRRY

Sequences:

>Translated_362_residues
MACKMKKILALLVIAPLLVSCSGNKNQVENEVFVKDTNGFEILMGQFAHNIENIWGLKEVLIAGPKDYVKYTDQYQTRSH
INFDAGTITIETIATTNPAAHLRQAIITTLLMGDDPGSIDLYSDVNDIQISKEPFLYGQVLDNNGEPIRWEWRAAHFADY
LLQNKMQTRTSGLHVISFVTIQLVPNHLDKRAHKYLPLVRKSAARYGVEESLILAIMQTESSFNPYAVSRSDALGLMQVV
QHTAGKDVFKLKGKSGQPSRSYLFDPENNIDAGTAYLSILQNTYLGGIQNATSRRYAVITSYNGGAGSVLRVFHSDKNKA
VGIINTMSPGDVFQTLTTKHPSGESRRYLVKVNSAQKNYRRY
>Mature_361_residues
ACKMKKILALLVIAPLLVSCSGNKNQVENEVFVKDTNGFEILMGQFAHNIENIWGLKEVLIAGPKDYVKYTDQYQTRSHI
NFDAGTITIETIATTNPAAHLRQAIITTLLMGDDPGSIDLYSDVNDIQISKEPFLYGQVLDNNGEPIRWEWRAAHFADYL
LQNKMQTRTSGLHVISFVTIQLVPNHLDKRAHKYLPLVRKSAARYGVEESLILAIMQTESSFNPYAVSRSDALGLMQVVQ
HTAGKDVFKLKGKSGQPSRSYLFDPENNIDAGTAYLSILQNTYLGGIQNATSRRYAVITSYNGGAGSVLRVFHSDKNKAV
GIINTMSPGDVFQTLTTKHPSGESRRYLVKVNSAQKNYRRY

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082191, Length=358, Percent_Identity=77.6536312849162, Blast_Score=569, Evalue=1e-163,
Organism=Escherichia coli, GI87081855, Length=166, Percent_Identity=41.566265060241, Blast_Score=145, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008258
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 40382; Mature: 40250

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00922 TRANSGLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACKMKKILALLVIAPLLVSCSGNKNQVENEVFVKDTNGFEILMGQFAHNIENIWGLKEV
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCHHHH
LIAGPKDYVKYTDQYQTRSHINFDAGTITIETIATTNPAAHLRQAIITTLLMGDDPGSID
HHCCCHHHHHHCCCCCCCCCCEECCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCEE
LYSDVNDIQISKEPFLYGQVLDNNGEPIRWEWRAAHFADYLLQNKMQTRTSGLHVISFVT
EECCCCCEEECCCCEEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCEEEEEEEE
IQLVPNHLDKRAHKYLPLVRKSAARYGVEESLILAIMQTESSFNPYAVSRSDALGLMQVV
EEECHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEECCCCCCCEEECCCHHHHHHHHH
QHTAGKDVFKLKGKSGQPSRSYLFDPENNIDAGTAYLSILQNTYLGGIQNATSRRYAVIT
HHHCCCCEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
SYNGGAGSVLRVFHSDKNKAVGIINTMSPGDVFQTLTTKHPSGESRRYLVKVNSAQKNYR
ECCCCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEEECCCCHHHC
RY
CC
>Mature Secondary Structure 
ACKMKKILALLVIAPLLVSCSGNKNQVENEVFVKDTNGFEILMGQFAHNIENIWGLKEV
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCHHHH
LIAGPKDYVKYTDQYQTRSHINFDAGTITIETIATTNPAAHLRQAIITTLLMGDDPGSID
HHCCCHHHHHHCCCCCCCCCCEECCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCEE
LYSDVNDIQISKEPFLYGQVLDNNGEPIRWEWRAAHFADYLLQNKMQTRTSGLHVISFVT
EECCCCCEEECCCCEEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCEEEEEEEE
IQLVPNHLDKRAHKYLPLVRKSAARYGVEESLILAIMQTESSFNPYAVSRSDALGLMQVV
EEECHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEECCCCCCCEEECCCHHHHHHHHH
QHTAGKDVFKLKGKSGQPSRSYLFDPENNIDAGTAYLSILQNTYLGGIQNATSRRYAVIT
HHHCCCCEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
SYNGGAGSVLRVFHSDKNKAVGIINTMSPGDVFQTLTTKHPSGESRRYLVKVNSAQKNYR
ECCCCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEEECCCCHHHC
RY
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA