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The map label for this gene is degS [H]

Identifier: 170022770

GI number: 170022770

Start: 568477

End: 569628

Strand: Reverse

Name: degS [H]

Synonym: YPK_0519

Alternate gene names: 170022770

Gene position: 569628-568477 (Counterclockwise)

Preceding gene: 170022771

Following gene: 170022762

Centisome position: 12.15

GC content: 47.74

Gene sequence:

>1152_bases
ATGCTGTGTCCGCCTAACTCATGCTATTCTCCTTTTCACCCATTCATTTATGCCTTAAACCTCATGTTTCTTAAGCTATT
GCGTTCTATTATTTTGGGGCTAATTGTTGCCGGTATTCTGCTGGTTGCCCTACCCATGCTCCGCAGCCCAGGTTATTTAT
TCTCTGGAAAAAGCAATAACGTAAATGAAGAGGTTCCTACCAGTTATAACCAAGCAGTACGTCGTGCCGCACCGGCGGTG
GTCAATGTCTATAACCGGAGCCTGAGCGCTACACAGCAGGGGTTAGCCATCCGTACGCTGGGCTCGGGTGTGATCATGAG
CGATAAGGGCTATATCCTTACCAATAAACACGTTATCAATGATGCAGAACAGATCATTGTCGCCATGCAAAATGGCCGTA
TCTCAGAAGCTTTATTGGTCGGTTCAGATAATCTGACAGATTTAGCCGTCCTAAAGATTGACGCAACAAACCTGCCGGTG
ATCCCCATTAATATTAACCGCACACCACATATTGGTGACGTCGTGTTGGCAATTGGTAACCCTTATAACCTTGGGCAGAC
AGTAACGCAGGGGATTATCAGTGCAACCGGGCGTATTGGTTTAAGCTCTTCCGGGCGGCAAAATTTCCTGCAAACAGATG
CATCAATTAATCAGGGTAATTCCGGCGGTGCGCTGGTCAACACCCTTGGCGAGCTAATGGGGATCAACACGCTCTCATTT
GATAAAAGCAATAATGGCGAAACACCGGAAGGCATCGGCTTTGCGATCCCAACAGCACTGGCAACGAAAGTGATGGAAAA
ACTGATCCGTGATGGGCGGGTGATCCGTGGTTATATCGGTATTACCGGCGAGGAGTACCCACCGTTTAATGCTAACGATA
ATGGCTCAGATCGGGTACACGGTATTAAGGTCAAAAAAGTTTCACCAGACGGCCCAGCGGCCCAGGCAGGAATACACGTT
GGCGATATCATTCTTAACGTGAATAATAAACCGGCAACCTCCGTGATCGAAACTATGGATCAGGTCGCAGAAGTCCGCCC
TGGTACGACCATTCCTGTTTTACTATTACGTAATGGTCAGCAGATAGCGGTTCAAATCACCATCACTGAACTCGATCAGA
ATGAGATGCTGACCACCCAAGCAGCAGATTAA

Upstream 100 bases:

>100_bases
TCGAAGCCAAACCTGCCGTGATTGCACTGAATATCGTGCGTGGTGAAGATAATATTTACTTATTAATCCGCTAATTTGCA
GAAAAATCGGACACAGCACG

Downstream 100 bases:

>100_bases
CGCGCAAGCAGCCAATACCCGTGTCACTTAACGGTATGACGGGTATGTATAAAGAATAATGGGTACCTTGACGCCGATGA
ATATAAACATAAAAAATGCC

Product: serine endoprotease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MLCPPNSCYSPFHPFIYALNLMFLKLLRSIILGLIVAGILLVALPMLRSPGYLFSGKSNNVNEEVPTSYNQAVRRAAPAV
VNVYNRSLSATQQGLAIRTLGSGVIMSDKGYILTNKHVINDAEQIIVAMQNGRISEALLVGSDNLTDLAVLKIDATNLPV
IPININRTPHIGDVVLAIGNPYNLGQTVTQGIISATGRIGLSSSGRQNFLQTDASINQGNSGGALVNTLGELMGINTLSF
DKSNNGETPEGIGFAIPTALATKVMEKLIRDGRVIRGYIGITGEEYPPFNANDNGSDRVHGIKVKKVSPDGPAAQAGIHV
GDIILNVNNKPATSVIETMDQVAEVRPGTTIPVLLLRNGQQIAVQITITELDQNEMLTTQAAD

Sequences:

>Translated_383_residues
MLCPPNSCYSPFHPFIYALNLMFLKLLRSIILGLIVAGILLVALPMLRSPGYLFSGKSNNVNEEVPTSYNQAVRRAAPAV
VNVYNRSLSATQQGLAIRTLGSGVIMSDKGYILTNKHVINDAEQIIVAMQNGRISEALLVGSDNLTDLAVLKIDATNLPV
IPININRTPHIGDVVLAIGNPYNLGQTVTQGIISATGRIGLSSSGRQNFLQTDASINQGNSGGALVNTLGELMGINTLSF
DKSNNGETPEGIGFAIPTALATKVMEKLIRDGRVIRGYIGITGEEYPPFNANDNGSDRVHGIKVKKVSPDGPAAQAGIHV
GDIILNVNNKPATSVIETMDQVAEVRPGTTIPVLLLRNGQQIAVQITITELDQNEMLTTQAAD
>Mature_383_residues
MLCPPNSCYSPFHPFIYALNLMFLKLLRSIILGLIVAGILLVALPMLRSPGYLFSGKSNNVNEEVPTSYNQAVRRAAPAV
VNVYNRSLSATQQGLAIRTLGSGVIMSDKGYILTNKHVINDAEQIIVAMQNGRISEALLVGSDNLTDLAVLKIDATNLPV
IPININRTPHIGDVVLAIGNPYNLGQTVTQGIISATGRIGLSSSGRQNFLQTDASINQGNSGGALVNTLGELMGINTLSF
DKSNNGETPEGIGFAIPTALATKVMEKLIRDGRVIRGYIGITGEEYPPFNANDNGSDRVHGIKVKKVSPDGPAAQAGIHV
GDIILNVNNKPATSVIETMDQVAEVRPGTTIPVLLLRNGQQIAVQITITELDQNEMLTTQAAD

Specific function: Senses the OMP signal triggered by the accumulation of unassembled porins in the envelope and then initiates rseA degradation by cleaving it in its periplasmic domain, making it an attractive substrate for subsequent cleavage by rseP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=352, Percent_Identity=33.5227272727273, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4506141, Length=317, Percent_Identity=33.7539432176656, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI24308541, Length=295, Percent_Identity=33.2203389830508, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI7019477, Length=286, Percent_Identity=31.1188811188811, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI1789630, Length=351, Percent_Identity=71.2250712250712, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1789629, Length=271, Percent_Identity=45.3874538745387, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1786356, Length=281, Percent_Identity=42.7046263345196, Blast_Score=202, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24646839, Length=288, Percent_Identity=34.0277777777778, Blast_Score=127, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011783
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 40784; Mature: 40784

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLCPPNSCYSPFHPFIYALNLMFLKLLRSIILGLIVAGILLVALPMLRSPGYLFSGKSNN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
VNEEVPTSYNQAVRRAAPAVVNVYNRSLSATQQGLAIRTLGSGVIMSDKGYILTNKHVIN
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEECCCEEECCCCEEEECCHHHC
DAEQIIVAMQNGRISEALLVGSDNLTDLAVLKIDATNLPVIPININRTPHIGDVVLAIGN
CHHEEEEEECCCCCEEEEEECCCCCCEEEEEEEECCCCCEEEEECCCCCCCCEEEEEECC
PYNLGQTVTQGIISATGRIGLSSSGRQNFLQTDASINQGNSGGALVNTLGELMGINTLSF
CCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEC
DKSNNGETPEGIGFAIPTALATKVMEKLIRDGRVIRGYIGITGEEYPPFNANDNGSDRVH
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCEE
GIKVKKVSPDGPAAQAGIHVGDIILNVNNKPATSVIETMDQVAEVRPGTTIPVLLLRNGQ
EEEEEEECCCCCHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCC
QIAVQITITELDQNEMLTTQAAD
EEEEEEEEEECCCCCEEEECCCC
>Mature Secondary Structure
MLCPPNSCYSPFHPFIYALNLMFLKLLRSIILGLIVAGILLVALPMLRSPGYLFSGKSNN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
VNEEVPTSYNQAVRRAAPAVVNVYNRSLSATQQGLAIRTLGSGVIMSDKGYILTNKHVIN
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEECCCEEECCCCEEEECCHHHC
DAEQIIVAMQNGRISEALLVGSDNLTDLAVLKIDATNLPVIPININRTPHIGDVVLAIGN
CHHEEEEEECCCCCEEEEEECCCCCCEEEEEEEECCCCCEEEEECCCCCCCCEEEEEECC
PYNLGQTVTQGIISATGRIGLSSSGRQNFLQTDASINQGNSGGALVNTLGELMGINTLSF
CCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEC
DKSNNGETPEGIGFAIPTALATKVMEKLIRDGRVIRGYIGITGEEYPPFNANDNGSDRVH
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCEE
GIKVKKVSPDGPAAQAGIHVGDIILNVNNKPATSVIETMDQVAEVRPGTTIPVLLLRNGQ
EEEEEEECCCCCHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCC
QIAVQITITELDQNEMLTTQAAD
EEEEEEEEEECCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]