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The map label for this gene is shlA [H]

Identifier: 170022624

GI number: 170022624

Start: 401575

End: 402360

Strand: Reverse

Name: shlA [H]

Synonym: YPK_0369

Alternate gene names: 170022624

Gene position: 402360-401575 (Counterclockwise)

Preceding gene: 170022625

Following gene: 170022622

Centisome position: 8.58

GC content: 46.31

Gene sequence:

>786_bases
TTGGCAGGCGCAGTACTCCAGGCTAACCAGATTAGTGGGCAAATCGGTGGGGATCTAAACGTCATTAGCCGCGAAAACAG
ACTCAATAAAGTCAATGTTTCTGCCGCACTTGGCGGCAGCCACAGCAATGCAAAACAAGACAGTTTGATCAGCCAGGTAG
CGAATGCCAGCCCAATTATGTCTGATAAAATCAAGAATAAACTGGAAGAGAAATCTACCAAGATCTTCGACAAAGTCGAA
AATAAATTCAACACCTTAGGAAAAGAAAAGGACGATAGCGTCCAGACCATCAGCTATACCAAAGACGGTCAAACAGTGAA
GATCAGCGAAGCCGATGAGAAGAAGGAAACCAAAGATAAATGGTGGCAGAAAGGGGCTAAATCTGTCGGTAAGAAAATCA
AAAGCGCGGTACAGGATGAACAAGTCGTCGGGGGTAACGGCAGCGTCAAAGCGAACGTAGAGGTTGTCGAGAGCCAAGGG
GTTGAGGAGCAATCAGCTATCCGGGGTACACAGAATGTGGATCTGACCGTTAAGGGTAAAACTGACCTGGTTGGCGGGAA
AATATCCAGTAAAAATTCGGATGTTAAGCTAAAAACCAATGGGTTAGAGACGCAGGATATCAACGGGAAATATACCGAAG
GGGGTGCACGATTGAACGCTTCTTCATCGGTTATGGATATGATTAGCGATGGCGCTAAGGATGTAATGGATGGCAAGGCA
CCGCTGGTCAGTGGACATGGTAAATCTGAACAGAAAAATGCAACGGGTGGTATCACCAGAGAATGA

Upstream 100 bases:

>100_bases
AGTAACAGCACCAGTGAAAATGATGATGGCACAAAAACGCATACTAACAACAAAGGGTTCAGCGCAGGAGCAGACCCTGA
ACAGCGCTAAAAATACCGAA

Downstream 100 bases:

>100_bases
TCAATCCATTAATTAAACTGTAATATCGAAGGGGATAAACCAATCACGGTTTATCCCCCTCGTTAGATCAACATTATCTC
GCCTTTAAACGCACATCAAT

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MAGAVLQANQISGQIGGDLNVISRENRLNKVNVSAALGGSHSNAKQDSLISQVANASPIMSDKIKNKLEEKSTKIFDKVE
NKFNTLGKEKDDSVQTISYTKDGQTVKISEADEKKETKDKWWQKGAKSVGKKIKSAVQDEQVVGGNGSVKANVEVVESQG
VEEQSAIRGTQNVDLTVKGKTDLVGGKISSKNSDVKLKTNGLETQDINGKYTEGGARLNASSSVMDMISDGAKDVMDGKA
PLVSGHGKSEQKNATGGITRE

Sequences:

>Translated_261_residues
MAGAVLQANQISGQIGGDLNVISRENRLNKVNVSAALGGSHSNAKQDSLISQVANASPIMSDKIKNKLEEKSTKIFDKVE
NKFNTLGKEKDDSVQTISYTKDGQTVKISEADEKKETKDKWWQKGAKSVGKKIKSAVQDEQVVGGNGSVKANVEVVESQG
VEEQSAIRGTQNVDLTVKGKTDLVGGKISSKNSDVKLKTNGLETQDINGKYTEGGARLNASSSVMDMISDGAKDVMDGKA
PLVSGHGKSEQKNATGGITRE
>Mature_260_residues
AGAVLQANQISGQIGGDLNVISRENRLNKVNVSAALGGSHSNAKQDSLISQVANASPIMSDKIKNKLEEKSTKIFDKVEN
KFNTLGKEKDDSVQTISYTKDGQTVKISEADEKKETKDKWWQKGAKSVGKKIKSAVQDEQVVGGNGSVKANVEVVESQGV
EEQSAIRGTQNVDLTVKGKTDLVGGKISSKNSDVKLKTNGLETQDINGKYTEGGARLNASSSVMDMISDGAKDVMDGKAP
LVSGHGKSEQKNATGGITRE

Specific function: Cell-bound hemolysin, which releases heme-iron from erythrocytes by interaction with the erythrocyte membrane. ShlA requires shlB function [H]

COG id: COG3210

COG function: function code U; Large exoproteins involved in heme utilization or adhesion

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010069
- InterPro:   IPR008638
- InterPro:   IPR012334
- InterPro:   IPR011050
- InterPro:   IPR011102 [H]

Pfam domain/function: PF05860 Haemagg_act [H]

EC number: NA

Molecular weight: Translated: 27708; Mature: 27577

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGAVLQANQISGQIGGDLNVISRENRLNKVNVSAALGGSHSNAKQDSLISQVANASPIM
CCCCEEEHHHCCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCHH
SDKIKNKLEEKSTKIFDKVENKFNTLGKEKDDSVQTISYTKDGQTVKISEADEKKETKDK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEECCCHHHHHHHHH
WWQKGAKSVGKKIKSAVQDEQVVGGNGSVKANVEVVESQGVEEQSAIRGTQNVDLTVKGK
HHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEEEEECCCCCHHHHHCCCCCCEEEECCC
TDLVGGKISSKNSDVKLKTNGLETQDINGKYTEGGARLNASSSVMDMISDGAKDVMDGKA
CCCCCCEECCCCCCEEEEECCCCCCCCCCEECCCCCEECCHHHHHHHHHCCHHHHHCCCC
PLVSGHGKSEQKNATGGITRE
CEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AGAVLQANQISGQIGGDLNVISRENRLNKVNVSAALGGSHSNAKQDSLISQVANASPIM
CCCEEEHHHCCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCHH
SDKIKNKLEEKSTKIFDKVENKFNTLGKEKDDSVQTISYTKDGQTVKISEADEKKETKDK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEECCCHHHHHHHHH
WWQKGAKSVGKKIKSAVQDEQVVGGNGSVKANVEVVESQGVEEQSAIRGTQNVDLTVKGK
HHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEEEEECCCCCHHHHHCCCCCCEEEECCC
TDLVGGKISSKNSDVKLKTNGLETQDINGKYTEGGARLNASSSVMDMISDGAKDVMDGKA
CCCCCCEECCCCCCEEEEECCCCCCCCCCEECCCCCEECCHHHHHHHHHCCHHHHHCCCC
PLVSGHGKSEQKNATGGITRE
CEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3290200 [H]