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The map label for this gene is argD

Identifier: 170022506

GI number: 170022506

Start: 287394

End: 288611

Strand: Direct

Name: argD

Synonym: YPK_0245

Alternate gene names: 170022506

Gene position: 287394-288611 (Clockwise)

Preceding gene: 170022505

Following gene: 170022507

Centisome position: 6.13

GC content: 53.04

Gene sequence:

>1218_bases
ATGACAGATAAGTTAGCAGTGAATCGCAACACATTCGATCAGGTCATTTTGCCTGTTTATGCACCCGCGCAGTTTATCCC
AGTAAAAGGGAAAGGCAGCCGAGTGTGGGATCAACAAGGTACGGAGTACATTGATTTCGCCGGTGGCATTGCGGTTACCG
CACTGGGCCATTGCCATCCGGCACTGGTATCCGCATTGCATCAGCAGGGTGAAACGTTGTGGCACACCAGTAATGTGTTT
ACCAATGAGCCAGCACTGCGTTTAGCACAGAAGCTGATTGCCGCAACCTTTGCTGACCGGGTTTTCTTTGCCAACTCGGG
TGCTGAAGCGAATGAAGCGGCATTTAAGTTAGCTCGCCATTACGCTATTGAGCGTCATAGCCCCTATAAAACCAAGATTA
TTGCTTTCCACAATGCGTTTCATGGCCGCACCCTGTTTACGGTCTCTGTCGGGGGGCAGCCAAAGTATTCCGATGGTTTT
GGCCCGAAACCCGCGGATATCATCCATGTCCCGTTTAATGATCTGGCGGCAGTGAAAGCGGTGATGGATGATCACACCTG
TGCCGTGGTACTGGAACCGATTCAGGGAGAGGGCGGGATCACTTCTGCCACGCCAGAGTTCCTACAAGGGGTGCGCGCGT
TGTGCGATCAACATAACGCCCTGCTGGTGTTTGATGAAGTGCAAAGCGGTATGGGGCGCAGTGGCAAGTTGTTTAGCTAT
ATGCATTATGGTGTGACGCCGGATATCCTTACCACGGCGAAGGCATTGGGCGGTGGCTTCCCAATCAGTGCGATGCTAAC
GACCGAAGAGATCGCTTCAGTGATGACGGTGGGTACCCACGGAACCACCTATGGGGGTAATCCTCTGGCCTGTGCGGTCG
CTGAGGCCGCGTTGGATGTGATTAATACCCCTGAGGTACTTAATGGTATTGAACAGCGCCATGGTCTGTTTGTGCAGGCG
CTACAAAGCATCAACAGCAAGTATGATGTTTTCAGTGATATTCGTGGTATGGGGTTGTTGATTGGCGCGGAGTTAACCGC
GAAATACCGGGGGCAGGCGCGTGAGTTCCTGGCCGCCGCTGCCGCTAACGGCTTGATGATCCTCAATGCGGGTCCAGATG
TTCTGCGGTTAGCGCCCTCGCTGGTGATTGAATTGGAGGATATCCAGCAAGGGATGGCGCGGTTGGAGAAAGCAATGGCG
AGTGTGATCAAAGGTTAA

Upstream 100 bases:

>100_bases
TTATCATTTGCTTGCGGATGATTTTTTATGCATATTTTGTGAGTATATTTTCACGCATCAATAAATAACAGCTTAGTGGT
TTATTAGGGTGGGCAGCGTA

Downstream 100 bases:

>100_bases
GCAGCCAATAACCGCGTTATGGAGAGGCGCTAGCCTCTCAGACTGCTGACAAACCCCGATGACGTGATCTTGAACGGTGA
GGATAGGCAGAGGAGTAAAG

Product: bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein

Products: NA

Alternate protein names: ACOAT; DapATase; Succinyldiaminopimelate transferase

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MTDKLAVNRNTFDQVILPVYAPAQFIPVKGKGSRVWDQQGTEYIDFAGGIAVTALGHCHPALVSALHQQGETLWHTSNVF
TNEPALRLAQKLIAATFADRVFFANSGAEANEAAFKLARHYAIERHSPYKTKIIAFHNAFHGRTLFTVSVGGQPKYSDGF
GPKPADIIHVPFNDLAAVKAVMDDHTCAVVLEPIQGEGGITSATPEFLQGVRALCDQHNALLVFDEVQSGMGRSGKLFSY
MHYGVTPDILTTAKALGGGFPISAMLTTEEIASVMTVGTHGTTYGGNPLACAVAEAALDVINTPEVLNGIEQRHGLFVQA
LQSINSKYDVFSDIRGMGLLIGAELTAKYRGQAREFLAAAAANGLMILNAGPDVLRLAPSLVIELEDIQQGMARLEKAMA
SVIKG

Sequences:

>Translated_405_residues
MTDKLAVNRNTFDQVILPVYAPAQFIPVKGKGSRVWDQQGTEYIDFAGGIAVTALGHCHPALVSALHQQGETLWHTSNVF
TNEPALRLAQKLIAATFADRVFFANSGAEANEAAFKLARHYAIERHSPYKTKIIAFHNAFHGRTLFTVSVGGQPKYSDGF
GPKPADIIHVPFNDLAAVKAVMDDHTCAVVLEPIQGEGGITSATPEFLQGVRALCDQHNALLVFDEVQSGMGRSGKLFSY
MHYGVTPDILTTAKALGGGFPISAMLTTEEIASVMTVGTHGTTYGGNPLACAVAEAALDVINTPEVLNGIEQRHGLFVQA
LQSINSKYDVFSDIRGMGLLIGAELTAKYRGQAREFLAAAAANGLMILNAGPDVLRLAPSLVIELEDIQQGMARLEKAMA
SVIKG
>Mature_404_residues
TDKLAVNRNTFDQVILPVYAPAQFIPVKGKGSRVWDQQGTEYIDFAGGIAVTALGHCHPALVSALHQQGETLWHTSNVFT
NEPALRLAQKLIAATFADRVFFANSGAEANEAAFKLARHYAIERHSPYKTKIIAFHNAFHGRTLFTVSVGGQPKYSDGFG
PKPADIIHVPFNDLAAVKAVMDDHTCAVVLEPIQGEGGITSATPEFLQGVRALCDQHNALLVFDEVQSGMGRSGKLFSYM
HYGVTPDILTTAKALGGGFPISAMLTTEEIASVMTVGTHGTTYGGNPLACAVAEAALDVINTPEVLNGIEQRHGLFVQAL
QSINSKYDVFSDIRGMGLLIGAELTAKYRGQAREFLAAAAANGLMILNAGPDVLRLAPSLVIELEDIQQGMARLEKAMAS
VIKG

Specific function: Involved in both the arginine and lysine biosynthetic pathways

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=387, Percent_Identity=35.9173126614987, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI284507298, Length=301, Percent_Identity=36.5448504983389, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI13994255, Length=412, Percent_Identity=28.3980582524272, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI37574042, Length=413, Percent_Identity=28.5714285714286, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI226442709, Length=386, Percent_Identity=29.0155440414508, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI24119277, Length=412, Percent_Identity=26.9417475728155, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI226442705, Length=413, Percent_Identity=27.3607748184019, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI1789759, Length=401, Percent_Identity=77.5561097256858, Blast_Score=663, Evalue=0.0,
Organism=Escherichia coli, GI1788044, Length=392, Percent_Identity=63.265306122449, Blast_Score=536, Evalue=1e-154,
Organism=Escherichia coli, GI1789016, Length=395, Percent_Identity=36.4556962025316, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI145693181, Length=389, Percent_Identity=35.73264781491, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI1787560, Length=403, Percent_Identity=33.4987593052109, Blast_Score=197, Evalue=7e-52,
Organism=Escherichia coli, GI1786991, Length=315, Percent_Identity=32.3809523809524, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1786349, Length=302, Percent_Identity=31.4569536423841, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25144271, Length=376, Percent_Identity=37.5, Blast_Score=248, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI25144274, Length=260, Percent_Identity=38.4615384615385, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI32564660, Length=423, Percent_Identity=30.4964539007092, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71992977, Length=429, Percent_Identity=28.2051282051282, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17541228, Length=438, Percent_Identity=24.6575342465753, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71981843, Length=165, Percent_Identity=32.7272727272727, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324432, Length=396, Percent_Identity=39.6464646464646, Blast_Score=290, Evalue=4e-79,
Organism=Saccharomyces cerevisiae, GI6323470, Length=402, Percent_Identity=35.5721393034826, Blast_Score=223, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6324386, Length=314, Percent_Identity=30.5732484076433, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6321456, Length=429, Percent_Identity=24.7086247086247, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357415, Length=388, Percent_Identity=35.5670103092784, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI161085790, Length=415, Percent_Identity=28.9156626506024, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI28574759, Length=404, Percent_Identity=29.2079207920792, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI21356575, Length=422, Percent_Identity=27.2511848341232, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI281366494, Length=438, Percent_Identity=22.8310502283105, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24667139, Length=438, Percent_Identity=22.8310502283105, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24667143, Length=438, Percent_Identity=22.8310502283105, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ARGD_YERPE (P59324)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- RefSeq:   NP_671247.1
- RefSeq:   NP_991572.1
- ProteinModelPortal:   P59324
- IntAct:   P59324
- GeneID:   1148901
- GeneID:   2763451
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- KEGG:   ypk:y3954
- KEGG:   ypm:YP_0172
- HOGENOM:   HBG725944
- ProtClustDB:   PRK05093
- BioCyc:   YPES187410:Y3954-MONOMER
- BRENDA:   2.6.1.11
- BRENDA:   2.6.1.17
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR03246
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11; =2.6.1.17

Molecular weight: Translated: 43331; Mature: 43200

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 140-140 BINDING 143-143 BINDING 282-282 BINDING 283-283

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKLAVNRNTFDQVILPVYAPAQFIPVKGKGSRVWDQQGTEYIDFAGGIAVTALGHCHP
CCCCEECCCCCHHHEEEEEECCCEEEEECCCCCCCHHCCCCEEEECCCCHHHHHHHCCHH
ALVSALHQQGETLWHTSNVFTNEPALRLAQKLIAATFADRVFFANSGAEANEAAFKLARH
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHH
YAIERHSPYKTKIIAFHNAFHGRTLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLAAVKA
HHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCHHHHHHHH
VMDDHTCAVVLEPIQGEGGITSATPEFLQGVRALCDQHNALLVFDEVQSGMGRSGKLFSY
HHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCEEEE
MHYGVTPDILTTAKALGGGFPISAMLTTEEIASVMTVGTHGTTYGGNPLACAVAEAALDV
HHCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHH
INTPEVLNGIEQRHGLFVQALQSINSKYDVFSDIRGMGLLIGAELTAKYRGQAREFLAAA
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHH
AANGLMILNAGPDVLRLAPSLVIELEDIQQGMARLEKAMASVIKG
HCCCEEEEECCCHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDKLAVNRNTFDQVILPVYAPAQFIPVKGKGSRVWDQQGTEYIDFAGGIAVTALGHCHP
CCCEECCCCCHHHEEEEEECCCEEEEECCCCCCCHHCCCCEEEECCCCHHHHHHHCCHH
ALVSALHQQGETLWHTSNVFTNEPALRLAQKLIAATFADRVFFANSGAEANEAAFKLARH
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHH
YAIERHSPYKTKIIAFHNAFHGRTLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLAAVKA
HHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCHHHHHHHH
VMDDHTCAVVLEPIQGEGGITSATPEFLQGVRALCDQHNALLVFDEVQSGMGRSGKLFSY
HHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCEEEE
MHYGVTPDILTTAKALGGGFPISAMLTTEEIASVMTVGTHGTTYGGNPLACAVAEAALDV
HHCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHH
INTPEVLNGIEQRHGLFVQALQSINSKYDVFSDIRGMGLLIGAELTAKYRGQAREFLAAA
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHH
AANGLMILNAGPDVLRLAPSLVIELEDIQQGMARLEKAMASVIKG
HCCCEEEEECCCHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430