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The map label for this gene is nirC [H]

Identifier: 170022494

GI number: 170022494

Start: 271576

End: 272382

Strand: Reverse

Name: nirC [H]

Synonym: YPK_0233

Alternate gene names: 170022494

Gene position: 272382-271576 (Counterclockwise)

Preceding gene: 170022495

Following gene: 170022493

Centisome position: 5.81

GC content: 53.78

Gene sequence:

>807_bases
ATGTACACTGACACCATCAATAAATGCGCGGCCAATGCGGCCCGAATCGTCAAGCTGGCCAAAGAGAGCCCACTAGGTTT
TTGGATTGGTTCCGCCATGGCGGGTGCCTATGTGGGCTTGGGTATCATCCTGATTTTCACCTTGGGTAACCTCATCGACC
CCGCCCTTCGCCCATTGGTGATGGGGGCCACCTTTGGTCTGGCTCTAACATTAGTCATCATTGCCGGTTCTGAATTATTT
ACCGGTCACACCATGTTCCTGACCTTCGGTGTGAAAGCAGGCACCATCAAATCCAGCCAAATGTGGGCAGTATTACCGCA
AACCTGGTTGGGAAATCTACTGGGGTCGATTTTCGTTGCCCTGCTCTATTACTACGGTGGCGGCAACCTGCTCTCCGTGG
ACACCAGCCTGGTACACACCGCGGCACTGGCAAAAACCACAGCACCGGCGATGGCCTTATTCTTTAAAGGCGTCTTATGT
AACTGGCTGGTTTGTCTGGCGATCTGGATGGCGATCCGCGTTGAAGGCGCAGCGAAATTTATCGCTATCTGGTGGTGTTT
GCTGGCCTTTATTGCCTCGGGTTACGAACACTCCGTAGCGAACATGACCTTGCTTGCGTTGTCTTGGTTTGGCCATCACA
GCGAGGCATACACCTTAAGCGGCATCGGCCATAACCTGTTATGGGTCACGCTGGGTAATACCCTGTCAGGCGCGGTCTTT
ATGGGCCTGGGTTATTGGTATGCCACCCCTCGGGCGCAACGGCCACAACCGGCAACGATTAACGCCCCACACAGCGCAAA
ATCATAA

Upstream 100 bases:

>100_bases
CCCCTACGTCGTGGGTATTGTCGTTGATATTGTCGTTGATATTGTCGCAAGGCAGTAAACACCGCTGCGGCACCAAGAAC
GAAGGGGGTTTGGGAAAAAA

Downstream 100 bases:

>100_bases
TAATTTGGCAGCGCTGTGATAACTCGTTGCCCTGCAACAGACTGAAAACTGAAGGATTGCCGATGGACTACTTCCCGATC
TTCTGCCAACTGCAACACAA

Product: nitrite transporter NirC

Products: Proton [Cytoplasm]; nitrite [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MYTDTINKCAANAARIVKLAKESPLGFWIGSAMAGAYVGLGIILIFTLGNLIDPALRPLVMGATFGLALTLVIIAGSELF
TGHTMFLTFGVKAGTIKSSQMWAVLPQTWLGNLLGSIFVALLYYYGGGNLLSVDTSLVHTAALAKTTAPAMALFFKGVLC
NWLVCLAIWMAIRVEGAAKFIAIWWCLLAFIASGYEHSVANMTLLALSWFGHHSEAYTLSGIGHNLLWVTLGNTLSGAVF
MGLGYWYATPRAQRPQPATINAPHSAKS

Sequences:

>Translated_268_residues
MYTDTINKCAANAARIVKLAKESPLGFWIGSAMAGAYVGLGIILIFTLGNLIDPALRPLVMGATFGLALTLVIIAGSELF
TGHTMFLTFGVKAGTIKSSQMWAVLPQTWLGNLLGSIFVALLYYYGGGNLLSVDTSLVHTAALAKTTAPAMALFFKGVLC
NWLVCLAIWMAIRVEGAAKFIAIWWCLLAFIASGYEHSVANMTLLALSWFGHHSEAYTLSGIGHNLLWVTLGNTLSGAVF
MGLGYWYATPRAQRPQPATINAPHSAKS
>Mature_268_residues
MYTDTINKCAANAARIVKLAKESPLGFWIGSAMAGAYVGLGIILIFTLGNLIDPALRPLVMGATFGLALTLVIIAGSELF
TGHTMFLTFGVKAGTIKSSQMWAVLPQTWLGNLLGSIFVALLYYYGGGNLLSVDTSLVHTAALAKTTAPAMALFFKGVLC
NWLVCLAIWMAIRVEGAAKFIAIWWCLLAFIASGYEHSVANMTLLALSWFGHHSEAYTLSGIGHNLLWVTLGNTLSGAVF
MGLGYWYATPRAQRPQPATINAPHSAKS

Specific function: May act as a nitrite transporter [H]

COG id: COG2116

COG function: function code P; Formate/nitrite family of transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FNT transporter (TC 2.A.44) family [H]

Homologues:

Organism=Escherichia coli, GI87082249, Length=266, Percent_Identity=82.3308270676692, Blast_Score=454, Evalue=1e-129,
Organism=Escherichia coli, GI1787132, Length=280, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788837, Length=277, Percent_Identity=29.2418772563177, Blast_Score=64, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6321779, Length=160, Percent_Identity=30.625, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000292 [H]

Pfam domain/function: PF01226 Form_Nir_trans [H]

EC number: NA

Molecular weight: Translated: 28678; Mature: 28678

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS01005 FORMATE_NITRITE_TP_1 ; PS01006 FORMATE_NITRITE_TP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTDTINKCAANAARIVKLAKESPLGFWIGSAMAGAYVGLGIILIFTLGNLIDPALRPLV
CCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGATFGLALTLVIIAGSELFTGHTMFLTFGVKAGTIKSSQMWAVLPQTWLGNLLGSIFVA
HHHHHHHHHHHHHHCCCCHHCCEEEEEEECCCCCCCCCCCCEEECHHHHHHHHHHHHHHH
LLYYYGGGNLLSVDTSLVHTAALAKTTAPAMALFFKGVLCNWLVCLAIWMAIRVEGAAKF
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAIWWCLLAFIASGYEHSVANMTLLALSWFGHHSEAYTLSGIGHNLLWVTLGNTLSGAVF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEEEECCCHHHHHH
MGLGYWYATPRAQRPQPATINAPHSAKS
HHHHHHEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MYTDTINKCAANAARIVKLAKESPLGFWIGSAMAGAYVGLGIILIFTLGNLIDPALRPLV
CCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGATFGLALTLVIIAGSELFTGHTMFLTFGVKAGTIKSSQMWAVLPQTWLGNLLGSIFVA
HHHHHHHHHHHHHHCCCCHHCCEEEEEEECCCCCCCCCCCCEEECHHHHHHHHHHHHHHH
LLYYYGGGNLLSVDTSLVHTAALAKTTAPAMALFFKGVLCNWLVCLAIWMAIRVEGAAKF
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAIWWCLLAFIASGYEHSVANMTLLALSWFGHHSEAYTLSGIGHNLLWVTLGNTLSGAVF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEEEECCCHHHHHH
MGLGYWYATPRAQRPQPATINAPHSAKS
HHHHHHEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; nitrite [Periplasm] [C]

Specific reaction: Proton [Periplasm] + nitrite [Periplasm] = Proton [Cytoplasm] + nitrite [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1987123; 11677609 [H]