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The map label for this gene is envZ [H]

Identifier: 170022434

GI number: 170022434

Start: 223976

End: 225328

Strand: Direct

Name: envZ [H]

Synonym: YPK_0173

Alternate gene names: 170022434

Gene position: 223976-225328 (Clockwise)

Preceding gene: 170022433

Following gene: 170022440

Centisome position: 4.78

GC content: 51.52

Gene sequence:

>1353_bases
ATGAAGTGGTGGCGCTTTTCTCCACGTAGTTCATTCGCCCGAACCTTATTACTGATCGTGACCTTGCTGTTTGTCAGTTT
GGTCACTACGTATCTGGTGGTGCTGAATTTCGCTATCTTACCTAGCTTGCAACAGTTCAATAAAGTGTTGGCGTATGAAG
TCCGTATGCTGATGACTGATCGGCTGCAATTGGAAGATGGCACACTACTTGAAGTCCCGCCCGCGTTCCGGCGTGAGATT
TACCGTGAGTTGGGTATTTCGCTTTATACCAACGCGGCGGCAGAGGAAAGTGGCCTACGTTGGGCACAGCATTATAAATT
TCTCAGTGATCAAATGGCCCAGCAGTTGGGCGGGCCAACCGATGTCCGGGTCGAGGTCAATAAAAACTCACCTGTAGTTT
GGCTCAAAACCTGGCTGTCGCCAGATATCTGGGTGCGCGTCCCCCTCACGGAGATTCACCAAGGCGATTTCTCGCCGCTG
TTCCGTTATACCTTGGCCATTATGCTACTGGCGGTGGGTGGGGCCTGGTTATTTATCCGTATTCAGAATCGGCCTTTGGT
GGAACTGGAACATGCGGCTTTACAGGTCGGTAAGGGGAATATTCCGCCACCGTTGCGGGAATACGGTGCTTCTGAAGTTC
GCTCGGTGACACGGGCATTTAACCAAATGGCCGCCGGGGTCAAATTGTTGTCTGATGACCGGACCTTGTTGATGGCGGGC
GTGAGCCATGATTTACGTACTCCGTTGACGCGTATTCGCTTGGCAACGGAAATGATGAGTGAAGACGACGCTTACCTGTC
TGAATCGATCAATAAAGACATTGAAGAGTGCAATGCGATTATTGAGCAATTTATCGACTATCTGCGCACCGGGCAGGAGA
TGCCGACCGAACCGAGCGATCTTAATTCTGTATTAGGTGAAGTGATTGCGGCAGAAAGTGGTTATGAGCGGGTGATTGAG
ACGGATTTAGCTGAAGGTGAAGTGTTGGTGGATATTCATCCATTATCGATTAAACGCGCGCTAACCAATATGGTGGTGAA
TGCGGCCCGTTACGGTAATGGCTGGATAAAAGTGAGCAGTGGTAAGGAGTTGCAGCGGGCTTGGTTCCAGGTTGAAGATG
ATGGCCCCGGTATAAAACCCGAGGATTTGAAGCACTTGCTCCAGCCTTTCGTGCGCGGTGATAGTGCCCGCAGCACCAGC
GGTACTGGGCTAGGCCTGGCAATTGTTCAGCGAATCATTGATGCGCACGCGGGGTCATTGGAGATTGGTACCAGTAAGCG
AGGCGGGTTACGGATCCGCGCATATATTCCATTGCCATTGGATGTGAAGCCCAAGCCACCAGCGGTGGCTTGA

Upstream 100 bases:

>100_bases
CTCGTTTGCGTCGGATGGTGGAAGAAGATCCGGCCCATCCGCGTTATATCCAGACGGTGTGGGGTCTAGGCTACGTCTTT
GTACCGGACGGCAATAAAGC

Downstream 100 bases:

>100_bases
GGTTATTGACAAAGTGCCCGCGACGGAGAGAACAGGCAGATCGTAAAGACGCCGTAAATACATCCATGTAGGCTCGAGCC
GCGCCATCCTTGGCGCGGAC

Product: osmolarity sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MKWWRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDRLQLEDGTLLEVPPAFRREI
YRELGISLYTNAAAEESGLRWAQHYKFLSDQMAQQLGGPTDVRVEVNKNSPVVWLKTWLSPDIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAVGGAWLFIRIQNRPLVELEHAALQVGKGNIPPPLREYGASEVRSVTRAFNQMAAGVKLLSDDRTLLMAG
VSHDLRTPLTRIRLATEMMSEDDAYLSESINKDIEECNAIIEQFIDYLRTGQEMPTEPSDLNSVLGEVIAAESGYERVIE
TDLAEGEVLVDIHPLSIKRALTNMVVNAARYGNGWIKVSSGKELQRAWFQVEDDGPGIKPEDLKHLLQPFVRGDSARSTS
GTGLGLAIVQRIIDAHAGSLEIGTSKRGGLRIRAYIPLPLDVKPKPPAVA

Sequences:

>Translated_450_residues
MKWWRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDRLQLEDGTLLEVPPAFRREI
YRELGISLYTNAAAEESGLRWAQHYKFLSDQMAQQLGGPTDVRVEVNKNSPVVWLKTWLSPDIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAVGGAWLFIRIQNRPLVELEHAALQVGKGNIPPPLREYGASEVRSVTRAFNQMAAGVKLLSDDRTLLMAG
VSHDLRTPLTRIRLATEMMSEDDAYLSESINKDIEECNAIIEQFIDYLRTGQEMPTEPSDLNSVLGEVIAAESGYERVIE
TDLAEGEVLVDIHPLSIKRALTNMVVNAARYGNGWIKVSSGKELQRAWFQVEDDGPGIKPEDLKHLLQPFVRGDSARSTS
GTGLGLAIVQRIIDAHAGSLEIGTSKRGGLRIRAYIPLPLDVKPKPPAVA
>Mature_450_residues
MKWWRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTDRLQLEDGTLLEVPPAFRREI
YRELGISLYTNAAAEESGLRWAQHYKFLSDQMAQQLGGPTDVRVEVNKNSPVVWLKTWLSPDIWVRVPLTEIHQGDFSPL
FRYTLAIMLLAVGGAWLFIRIQNRPLVELEHAALQVGKGNIPPPLREYGASEVRSVTRAFNQMAAGVKLLSDDRTLLMAG
VSHDLRTPLTRIRLATEMMSEDDAYLSESINKDIEECNAIIEQFIDYLRTGQEMPTEPSDLNSVLGEVIAAESGYERVIE
TDLAEGEVLVDIHPLSIKRALTNMVVNAARYGNGWIKVSSGKELQRAWFQVEDDGPGIKPEDLKHLLQPFVRGDSARSTS
GTGLGLAIVQRIIDAHAGSLEIGTSKRGGLRIRAYIPLPLDVKPKPPAVA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=440, Percent_Identity=86.5909090909091, Blast_Score=781, Evalue=0.0,
Organism=Escherichia coli, GI1787894, Length=272, Percent_Identity=33.8235294117647, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1790346, Length=274, Percent_Identity=31.021897810219, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786600, Length=256, Percent_Identity=30.46875, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=217, Percent_Identity=28.110599078341, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1790551, Length=254, Percent_Identity=27.9527559055118, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87081816, Length=320, Percent_Identity=25.3125, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87082128, Length=274, Percent_Identity=24.4525547445255, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1786783, Length=294, Percent_Identity=27.2108843537415, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789403, Length=265, Percent_Identity=27.1698113207547, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=205, Percent_Identity=30.2439024390244, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789149, Length=232, Percent_Identity=30.1724137931034, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=23.3183856502242, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI145693157, Length=239, Percent_Identity=24.2677824267782, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=275, Percent_Identity=25.4545454545455, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50329; Mature: 50329

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWWRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLQLEDGTLLEVPPAFRREIYRELGISLYTNAAAEESGLRWAQHYKFLSDQMAQQLGGPT
CEEECCCCEEECCHHHHHHHHHHHCCHHEECCHHHHHCCHHHHHHHHHHHHHHHHCCCCC
DVRVEVNKNSPVVWLKTWLSPDIWVRVPLTEIHQGDFSPLFRYTLAIMLLAVGGAWLFIR
EEEEEECCCCCEEEEEECCCCCEEEECCHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEE
IQNRPLVELEHAALQVGKGNIPPPLREYGASEVRSVTRAFNQMAAGVKLLSDDRTLLMAG
ECCCCCCHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCEEECCCCEEEEEC
VSHDLRTPLTRIRLATEMMSEDDAYLSESINKDIEECNAIIEQFIDYLRTGQEMPTEPSD
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LNSVLGEVIAAESGYERVIETDLAEGEVLVDIHPLSIKRALTNMVVNAARYGNGWIKVSS
HHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCEEEECC
GKELQRAWFQVEDDGPGIKPEDLKHLLQPFVRGDSARSTSGTGLGLAIVQRIIDAHAGSL
CHHHHHHHEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCE
EIGTSKRGGLRIRAYIPLPLDVKPKPPAVA
EECCCCCCCEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKWWRFSPRSSFARTLLLIVTLLFVSLVTTYLVVLNFAILPSLQQFNKVLAYEVRMLMTD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLQLEDGTLLEVPPAFRREIYRELGISLYTNAAAEESGLRWAQHYKFLSDQMAQQLGGPT
CEEECCCCEEECCHHHHHHHHHHHCCHHEECCHHHHHCCHHHHHHHHHHHHHHHHCCCCC
DVRVEVNKNSPVVWLKTWLSPDIWVRVPLTEIHQGDFSPLFRYTLAIMLLAVGGAWLFIR
EEEEEECCCCCEEEEEECCCCCEEEECCHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEE
IQNRPLVELEHAALQVGKGNIPPPLREYGASEVRSVTRAFNQMAAGVKLLSDDRTLLMAG
ECCCCCCHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCEEECCCCEEEEEC
VSHDLRTPLTRIRLATEMMSEDDAYLSESINKDIEECNAIIEQFIDYLRTGQEMPTEPSD
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LNSVLGEVIAAESGYERVIETDLAEGEVLVDIHPLSIKRALTNMVVNAARYGNGWIKVSS
HHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCEEEECC
GKELQRAWFQVEDDGPGIKPEDLKHLLQPFVRGDSARSTSGTGLGLAIVQRIIDAHAGSL
CHHHHHHHEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCE
EIGTSKRGGLRIRAYIPLPLDVKPKPPAVA
EECCCCCCCEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]