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The map label for this gene is dnaA [H]

Identifier: 170022263

GI number: 170022263

Start: 37

End: 1389

Strand: Direct

Name: dnaA [H]

Synonym: YPK_0001

Alternate gene names: 170022263

Gene position: 37-1389 (Clockwise)

Preceding gene: NA

Following gene: 170022264

Centisome position: 0.0

GC content: 47.6

Gene sequence:

>1353_bases
TTGCAGGATGAGTTACCTGCCACAGAATTTAGTATGTGGATACGCCCCCTACAGGCGGAACTGAGTGACAATACTCTGGC
GCTTTACGCACCTAATCGTTTTGTACTGGACTGGGTCCGTGATAAGTACTTAAACAATATCAATGGCTTACTTAATGATT
TTTGTGGCACCGAGGTCCCTTTACTGCGTTTTGAGGTAGGGAGTAAACCTGCGGCAAGAGCACACAATAATCCAGTTACA
GCCAGCGTGAGTGCGCCTGTTGCTCCGGTTACCCGCAGTGCACCTATGCGCCCGAGCTGGGACAACTCACCTGCTCAGCC
TGAACTTTCTTATCGTTCGAATGTGAATCCAAAACACACATTTGATAACTTTGTTGAAGGTAAATCTAACCAGTTGGCCC
GCGCTGCCGCCCGTCAGGTAGCCGATAACCCAGGTGGTGCCTATAACCCGTTATTTCTTTATGGCGGAACAGGCTTGGGT
AAAACCCATCTGCTACACGCGGTGGGGAATGGCATTATGGCCCGTAAAGCCAATGCTAAAGTGGTCTATATGCATTCCGA
GCGTTTTGTGCAAGATATGGTCAAAGCCTTGCAAAATAATGCTATCGAAGAGTTTAAACGCTATTATCGTTCGGTTGATG
CTTTATTAATCGATGATATTCAATTTTTTGCCAATAAAGAGCGTTCTCAAGAAGAGTTTTTCCACACCTTTAATGCGTTG
CTAGAGGGTAATCAGCAGATCATTTTGACCTCAGATCGCTATCCAAAAGAGATTAACGGGGTGGAAGATCGTCTGAAGTC
GCGTTTTGGTTGGGGGCTGACGGTCGCCATTGAGCCACCAGAGCTGGAAACGCGTGTAGCGATCCTAATGAAGAAAGCGG
ATGAAAATGATATTCGCTTACCAGGAGAGGTCGCGTTCTTTATTGCCAAGCGTCTGCGTTCCAATGTGCGTGAATTGGAA
GGGGCATTGAACCGTGTGATCGCCAATGCCAATTTTACTGGCCGCGCTATCACGATTGATTTTGTTCGCGAAGCCCTGCG
TGATTTGTTGGCGTTGCAAGAAAAGCTGGTCACTATCGATAATATTCAAAAGACTGTTGCTGAATATTATAAAATTAAGG
TCGCTGACCTGCTCTCCAAACGGCGTTCCCGTTCGGTTGCCCGCCCTCGCCAAATGGCGATGGCATTGGCAAAAGAGCTA
ACCAACCACAGCCTGCCTGAAATCGGCGATGCGTTTGGTGGCCGCGACCATACCACGGTGTTGCACGCTTGCCGGAAGAT
TGAGCAATTGCGTGAGGAAAGTCACGACATCAAAGAAGATTTCTCTAACTTAATCAGAACATTATCCTCCTAG

Upstream 100 bases:

>100_bases
AACGATGAGTTACAAAATATCCTGATTTCTTTCTTTTATTGATCTTGTTCGAGTGGAGTCCGCCGTGTCACTTTCGCTTT
GGCAGCAGTGTCTTGCCCGA

Downstream 100 bases:

>100_bases
CGCTATGAAATTTATCATTGAACGTGAGCATCTGCTAAAACCACTGCAACAGGTCAGTAGCCCGCTGGGTGGACGCCCTA
CGTTGCCTATTTTGGGTAAC

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLNDFCGTEVPLLRFEVGSKPAARAHNNPVT
ASVSAPVAPVTRSAPMRPSWDNSPAQPELSYRSNVNPKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLG
KTHLLHAVGNGIMARKANAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNAL
LEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELE
GALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKEL
TNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS

Sequences:

>Translated_450_residues
MQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLNDFCGTEVPLLRFEVGSKPAARAHNNPVT
ASVSAPVAPVTRSAPMRPSWDNSPAQPELSYRSNVNPKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLG
KTHLLHAVGNGIMARKANAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNAL
LEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELE
GALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKEL
TNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS
>Mature_450_residues
MQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLNDFCGTEVPLLRFEVGSKPAARAHNNPVT
ASVSAPVAPVTRSAPMRPSWDNSPAQPELSYRSNVNPKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLG
KTHLLHAVGNGIMARKANAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNAL
LEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELE
GALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKEL
TNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=456, Percent_Identity=91.4473684210526, Blast_Score=847, Evalue=0.0,
Organism=Escherichia coli, GI226510964, Length=249, Percent_Identity=28.1124497991968, Blast_Score=85, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 50777; Mature: 50777

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLNDFCGTEVP
CCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LLRFEVGSKPAARAHNNPVTASVSAPVAPVTRSAPMRPSWDNSPAQPELSYRSNVNPKHT
EEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
FDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKANAK
HHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCEEECCCCE
VVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNAL
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRL
HCCCCEEEEECCCCCHHCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCC
PGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTID
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHH
NIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTV
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHH
LHACRKIEQLREESHDIKEDFSNLIRTLSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLNDFCGTEVP
CCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LLRFEVGSKPAARAHNNPVTASVSAPVAPVTRSAPMRPSWDNSPAQPELSYRSNVNPKHT
EEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
FDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKANAK
HHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCEEECCCCE
VVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNAL
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRL
HCCCCEEEEECCCCCHHCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCC
PGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTID
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHH
NIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTV
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHH
LHACRKIEQLREESHDIKEDFSNLIRTLSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA