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The map label for this gene is rnr [H]

Identifier: 169834018

GI number: 169834018

Start: 991080

End: 993434

Strand: Direct

Name: rnr [H]

Synonym: SPH_1076

Alternate gene names: 169834018

Gene position: 991080-993434 (Clockwise)

Preceding gene: 169832411

Following gene: 169833807

Centisome position: 44.13

GC content: 42.38

Gene sequence:

>2355_bases
ATGAAAGATAGAATAAAAGAATATTTACAAGACAAGGGAAAGGTGACTGTTAATGATTTGGCTCAGGCTTTGGGAAAAGA
CAGTTCCAAGGATTTTCGTGAGTTGATTAAAACCTTGTCCTTAATGGAAAGAAAGCACCAGATTCGCTTTGAAGAAGATG
GCAGTCTGACCTTGGAAGCCAAGAAAAAACATGAGATTACCCTCAAGGGGATTTTTCATGCCCATAAAAATGGTTTTGGT
TTTGTCAGCCTAGAAGGGGAAGAGGACGACCTTTTTGTAGGGAAAAATGATGTCAACTATGCTATTGATGGTGATACCGT
CGAGGTAGTGATTAAGAAAGTCGCTGACCGCAATAAGGGAACAGCAGCAGAAGCCAAAATTATTGATATCCTAGAACACA
GTTTGACAACAGTTGTCGGGCAAATCGTTCTGGATCAGGAAAAGCCTAAGTATGCTGGCTATATTCGTTCAAAAAATCAG
AAAATCAGTCAACCGATTTATGTTAAGAAACCAGCCCTAAAGTTAGAAGGAACAGAAGTTCTCAAGGTCTTTATCGATAA
ATACCCAAGCAAGAAACATGATTTCTTTGTCGCGAGTGTTCTCGATGTGGTGGGACACTCAACGGATGTCGGAATTGATG
TTCTTGAGGTTTTGGAATCAATGGACATTGTATCCGAGTTTCCAGAAGCTGTTGTTAAGGAAGCAGAAAGTGTGCCTGAT
GCTCCGTCTCAAAAGGATATGGAAGGTCGTCTGGATCTAAGAGATGAAATTACCTTTACCATTGACGGTGCGGATGCCAA
GGACTTGGACGATGCAGTGCATATCAAGGCTCTGAAAAATGGCAATCTGGAGCTTGGGGTTCACATCGCAGATGTTTCTT
ATTATGTGACCGAGGGGTCTGCCCTTGACAAGGAAGCCCTTAACCGTGCGACTTCTGTTTACGTGACAGACCGAGTGGTG
CCAATGCTTCCAGAACGACTATCAAATGGCATCTGCTCTCTCAATCCCCAAGTTGACCGCCTGACCCAGTCTGCTATTAT
GGAGATTGATAAACATGGTCGTGTGGTCAACTATACCATTACACAAACAGTTATCAAGACCAGTTTTCGTATGACCTATA
GCGATGTCAATGATATCCTAGCTGGCGATGAAGAAAAGAGAAAAAAATATCATAAAATTGTACCAAGTATCGAACTCATG
GCCAAGCTTCATGAAACTTTAGAAAACATGCGTGTGAAACGTGGAGCTCTCAATTTTGATACCAATGAAGCGAAGATTTT
AGTGGATAAACAAGGTAAGCCTGTTGATATCGTTCTTCGGCAGCGTGGTATTGCCGAGCGGATTATTGAGTCTTTTATGT
TGATGGCTAATGAAACAGTTGCCGAACATTTCAGCAAGTTGGATTTGCCTTTTATCTATCGAATTCACGAGGAGCCTAAG
GCTGAAAAGGTTCAGAAGTTTATTGATTATGCTTCGAGTTTTGGCTTGCGCATTTATGGGACTGCCAGTGAGATTAGTCA
GGAGGCACTTCAAGACATCATGCGTGCTGTTGAGGGAGAACCTTATGCAGATGTATTGTCCATGATGCTTCTTCGCTCTA
TGCAGCAGGCTCGTTATTCGGAGCACAATCACGGCCACTATGGACTAGCTGCTGACTATTATACTCACTTTACCAGTCCA
ATTCGTCGTTATCCAGACCTTCTTGTTCACCGTATGATTCGAGATTACGGCTGTTCTAAGGAAATAGCAGAGCATTTTGA
ACAAGTGATTCCAGAGATTGCGACCCAGTCTTCCAACCGTGAACGTCGTGCCATAGAAGCTGAGCGTGAAGTCGAAGCCA
TGAAAAAGGCTGAGTATATGGAAGAATACGTGGGTGAAGAGTATGATGCAGTTGTATCAAGTATTGTCAAATTCGGTCTC
TTTGTCGAATTGCCAAACACAGTTGAAGGCTTGATTCACATCACTAATCTACCTGAATTTTATCATTTCAATGAGCGTGA
TTTGACTCTTCGTGGAGAAAAATCAGGTATCACTTTCCGAGTGGGTCAGCAGATCCGTATCCGTGTTGAAAGAGCGGATA
AAATGACTGGAGAGATTGATTTTTCATTCGTACCTAGTGAGTTTGATGTGATTGAAAAAGGCTTGAAACAGTCTAGTCGT
AGTGGCAGAGGGCGTGGTTCAAATCGTCGTTCGGATAAGAAGGAAGACAAGAGAAAATTAGGACGCTCAAATGATAAGCG
TAAGCATTCACAAAAAGACAAGAAGAAAAAAGGAAAGAAACCTTTTTACAAGGAAGTAGCTAAGAAAGGAGCCAAGCATG
GCAAAGGGCGAGGGAAAGGTCGTCGCACAAAATAA

Upstream 100 bases:

>100_bases
AAAATAATGGGCAGGACTAGGTCTTTGCCTCTTTTTATTTTTAAAGGATGTTTGAGAAGGTTTTACAGTAAAAGAAAATT
AAAAAATCTAGAAAGAAAAT

Downstream 100 bases:

>100_bases
AAAGGCACGCCACGACTATACAATCGTAGATACGCTAGAGGCAGGGATGGTCCTGACTGGAACTGAAATCAAGAGTGTAC
GAGCTGCTCGAATTAATCTC

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R 1; VacB protein homolog 1 [H]

Number of amino acids: Translated: 784; Mature: 784

Protein sequence:

>784_residues
MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEAKKKHEITLKGIFHAHKNGFG
FVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKGTAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQ
KISQPIYVKKPALKLEGTEVLKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSEFPEAVVKEAESVPD
APSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLELGVHIADVSYYVTEGSALDKEALNRATSVYVTDRVV
PMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTITQTVIKTSFRMTYSDVNDILAGDEEKRKKYHKIVPSIELM
AKLHETLENMRVKRGALNFDTNEAKILVDKQGKPVDIVLRQRGIAERIIESFMLMANETVAEHFSKLDLPFIYRIHEEPK
AEKVQKFIDYASSFGLRIYGTASEISQEALQDIMRAVEGEPYADVLSMMLLRSMQQARYSEHNHGHYGLAADYYTHFTSP
IRRYPDLLVHRMIRDYGCSKEIAEHFEQVIPEIATQSSNRERRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIVKFGL
FVELPNTVEGLIHITNLPEFYHFNERDLTLRGEKSGITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSR
SGRGRGSNRRSDKKEDKRKLGRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKGRRTK

Sequences:

>Translated_784_residues
MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEAKKKHEITLKGIFHAHKNGFG
FVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKGTAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQ
KISQPIYVKKPALKLEGTEVLKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSEFPEAVVKEAESVPD
APSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLELGVHIADVSYYVTEGSALDKEALNRATSVYVTDRVV
PMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTITQTVIKTSFRMTYSDVNDILAGDEEKRKKYHKIVPSIELM
AKLHETLENMRVKRGALNFDTNEAKILVDKQGKPVDIVLRQRGIAERIIESFMLMANETVAEHFSKLDLPFIYRIHEEPK
AEKVQKFIDYASSFGLRIYGTASEISQEALQDIMRAVEGEPYADVLSMMLLRSMQQARYSEHNHGHYGLAADYYTHFTSP
IRRYPDLLVHRMIRDYGCSKEIAEHFEQVIPEIATQSSNRERRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIVKFGL
FVELPNTVEGLIHITNLPEFYHFNERDLTLRGEKSGITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSR
SGRGRGSNRRSDKKEDKRKLGRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKGRRTK
>Mature_784_residues
MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEAKKKHEITLKGIFHAHKNGFG
FVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKGTAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQ
KISQPIYVKKPALKLEGTEVLKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSEFPEAVVKEAESVPD
APSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLELGVHIADVSYYVTEGSALDKEALNRATSVYVTDRVV
PMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTITQTVIKTSFRMTYSDVNDILAGDEEKRKKYHKIVPSIELM
AKLHETLENMRVKRGALNFDTNEAKILVDKQGKPVDIVLRQRGIAERIIESFMLMANETVAEHFSKLDLPFIYRIHEEPK
AEKVQKFIDYASSFGLRIYGTASEISQEALQDIMRAVEGEPYADVLSMMLLRSMQQARYSEHNHGHYGLAADYYTHFTSP
IRRYPDLLVHRMIRDYGCSKEIAEHFEQVIPEIATQSSNRERRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIVKFGL
FVELPNTVEGLIHITNLPEFYHFNERDLTLRGEKSGITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSR
SGRGRGSNRRSDKKEDKRKLGRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKGRRTK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=416, Percent_Identity=33.6538461538462, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI190014625, Length=416, Percent_Identity=33.6538461538462, Blast_Score=211, Evalue=3e-54,
Organism=Homo sapiens, GI134288890, Length=391, Percent_Identity=32.9923273657289, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI19115966, Length=404, Percent_Identity=30.1980198019802, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI219521928, Length=404, Percent_Identity=30.1980198019802, Blast_Score=167, Evalue=5e-41,
Organism=Homo sapiens, GI156105695, Length=133, Percent_Identity=32.3308270676692, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI156105693, Length=133, Percent_Identity=32.3308270676692, Blast_Score=72, Evalue=3e-12,
Organism=Escherichia coli, GI87082383, Length=721, Percent_Identity=33.9805825242718, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI1787542, Length=677, Percent_Identity=24.8153618906942, Blast_Score=141, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17553506, Length=457, Percent_Identity=30.4157549234136, Blast_Score=199, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI212645896, Length=570, Percent_Identity=26.8421052631579, Blast_Score=170, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324552, Length=599, Percent_Identity=29.3823038397329, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320499, Length=319, Percent_Identity=25.0783699059561, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323943, Length=468, Percent_Identity=23.2905982905983, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24649634, Length=571, Percent_Identity=29.4220665499124, Blast_Score=216, Evalue=7e-56,
Organism=Drosophila melanogaster, GI19922976, Length=517, Percent_Identity=28.2398452611219, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24654597, Length=517, Percent_Identity=28.2398452611219, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24654592, Length=517, Percent_Identity=28.2398452611219, Blast_Score=166, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 89113; Mature: 89113

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEA
CCHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
KKKHEITLKGIFHAHKNGFGFVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKG
CCCCEEEEEHHHHHCCCCEEEEEEECCCCCEEECCCCCCEEECCHHHHHHHHHHHCCCCC
TAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQKISQPIYVKKPALKLEGTEV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEECCCCCCCHHHH
LKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSEFPEAVVKEAESVPD
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
APSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLELGVHIADVSYYVTEGS
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHEEEEECCCCEEEEEEEEEEEEEEECCC
ALDKEALNRATSVYVTDRVVPMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTI
CCCHHHHHHHHEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEH
TQTVIKTSFRMTYSDVNDILAGDEEKRKKYHKIVPSIELMAKLHETLENMRVKRGALNFD
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCC
TNEAKILVDKQGKPVDIVLRQRGIAERIIESFMLMANETVAEHFSKLDLPFIYRIHEEPK
CCCCEEEEECCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
AEKVQKFIDYASSFGLRIYGTASEISQEALQDIMRAVEGEPYADVLSMMLLRSMQQARYS
HHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
EHNHGHYGLAADYYTHFTSPIRRYPDLLVHRMIRDYGCSKEIAEHFEQVIPEIATQSSNR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
ERRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIVKFGLFVELPNTVEGLIHITNLPEF
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCHHHHHEEECCCCHH
YHFNERDLTLRGEKSGITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSR
HCCCCCCEEEECCCCCCEEEECCEEEEEEEHHHCCCCCEEEEECCCHHHHHHHHHHHHCC
SGRGRGSNRRSDKKEDKRKLGRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKG
CCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC
RRTK
CCCC
>Mature Secondary Structure
MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEA
CCHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
KKKHEITLKGIFHAHKNGFGFVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKG
CCCCEEEEEHHHHHCCCCEEEEEEECCCCCEEECCCCCCEEECCHHHHHHHHHHHCCCCC
TAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQKISQPIYVKKPALKLEGTEV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEECCCCCCCHHHH
LKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSEFPEAVVKEAESVPD
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
APSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLELGVHIADVSYYVTEGS
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHEEEEECCCCEEEEEEEEEEEEEEECCC
ALDKEALNRATSVYVTDRVVPMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTI
CCCHHHHHHHHEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEH
TQTVIKTSFRMTYSDVNDILAGDEEKRKKYHKIVPSIELMAKLHETLENMRVKRGALNFD
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCC
TNEAKILVDKQGKPVDIVLRQRGIAERIIESFMLMANETVAEHFSKLDLPFIYRIHEEPK
CCCCEEEEECCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
AEKVQKFIDYASSFGLRIYGTASEISQEALQDIMRAVEGEPYADVLSMMLLRSMQQARYS
HHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
EHNHGHYGLAADYYTHFTSPIRRYPDLLVHRMIRDYGCSKEIAEHFEQVIPEIATQSSNR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
ERRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIVKFGLFVELPNTVEGLIHITNLPEF
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCHHHHHEEECCCCHH
YHFNERDLTLRGEKSGITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSR
HCCCCCCEEEECCCCCCEEEECCEEEEEEEHHHCCCCCEEEEECCCHHHHHHHHHHHHCC
SGRGRGSNRRSDKKEDKRKLGRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKG
CCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC
RRTK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]