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The map label for this gene is msrAB2 [H]

Identifier: 169833892

GI number: 169833892

Start: 704858

End: 705970

Strand: Direct

Name: msrAB2 [H]

Synonym: SPH_0755

Alternate gene names: 169833892

Gene position: 704858-705970 (Clockwise)

Preceding gene: 169834506

Following gene: 169832464

Centisome position: 31.39

GC content: 42.14

Gene sequence:

>1113_bases
ATGAATGATAAGTTAAAAATCTTCTTGTTGCTAGGAGTATTTTTTCTAGCCATAACCGGTTTCTATGTTCTATTGATACG
AAATGCAGGGCAGACAGATGCCTCGCAAATTGAAAAGGCGGCAGTTAGCCAAGGAGGAAAAGCAGTGAAAAAAACAGAAA
TTAGTAAAGACGCAGACTTGCACGAAATTTATCTAGCTGGAGGTTGTTTCTGGGGAGTGGAGGAATATTTCTCACGCGTT
CCCGGGGTGACGGATGCCGTTTCAGGCTATGCAAATGGTAGAGGAGAAACAACCAAGTACGAATTGATTAACCAAACAGG
TCATGCAGAAACCGTCCATGTCACCTATGATGCCAAGCAAATTTCTCTCAAGGAAATCCTGCTTCACTATTTCCGCATTA
TCAATCCAACCAGCAAAAATAAACAAGGAAATGATGTGGGGACCCAGTACCGTACTGGTGTTTATTACACAGATGACAAG
GATTTGGAAGTGATTAACCAAGTCTTTGATGAGGTGGCTAAGAAATACGATCAACCTCTAGCAGTTGAAAAGGAAAACTT
GAAGAATTTTGTGGTGGCTGAGGATTACCATCAAGACTATCTCAAGAAAAATCCAAATGGCTACTGCCATATCAATGTTA
ATCAGGCGGCCTATCCTGTCATTGATGCCAGCAAATATCCAAAACCAAGTGATGAGGAATTGAAAAAGACCCTGTCACCT
GAGGAGTATGCAGTTACCCAGGAAAATCAAACAGAACGAGCTTTCTCAAACCGTTACTGGGATAAATTTGAATCCGGTAT
CTATGTGGATATAGCAACTGGGGAACCTCTCTTTTCATCAAAAGACAAATTTGAGTCTGGTTGTGGCTGGCCTAGTTTTA
CCCAACCCATCAGTCCAGATGTTGTCACCTACAAGGAAGATAAGTCCTACAATATGACGCGTATGGAAGTGCGGAGCCGA
GTAGGAGATTCTCACCTTGGGCATGTCTTTACGGATGGTCCACAGGACAAGGGCGGCTTACGTTACTGTATCAATAGCCT
CTCTATCCGCTTTATTCCCAAAGACCAAATGGAAGAAAAAGGCTACGCTTATTTACTAGATTATGTTGATTAA

Upstream 100 bases:

>100_bases
TTTATAGACAAAGAAGGCAAGCTGGTCAAAACACATCCAGGATTCATGGAAAAAGATGCAATTTTGCAAACTTTGAAGGA
ATTAGCCTAGGAGGTGTCTT

Downstream 100 bases:

>100_bases
TACTCTTCGAAAATCTCTTCAAACCACGTCAGCGTCGCCTTACCGTATGTAGGGTTACTGACTTCGTCAGTTTTATCTAC
AACCTCAAAGCTATACTTTG

Product: peptide methionine sulfoxide reductase MsrA/msrB

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MNDKLKIFLLLGVFFLAITGFYVLLIRNAGQTDASQIEKAAVSQGGKAVKKTEISKDADLHEIYLAGGCFWGVEEYFSRV
PGVTDAVSGYANGRGETTKYELINQTGHAETVHVTYDAKQISLKEILLHYFRIINPTSKNKQGNDVGTQYRTGVYYTDDK
DLEVINQVFDEVAKKYDQPLAVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAYPVIDASKYPKPSDEELKKTLSP
EEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEPLFSSKDKFESGCGWPSFTQPISPDVVTYKEDKSYNMTRMEVRSR
VGDSHLGHVFTDGPQDKGGLRYCINSLSIRFIPKDQMEEKGYAYLLDYVD

Sequences:

>Translated_370_residues
MNDKLKIFLLLGVFFLAITGFYVLLIRNAGQTDASQIEKAAVSQGGKAVKKTEISKDADLHEIYLAGGCFWGVEEYFSRV
PGVTDAVSGYANGRGETTKYELINQTGHAETVHVTYDAKQISLKEILLHYFRIINPTSKNKQGNDVGTQYRTGVYYTDDK
DLEVINQVFDEVAKKYDQPLAVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAYPVIDASKYPKPSDEELKKTLSP
EEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEPLFSSKDKFESGCGWPSFTQPISPDVVTYKEDKSYNMTRMEVRSR
VGDSHLGHVFTDGPQDKGGLRYCINSLSIRFIPKDQMEEKGYAYLLDYVD
>Mature_370_residues
MNDKLKIFLLLGVFFLAITGFYVLLIRNAGQTDASQIEKAAVSQGGKAVKKTEISKDADLHEIYLAGGCFWGVEEYFSRV
PGVTDAVSGYANGRGETTKYELINQTGHAETVHVTYDAKQISLKEILLHYFRIINPTSKNKQGNDVGTQYRTGVYYTDDK
DLEVINQVFDEVAKKYDQPLAVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAYPVIDASKYPKPSDEELKKTLSP
EEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEPLFSSKDKFESGCGWPSFTQPISPDVVTYKEDKSYNMTRMEVRSR
VGDSHLGHVFTDGPQDKGGLRYCINSLSIRFIPKDQMEEKGYAYLLDYVD

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=126, Percent_Identity=46.8253968253968, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI301336162, Length=126, Percent_Identity=46.8253968253968, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI73089054, Length=126, Percent_Identity=46.8253968253968, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI37620216, Length=126, Percent_Identity=46.8253968253968, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=37.1069182389937, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=37.1069182389937, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI117606353, Length=134, Percent_Identity=38.8059701492537, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI208609993, Length=129, Percent_Identity=37.2093023255814, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1788077, Length=132, Percent_Identity=47.7272727272727, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1790665, Length=168, Percent_Identity=36.9047619047619, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17553450, Length=137, Percent_Identity=42.3357664233577, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI115532676, Length=137, Percent_Identity=42.3357664233577, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320881, Length=156, Percent_Identity=39.7435897435897, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319816, Length=130, Percent_Identity=34.6153846153846, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221378664, Length=122, Percent_Identity=47.5409836065574, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI45553335, Length=125, Percent_Identity=46.4, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356369, Length=125, Percent_Identity=46.4, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221378662, Length=129, Percent_Identity=44.9612403100775, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24645799, Length=125, Percent_Identity=46.4, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24645804, Length=136, Percent_Identity=42.6470588235294, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24645801, Length=136, Percent_Identity=42.6470588235294, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 41961; Mature: 41961

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDKLKIFLLLGVFFLAITGFYVLLIRNAGQTDASQIEKAAVSQGGKAVKKTEISKDADL
CCCCEEHHHHHHHHHHHHHHHHEEHCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCC
HEIYLAGGCFWGVEEYFSRVPGVTDAVSGYANGRGETTKYELINQTGHAETVHVTYDAKQ
EEEEEECCHHHCHHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHCCCCCCEEEEEEECCHH
ISLKEILLHYFRIINPTSKNKQGNDVGTQYRTGVYYTDDKDLEVINQVFDEVAKKYDQPL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCEEEECCCHHHHHHHHHHHHHHHCCCCC
AVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAYPVIDASKYPKPSDEELKKTLSP
CEEHHCCCCEEEECHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCCCCCHHHHHHHCCC
EEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEPLFSSKDKFESGCGWPSFTQPISPD
CCEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHCCCCCCCCCCCCCCC
VVTYKEDKSYNMTRMEVRSRVGDSHLGHVFTDGPQDKGGLRYCINSLSIRFIPKDQMEEK
EEEEECCCCCCHHHHHHHHHCCCCCCCCEECCCCCCCCHHHHHHHCCEEEEECHHHHCCC
GYAYLLDYVD
CCEEEEEECC
>Mature Secondary Structure
MNDKLKIFLLLGVFFLAITGFYVLLIRNAGQTDASQIEKAAVSQGGKAVKKTEISKDADL
CCCCEEHHHHHHHHHHHHHHHHEEHCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCC
HEIYLAGGCFWGVEEYFSRVPGVTDAVSGYANGRGETTKYELINQTGHAETVHVTYDAKQ
EEEEEECCHHHCHHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHCCCCCCEEEEEEECCHH
ISLKEILLHYFRIINPTSKNKQGNDVGTQYRTGVYYTDDKDLEVINQVFDEVAKKYDQPL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCEEEECCCHHHHHHHHHHHHHHHCCCCC
AVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAYPVIDASKYPKPSDEELKKTLSP
CEEHHCCCCEEEECHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCCCCCHHHHHHHCCC
EEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEPLFSSKDKFESGCGWPSFTQPISPD
CCEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHCCCCCCCCCCCCCCC
VVTYKEDKSYNMTRMEVRSRVGDSHLGHVFTDGPQDKGGLRYCINSLSIRFIPKDQMEEK
EEEEECCCCCCHHHHHHHHHCCCCCCCCEECCCCCCCCHHHHHHHCCEEEEECHHHHCCC
GYAYLLDYVD
CCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]