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The map label for this gene is pabB [H]

Identifier: 169833881

GI number: 169833881

Start: 715321

End: 717042

Strand: Direct

Name: pabB [H]

Synonym: SPH_0760

Alternate gene names: 169833881

Gene position: 715321-717042 (Clockwise)

Preceding gene: 169833025

Following gene: 169833258

Centisome position: 31.85

GC content: 45.35

Gene sequence:

>1722_bases
ATGCATAGAAAAACAGTGATTGATTTTAGGACTTTGGGGGAGAGATATACCTTTACCCAGCCTATTAAAGAGTTGAAAAC
GAGAAATGTAGAAGAAGTGGCAGATTTGCTGGCACAAGTGGAAAGCTACCAAGAGCAAGGTTATTATGTGGTGGGGTATG
TCAGCTACGAGGCTGCACCTGCTTTTGAGGAGAAATTAGCAGTTCACAAGGTTCCTCTACTGGGCGAGTACTTGCTTTAC
TTTACTGTTCACGATAGGGTAGAGACCTCCCCTATTCCTCTGACTTATGAGGATATTGATTTGCCCTCAAATTGGCAGGA
AGTGACGTCTGCAGCAGACTATGAAAAGGCCATTGCCCAGATACACCATCACTTGAGGCAGGGAGACACCTATCAGGTCA
ACTACACCGTCCAACTCAAGCAAAAGTTAAGTGCCAATCCTTTTGCCATCTACAATCGTATGGTGGTAGAGCAGGAGGCG
GGCTACAATGCCTATGTGGAACATGACGAGATGGCAGTGATTTCCATGAGCCCAGAGCTCTTTTTTGAGCAAAATGATCG
CGAGTTGACAACACGACCAATGAAGGGGACGACTCAGCGTGGGGTAACTGACCAAGAAGATCTTGAACAGGCCAGTTGGT
TGGAACAGGATCCCAAAAATCGCTCTGAAAATATGATGATTGTGGACCTCTTGCGCAATGATATGAACCGTATTTCTGAA
GTTGGGAGCGAGCACGTGGAGCGTCTGTGTCAGGTAGAGCAGTATTCAACTGTTTGGCAGATGACTTCGACCATCAAGAG
TCAGTTGCGAGAGGATGTGGACCTTGTTGAAATCTTCCGCTCACTCTTTCCTTGTGGTTCCATAACGGGTGCACCGAAAA
TTGCGACAATGGAGATTATCAAGGACTTGGAGCCTCAACCGCGTGGAGTCTACTGTGGAACGATTGGTCTCTTGCTTCCA
AATGGACGACGGATTTTTAATGTGGCCATTCGTACCATTCAACTTCACAAAGGTCAAGCCATTTATGGAGTTGGCGGAGG
GATTACTTGGGATAGCACATGGGAATCTGAATACCGAGAGGTTCATCAAAAGGCAGCAGTTCTTTATCGTAAACAAGCTC
GCTTCCAACTGATTACGACAGGGGAAATCAGCCAGAAGAACCTGCTGTTTGAAGATCAACATCTGGAAAGACTGAGAAAA
GCTAGTCGTTATTTTGCTTTTCCTTTTGATGCAGAAGACTTGGGACACAAGATTGAGGAAGAGTGTCAGGATTGTGAAGC
TAATCGAGATTACCGCTTGCGAATCAGCCTTAGCAAATCTGGAGAGATAGAAGTCAATCGTCAAGTATTAACCCCTCTCA
GTACAAGCTTTTGTCAGGCCCAAGTCTGTCTTCAGGAAGCTGCTTTGAATCAATCCTTTACCTACTTTAAAACCACTCAC
CGACCGCATTTGAGCCTAGGAGAACAAGAGAAGATTTACCACAATAAGTCAGGAGAACTGCTTGAAACCTCTATAGGAAA
TTTGGTTCTGAAAATCGCTGGAAAACTCTACACACCGCCTATCCGACTTGGAATCTTGCCAGGAATTTACCGTCAGCATT
TGCTAGAAACAGGACAGGTAGAAGAGAAAGTCTTGACCTTGGCAGATTTAACCCAAGCAGAAGCTATTTACGGCTGTAAT
GCAGTGAGAGGCTTGTATGAACTAAGCCTTGAGGAGAACTAG

Upstream 100 bases:

>100_bases
TTGTAGGAAATCTTTTTAAAGCATAGATTGTATTAAATAGATGAGTAAAAAAGGTAGATTAAGTTTTTCTTGATCTGCCT
TTTTATGCTATACTTAAGGT

Downstream 100 bases:

>100_bases
ATGAAATTGATATTTTTGCATGGGTTAGGGCAGTCAGCAGAGTCTTGGAAAGAAGTTCGGAATCTACTGACAGATTATCC
TTCTGAGGCTATCGAGTTAT

Product: chorismate binding enzyme

Products: NA

Alternate protein names: ADC synthase; Para-aminobenzoate synthase component I [H]

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MHRKTVIDFRTLGERYTFTQPIKELKTRNVEEVADLLAQVESYQEQGYYVVGYVSYEAAPAFEEKLAVHKVPLLGEYLLY
FTVHDRVETSPIPLTYEDIDLPSNWQEVTSAADYEKAIAQIHHHLRQGDTYQVNYTVQLKQKLSANPFAIYNRMVVEQEA
GYNAYVEHDEMAVISMSPELFFEQNDRELTTRPMKGTTQRGVTDQEDLEQASWLEQDPKNRSENMMIVDLLRNDMNRISE
VGSEHVERLCQVEQYSTVWQMTSTIKSQLREDVDLVEIFRSLFPCGSITGAPKIATMEIIKDLEPQPRGVYCGTIGLLLP
NGRRIFNVAIRTIQLHKGQAIYGVGGGITWDSTWESEYREVHQKAAVLYRKQARFQLITTGEISQKNLLFEDQHLERLRK
ASRYFAFPFDAEDLGHKIEEECQDCEANRDYRLRISLSKSGEIEVNRQVLTPLSTSFCQAQVCLQEAALNQSFTYFKTTH
RPHLSLGEQEKIYHNKSGELLETSIGNLVLKIAGKLYTPPIRLGILPGIYRQHLLETGQVEEKVLTLADLTQAEAIYGCN
AVRGLYELSLEEN

Sequences:

>Translated_573_residues
MHRKTVIDFRTLGERYTFTQPIKELKTRNVEEVADLLAQVESYQEQGYYVVGYVSYEAAPAFEEKLAVHKVPLLGEYLLY
FTVHDRVETSPIPLTYEDIDLPSNWQEVTSAADYEKAIAQIHHHLRQGDTYQVNYTVQLKQKLSANPFAIYNRMVVEQEA
GYNAYVEHDEMAVISMSPELFFEQNDRELTTRPMKGTTQRGVTDQEDLEQASWLEQDPKNRSENMMIVDLLRNDMNRISE
VGSEHVERLCQVEQYSTVWQMTSTIKSQLREDVDLVEIFRSLFPCGSITGAPKIATMEIIKDLEPQPRGVYCGTIGLLLP
NGRRIFNVAIRTIQLHKGQAIYGVGGGITWDSTWESEYREVHQKAAVLYRKQARFQLITTGEISQKNLLFEDQHLERLRK
ASRYFAFPFDAEDLGHKIEEECQDCEANRDYRLRISLSKSGEIEVNRQVLTPLSTSFCQAQVCLQEAALNQSFTYFKTTH
RPHLSLGEQEKIYHNKSGELLETSIGNLVLKIAGKLYTPPIRLGILPGIYRQHLLETGQVEEKVLTLADLTQAEAIYGCN
AVRGLYELSLEEN
>Mature_573_residues
MHRKTVIDFRTLGERYTFTQPIKELKTRNVEEVADLLAQVESYQEQGYYVVGYVSYEAAPAFEEKLAVHKVPLLGEYLLY
FTVHDRVETSPIPLTYEDIDLPSNWQEVTSAADYEKAIAQIHHHLRQGDTYQVNYTVQLKQKLSANPFAIYNRMVVEQEA
GYNAYVEHDEMAVISMSPELFFEQNDRELTTRPMKGTTQRGVTDQEDLEQASWLEQDPKNRSENMMIVDLLRNDMNRISE
VGSEHVERLCQVEQYSTVWQMTSTIKSQLREDVDLVEIFRSLFPCGSITGAPKIATMEIIKDLEPQPRGVYCGTIGLLLP
NGRRIFNVAIRTIQLHKGQAIYGVGGGITWDSTWESEYREVHQKAAVLYRKQARFQLITTGEISQKNLLFEDQHLERLRK
ASRYFAFPFDAEDLGHKIEEECQDCEANRDYRLRISLSKSGEIEVNRQVLTPLSTSFCQAQVCLQEAALNQSFTYFKTTH
RPHLSLGEQEKIYHNKSGELLETSIGNLVLKIAGKLYTPPIRLGILPGIYRQHLLETGQVEEKVLTLADLTQAEAIYGCN
AVRGLYELSLEEN

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=268, Percent_Identity=39.5522388059701, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1787518, Length=261, Percent_Identity=29.8850574712644, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1786809, Length=221, Percent_Identity=23.5294117647059, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87082077, Length=209, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320935, Length=280, Percent_Identity=33.2142857142857, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324361, Length=282, Percent_Identity=29.4326241134752, Blast_Score=124, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =2.6.1.85 [H]

Molecular weight: Translated: 65742; Mature: 65742

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRKTVIDFRTLGERYTFTQPIKELKTRNVEEVADLLAQVESYQEQGYYVVGYVSYEAAP
CCCCEEEHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
AFEEKLAVHKVPLLGEYLLYFTVHDRVETSPIPLTYEDIDLPSNWQEVTSAADYEKAIAQ
HHHHHHHHHCCCHHHCEEEEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHH
IHHHLRQGDTYQVNYTVQLKQKLSANPFAIYNRMVVEQEAGYNAYVEHDEMAVISMSPEL
HHHHHHCCCEEEEEEEEEEHHHCCCCCHHHHHHHHEECCCCCCEEEECCCEEEEEECCHH
FFEQNDRELTTRPMKGTTQRGVTDQEDLEQASWLEQDPKNRSENMMIVDLLRNDMNRISE
EEECCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHH
VGSEHVERLCQVEQYSTVWQMTSTIKSQLREDVDLVEIFRSLFPCGSITGAPKIATMEII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCHHHHHHH
KDLEPQPRGVYCGTIGLLLPNGRRIFNVAIRTIQLHKGQAIYGVGGGITWDSTWESEYRE
HHCCCCCCEEEEEEEEEEECCCCEEEEEEEEEEEEECCCEEEECCCCCCCCCCHHHHHHH
VHQKAAVLYRKQARFQLITTGEISQKNLLFEDQHLERLRKASRYFAFPFDAEDLGHKIEE
HHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHH
ECQDCEANRDYRLRISLSKSGEIEVNRQVLTPLSTSFCQAQVCLQEAALNQSFTYFKTTH
HHHHCCCCCCEEEEEEECCCCCEEECHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECC
RPHLSLGEQEKIYHNKSGELLETSIGNLVLKIAGKLYTPPIRLGILPGIYRQHLLETGQV
CCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHCCCH
EEKVLTLADLTQAEAIYGCNAVRGLYELSLEEN
HHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MHRKTVIDFRTLGERYTFTQPIKELKTRNVEEVADLLAQVESYQEQGYYVVGYVSYEAAP
CCCCEEEHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
AFEEKLAVHKVPLLGEYLLYFTVHDRVETSPIPLTYEDIDLPSNWQEVTSAADYEKAIAQ
HHHHHHHHHCCCHHHCEEEEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHH
IHHHLRQGDTYQVNYTVQLKQKLSANPFAIYNRMVVEQEAGYNAYVEHDEMAVISMSPEL
HHHHHHCCCEEEEEEEEEEHHHCCCCCHHHHHHHHEECCCCCCEEEECCCEEEEEECCHH
FFEQNDRELTTRPMKGTTQRGVTDQEDLEQASWLEQDPKNRSENMMIVDLLRNDMNRISE
EEECCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHH
VGSEHVERLCQVEQYSTVWQMTSTIKSQLREDVDLVEIFRSLFPCGSITGAPKIATMEII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCHHHHHHH
KDLEPQPRGVYCGTIGLLLPNGRRIFNVAIRTIQLHKGQAIYGVGGGITWDSTWESEYRE
HHCCCCCCEEEEEEEEEEECCCCEEEEEEEEEEEEECCCEEEECCCCCCCCCCHHHHHHH
VHQKAAVLYRKQARFQLITTGEISQKNLLFEDQHLERLRKASRYFAFPFDAEDLGHKIEE
HHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHH
ECQDCEANRDYRLRISLSKSGEIEVNRQVLTPLSTSFCQAQVCLQEAALNQSFTYFKTTH
HHHHCCCCCCEEEEEEECCCCCEEECHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECC
RPHLSLGEQEKIYHNKSGELLETSIGNLVLKIAGKLYTPPIRLGILPGIYRQHLLETGQV
CCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHCCCH
EEKVLTLADLTQAEAIYGCNAVRGLYELSLEEN
HHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]