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The map label for this gene is folP [H]

Identifier: 169833864

GI number: 169833864

Start: 358746

End: 359726

Strand: Direct

Name: folP [H]

Synonym: SPH_0406

Alternate gene names: 169833864

Gene position: 358746-359726 (Clockwise)

Preceding gene: 169834172

Following gene: 169832986

Centisome position: 15.98

GC content: 45.57

Gene sequence:

>981_bases
ATGGTGAAAAGCCTTGAGGGAGTGACCGATATGTCAACTAAAGTAAATCATGCAAAGACAGCTATTTGCGGAATTATCAA
TGTAACCCCAGATTCCTTTTCGGATGGTGGTCAATTTTTTGCTCTTGAGCAGGCACTCCAGCAGGCTCGTAAATTGATAG
CAGAAGGGGCTAGTATGCTAGATATCGGCGGAGAATCGACTCGGCCGGGAAGTAGCTATGTTGAGATAGAAATAGAAGAG
GAAATCCAGCGTGTTGTTCCAGTGATTAAAGCGATTCGCAAGGAAAGTGATGTCCTCATCTCTATTGATACTTGGAAGAG
TCAAGTAGCAGAGGCTGCTTTGGCTGCTGGTGCCGATCTAGTCAATGATATCACTGGTCTTATGGGTGATGAGAAAATGG
CTCATGTGGTAGCTGAAGCGAGAGCGCAAGTGGTCATCATGTTTAATCCAGTTATGGCGCGACCTCAGCACCCTAGCTCG
CTCATCTTCCCTCATTTTGGTTTTGGTCAAGCTTTTACAGAGGAAGAGTTAGCTGACTTTGAAACATTGCCAATCGAAGA
ATTGATGGAGGCTTTCTTTGAACGAGCACTAGCGAGAGCGGCAGAAGCTGGTATTGCACCAGAAAATATCCTGTTGGATC
CAGGAATTGGCTTTGGTCTGACCAAGAAAGAAAATCTGCTTCTTTTACGGGACCTGGATAAACTACATCAGAAGGGCTAT
CCAATCTTTCTCGGAGTGTCGCGCAAGCGATTTGTCATCAATATCCTTGAAGAAATTGGGTTTGAAGTCAATCCTGAGAC
AGAGCTTGGTTTCCGCAATCGGGACACGGCTTCGGCTCATGTAACCAGTATCGCTGCGAGACAGGGTGTAGAAGTGGTGC
GCGTGCATGACGTAGCTAGTCACAGGATGGCAGTTGAAATTGCCTCTGCCATTCGTCTGGCTGATGAAGCGGAAAATTTA
GATTTAAAACAATATAAATAA

Upstream 100 bases:

>100_bases
AGTATAAGATTATTGACAATTGCTTACTTGTTTCTACTGGGAAAAAGATGAATGCAATCGTGTCCATCTTTTTCTTTTTA
TGGTAAAATAGAGAAATAAT

Downstream 100 bases:

>100_bases
GATGAAAGAAATTGAAAACAATCAGTGGATTGCTAACTACCGGACGGATCAACCGCATTTTGGCTTGGAACGAATGGTGG
AACTGTTAGCTTTGCGTGGC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MVKSLEGVTDMSTKVNHAKTAICGIINVTPDSFSDGGQFFALEQALQQARKLIAEGASMLDIGGESTRPGSSYVEIEIEE
EIQRVVPVIKAIRKESDVLISIDTWKSQVAEAALAAGADLVNDITGLMGDEKMAHVVAEARAQVVIMFNPVMARPQHPSS
LIFPHFGFGQAFTEEELADFETLPIEELMEAFFERALARAAEAGIAPENILLDPGIGFGLTKKENLLLLRDLDKLHQKGY
PIFLGVSRKRFVINILEEIGFEVNPETELGFRNRDTASAHVTSIAARQGVEVVRVHDVASHRMAVEIASAIRLADEAENL
DLKQYK

Sequences:

>Translated_326_residues
MVKSLEGVTDMSTKVNHAKTAICGIINVTPDSFSDGGQFFALEQALQQARKLIAEGASMLDIGGESTRPGSSYVEIEIEE
EIQRVVPVIKAIRKESDVLISIDTWKSQVAEAALAAGADLVNDITGLMGDEKMAHVVAEARAQVVIMFNPVMARPQHPSS
LIFPHFGFGQAFTEEELADFETLPIEELMEAFFERALARAAEAGIAPENILLDPGIGFGLTKKENLLLLRDLDKLHQKGY
PIFLGVSRKRFVINILEEIGFEVNPETELGFRNRDTASAHVTSIAARQGVEVVRVHDVASHRMAVEIASAIRLADEAENL
DLKQYK
>Mature_326_residues
MVKSLEGVTDMSTKVNHAKTAICGIINVTPDSFSDGGQFFALEQALQQARKLIAEGASMLDIGGESTRPGSSYVEIEIEE
EIQRVVPVIKAIRKESDVLISIDTWKSQVAEAALAAGADLVNDITGLMGDEKMAHVVAEARAQVVIMFNPVMARPQHPSS
LIFPHFGFGQAFTEEELADFETLPIEELMEAFFERALARAAEAGIAPENILLDPGIGFGLTKKENLLLLRDLDKLHQKGY
PIFLGVSRKRFVINILEEIGFEVNPETELGFRNRDTASAHVTSIAARQGVEVVRVHDVASHRMAVEIASAIRLADEAENL
DLKQYK

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=304, Percent_Identity=34.8684210526316, Blast_Score=161, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6324073, Length=349, Percent_Identity=31.5186246418338, Blast_Score=152, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 35708; Mature: 35708

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKSLEGVTDMSTKVNHAKTAICGIINVTPDSFSDGGQFFALEQALQQARKLIAEGASML
CCCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEE
DIGGESTRPGSSYVEIEIEEEIQRVVPVIKAIRKESDVLISIDTWKSQVAEAALAAGADL
ECCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCHHH
VNDITGLMGDEKMAHVVAEARAQVVIMFNPVMARPQHPSSLIFPHFGFGQAFTEEELADF
HHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCEECCCCCCCCCCCHHHHHCC
ETLPIEELMEAFFERALARAAEAGIAPENILLDPGIGFGLTKKENLLLLRDLDKLHQKGY
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEEEHHHHHHHHHCCC
PIFLGVSRKRFVINILEEIGFEVNPETELGFRNRDTASAHVTSIAARQGVEVVRVHDVAS
CEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEHHHH
HRMAVEIASAIRLADEAENLDLKQYK
HHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MVKSLEGVTDMSTKVNHAKTAICGIINVTPDSFSDGGQFFALEQALQQARKLIAEGASML
CCCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEE
DIGGESTRPGSSYVEIEIEEEIQRVVPVIKAIRKESDVLISIDTWKSQVAEAALAAGADL
ECCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCHHH
VNDITGLMGDEKMAHVVAEARAQVVIMFNPVMARPQHPSSLIFPHFGFGQAFTEEELADF
HHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCEECCCCCCCCCCCHHHHHCC
ETLPIEELMEAFFERALARAAEAGIAPENILLDPGIGFGLTKKENLLLLRDLDKLHQKGY
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEEEHHHHHHHHHCCC
PIFLGVSRKRFVINILEEIGFEVNPETELGFRNRDTASAHVTSIAARQGVEVVRVHDVAS
CEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEHHHH
HRMAVEIASAIRLADEAENLDLKQYK
HHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3114239; 11463916 [H]