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The map label for this gene is dtxR [H]

Identifier: 169833826

GI number: 169833826

Start: 1610492

End: 1611142

Strand: Direct

Name: dtxR [H]

Synonym: SPH_1749

Alternate gene names: 169833826

Gene position: 1610492-1611142 (Clockwise)

Preceding gene: 169833574

Following gene: 169834426

Centisome position: 71.72

GC content: 44.09

Gene sequence:

>651_bases
ATGACCCCAAACAAAGAAGACTATCTAAAATGTATTTATGAAATTGGCATAGACCTGCATAAGATTACCAACAAGGAAAT
TGCGGCTCGCATGCAAGTCTCTCCCCCTGCCGTAACTGAAATGATCAAACGAATGAAAAGTGAAAATCTCATCCTAAAGG
ACAAGGAATGTGGCTATCTACTGACTGACCTCGGTCTCAAACTGGTCTCTGAGCTCTATCGTAAGCACCGCTTGATTGAA
GTTTTTCTAGTTCATCATTTAGACTATACAAGTGACCAGATTCACGAGGAAGCTGAGGTCTTGGAACACACTGTCTCTGA
CCTGTTCGTGGAAAGACTAGATAAACTGCTAGGTTTCCCTAAAACCTGCCCCCACGGAGGAACTATTCCTGCCAAGGGAG
AACTCCTCGTTGAAATCAATAACCTCCCACTAGCTGATATCAAGGAAGCTGGCGCCTACCGCCTGACTCGGGTGCACGAT
AGTTTTGACATTCTCCATTATCTGGACAAGCACTCACTTCACATCGGTGACCAGCTCCAAGTCAAGCAGTTTGATGGCTT
CAGCAATACCTTCACTATCCTCAGTAACGACGAGGATTTACAAGTGAATATGGACATTGCAAAACAACTCTATGTCGAGA
AAATCAACTAA

Upstream 100 bases:

>100_bases
CGTTTTTTCTCTTGCAATAAGTATAACATAAAAAGTCACAGCTAGAGAAATCTAGCTTTTTTTGATATACTAGATAAAGA
TATTAGACAAGAGGAAACGA

Downstream 100 bases:

>100_bases
TTTCTCAAGTCCCCTACCAACCCTGAAAGTTTTATTTTCAGGGTTTTCTTATCTATTTTTTATATCAAAAACGATAGTAA
ACGTTTTCATATCCCGACTG

Product: iron-dependent transcriptional regulator

Products: NA

Alternate protein names: Iron-dependent diphtheria tox regulatory element; Tox regulatory factor [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTPNKEDYLKCIYEIGIDLHKITNKEIAARMQVSPPAVTEMIKRMKSENLILKDKECGYLLTDLGLKLVSELYRKHRLIE
VFLVHHLDYTSDQIHEEAEVLEHTVSDLFVERLDKLLGFPKTCPHGGTIPAKGELLVEINNLPLADIKEAGAYRLTRVHD
SFDILHYLDKHSLHIGDQLQVKQFDGFSNTFTILSNDEDLQVNMDIAKQLYVEKIN

Sequences:

>Translated_216_residues
MTPNKEDYLKCIYEIGIDLHKITNKEIAARMQVSPPAVTEMIKRMKSENLILKDKECGYLLTDLGLKLVSELYRKHRLIE
VFLVHHLDYTSDQIHEEAEVLEHTVSDLFVERLDKLLGFPKTCPHGGTIPAKGELLVEINNLPLADIKEAGAYRLTRVHD
SFDILHYLDKHSLHIGDQLQVKQFDGFSNTFTILSNDEDLQVNMDIAKQLYVEKIN
>Mature_215_residues
TPNKEDYLKCIYEIGIDLHKITNKEIAARMQVSPPAVTEMIKRMKSENLILKDKECGYLLTDLGLKLVSELYRKHRLIEV
FLVHHLDYTSDQIHEEAEVLEHTVSDLFVERLDKLLGFPKTCPHGGTIPAKGELLVEINNLPLADIKEAGAYRLTRVHDS
FDILHYLDKHSLHIGDQLQVKQFDGFSNTFTILSNDEDLQVNMDIAKQLYVEKIN

Specific function: Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess [H]

COG id: COG1321

COG function: function code K; Mn-dependent transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH dtxR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007167
- InterPro:   IPR001367
- InterPro:   IPR022689
- InterPro:   IPR022687
- InterPro:   IPR008988
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02742 Fe_dep_repr_C; PF01325 Fe_dep_repress [H]

EC number: NA

Molecular weight: Translated: 24826; Mature: 24695

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS50944 HTH_DTXR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPNKEDYLKCIYEIGIDLHKITNKEIAARMQVSPPAVTEMIKRMKSENLILKDKECGYL
CCCCHHHHHHHHHHHCCHHHHHCCHHHHHEECCCCHHHHHHHHHHCCCCCEEECCCCCHH
LTDLGLKLVSELYRKHRLIEVFLVHHLDYTSDQIHEEAEVLEHTVSDLFVERLDKLLGFP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KTCPHGGTIPAKGELLVEINNLPLADIKEAGAYRLTRVHDSFDILHYLDKHSLHIGDQLQ
CCCCCCCCCCCCCEEEEEECCCCCHHHHHCCCEEEEHHCCHHHHHHHHHHCCCCCCCCEE
VKQFDGFSNTFTILSNDEDLQVNMDIAKQLYVEKIN
EEECCCCCCEEEEEECCCCEEEEHHHHHHHHHHCCC
>Mature Secondary Structure 
TPNKEDYLKCIYEIGIDLHKITNKEIAARMQVSPPAVTEMIKRMKSENLILKDKECGYL
CCCHHHHHHHHHHHCCHHHHHCCHHHHHEECCCCHHHHHHHHHHCCCCCEEECCCCCHH
LTDLGLKLVSELYRKHRLIEVFLVHHLDYTSDQIHEEAEVLEHTVSDLFVERLDKLLGFP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KTCPHGGTIPAKGELLVEINNLPLADIKEAGAYRLTRVHDSFDILHYLDKHSLHIGDQLQ
CCCCCCCCCCCCCEEEEEECCCCCHHHHHCCCEEEEHHCCHHHHHHHHHHCCCCCCCCEE
VKQFDGFSNTFTILSNDEDLQVNMDIAKQLYVEKIN
EEECCCCCCEEEEEECCCCEEEEHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2116013; 1735717; 14602910; 1502169; 1400485; 8823163; 7568230; 9697776; 10085021; 10339551 [H]