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The map label for this gene is zwf [H]

Identifier: 169833811

GI number: 169833811

Start: 1257853

End: 1259340

Strand: Direct

Name: zwf [H]

Synonym: SPH_1358

Alternate gene names: 169833811

Gene position: 1257853-1259340 (Clockwise)

Preceding gene: 169832847

Following gene: 169834344

Centisome position: 56.01

GC content: 41.8

Gene sequence:

>1488_bases
ATGTCATCTAAGGTTATTGTTACAATTTTCGGTGCGAGTGGAGACCTGGCTAAACGCAAGCTCTACCCTTCCCTTTTTAG
ACTATATAAATCCGGCAATCTTTCCAAGCACTTTGCCGTTATTGGAACTGCCCGTAGACCTTGGAGTAAGGAATATTTTG
AATCTGTAGTTGTCGAGTCCATCCTTGATTTGGCAGATAGTACCGAGCAAGCCCAAGAATTTGCTAGCCACTTCTACTAT
CAAAGCCATGATGTCAATGATTCGGAACATTATATTGCTTTGCGTCAATTACAAGCTGAGCTTAATGAAAAATACCAAGC
TGAACACAATAAACTCTTCTTCTTGTCTATGGCACCTCAGTTCTTTGGAACCATTGCCAAACACCTCAAATCTGAAAACA
TTGTCGATGGCAAAGGTTTTGAGCGCTTGATCGTTGAAAAACCATTTGGTACAGATTACGCAACTGCAAGCAAGTTGAAT
GACGAACTCCTAGCAACATTTGACGAAGAACAAATTTTCCGTATTGACCATTATCTTGGTAAGGAAATGATCCAAAGCAT
CTTTGCAGTTCGCTTTGCAAACTTGATTTTTGAAAACGTTTGGAACAAGGATTTTATCGACAATGTTCAAATTACCTTTG
CGGAGCGCTTGGGTGTAGAAGAACGTGGTGGCTACTATGACCAATCCGGTGCCCTCCGTGACATGGTCCAAAACCACACT
CTACAACTTCTTTCGCTCCTCGCCATGGACAAACCAGCAAGCTTCACAAAAGACGAGATTCGTGCTGAAAAGATTAAGGT
CTTTAAAAACCTCTATCATCCAACTGATGAAGAACTCAAAGAACACTTTATCCGTGGACAATACCGCTCTGGTAAGATTG
ATGGCATGAAATACATCTCTTATCGTAGCGAACCAAATGTGAATCCAGAATCAACAACTGAAACCTTTACATCTGGTGCC
TTCTTTGTAGACAGCGATCGATTCCGTGGTGTTCCTTTCTTTTTCCGTACAGGTAAACGACTGACTGAAAAAGGAACTCA
TGTCAACATCGTCTTTAAACAAATGGATTCTATCTTTGGAGAACCACTTGCTCCAAATATTTTGACCATCTATATTCAAC
CAACAGAAGGCTTCTCTCTTAGCCTAAATGGGAAGCAAGTAGGAGAAGAATTTAACTTGGCTCCTAACTCACTTGATTAT
CGTACAGACGCGACTGCAACTGGTGCTTCTCCAGAACCATACGAGAAATTGATTTATGATGTCCTAAATAACAACTCAAC
TAACTTTAGCCACTGGGATGAGGTTGGTGCGTCATGGAAGTTGATTGACCGTATTGAAGAGCTCTGGGCCGAAAATGGTG
CCCCACTTCATGACTATAAAGCTGGAAGCATGGGACCTCAAGCCAGCTTTGACCTACTTGAAAAATTCGGTGCCAAATGG
ACTTGGCAACCAGATATCGCCTATCGTCAAGATGGTCGCTTAGAATAA

Upstream 100 bases:

>100_bases
TTTTTGATTTTTCGGAAAATTATGTTAGAATTAAGTTTATGAAATGAGGTTTCCTCATACCTAGCAAGACTAGGAATAAA
AATAGAAATTAGGTAGCTAG

Downstream 100 bases:

>100_bases
AAAAATTTCCTGCAAGTTTATGCCTTGCAGGATTTTTGCTTCTGATTAGATTAAACCTTCCAAGAGACCTTTCATGAAGT
TTTCTGAGTTAAACTCTCCA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MSSKVIVTIFGASGDLAKRKLYPSLFRLYKSGNLSKHFAVIGTARRPWSKEYFESVVVESILDLADSTEQAQEFASHFYY
QSHDVNDSEHYIALRQLQAELNEKYQAEHNKLFFLSMAPQFFGTIAKHLKSENIVDGKGFERLIVEKPFGTDYATASKLN
DELLATFDEEQIFRIDHYLGKEMIQSIFAVRFANLIFENVWNKDFIDNVQITFAERLGVEERGGYYDQSGALRDMVQNHT
LQLLSLLAMDKPASFTKDEIRAEKIKVFKNLYHPTDEELKEHFIRGQYRSGKIDGMKYISYRSEPNVNPESTTETFTSGA
FFVDSDRFRGVPFFFRTGKRLTEKGTHVNIVFKQMDSIFGEPLAPNILTIYIQPTEGFSLSLNGKQVGEEFNLAPNSLDY
RTDATATGASPEPYEKLIYDVLNNNSTNFSHWDEVGASWKLIDRIEELWAENGAPLHDYKAGSMGPQASFDLLEKFGAKW
TWQPDIAYRQDGRLE

Sequences:

>Translated_495_residues
MSSKVIVTIFGASGDLAKRKLYPSLFRLYKSGNLSKHFAVIGTARRPWSKEYFESVVVESILDLADSTEQAQEFASHFYY
QSHDVNDSEHYIALRQLQAELNEKYQAEHNKLFFLSMAPQFFGTIAKHLKSENIVDGKGFERLIVEKPFGTDYATASKLN
DELLATFDEEQIFRIDHYLGKEMIQSIFAVRFANLIFENVWNKDFIDNVQITFAERLGVEERGGYYDQSGALRDMVQNHT
LQLLSLLAMDKPASFTKDEIRAEKIKVFKNLYHPTDEELKEHFIRGQYRSGKIDGMKYISYRSEPNVNPESTTETFTSGA
FFVDSDRFRGVPFFFRTGKRLTEKGTHVNIVFKQMDSIFGEPLAPNILTIYIQPTEGFSLSLNGKQVGEEFNLAPNSLDY
RTDATATGASPEPYEKLIYDVLNNNSTNFSHWDEVGASWKLIDRIEELWAENGAPLHDYKAGSMGPQASFDLLEKFGAKW
TWQPDIAYRQDGRLE
>Mature_494_residues
SSKVIVTIFGASGDLAKRKLYPSLFRLYKSGNLSKHFAVIGTARRPWSKEYFESVVVESILDLADSTEQAQEFASHFYYQ
SHDVNDSEHYIALRQLQAELNEKYQAEHNKLFFLSMAPQFFGTIAKHLKSENIVDGKGFERLIVEKPFGTDYATASKLND
ELLATFDEEQIFRIDHYLGKEMIQSIFAVRFANLIFENVWNKDFIDNVQITFAERLGVEERGGYYDQSGALRDMVQNHTL
QLLSLLAMDKPASFTKDEIRAEKIKVFKNLYHPTDEELKEHFIRGQYRSGKIDGMKYISYRSEPNVNPESTTETFTSGAF
FVDSDRFRGVPFFFRTGKRLTEKGTHVNIVFKQMDSIFGEPLAPNILTIYIQPTEGFSLSLNGKQVGEEFNLAPNSLDYR
TDATATGASPEPYEKLIYDVLNNNSTNFSHWDEVGASWKLIDRIEELWAENGAPLHDYKAGSMGPQASFDLLEKFGAKWT
WQPDIAYRQDGRLE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=488, Percent_Identity=34.8360655737705, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI108773793, Length=488, Percent_Identity=34.8360655737705, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI52145310, Length=369, Percent_Identity=28.7262872628726, Blast_Score=159, Evalue=5e-39,
Organism=Escherichia coli, GI1788158, Length=485, Percent_Identity=38.5567010309278, Blast_Score=317, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI17538218, Length=492, Percent_Identity=34.5528455284553, Blast_Score=268, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6324088, Length=488, Percent_Identity=35.0409836065574, Blast_Score=264, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24643350, Length=486, Percent_Identity=33.9506172839506, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI24643352, Length=486, Percent_Identity=33.9506172839506, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI221513548, Length=483, Percent_Identity=27.7432712215321, Blast_Score=198, Evalue=6e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56715; Mature: 56584

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKVIVTIFGASGDLAKRKLYPSLFRLYKSGNLSKHFAVIGTARRPWSKEYFESVVVES
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
ILDLADSTEQAQEFASHFYYQSHDVNDSEHYIALRQLQAELNEKYQAEHNKLFFLSMAPQ
HHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHH
FFGTIAKHLKSENIVDGKGFERLIVEKPFGTDYATASKLNDELLATFDEEQIFRIDHYLG
HHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHCCHHHHHHCCHHHHHHHHHHHH
KEMIQSIFAVRFANLIFENVWNKDFIDNVQITFAERLGVEERGGYYDQSGALRDMVQNHT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCHHCCCCCCCCCHHHHHHHHHH
LQLLSLLAMDKPASFTKDEIRAEKIKVFKNLYHPTDEELKEHFIRGQYRSGKIDGMKYIS
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEE
YRSEPNVNPESTTETFTSGAFFVDSDRFRGVPFFFRTGKRLTEKGTHVNIVFKQMDSIFG
ECCCCCCCCCCCHHHHCCCEEEEECCCCCCCCHHHHCCCHHHHCCCEEEEHHHHHHHHHC
EPLAPNILTIYIQPTEGFSLSLNGKQVGEEFNLAPNSLDYRTDATATGASPEPYEKLIYD
CCCCCCEEEEEEECCCCCEEEECHHHHCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
VLNNNSTNFSHWDEVGASWKLIDRIEELWAENGAPLHDYKAGSMGPQASFDLLEKFGAKW
HHCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCE
TWQPDIAYRQDGRLE
EECCCCCCCCCCCCC
>Mature Secondary Structure 
SSKVIVTIFGASGDLAKRKLYPSLFRLYKSGNLSKHFAVIGTARRPWSKEYFESVVVES
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
ILDLADSTEQAQEFASHFYYQSHDVNDSEHYIALRQLQAELNEKYQAEHNKLFFLSMAPQ
HHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHH
FFGTIAKHLKSENIVDGKGFERLIVEKPFGTDYATASKLNDELLATFDEEQIFRIDHYLG
HHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHCCHHHHHHCCHHHHHHHHHHHH
KEMIQSIFAVRFANLIFENVWNKDFIDNVQITFAERLGVEERGGYYDQSGALRDMVQNHT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCHHCCCCCCCCCHHHHHHHHHH
LQLLSLLAMDKPASFTKDEIRAEKIKVFKNLYHPTDEELKEHFIRGQYRSGKIDGMKYIS
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEE
YRSEPNVNPESTTETFTSGAFFVDSDRFRGVPFFFRTGKRLTEKGTHVNIVFKQMDSIFG
ECCCCCCCCCCCHHHHCCCEEEEECCCCCCCCHHHHCCCHHHHCCCEEEEHHHHHHHHHC
EPLAPNILTIYIQPTEGFSLSLNGKQVGEEFNLAPNSLDYRTDATATGASPEPYEKLIYD
CCCCCCEEEEEEECCCCCEEEECHHHHCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
VLNNNSTNFSHWDEVGASWKLIDRIEELWAENGAPLHDYKAGSMGPQASFDLLEKFGAKW
HHCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCE
TWQPDIAYRQDGRLE
EECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916; 9466257; 9533725 [H]