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The map label for this gene is clpC [H]

Identifier: 169833795

GI number: 169833795

Start: 397277

End: 399382

Strand: Direct

Name: clpC [H]

Synonym: SPH_0449

Alternate gene names: 169833795

Gene position: 397277-399382 (Clockwise)

Preceding gene: 169833188

Following gene: 169833166

Centisome position: 17.69

GC content: 42.83

Gene sequence:

>2106_bases
ATGAATAACAACTTTAATAATTTTAACAACATGGATGATTTATTTAACCAATTGATGGGTGGTATGCGAGGATACAGTTC
TGAAAATCGCCGTTACTTGATTAATGGACGTGAAGTGACACCTGAGGAATTTGCTCACTATCGTGCAACTGGCCAATTGC
CAGGAAATGCAGAAGTTGATGGAAAAATGCCACAACAGGCTTCAAGTATGAAACAAGACGGTGTTCTTGCTAAACTAGGT
CGTAACCTGACAGCAGAAGCACGTGAGGGCAAGCTGGATCCTGTTATCGGACGAAACAAGGAAATTCAAGAAACATCTGA
AATTCTTTCACGCCGTACCAAGAACAATCCTGTTTTAGTCGGAGACGCTGGCGTTGGTAAGACAGCCGTTGTCGAAGGTC
TAGCACAAGCCATTGTGAACGGTGATGTTCCAGCTGCCATTAAGAATAAGGAAATTATTTCCATTGATATCTCTGGTCTT
GAGGCTGGGACTCAATACCGTGGTAGCTTTGAAGAAAACGTTCAAAACTTAGTCAATGAAGTAAAAGAAGCGGGAAATAT
CATTCTCTTCTTTGATGAAATTCATCAAATTCTCGGTGCTGGTAGCACTGGTGGAGATAGTGGATCTAAGGGACTTGCAG
ACATTCTTAAACCAGCTCTATCTCGTGGAGAATTGACAGTGATTGGGGCAACAACTCAAGACGAATACCGTAACACCATC
TTGAAGAATGCTGCTCTTGCTCGTCGTTTCAACGAAGTGAAGGTCAATGCTCCTTCGGCAGAGAATACTTTTAAAATTCT
TCAAGGAATTCGTGACCTCTATCAACAACACCACAATGTCATCTTGCCAGACGAAGTCTTGAAAGCAGCGGTGGATTATT
CTGTTCAATACATTCCTCAACGTAGCTTGCCAGATAAGGCTATTGACCTTGTCGATGTAACGGCTGCTCACTTGGCGGCT
CAACATCCAGTAACAGATGTGCATGCTGTTGAACGAGAAATCGAAACGGAAAAAGACAAGCAAGAAAAAGCAGTTGAAGC
AGAAGATTTTGAAGCAGCTCTAAACTATAAAACACGCATTGCAGAATTGGAAAAGAAAATCGAAAACCACACAGAAGATA
TGAAAGTGACTGCAAGTGTCAACGATGTGGCTGAATCTGTGGAACGAATGACAGGTATCCCAGTATCGCAAATGGGAGCT
TCAGATATCGAACGTTTGAAAGATATGGCTCATCGCTTGCAAGACAAGGTGATTGGTCAAGATAAGGCCGTAGAAGCTGT
AGCTCGTGCTATCCGTCGTAACCGTGCTGGTTTTGATGAAGGAAATCGCCCAATCGGCAGCTTCCTCTTTGTAGGGTCTA
CTGGGGTTGGTAAGACGGAGCTTGCTAAGCAATTGGCACTCGATATGTTTGGAACCCAGGATGCGATTATCCGTTTGGAT
ATGTCTGAATACAGTGACCGCACAGCTGTTTCTAAGCTAATTGGTACAACAGCAGGCTATGTGGGTTATGATGACAATAG
CAATACCTTAACAGAACGTGTTCGTCGCAATCCATACTCTATCATTCTCTTGGATGAAATTGAAAAGGCTGATCCTCAAG
TTATTACCCTTCTCCTCCAAGTTCTAGATGATGGTCGTTTGACAGATGGTCAAGGAAATACAGTAAACTTCAAGAATACT
GTCGTTATTGCGACCTCAAATGCTGGATTTGGCTATGAAGCCAATTTGACAGAAGATGCGGATAAACCAGAATTGATGGA
CCGTTTGAAACCCTTCTTCCGTCCAGAATTCCTCAACCGCTTTAATGCAGTCATCGAGTTCTCACACTTGACTAAGGAAA
ACCTTTCTAAGATTGTAGATTTGATGTTGGCTGAAGTTAACCAAACCTTGGCTAAGAAAGACATTGACTTGGTAGTCAGT
CAAGCGGCTAAAGATTATATCACAGAAGAAGGTTACGACGAAGTCATGGGGGTTCGTCCTCTCCGTCGCGTGGTTGAACA
AGAAATTCGTGATAAGGTGACAGACTTCCACTTGGATCATTTAGATGCTAAACATCTGGAAGCAGATATGGAAGATGGCG
TTTTGGTTATTCGTGAGAAAGCCTAA

Upstream 100 bases:

>100_bases
TAGTACGTAGAGTAGCGATTTAGCTAGTCTAAATTTTTTAAAACAAAGGTCAAAGATAGTCAATATCAGTAATAATAAAT
AACAAAAAGAGGTAAAGAAT

Downstream 100 bases:

>100_bases
GACAGAGTTTTGAGGATAAAAAAGAAGGAGCCAGCTGAAAAAAACTGGTTCCTTTTGAGGTACGACGGGCATGTCGTGTA
GTAGAGATGTACTATTCTAG

Product: ATP-dependent Clp protease ATP-binding subunit ClpL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 701; Mature: 701

Protein sequence:

>701_residues
MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEFAHYRATGQLPGNAEVDGKMPQQASSMKQDGVLAKLG
RNLTAEAREGKLDPVIGRNKEIQETSEILSRRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGL
EAGTQYRGSFEENVQNLVNEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAENTFKILQGIRDLYQQHHNVILPDEVLKAAVDYSVQYIPQRSLPDKAIDLVDVTAAHLAA
QHPVTDVHAVEREIETEKDKQEKAVEAEDFEAALNYKTRIAELEKKIENHTEDMKVTASVNDVAESVERMTGIPVSQMGA
SDIERLKDMAHRLQDKVIGQDKAVEAVARAIRRNRAGFDEGNRPIGSFLFVGSTGVGKTELAKQLALDMFGTQDAIIRLD
MSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNT
VVIATSNAGFGYEANLTEDADKPELMDRLKPFFRPEFLNRFNAVIEFSHLTKENLSKIVDLMLAEVNQTLAKKDIDLVVS
QAAKDYITEEGYDEVMGVRPLRRVVEQEIRDKVTDFHLDHLDAKHLEADMEDGVLVIREKA

Sequences:

>Translated_701_residues
MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEFAHYRATGQLPGNAEVDGKMPQQASSMKQDGVLAKLG
RNLTAEAREGKLDPVIGRNKEIQETSEILSRRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGL
EAGTQYRGSFEENVQNLVNEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAENTFKILQGIRDLYQQHHNVILPDEVLKAAVDYSVQYIPQRSLPDKAIDLVDVTAAHLAA
QHPVTDVHAVEREIETEKDKQEKAVEAEDFEAALNYKTRIAELEKKIENHTEDMKVTASVNDVAESVERMTGIPVSQMGA
SDIERLKDMAHRLQDKVIGQDKAVEAVARAIRRNRAGFDEGNRPIGSFLFVGSTGVGKTELAKQLALDMFGTQDAIIRLD
MSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNT
VVIATSNAGFGYEANLTEDADKPELMDRLKPFFRPEFLNRFNAVIEFSHLTKENLSKIVDLMLAEVNQTLAKKDIDLVVS
QAAKDYITEEGYDEVMGVRPLRRVVEQEIRDKVTDFHLDHLDAKHLEADMEDGVLVIREKA
>Mature_701_residues
MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEFAHYRATGQLPGNAEVDGKMPQQASSMKQDGVLAKLG
RNLTAEAREGKLDPVIGRNKEIQETSEILSRRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGL
EAGTQYRGSFEENVQNLVNEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAENTFKILQGIRDLYQQHHNVILPDEVLKAAVDYSVQYIPQRSLPDKAIDLVDVTAAHLAA
QHPVTDVHAVEREIETEKDKQEKAVEAEDFEAALNYKTRIAELEKKIENHTEDMKVTASVNDVAESVERMTGIPVSQMGA
SDIERLKDMAHRLQDKVIGQDKAVEAVARAIRRNRAGFDEGNRPIGSFLFVGSTGVGKTELAKQLALDMFGTQDAIIRLD
MSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNT
VVIATSNAGFGYEANLTEDADKPELMDRLKPFFRPEFLNRFNAVIEFSHLTKENLSKIVDLMLAEVNQTLAKKDIDLVVS
QAAKDYITEEGYDEVMGVRPLRRVVEQEIRDKVTDFHLDHLDAKHLEADMEDGVLVIREKA

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family. ClpC subfamily [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=302, Percent_Identity=31.7880794701987, Blast_Score=157, Evalue=4e-38,
Organism=Escherichia coli, GI1787109, Length=651, Percent_Identity=37.9416282642089, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1788943, Length=390, Percent_Identity=42.8205128205128, Blast_Score=284, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6320464, Length=707, Percent_Identity=39.4625176803395, Blast_Score=474, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6323002, Length=297, Percent_Identity=43.0976430976431, Blast_Score=254, Evalue=4e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR019489 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 77537; Mature: 77537

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS50151 UVR ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEFAHYRATGQLPGNAEVD
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCC
GKMPQQASSMKQDGVLAKLGRNLTAEAREGKLDPVIGRNKEIQETSEILSRRTKNNPVLV
CCCCHHHHHHHHCCHHHHHCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEE
GDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGLEAGTQYRGSFEENVQNLVNE
ECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHCCCHHHHHHHHHHH
VKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRNTI
HHHHCCEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHH
LKNAALARRFNEVKVNAPSAENTFKILQGIRDLYQQHHNVILPDEVLKAAVDYSVQYIPQ
HHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHCCCC
RSLPDKAIDLVDVTAAHLAAQHPVTDVHAVEREIETEKDKQEKAVEAEDFEAALNYKTRI
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AELEKKIENHTEDMKVTASVNDVAESVERMTGIPVSQMGASDIERLKDMAHRLQDKVIGQ
HHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHCCC
DKAVEAVARAIRRNRAGFDEGNRPIGSFLFVGSTGVGKTELAKQLALDMFGTQDAIIRLD
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEE
MSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQ
HHHCCHHHHHHHHHHHHCCCCEECCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH
VLDDGRLTDGQGNTVNFKNTVVIATSNAGFGYEANLTEDADKPELMDRLKPFFRPEFLNR
HHCCCCEECCCCCEEEECCEEEEEECCCCCCEECCCCCCCCCHHHHHHHHHHCCHHHHHH
FNAVIEFSHLTKENLSKIVDLMLAEVNQTLAKKDIDLVVSQAAKDYITEEGYDEVMGVRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHH
LRRVVEQEIRDKVTDFHLDHLDAKHLEADMEDGVLVIREKA
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEFAHYRATGQLPGNAEVD
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCC
GKMPQQASSMKQDGVLAKLGRNLTAEAREGKLDPVIGRNKEIQETSEILSRRTKNNPVLV
CCCCHHHHHHHHCCHHHHHCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEE
GDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGLEAGTQYRGSFEENVQNLVNE
ECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHCCCHHHHHHHHHHH
VKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRNTI
HHHHCCEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHH
LKNAALARRFNEVKVNAPSAENTFKILQGIRDLYQQHHNVILPDEVLKAAVDYSVQYIPQ
HHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHCCCC
RSLPDKAIDLVDVTAAHLAAQHPVTDVHAVEREIETEKDKQEKAVEAEDFEAALNYKTRI
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AELEKKIENHTEDMKVTASVNDVAESVERMTGIPVSQMGASDIERLKDMAHRLQDKVIGQ
HHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHCCC
DKAVEAVARAIRRNRAGFDEGNRPIGSFLFVGSTGVGKTELAKQLALDMFGTQDAIIRLD
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEE
MSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQ
HHHCCHHHHHHHHHHHHCCCCEECCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH
VLDDGRLTDGQGNTVNFKNTVVIATSNAGFGYEANLTEDADKPELMDRLKPFFRPEFLNR
HHCCCCEECCCCCEEEECCEEEEEECCCCCCEECCCCCCCCCHHHHHHHHHHCCHHHHHH
FNAVIEFSHLTKENLSKIVDLMLAEVNQTLAKKDIDLVVSQAAKDYITEEGYDEVMGVRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHH
LRRVVEQEIRDKVTDFHLDHLDAKHLEADMEDGVLVIREKA
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA