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The map label for this gene is hpt [H]

Identifier: 169833613

GI number: 169833613

Start: 11812

End: 12354

Strand: Direct

Name: hpt [H]

Synonym: SPH_0012

Alternate gene names: 169833613

Gene position: 11812-12354 (Clockwise)

Preceding gene: 169834329

Following gene: 169833372

Centisome position: 0.53

GC content: 33.33

Gene sequence:

>543_bases
ATGTTAGAAAACGATATTAAAAAAGTCCTCGTTTCACACGATGAAATTACAGAAGCAGCTAAAAAACTAGGTGCTCAATT
AACTAAAGATTATGCAGGAAAAAATCCAATCTTAGTTGGGATTTTAAAAGGATCTATTCCTTTTATGGCTGAATTGGTCA
AACATATTGATACACATATTGAAATGGACTTCATGATGGTTTCTAGCTACCATGGTGGAACAGCAAGTAGTGGTGTTATC
AATATTAAACAAGATGTGACTCAAGATATCAAAGGAAGACATGTTCTATTTGTAGAAGATATCATTGATACAGGTCAAAC
TTTGAAGAATTTGCGAGATATGTTTAAAGCAAGAGAAGCAGCTTCTGTTAAAATTGCAACCTTGTTGGATAAACCAGAAG
GACGTGTTGTAGAAATTGAGGCAGACTATACCTGCTTTACTATCCCAAATGAGTTTGTAGTAGGTTATGGTTTAGACTAC
AAAGAAAATTATCGTAATCTTCCTTATATTGGAGTATTGAAAGAGGAAGTGTATTCAAATTAG

Upstream 100 bases:

>100_bases
TGTCTCAATTTTGGGAATTGCGACCAATAATTTGAGTAAAAAAACGAAAAATGATATAATGAACACTGTACTTTATATAG
AAAAAATAGATAGGTAAAAA

Downstream 100 bases:

>100_bases
AAAGAATAATCTTTAATGAAAAAACAAAATAATGGTTTAATTAAAAATCCTTTTCTATGGTTATTATTTATCTTTTTCCT
TGTGACAGGATTCCAGTATT

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MLENDIKKVLVSHDEITEAAKKLGAQLTKDYAGKNPILVGILKGSIPFMAELVKHIDTHIEMDFMMVSSYHGGTASSGVI
NIKQDVTQDIKGRHVLFVEDIIDTGQTLKNLRDMFKAREAASVKIATLLDKPEGRVVEIEADYTCFTIPNEFVVGYGLDY
KENYRNLPYIGVLKEEVYSN

Sequences:

>Translated_180_residues
MLENDIKKVLVSHDEITEAAKKLGAQLTKDYAGKNPILVGILKGSIPFMAELVKHIDTHIEMDFMMVSSYHGGTASSGVI
NIKQDVTQDIKGRHVLFVEDIIDTGQTLKNLRDMFKAREAASVKIATLLDKPEGRVVEIEADYTCFTIPNEFVVGYGLDY
KENYRNLPYIGVLKEEVYSN
>Mature_180_residues
MLENDIKKVLVSHDEITEAAKKLGAQLTKDYAGKNPILVGILKGSIPFMAELVKHIDTHIEMDFMMVSSYHGGTASSGVI
NIKQDVTQDIKGRHVLFVEDIIDTGQTLKNLRDMFKAREAASVKIATLLDKPEGRVVEIEADYTCFTIPNEFVVGYGLDY
KENYRNLPYIGVLKEEVYSN

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=180, Percent_Identity=33.8888888888889, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI9910262, Length=180, Percent_Identity=33.8888888888889, Blast_Score=100, Evalue=7e-22,
Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=45.1807228915663, Blast_Score=157, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17510817, Length=178, Percent_Identity=29.7752808988764, Blast_Score=90, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20154; Mature: 20154

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLENDIKKVLVSHDEITEAAKKLGAQLTKDYAGKNPILVGILKGSIPFMAELVKHIDTHI
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHH
EMDFMMVSSYHGGTASSGVINIKQDVTQDIKGRHVLFVEDIIDTGQTLKNLRDMFKAREA
EEEEEEEECCCCCCCCCCEEEEHHHHHHHHCCCEEEEHHHHHCCHHHHHHHHHHHHHHHH
ASVKIATLLDKPEGRVVEIEADYTCFTIPNEFVVGYGLDYKENYRNLPYIGVLKEEVYSN
CCEEEEEEECCCCCCEEEEECCEEEEECCCCEEEECCCCHHHCCCCCCEEEHHHHHHCCC
>Mature Secondary Structure
MLENDIKKVLVSHDEITEAAKKLGAQLTKDYAGKNPILVGILKGSIPFMAELVKHIDTHI
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHH
EMDFMMVSSYHGGTASSGVINIKQDVTQDIKGRHVLFVEDIIDTGQTLKNLRDMFKAREA
EEEEEEEECCCCCCCCCCEEEEHHHHHHHHCCCEEEEHHHHHCCHHHHHHHHHHHHHHHH
ASVKIATLLDKPEGRVVEIEADYTCFTIPNEFVVGYGLDYKENYRNLPYIGVLKEEVYSN
CCEEEEEEECCCCCCEEEEECCEEEEECCCCEEEECCCCHHHCCCCCCEEEHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]