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The map label for this gene is rnz [H]

Identifier: 169833589

GI number: 169833589

Start: 723816

End: 724745

Strand: Direct

Name: rnz [H]

Synonym: SPH_0769

Alternate gene names: 169833589

Gene position: 723816-724745 (Clockwise)

Preceding gene: 169833381

Following gene: 169834045

Centisome position: 32.23

GC content: 45.38

Gene sequence:

>930_bases
ATGGATATTCAATTTTTAGGAACGGGGGCTGGTCAGCCCTCTAAAGCCCGCAACGTTTCAAGTCTCGCCCTGAAACTTTT
GGACGAGATTAACGAAGTTTGGCTCTTTGACTGTGGAGAAGGTACGCAAAATCGCATTCTGGAAACCACAATTCGACCAC
GTAAGGTCAGCAAAATCTTTATTACCCATCTGCATGGAGACCACATTTTTGGTTTGCCAGGTTTCCTTTCTAGCCGTGCC
TTTCAGGCCAATGAAGAGCAGACAGATTTGGAAATCTACGGACCTCAAGGAATCAAGTCATTTGTCTTAACCAGCCTTCG
TGTGTCAGGTTCTCGTCTGCCCTACCGCATTCATTTCCATGAGTTTGACCAAGATTCTCTGGGTAAAATTCTTGAAACCG
ATAAATTCACTGTGTATGCAGAGGAGCTGGACCACACTATTTTCTGTGTTGGCTATCGTGTCATGCAAAAGGATCTAGAA
GGGACGCTGGATGCTGAAAAACTCAAGGCTGCTGGTGTTCCGTTCGGCCCGCTTTTTGGTAAAATCAAAAACGGCCAGGA
TCTTGTTTTGGAAGACGGAACTGAAATCAAGGCAGCAGACTATATCTCAGCGCCACGTCCAGGTAAGATTATCACTATTT
TAGGAGACACTCGAAAAACGGATGCCAGTGTGCGTCTGGCTGTCAATGCAGATGTCCTAGTTCATGAGTCCACTTATGGC
AAGGGTGATGAAAAAATTGCTCGTAACCATGGTCACTCAACTAATATGCAAGCTGCACAAGTAGCGGTAGAAGCAGGTGC
CAAACGCCTCCTACTCAACCATATCAGTGCCCGTTTCCTCTCAAAAGATATAAGCAAACTCAAGAAGGACGCTGCCACAA
TTTTTGAAAATGTCCATGTGGTCAAAGACTTGGAAGAAGTGGAAATCTAG

Upstream 100 bases:

>100_bases
AGGATTTATTGCAAGAAGCTGCTGCTTTTTCTGGCAAACGCTATTTCCGATCGGAAAACCGCACAGCCATGTTATATATT
GATTAATTAGAAAGTATCGA

Downstream 100 bases:

>100_bases
CAGTCACAGAAAGGATAAGTATGCCTACTATTCTCATTACCGGAGCTAGCGGTGGTCTAGCTCAAGAAATGGTCAAACTC
CTGCCCAATGACCAACTCAT

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MDIQFLGTGAGQPSKARNVSSLALKLLDEINEVWLFDCGEGTQNRILETTIRPRKVSKIFITHLHGDHIFGLPGFLSSRA
FQANEEQTDLEIYGPQGIKSFVLTSLRVSGSRLPYRIHFHEFDQDSLGKILETDKFTVYAEELDHTIFCVGYRVMQKDLE
GTLDAEKLKAAGVPFGPLFGKIKNGQDLVLEDGTEIKAADYISAPRPGKIITILGDTRKTDASVRLAVNADVLVHESTYG
KGDEKIARNHGHSTNMQAAQVAVEAGAKRLLLNHISARFLSKDISKLKKDAATIFENVHVVKDLEEVEI

Sequences:

>Translated_309_residues
MDIQFLGTGAGQPSKARNVSSLALKLLDEINEVWLFDCGEGTQNRILETTIRPRKVSKIFITHLHGDHIFGLPGFLSSRA
FQANEEQTDLEIYGPQGIKSFVLTSLRVSGSRLPYRIHFHEFDQDSLGKILETDKFTVYAEELDHTIFCVGYRVMQKDLE
GTLDAEKLKAAGVPFGPLFGKIKNGQDLVLEDGTEIKAADYISAPRPGKIITILGDTRKTDASVRLAVNADVLVHESTYG
KGDEKIARNHGHSTNMQAAQVAVEAGAKRLLLNHISARFLSKDISKLKKDAATIFENVHVVKDLEEVEI
>Mature_309_residues
MDIQFLGTGAGQPSKARNVSSLALKLLDEINEVWLFDCGEGTQNRILETTIRPRKVSKIFITHLHGDHIFGLPGFLSSRA
FQANEEQTDLEIYGPQGIKSFVLTSLRVSGSRLPYRIHFHEFDQDSLGKILETDKFTVYAEELDHTIFCVGYRVMQKDLE
GTLDAEKLKAAGVPFGPLFGKIKNGQDLVLEDGTEIKAADYISAPRPGKIITILGDTRKTDASVRLAVNADVLVHESTYG
KGDEKIARNHGHSTNMQAAQVAVEAGAKRLLLNHISARFLSKDISKLKKDAATIFENVHVVKDLEEVEI

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=358, Percent_Identity=36.8715083798883, Blast_Score=216, Evalue=2e-56,
Organism=Escherichia coli, GI87082078, Length=305, Percent_Identity=45.5737704918033, Blast_Score=270, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24652403, Length=212, Percent_Identity=30.6603773584906, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 34198; Mature: 34198

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQFLGTGAGQPSKARNVSSLALKLLDEINEVWLFDCGEGTQNRILETTIRPRKVSKIF
CCEEEEECCCCCCHHHCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEHHCCCCCEEEEEE
ITHLHGDHIFGLPGFLSSRAFQANEEQTDLEIYGPQGIKSFVLTSLRVSGSRLPYRIHFH
EEEECCCEEECCCCHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEEE
EFDQDSLGKILETDKFTVYAEELDHTIFCVGYRVMQKDLEGTLDAEKLKAAGVPFGPLFG
ECCHHHHHHHHCCCCEEEEHHHHCCEEEEHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHH
KIKNGQDLVLEDGTEIKAADYISAPRPGKIITILGDTRKTDASVRLAVNADVLVHESTYG
CCCCCCEEEEECCCCEEEHHCCCCCCCCEEEEEECCCCCCCCEEEEEEECEEEEEECCCC
KGDEKIARNHGHSTNMQAAQVAVEAGAKRLLLNHISARFLSKDISKLKKDAATIFENVHV
CCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKDLEEVEI
HHHHHHHCC
>Mature Secondary Structure
MDIQFLGTGAGQPSKARNVSSLALKLLDEINEVWLFDCGEGTQNRILETTIRPRKVSKIF
CCEEEEECCCCCCHHHCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEHHCCCCCEEEEEE
ITHLHGDHIFGLPGFLSSRAFQANEEQTDLEIYGPQGIKSFVLTSLRVSGSRLPYRIHFH
EEEECCCEEECCCCHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEEE
EFDQDSLGKILETDKFTVYAEELDHTIFCVGYRVMQKDLEGTLDAEKLKAAGVPFGPLFG
ECCHHHHHHHHCCCCEEEEHHHHCCEEEEHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHH
KIKNGQDLVLEDGTEIKAADYISAPRPGKIITILGDTRKTDASVRLAVNADVLVHESTYG
CCCCCCEEEEECCCCEEEHHCCCCCCCCEEEEEECCCCCCCCEEEEEEECEEEEEECCCC
KGDEKIARNHGHSTNMQAAQVAVEAGAKRLLLNHISARFLSKDISKLKKDAATIFENVHV
CCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKDLEEVEI
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA