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The map label for this gene is purE [H]

Identifier: 169833068

GI number: 169833068

Start: 135468

End: 135956

Strand: Direct

Name: purE [H]

Synonym: SPH_0160

Alternate gene names: 169833068

Gene position: 135468-135956 (Clockwise)

Preceding gene: 169834144

Following gene: 169832609

Centisome position: 6.03

GC content: 50.31

Gene sequence:

>489_bases
ATGAAACCAGTAATTTCCATCATCATGGGCTCAAAATCCGACTGGGCAACCATGCAAAAAACAGCAGAAGTCCTAGACCG
CTTCGGTGTAGCCTACGAAAAGAAAGTTGTTTCCGCACACCGTACACCAGACCTCATGTTCAAACATGCAGAAGAAGCCC
GTAGTCGTGGCATCAAGATCATCATCGCAGGTGCTGGTGGCGCAGCGCATTTGCCAGGCATGGTAGCTGCCAAAACAACC
CTTCCAGTCATTGGTGTGCCAGTCAAGTCTCGTGCTCTTAGTGGAGTGGATTCACTCTATTCTATCGTTCAGATGCCGGG
TGGGGTGCCTGTTGCGACCATGGCTATCGGTGAAGCTGGAGCGACTAACGCAGCTCTCTTTGCCCTCCGTCTCCTCTCTG
TAGAAGATAAGTCCATTGCGGATGCACTTGCCAACTTTGCTGAAGAACAAGGAAAAATCGCAGAGGAGTCGTCAAATGAG
CTCATCTAA

Upstream 100 bases:

>100_bases
AGACCTTGGGTTTCCAATTTAGGCATGAGACACCTTTGGTGGCTGCTGCCGTTCCTCACAAGCTAAGGTGATTGTTGAAA
AAGAGGAAAAAGGAGAAGAA

Downstream 100 bases:

>100_bases
AACAATCGGAATTATCGGTGGCGGTCAACTGGGTCAGATGATGGCCATTTCTGCTATCTACATGGGCCACAAGGTTATCG
CGCTGGATCCTGCGGCGGAT

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MKPVISIIMGSKSDWATMQKTAEVLDRFGVAYEKKVVSAHRTPDLMFKHAEEARSRGIKIIIAGAGGAAHLPGMVAAKTT
LPVIGVPVKSRALSGVDSLYSIVQMPGGVPVATMAIGEAGATNAALFALRLLSVEDKSIADALANFAEEQGKIAEESSNE
LI

Sequences:

>Translated_162_residues
MKPVISIIMGSKSDWATMQKTAEVLDRFGVAYEKKVVSAHRTPDLMFKHAEEARSRGIKIIIAGAGGAAHLPGMVAAKTT
LPVIGVPVKSRALSGVDSLYSIVQMPGGVPVATMAIGEAGATNAALFALRLLSVEDKSIADALANFAEEQGKIAEESSNE
LI
>Mature_162_residues
MKPVISIIMGSKSDWATMQKTAEVLDRFGVAYEKKVVSAHRTPDLMFKHAEEARSRGIKIIIAGAGGAAHLPGMVAAKTT
LPVIGVPVKSRALSGVDSLYSIVQMPGGVPVATMAIGEAGATNAALFALRLLSVEDKSIADALANFAEEQGKIAEESSNE
LI

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=146, Percent_Identity=60.958904109589, Blast_Score=156, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6324702, Length=150, Percent_Identity=60, Blast_Score=167, Evalue=9e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16946; Mature: 16946

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVISIIMGSKSDWATMQKTAEVLDRFGVAYEKKVVSAHRTPDLMFKHAEEARSRGIKI
CCCHHEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCEEE
IIAGAGGAAHLPGMVAAKTTLPVIGVPVKSRALSGVDSLYSIVQMPGGVPVATMAIGEAG
EEECCCCCHHCCCHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
ATNAALFALRLLSVEDKSIADALANFAEEQGKIAEESSNELI
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKPVISIIMGSKSDWATMQKTAEVLDRFGVAYEKKVVSAHRTPDLMFKHAEEARSRGIKI
CCCHHEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHCCEEE
IIAGAGGAAHLPGMVAAKTTLPVIGVPVKSRALSGVDSLYSIVQMPGGVPVATMAIGEAG
EEECCCCCHHCCCHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
ATNAALFALRLLSVEDKSIADALANFAEEQGKIAEESSNELI
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]