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The map label for this gene is malR [H]

Identifier: 169832581

GI number: 169832581

Start: 2110601

End: 2111587

Strand: Direct

Name: malR [H]

Synonym: SPH_2301

Alternate gene names: 169832581

Gene position: 2110601-2111587 (Clockwise)

Preceding gene: 169834509

Following gene: 169833921

Centisome position: 93.99

GC content: 43.06

Gene sequence:

>987_bases
ATGCCCGTTACGATTAAAGACGTGGCCAAGGCTGCTGGTGTTTCACCTTCAACCGTAACCCGTGTTATTCAAAATAAATC
AACCATTAGCGACGAAACAAAAAAACGCGTTCGCAAGGCTATGAAGGAGCTCAACTACCACCCAAACCTCAACGCTCGTA
GCTTGGTAAGCAGTTATACGCAAGTTATCGGCTTAGTTCTTCCTGATGACTCAGATGCCTTCTACCAGAATCCTTTCTTT
CCATCGGTTCTACGTGGCATCTCTCAAGTCGCATCTGAAAACCACTATGCCATTCAGATAGCAACAGGGAAAGATGAGAA
GGAGCGTCTCAACGCTATTTCACAAATGGTCTACGGCAAGCGTGTAGATGGGCTAATCTTTCTCTATGCCCAAGAAGAAG
ATCCCCTCGTCAAACTCGTAGCAGAAGAACAGTTCCCCTTCCTTATCTTAGGTAAATCTCTATCTCCTTTCATCCCACTT
GTCGATAATGACAACGTTCAAGCTGGTTTTGATGCGACAGAATATTTCATCAAAAAAGGCTGCAAACGCATTGCCTTTAT
CGGAGGAAGTAAAAAGCTCTTCGTGACCAAAGATCGTTTAACAGGCTATGAACAGGCGCTGAAACATTACAAACTTACCA
CTGACAACAATCGCATCTACTTTGCAGACGAGTTTCTGGAAGAAAAGGGCTATAAATTTAGCAAGCGATTATTCAAGCAC
GATCCACAAATTGATGCCATCATCACAACCGATAGCCTCCTAGCTGAAGGAGTCTGTGACTATATTGCCAAACACCAGCT
GGATGTCCCTGTTCTCAGCTTTGACTCGGTTAATCCCAAGCTCAATTTGGCAGCCTATATAGATATCAATAGCCTAGCCC
TTGGACGCACTTCTTTAGAAACTATCCTCTGCATCATCAATGATTCTAAAGAAAATAGACAAATCTGCTACCGTCAGTTG
ATTGCCCACAAAATTATTGAAAAATAA

Upstream 100 bases:

>100_bases
CCTGATTACTGTACAAAACATTCTTTTTGTCCTTTATCTGGTCACTATCTTTTATAAAACGCATTTTCGTGATCCAGATT
ACCATAAATAGGAGATTTTT

Downstream 100 bases:

>100_bases
GAGGCTGGGCAAAAAGCCTTTAAAAGCAAAAAACGCATACTATCAGGTGTTAAAAACTTGATAGTCTGCGTTTTATTGTG
GGAAGACTCATTTTAAGTAC

Product: HTH-type transcriptional regulator MalR (maltose operontranscriptional repressor)

Products: NA

Alternate protein names: Maltose operon transcriptional repressor [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MPVTIKDVAKAAGVSPSTVTRVIQNKSTISDETKKRVRKAMKELNYHPNLNARSLVSSYTQVIGLVLPDDSDAFYQNPFF
PSVLRGISQVASENHYAIQIATGKDEKERLNAISQMVYGKRVDGLIFLYAQEEDPLVKLVAEEQFPFLILGKSLSPFIPL
VDNDNVQAGFDATEYFIKKGCKRIAFIGGSKKLFVTKDRLTGYEQALKHYKLTTDNNRIYFADEFLEEKGYKFSKRLFKH
DPQIDAIITTDSLLAEGVCDYIAKHQLDVPVLSFDSVNPKLNLAAYIDINSLALGRTSLETILCIINDSKENRQICYRQL
IAHKIIEK

Sequences:

>Translated_328_residues
MPVTIKDVAKAAGVSPSTVTRVIQNKSTISDETKKRVRKAMKELNYHPNLNARSLVSSYTQVIGLVLPDDSDAFYQNPFF
PSVLRGISQVASENHYAIQIATGKDEKERLNAISQMVYGKRVDGLIFLYAQEEDPLVKLVAEEQFPFLILGKSLSPFIPL
VDNDNVQAGFDATEYFIKKGCKRIAFIGGSKKLFVTKDRLTGYEQALKHYKLTTDNNRIYFADEFLEEKGYKFSKRLFKH
DPQIDAIITTDSLLAEGVCDYIAKHQLDVPVLSFDSVNPKLNLAAYIDINSLALGRTSLETILCIINDSKENRQICYRQL
IAHKIIEK
>Mature_327_residues
PVTIKDVAKAAGVSPSTVTRVIQNKSTISDETKKRVRKAMKELNYHPNLNARSLVSSYTQVIGLVLPDDSDAFYQNPFFP
SVLRGISQVASENHYAIQIATGKDEKERLNAISQMVYGKRVDGLIFLYAQEEDPLVKLVAEEQFPFLILGKSLSPFIPLV
DNDNVQAGFDATEYFIKKGCKRIAFIGGSKKLFVTKDRLTGYEQALKHYKLTTDNNRIYFADEFLEEKGYKFSKRLFKHD
PQIDAIITTDSLLAEGVCDYIAKHQLDVPVLSFDSVNPKLNLAAYIDINSLALGRTSLETILCIINDSKENRQICYRQLI
AHKIIEK

Specific function: Transcriptional repressor of the maltosaccharide utilization operons malxCD and malMP [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=282, Percent_Identity=28.7234042553192, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1790194, Length=282, Percent_Identity=30.1418439716312, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1787580, Length=322, Percent_Identity=27.639751552795, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1789202, Length=300, Percent_Identity=29.3333333333333, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1787948, Length=321, Percent_Identity=27.7258566978193, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1789068, Length=286, Percent_Identity=29.020979020979, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787906, Length=264, Percent_Identity=29.1666666666667, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788474, Length=297, Percent_Identity=25.9259259259259, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790715, Length=310, Percent_Identity=24.8387096774194, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI48994940, Length=272, Percent_Identity=26.8382352941176, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1786268, Length=276, Percent_Identity=25.7246376811594, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786540, Length=285, Percent_Identity=24.2105263157895, Blast_Score=71, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36994; Mature: 36863

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVTIKDVAKAAGVSPSTVTRVIQNKSTISDETKKRVRKAMKELNYHPNLNARSLVSSYT
CCCCHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
QVIGLVLPDDSDAFYQNPFFPSVLRGISQVASENHYAIQIATGKDEKERLNAISQMVYGK
HHHEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCC
RVDGLIFLYAQEEDPLVKLVAEEQFPFLILGKSLSPFIPLVDNDNVQAGFDATEYFIKKG
CCCCEEEEEECCCCCEEEEEECCCCCEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHC
CKRIAFIGGSKKLFVTKDRLTGYEQALKHYKLTTDNNRIYFADEFLEEKGYKFSKRLFKH
CCEEEEECCCCEEEEEHHHHCCHHHHHHHEEEECCCCEEEEHHHHHHHCCCHHHHHHHHC
DPQIDAIITTDSLLAEGVCDYIAKHQLDVPVLSFDSVNPKLNLAAYIDINSLALGRTSLE
CCCCEEEEECHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEEEEECCEECCCCCCE
TILCIINDSKENRQICYRQLIAHKIIEK
EEEEEEECCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVTIKDVAKAAGVSPSTVTRVIQNKSTISDETKKRVRKAMKELNYHPNLNARSLVSSYT
CCCHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
QVIGLVLPDDSDAFYQNPFFPSVLRGISQVASENHYAIQIATGKDEKERLNAISQMVYGK
HHHEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCC
RVDGLIFLYAQEEDPLVKLVAEEQFPFLILGKSLSPFIPLVDNDNVQAGFDATEYFIKKG
CCCCEEEEEECCCCCEEEEEECCCCCEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHC
CKRIAFIGGSKKLFVTKDRLTGYEQALKHYKLTTDNNRIYFADEFLEEKGYKFSKRLFKH
CCEEEEECCCCEEEEEHHHHCCHHHHHHHEEEECCCCEEEEHHHHHHHCCCHHHHHHHHC
DPQIDAIITTDSLLAEGVCDYIAKHQLDVPVLSFDSVNPKLNLAAYIDINSLALGRTSLE
CCCCEEEEECHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEEEEECCEECCCCCCE
TILCIINDSKENRQICYRQLIAHKIIEK
EEEEEEECCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]