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The map label for this gene is htrA [H]

Identifier: 169832575

GI number: 169832575

Start: 2243602

End: 2244783

Strand: Direct

Name: htrA [H]

Synonym: SPH_2438

Alternate gene names: 169832575

Gene position: 2243602-2244783 (Clockwise)

Preceding gene: 169833421

Following gene: 169833627

Centisome position: 99.91

GC content: 36.72

Gene sequence:

>1182_bases
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTAGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAGATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTGA

Upstream 100 bases:

>100_bases
TCAAAAGAGTTATCCACAGTTTGTGTAAAACTTTTGTGTTTAAGTTATAATTAAGCTAGTCAGTTTATACTTTCAGTAAT
TCAAACATATGGAGGCAAAT

Downstream 100 bases:

>100_bases
TTGACATCTATGTAAAGAAAGCTTTACATAAGAGAAAAGATGTGTTAGTGTAGAATCATGGAAAAATTTGAAATGATTTC
TATCACAGATATACAAAAAA

Product: trypsin domain-containing protein

Products: NA

Alternate protein names: HtrALl [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLRSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Sequences:

>Translated_393_residues
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLRSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES
>Mature_393_residues
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLRSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Specific function: Degrades abnormal exported proteins. Needed for the propeptide processing of a natural pro-protein and for the maturation of a native protein. Responsible for the housekeeping of exported proteins [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=320, Percent_Identity=31.875, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI4506141, Length=271, Percent_Identity=33.5793357933579, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI24308541, Length=342, Percent_Identity=29.8245614035088, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI7019477, Length=271, Percent_Identity=30.6273062730627, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1789629, Length=339, Percent_Identity=35.9882005899705, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1786356, Length=292, Percent_Identity=36.3013698630137, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1789630, Length=381, Percent_Identity=29.9212598425197, Blast_Score=129, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24646839, Length=304, Percent_Identity=35.8552631578947, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 41856; Mature: 41856

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENS
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCC
TTQAVNKVKDAVVSVITYSANRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTN
HHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCEEEEEEC
NHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISSEKVTTVAEFGDSSKLTVGET
CEEECCCCEEEEEECCCCCCCCEEECCCCCCCEEEEEECCCCEEEHHHCCCCCCEEECCE
AIAIGSPLGSEYANTVTQGIVSSLNRNVSLRSEDGQAISTKAIQTDTAINPGNSGGPLIN
EEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEECCCCCCCCCCCCCEEE
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSN
ECCEEEEEECCEEECCCCCCCCCCEEEECCCHHHHHHHHHHHCCCEECCCCCEEEEEECC
VSTSDIRRLNIPSNVTSGVVVRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYN
CCHHHEEEECCCCCCCCCCEEEEHHHCCCCCCCCCCEEEEEECCCHHHHCHHHHHHHHHC
HSIGDTIKITYYRNGKEETTSIKLNKSSGDLES
CCCCCEEEEEEEECCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENS
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCC
TTQAVNKVKDAVVSVITYSANRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTN
HHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCEEEEEEC
NHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISSEKVTTVAEFGDSSKLTVGET
CEEECCCCEEEEEECCCCCCCCEEECCCCCCCEEEEEECCCCEEEHHHCCCCCCEEECCE
AIAIGSPLGSEYANTVTQGIVSSLNRNVSLRSEDGQAISTKAIQTDTAINPGNSGGPLIN
EEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEECCCCCCCCCCCCCEEE
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSN
ECCEEEEEECCEEECCCCCCCCCCEEEECCCHHHHHHHHHHHCCCEECCCCCEEEEEECC
VSTSDIRRLNIPSNVTSGVVVRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYN
CCHHHEEEECCCCCCCCCCEEEEHHHCCCCCCCCCCEEEEEECCCHHHHCHHHHHHHHHC
HSIGDTIKITYYRNGKEETTSIKLNKSSGDLES
CCCCCEEEEEEEECCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10712686; 11337471 [H]