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The map label for this gene is dapA [H]

Identifier: 169832573

GI number: 169832573

Start: 1029754

End: 1030689

Strand: Direct

Name: dapA [H]

Synonym: SPH_1118

Alternate gene names: 169832573

Gene position: 1029754-1030689 (Clockwise)

Preceding gene: 169832642

Following gene: 169832921

Centisome position: 45.86

GC content: 43.16

Gene sequence:

>936_bases
GTGTCTTATCAAGATTTAAAAAAATGTAAAATCATTACAGCCTTTATTACCCCCTTCCATGAGGATGGTTCCATTAACTT
TGATGCTATTCCAGCCTTGATTGAGCATTTATTGGCCCATCATACGGATGGAATTCTTCTCGCAGGAACGACTGCTGAGA
GTCCAACTTTGACCCACGATGAGGAGTTGGAGTTGTTTGCGGCTGTACAAAAGGTTGTCAATGGACGCGTTCCTTTGATT
GCGGGTGTAGGTACTAATGATACGCGTGACTCTATTGAGTTTGTCAAAGAAGTAGCGGAATTTGGTGGTTTCGCAGCTGG
GCTTGCTATTGTTCCTTACTACAACAAACCTTCTCAAGAAGGGATGTATCAGCACTTTAAGACTATTGCAGATGCTTCTG
ACCTACCAATTATTATCTATAACATTCCAGGGCGTGTAGTTGTCGAATTGACTCCAGAAACCATGCTTCGCTTGGCTGAC
CATCCAAATATTATCGGTGTCAAAGAATGTACTAGCTTGGCTAATATGGCTTACTTGATTGAGCACAAGCCTGAAGAGTT
CTTGATTTATACAGGTGAGGATGGAGATGCTTTCCATGCCATGAACCTTGGGGCGGATGGGGTTATTTCTGTTGCCTCTC
ATACAAATGGGGATGAAATGCACGAGATGTTTACTGCGATTGCAGAAAGCGATATGAAGAAAGCCGCAGCAATTCAGCGT
AAATTCATTCCTAAGGTTAATGCTCTCTTCTCTTATCCAAGTCCTGCTCCAGTTAAGGCAATTCTTAACTATATGGGATT
TGAAGCTGGACCCACTCGTCTACCTCTTGTTCCAGCACCAGAAGAAGATGCCAAACGCATTATCAAGGTTGTCGTAGATG
GCGACTACGAAGCAACTAAGGCAACTGTAACAGGGGTCTTAAGACCAGATTACTAA

Upstream 100 bases:

>100_bases
GGATTGGTTCGTCCAACAGCCGAATTGAAATTTGAATTAAAATAGTCATATCGTTTAGGAGTTCAGATGAACTCCTTCTT
TGAAATAGAGAGGTGTTTTC

Downstream 100 bases:

>100_bases
TAAAGACAATAAAATCCATGACCGAATGAAGGATCATGGATTTTTCTTATTTTCCTAAACAGAATTGGCTAAAGAGTTGG
GTAATAAGTTCATCTGGAGC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSYQDLKKCKIITAFITPFHEDGSINFDAIPALIEHLLAHHTDGILLAGTTAESPTLTHDEELELFAAVQKVVNGRVPLI
AGVGTNDTRDSIEFVKEVAEFGGFAAGLAIVPYYNKPSQEGMYQHFKTIADASDLPIIIYNIPGRVVVELTPETMLRLAD
HPNIIGVKECTSLANMAYLIEHKPEEFLIYTGEDGDAFHAMNLGADGVISVASHTNGDEMHEMFTAIAESDMKKAAAIQR
KFIPKVNALFSYPSPAPVKAILNYMGFEAGPTRLPLVPAPEEDAKRIIKVVVDGDYEATKATVTGVLRPDY

Sequences:

>Translated_311_residues
MSYQDLKKCKIITAFITPFHEDGSINFDAIPALIEHLLAHHTDGILLAGTTAESPTLTHDEELELFAAVQKVVNGRVPLI
AGVGTNDTRDSIEFVKEVAEFGGFAAGLAIVPYYNKPSQEGMYQHFKTIADASDLPIIIYNIPGRVVVELTPETMLRLAD
HPNIIGVKECTSLANMAYLIEHKPEEFLIYTGEDGDAFHAMNLGADGVISVASHTNGDEMHEMFTAIAESDMKKAAAIQR
KFIPKVNALFSYPSPAPVKAILNYMGFEAGPTRLPLVPAPEEDAKRIIKVVVDGDYEATKATVTGVLRPDY
>Mature_310_residues
SYQDLKKCKIITAFITPFHEDGSINFDAIPALIEHLLAHHTDGILLAGTTAESPTLTHDEELELFAAVQKVVNGRVPLIA
GVGTNDTRDSIEFVKEVAEFGGFAAGLAIVPYYNKPSQEGMYQHFKTIADASDLPIIIYNIPGRVVVELTPETMLRLADH
PNIIGVKECTSLANMAYLIEHKPEEFLIYTGEDGDAFHAMNLGADGVISVASHTNGDEMHEMFTAIAESDMKKAAAIQRK
FIPKVNALFSYPSPAPVKAILNYMGFEAGPTRLPLVPAPEEDAKRIIKVVVDGDYEATKATVTGVLRPDY

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=279, Percent_Identity=25.8064516129032, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI13540533, Length=298, Percent_Identity=28.5234899328859, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1788823, Length=269, Percent_Identity=39.7769516728625, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI87082415, Length=294, Percent_Identity=27.2108843537415, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786463, Length=247, Percent_Identity=29.1497975708502, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789620, Length=274, Percent_Identity=25.1824817518248, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 33913; Mature: 33782

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQDLKKCKIITAFITPFHEDGSINFDAIPALIEHLLAHHTDGILLAGTTAESPTLTHD
CCHHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCH
EELELFAAVQKVVNGRVPLIAGVGTNDTRDSIEFVKEVAEFGGFAAGLAIVPYYNKPSQE
HHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
GMYQHFKTIADASDLPIIIYNIPGRVVVELTPETMLRLADHPNIIGVKECTSLANMAYLI
HHHHHHHHHCCCCCCCEEEEECCCEEEEEECHHHHHHHHCCCCEEEHHHHHHHHHHHHHE
EHKPEEFLIYTGEDGDAFHAMNLGADGVISVASHTNGDEMHEMFTAIAESDMKKAAAIQR
ECCCCEEEEEECCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
KFIPKVNALFSYPSPAPVKAILNYMGFEAGPTRLPLVPAPEEDAKRIIKVVVDGDYEATK
HHCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHEEEEECCCCCCCE
ATVTGVLRPDY
EEEEEEECCCC
>Mature Secondary Structure 
SYQDLKKCKIITAFITPFHEDGSINFDAIPALIEHLLAHHTDGILLAGTTAESPTLTHD
CHHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCH
EELELFAAVQKVVNGRVPLIAGVGTNDTRDSIEFVKEVAEFGGFAAGLAIVPYYNKPSQE
HHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
GMYQHFKTIADASDLPIIIYNIPGRVVVELTPETMLRLADHPNIIGVKECTSLANMAYLI
HHHHHHHHHCCCCCCCEEEEECCCEEEEEECHHHHHHHHCCCCEEEHHHHHHHHHHHHHE
EHKPEEFLIYTGEDGDAFHAMNLGADGVISVASHTNGDEMHEMFTAIAESDMKKAAAIQR
ECCCCEEEEEECCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
KFIPKVNALFSYPSPAPVKAILNYMGFEAGPTRLPLVPAPEEDAKRIIKVVVDGDYEATK
HHCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHEEEEECCCCCCCE
ATVTGVLRPDY
EEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA