BacMap

Definition	Streptococcus pneumoniae Hungary19A-6, complete genome.
Accession	NC_010380
Length	2,245,615

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The map label for this gene is dnaJ [H]

Identifier: 169832497

GI number: 169832497

Start: 579349

End: 580485

Strand: Direct

Name: dnaJ [H]

Synonym: SPH_0625

Alternate gene names: 169832497

Gene position: 579349-580485 (Clockwise)

Preceding gene: 169832493

Following gene: 169834080

Centisome position: 25.8

GC content: 46.44

Gene sequence:

>1137_bases
ATGAACAATACTGAATTTTATGATCGTCTGGGGGTATCCAAAAACGCTTCGGCAGACGAAATCAAAAAGGCTTATCGTAA
GCTTTCCAAAAAATATCACCCAGATATCAACAAGGAGCCTGGTGCTGAGGACAAGTACAAGGAAGTTCAAGAAGCCTATG
AGACTTTGAGTGACGACCAAAAACGTGCTGCCTATGACCAGTATGGTGCTGCAGGCGCCAATGGTGGTTTTGGTGGAGAT
GGTGGTTTCGGCGGTTTCAATGGGGCAGGTGGCTTCGGTGGTTTTGAGGATATTTTCTCAAGTTTCTTCGGCGGAGGCGG
TTCTTCGCGCAATCCAAACGCTCCTCGCCAAGGAGATGATCTCCAGTATCGTGTCAATTTGACCTTTGAAGAAGCTATCT
TCGGAACTGAGAAGGAAGTTAAGTATCATCGTGAAGCTGGCTGTCGTACATGTAATGGCTCTGGTGCTAAGCCAGGGACA
AGTCCAGTCACTTGTGGACGCTGTCATGGCGCTGGTGTTATTAACGTCGATACGCAGACTCCTCTTGGTATGATGCGTCG
CCAAGTAACCTGTGATGTCTGTCACGGCCAAGGAAAAGAAATCAAATATCCATGTACAACCTGTCATGGAACAGGTCATG
AGAAACAAGCTCATAGCGTACATGTGAAAATCCCTGCTGGTGTGGAAACAGGTCAACAAATTCGCCTCGCTGGTCAAGGT
GAAGCAGGCTTTAACGGTGGACCTTATGGTGACTTGTATGTAGTAGTTTCTGTGGAAGCTAGCGACAAGTTTGAACGTGA
AGGAACGACTATCTTCTACAATCTCAACCTCAACTTTGTCCAAGCGGCTCTTGGTGATACAGTAGATATTCCAACTGTTC
ACGGTGATGTTGAATTGGTTATTCCAGAGGGAACTCAGACTGGTAAGAAATTCCGCCTACGTAGTAAGGGGGCACCGAGC
CTTCGTGGCGGTGCAGTTGGTGACCAATACGTTACTGTTAATGTCGTAACACCGACAGGCTTGAACGACCGCCAAAAAGT
AGCCTTGAAAGAATTCGCGGCTGCTGGTGACTTGAAAGTAAATCCAAAGAAAAAAGGCTTCTTTGATCATATTAAAGATG
CCTTTGATGGAGAATAA

Upstream 100 bases:

>100_bases
ACGGACTGTGCCAAAAAGATAGTTTTTTCTAGGACATAAGCGTCCGTCGTCAAAACTCCTAGATGGCTGTGTCCGTTTGA
CGCCCTTTGTATCTTGAATT

Downstream 100 bases:

>100_bases
TACTCTTTGAAAATCTCTTCAAACCACGTCAGCGTCGGCTTGCCGTATATATGTGAGTCGTATCTACAACCTCAAAACAG
TGTTTTGAGCAGCCCGTGGC

Product: chaperone protein DnaJ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MNNTEFYDRLGVSKNASADEIKKAYRKLSKKYHPDINKEPGAEDKYKEVQEAYETLSDDQKRAAYDQYGAAGANGGFGGD
GGFGGFNGAGGFGGFEDIFSSFFGGGGSSRNPNAPRQGDDLQYRVNLTFEEAIFGTEKEVKYHREAGCRTCNGSGAKPGT
SPVTCGRCHGAGVINVDTQTPLGMMRRQVTCDVCHGQGKEIKYPCTTCHGTGHEKQAHSVHVKIPAGVETGQQIRLAGQG
EAGFNGGPYGDLYVVVSVEASDKFEREGTTIFYNLNLNFVQAALGDTVDIPTVHGDVELVIPEGTQTGKKFRLRSKGAPS
LRGGAVGDQYVTVNVVTPTGLNDRQKVALKEFAAAGDLKVNPKKKGFFDHIKDAFDGE

Sequences:

>Translated_378_residues
MNNTEFYDRLGVSKNASADEIKKAYRKLSKKYHPDINKEPGAEDKYKEVQEAYETLSDDQKRAAYDQYGAAGANGGFGGD
GGFGGFNGAGGFGGFEDIFSSFFGGGGSSRNPNAPRQGDDLQYRVNLTFEEAIFGTEKEVKYHREAGCRTCNGSGAKPGT
SPVTCGRCHGAGVINVDTQTPLGMMRRQVTCDVCHGQGKEIKYPCTTCHGTGHEKQAHSVHVKIPAGVETGQQIRLAGQG
EAGFNGGPYGDLYVVVSVEASDKFEREGTTIFYNLNLNFVQAALGDTVDIPTVHGDVELVIPEGTQTGKKFRLRSKGAPS
LRGGAVGDQYVTVNVVTPTGLNDRQKVALKEFAAAGDLKVNPKKKGFFDHIKDAFDGE
>Mature_378_residues
MNNTEFYDRLGVSKNASADEIKKAYRKLSKKYHPDINKEPGAEDKYKEVQEAYETLSDDQKRAAYDQYGAAGANGGFGGD
GGFGGFNGAGGFGGFEDIFSSFFGGGGSSRNPNAPRQGDDLQYRVNLTFEEAIFGTEKEVKYHREAGCRTCNGSGAKPGT
SPVTCGRCHGAGVINVDTQTPLGMMRRQVTCDVCHGQGKEIKYPCTTCHGTGHEKQAHSVHVKIPAGVETGQQIRLAGQG
EAGFNGGPYGDLYVVVSVEASDKFEREGTTIFYNLNLNFVQAALGDTVDIPTVHGDVELVIPEGTQTGKKFRLRSKGAPS
LRGGAVGDQYVTVNVVTPTGLNDRQKVALKEFAAAGDLKVNPKKKGFFDHIKDAFDGE

Specific function: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion. Unfolded proteins bind initially to dnaJ; upon

COG id: COG0484

COG function: function code O; DnaJ-class molecular chaperone with C-terminal Zn finger domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 J domain [H]

Homologues:

Organism=Homo sapiens, GI205360840, Length=357, Percent_Identity=35.8543417366947, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI205360838, Length=357, Percent_Identity=35.8543417366947, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI4504511, Length=324, Percent_Identity=32.4074074074074, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI194328760, Length=344, Percent_Identity=31.3953488372093, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI194328758, Length=344, Percent_Identity=31.6860465116279, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI5031741, Length=349, Percent_Identity=32.0916905444126, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI201862518, Length=352, Percent_Identity=30.9659090909091, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI56549115, Length=352, Percent_Identity=30.9659090909091, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI201862587, Length=352, Percent_Identity=30.9659090909091, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI7706495, Length=366, Percent_Identity=28.9617486338798, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI6631085, Length=370, Percent_Identity=27.027027027027, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI5453690, Length=360, Percent_Identity=26.3888888888889, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI194328762, Length=304, Percent_Identity=27.6315789473684, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI56687498, Length=68, Percent_Identity=58.8235294117647, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI9558755, Length=112, Percent_Identity=44.6428571428571, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI47777312, Length=105, Percent_Identity=48.5714285714286, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI194306642, Length=107, Percent_Identity=42.0560747663551, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI194306640, Length=107, Percent_Identity=42.0560747663551, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI27151736, Length=107, Percent_Identity=46.7289719626168, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI88501736, Length=107, Percent_Identity=45.7943925233645, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI72534740, Length=101, Percent_Identity=42.5742574257426, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI23503241, Length=103, Percent_Identity=45.6310679611651, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI39204547, Length=171, Percent_Identity=30.9941520467836, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI21553335, Length=75, Percent_Identity=53.3333333333333, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI17388799, Length=105, Percent_Identity=50.4761904761905, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI4885495, Length=105, Percent_Identity=50.4761904761905, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI22749377, Length=100, Percent_Identity=40, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI45504382, Length=68, Percent_Identity=52.9411764705882, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI68077168, Length=76, Percent_Identity=50, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI68077166, Length=76, Percent_Identity=50, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI217035105, Length=76, Percent_Identity=44.7368421052632, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI29126218, Length=68, Percent_Identity=50, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI24308127, Length=76, Percent_Identity=44.7368421052632, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI21361912, Length=61, Percent_Identity=49.1803278688525, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786197, Length=384, Percent_Identity=48.1770833333333, Blast_Score=318, Evalue=5e-88,
Organism=Escherichia coli, GI1787235, Length=369, Percent_Identity=30.3523035230352, Blast_Score=164, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17553096, Length=376, Percent_Identity=34.5744680851064, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17553098, Length=376, Percent_Identity=34.5744680851064, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17507263, Length=349, Percent_Identity=31.8051575931232, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17563890, Length=310, Percent_Identity=32.258064516129, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI212645553, Length=364, Percent_Identity=29.3956043956044, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17534355, Length=102, Percent_Identity=56.8627450980392, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17538236, Length=112, Percent_Identity=43.75, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI115532378, Length=95, Percent_Identity=36.8421052631579, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI86563276, Length=109, Percent_Identity=37.6146788990826, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554644, Length=108, Percent_Identity=39.8148148148148, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI115532476, Length=64, Percent_Identity=45.3125, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17568643, Length=69, Percent_Identity=47.8260869565217, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324265, Length=343, Percent_Identity=34.9854227405248, Blast_Score=174, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6321094, Length=390, Percent_Identity=37.4358974358974, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323119, Length=380, Percent_Identity=26.8421052631579, Blast_Score=113, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6323870, Length=362, Percent_Identity=30.6629834254144, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324252, Length=304, Percent_Identity=28.6184210526316, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323813, Length=106, Percent_Identity=44.3396226415094, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6322194, Length=108, Percent_Identity=45.3703703703704, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320888, Length=103, Percent_Identity=38.8349514563107, Blast_Score=66, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6322388, Length=68, Percent_Identity=48.5294117647059, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45552811, Length=379, Percent_Identity=35.0923482849604, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI45552813, Length=379, Percent_Identity=35.0923482849604, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI45549272, Length=379, Percent_Identity=35.0923482849604, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI20129487, Length=289, Percent_Identity=34.2560553633218, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24584014, Length=289, Percent_Identity=34.2560553633218, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI85726398, Length=374, Percent_Identity=30.2139037433155, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28574949, Length=364, Percent_Identity=28.2967032967033, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24646562, Length=361, Percent_Identity=29.6398891966759, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646560, Length=361, Percent_Identity=29.6398891966759, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646558, Length=361, Percent_Identity=29.6398891966759, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646556, Length=361, Percent_Identity=29.6398891966759, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21357547, Length=361, Percent_Identity=29.6398891966759, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19920464, Length=357, Percent_Identity=27.1708683473389, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24658562, Length=181, Percent_Identity=37.5690607734807, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24658555, Length=181, Percent_Identity=37.5690607734807, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI18858081, Length=366, Percent_Identity=25.1366120218579, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24654066, Length=121, Percent_Identity=39.6694214876033, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24654070, Length=121, Percent_Identity=39.6694214876033, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24654068, Length=121, Percent_Identity=39.6694214876033, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24654072, Length=121, Percent_Identity=39.6694214876033, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24668492, Length=68, Percent_Identity=45.5882352941176, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737735, Length=68, Percent_Identity=52.9411764705882, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28574723, Length=68, Percent_Identity=52.9411764705882, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24668523, Length=68, Percent_Identity=52.9411764705882, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21358273, Length=125, Percent_Identity=36, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012724
- InterPro:   IPR002939
- InterPro:   IPR001623
- InterPro:   IPR018253
- InterPro:   IPR008971
- InterPro:   IPR015609
- InterPro:   IPR003095
- InterPro:   IPR001305 [H]

Pfam domain/function: PF00226 DnaJ; PF01556 DnaJ_C; PF00684 DnaJ_CXXCXGXG [H]

EC number: NA

Molecular weight: Translated: 40518; Mature: 40518

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00626 RCC1_2 ; PS00636 DNAJ_1 ; PS50076 DNAJ_2 ; PS00637 DNAJ_CXXCXGXG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNTEFYDRLGVSKNASADEIKKAYRKLSKKYHPDINKEPGAEDKYKEVQEAYETLSDDQ
CCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHH
KRAAYDQYGAAGANGGFGGDGGFGGFNGAGGFGGFEDIFSSFFGGGGSSRNPNAPRQGDD
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
LQYRVNLTFEEAIFGTEKEVKYHREAGCRTCNGSGAKPGTSPVTCGRCHGAGVINVDTQT
EEEEEEEEEHHHHCCCHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCEEEECCCC
PLGMMRRQVTCDVCHGQGKEIKYPCTTCHGTGHEKQAHSVHVKIPAGVETGQQIRLAGQG
CHHHHHHHHEEEECCCCCCEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECC
EAGFNGGPYGDLYVVVSVEASDKFEREGTTIFYNLNLNFVQAALGDTVDIPTVHGDVELV
CCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCEECCCEEEE
IPEGTQTGKKFRLRSKGAPSLRGGAVGDQYVTVNVVTPTGLNDRQKVALKEFAAAGDLKV
ECCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEE
NPKKKGFFDHIKDAFDGE
CCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MNNTEFYDRLGVSKNASADEIKKAYRKLSKKYHPDINKEPGAEDKYKEVQEAYETLSDDQ
CCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHH
KRAAYDQYGAAGANGGFGGDGGFGGFNGAGGFGGFEDIFSSFFGGGGSSRNPNAPRQGDD
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
LQYRVNLTFEEAIFGTEKEVKYHREAGCRTCNGSGAKPGTSPVTCGRCHGAGVINVDTQT
EEEEEEEEEHHHHCCCHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCEEEECCCC
PLGMMRRQVTCDVCHGQGKEIKYPCTTCHGTGHEKQAHSVHVKIPAGVETGQQIRLAGQG
CHHHHHHHHEEEECCCCCCEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECC
EAGFNGGPYGDLYVVVSVEASDKFEREGTTIFYNLNLNFVQAALGDTVDIPTVHGDVELV
CCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCEECCCEEEE
IPEGTQTGKKFRLRSKGAPSLRGGAVGDQYVTVNVVTPTGLNDRQKVALKEFAAAGDLKV
ECCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEE
NPKKKGFFDHIKDAFDGE
CCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]