Definition Streptococcus pneumoniae Hungary19A-6, complete genome.
Accession NC_010380
Length 2,245,615

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The map label for this gene is fhuC [C]

Identifier: 169832436

GI number: 169832436

Start: 753698

End: 755083

Strand: Direct

Name: fhuC [C]

Synonym: SPH_0807

Alternate gene names: 169832436

Gene position: 753698-755083 (Clockwise)

Preceding gene: 169834143

Following gene: 169833801

Centisome position: 33.56

GC content: 44.16

Gene sequence:

>1386_bases
ATGGGTCTGGAACTACGAGCGATTCAGTCCCCAATCTTCTCTGAGCCGTTTGATTTTACTTTTCATGCGCAAGCCTTTAC
CTTGTTAGTTGGGAGCAATGGTTCAGGAAAATCCAGCCTCTTTCAAATGATTGCCCAAGTCAGTTCTCTTCCCTATAGTG
GTCAAGTCCTGATAGATGGGAGCGAGGTCAGTCAGCTTTCTATCATCGCACGTGTCCAGAAGGTTGGCATTCTCTTGCAA
AATCCCAATCATCAATTTACCATGGAGAACTTGTTTGAGGAGCTGATTTTCACCTTGGAGAATATCGGCTATCACCTTCA
GGAAATTGATTCTAAAATAGCAGAGGTTGTCCAGCAATGTCGTTGCGAGGCAATCTTACACCGTCCCATTCATCACCTAT
CAGGTGGGGAAAAGCAAAAAGCAGCGCTGGCTGTCCTCTTTGCCATGAATCCTAGGGTCTATCTCTTGGATGAGCCCTTC
GCTTCCATTGACCGCAAGAGTAGAATCGAGATATTGGAGATTCTAAAAGAGTTGGCTCTTGATGGGAAGACAGTCATTTT
GTGCGACCATGATTTATCTGACTATAAAGCCTATATCGACTATATGGTTGAGCTAAGAGACGGAAAACTAAGGGAAGTGT
TTCAAATCCCTTCCTATGAGATGACACAGGTTGCTTCAAAGGAAGTTGCTGCTAGCCCGGAATTATTCCATATGAACCGT
GTGACTGGTGAGCTTGGTAATCGCCCCCTCTTTTCAATTGCTGATTTCACATTCTATCAAGGGATTTCCTGTATCCTGGG
TGACAATGGTGTCGGGAAATCAACCCTCTTTCGGTCTATTCTTCAATTTCAAAAGTATAAGGGGCGCATTGCATGGAAGG
GGACAGTCCTGAAAAAGAAAAAGAGTTTGTACCGTGATCTGACGGGTGTTGTTCAGGAAGCTGAGAAGCAGTTTATCCGA
GTCAGTCTGCGAGAGGAGCTTCAATTAGATGGACCTGATTCTGAAAGAAATCAGCGGATTTTTCAAGCTTTACGATATTT
TGATTTGGAGCAGGCAGTCGATAAGAGTCCCTATCAATTAAGTGGTGGTCAGCAAAAAATTCTTCAGCTCCTGACCATCT
TGACCAGTAAGGCTTCCGTGATCTTGCTAGATGAACCTTTTGCAGGTTTGGATGATAGAGCCTGCCATTATTTTTGCAAG
TGGATTGTGGAGGAGAGGAACCAAGGAAGAAGTTTTCTGCTCATTAGTCATCGTTTAGACCCTTTGATTTCTGTGGTTGA
TTATTGGATTGAGATGACTAGTCAGGGTCTTCGGCATGTGAAAGAAGTGACCATTACCAAACCACTTACATCTCAGAGTA
GCAATACCCAAGGGGAGGTGAGATAG

Upstream 100 bases:

>100_bases
GCTTGTGGTACGTTTTATTTCTGTTTATTTCTTCTGTACCATCTTGGTTCGTGCCATTGTCAAACTCTATCATCAGTTTG
CAACTGGAGGAAAAGCATAG

Downstream 100 bases:

>100_bases
TATGGTCAAAGTAGCAACCCAGACACCGATTATCAGTCTCTTCTTGCTGATTTTATCCTTGGAAACATCTTTCATTCCTT
CGATTGCTCTGAATCTTTCG

Product: ABC transporter ATP-binding protein - cobalt or other cation transport

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MGLELRAIQSPIFSEPFDFTFHAQAFTLLVGSNGSGKSSLFQMIAQVSSLPYSGQVLIDGSEVSQLSIIARVQKVGILLQ
NPNHQFTMENLFEELIFTLENIGYHLQEIDSKIAEVVQQCRCEAILHRPIHHLSGGEKQKAALAVLFAMNPRVYLLDEPF
ASIDRKSRIEILEILKELALDGKTVILCDHDLSDYKAYIDYMVELRDGKLREVFQIPSYEMTQVASKEVAASPELFHMNR
VTGELGNRPLFSIADFTFYQGISCILGDNGVGKSTLFRSILQFQKYKGRIAWKGTVLKKKKSLYRDLTGVVQEAEKQFIR
VSLREELQLDGPDSERNQRIFQALRYFDLEQAVDKSPYQLSGGQQKILQLLTILTSKASVILLDEPFAGLDDRACHYFCK
WIVEERNQGRSFLLISHRLDPLISVVDYWIEMTSQGLRHVKEVTITKPLTSQSSNTQGEVR

Sequences:

>Translated_461_residues
MGLELRAIQSPIFSEPFDFTFHAQAFTLLVGSNGSGKSSLFQMIAQVSSLPYSGQVLIDGSEVSQLSIIARVQKVGILLQ
NPNHQFTMENLFEELIFTLENIGYHLQEIDSKIAEVVQQCRCEAILHRPIHHLSGGEKQKAALAVLFAMNPRVYLLDEPF
ASIDRKSRIEILEILKELALDGKTVILCDHDLSDYKAYIDYMVELRDGKLREVFQIPSYEMTQVASKEVAASPELFHMNR
VTGELGNRPLFSIADFTFYQGISCILGDNGVGKSTLFRSILQFQKYKGRIAWKGTVLKKKKSLYRDLTGVVQEAEKQFIR
VSLREELQLDGPDSERNQRIFQALRYFDLEQAVDKSPYQLSGGQQKILQLLTILTSKASVILLDEPFAGLDDRACHYFCK
WIVEERNQGRSFLLISHRLDPLISVVDYWIEMTSQGLRHVKEVTITKPLTSQSSNTQGEVR
>Mature_460_residues
GLELRAIQSPIFSEPFDFTFHAQAFTLLVGSNGSGKSSLFQMIAQVSSLPYSGQVLIDGSEVSQLSIIARVQKVGILLQN
PNHQFTMENLFEELIFTLENIGYHLQEIDSKIAEVVQQCRCEAILHRPIHHLSGGEKQKAALAVLFAMNPRVYLLDEPFA
SIDRKSRIEILEILKELALDGKTVILCDHDLSDYKAYIDYMVELRDGKLREVFQIPSYEMTQVASKEVAASPELFHMNRV
TGELGNRPLFSIADFTFYQGISCILGDNGVGKSTLFRSILQFQKYKGRIAWKGTVLKKKKSLYRDLTGVVQEAEKQFIRV
SLREELQLDGPDSERNQRIFQALRYFDLEQAVDKSPYQLSGGQQKILQLLTILTSKASVILLDEPFAGLDDRACHYFCKW
IVEERNQGRSFLLISHRLDPLISVVDYWIEMTSQGLRHVKEVTITKPLTSQSSNTQGEVR

Specific function: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system [H]

COG id: COG1122

COG function: function code P; ABC-type cobalt transport system, ATPase component

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI171184400, Length=217, Percent_Identity=30.8755760368664, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI31657092, Length=197, Percent_Identity=27.9187817258883, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI27477115, Length=193, Percent_Identity=27.979274611399, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI27436953, Length=193, Percent_Identity=24.8704663212435, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI42741659, Length=199, Percent_Identity=31.1557788944724, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI153792144, Length=193, Percent_Identity=25.9067357512953, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI9961250, Length=196, Percent_Identity=30.1020408163265, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI4505771, Length=196, Percent_Identity=30.1020408163265, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI9961252, Length=196, Percent_Identity=30.1020408163265, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI105990541, Length=194, Percent_Identity=25.2577319587629, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI108773784, Length=310, Percent_Identity=23.5483870967742, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI108773782, Length=310, Percent_Identity=23.5483870967742, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI116734710, Length=187, Percent_Identity=26.7379679144385, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1786345, Length=200, Percent_Identity=32.5, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1790739, Length=191, Percent_Identity=30.3664921465969, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI87081834, Length=210, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1787370, Length=208, Percent_Identity=27.8846153846154, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1786803, Length=256, Percent_Identity=26.171875, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI87081791, Length=215, Percent_Identity=28.8372093023256, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787792, Length=450, Percent_Identity=24.2222222222222, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786975, Length=469, Percent_Identity=23.6673773987207, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788761, Length=190, Percent_Identity=30, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790467, Length=206, Percent_Identity=28.1553398058252, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788450, Length=200, Percent_Identity=27.5, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789032, Length=195, Percent_Identity=28.7179487179487, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI145693107, Length=494, Percent_Identity=22.8744939271255, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1787029, Length=206, Percent_Identity=26.2135922330097, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1786398, Length=205, Percent_Identity=27.8048780487805, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87081709, Length=195, Percent_Identity=28.2051282051282, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788225, Length=217, Percent_Identity=26.2672811059908, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787089, Length=207, Percent_Identity=28.9855072463768, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87082267, Length=234, Percent_Identity=25.2136752136752, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789991, Length=464, Percent_Identity=23.4913793103448, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786563, Length=230, Percent_Identity=25.2173913043478, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790190, Length=444, Percent_Identity=22.0720720720721, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788506, Length=237, Percent_Identity=27.4261603375527, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1789593, Length=193, Percent_Identity=29.0155440414508, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786253, Length=196, Percent_Identity=27.5510204081633, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787547, Length=220, Percent_Identity=24.5454545454545, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081782, Length=215, Percent_Identity=28.8372093023256, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789672, Length=212, Percent_Identity=25.4716981132075, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789873, Length=197, Percent_Identity=25.8883248730964, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790162, Length=221, Percent_Identity=29.8642533936652, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788644, Length=180, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1789586, Length=215, Percent_Identity=28.8372093023256, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1786872, Length=188, Percent_Identity=26.063829787234, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789891, Length=142, Percent_Identity=33.8028169014084, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787712, Length=189, Percent_Identity=26.984126984127, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789962, Length=238, Percent_Identity=26.890756302521, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1787105, Length=211, Percent_Identity=26.5402843601896, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17558664, Length=198, Percent_Identity=30.3030303030303, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71992290, Length=214, Percent_Identity=27.1028037383178, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17551700, Length=193, Percent_Identity=27.979274611399, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551702, Length=193, Percent_Identity=27.979274611399, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510237, Length=192, Percent_Identity=26.0416666666667, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25146777, Length=197, Percent_Identity=28.4263959390863, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323959, Length=207, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320296, Length=174, Percent_Identity=26.4367816091954, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324498, Length=217, Percent_Identity=27.1889400921659, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221512771, Length=199, Percent_Identity=29.6482412060301, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI85724858, Length=177, Percent_Identity=27.683615819209, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI85724856, Length=177, Percent_Identity=27.683615819209, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24580547, Length=177, Percent_Identity=27.683615819209, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24580551, Length=177, Percent_Identity=27.683615819209, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24580549, Length=177, Percent_Identity=27.683615819209, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24580545, Length=177, Percent_Identity=27.683615819209, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28574744, Length=196, Percent_Identity=27.5510204081633, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24666092, Length=201, Percent_Identity=27.8606965174129, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI116007184, Length=196, Percent_Identity=27.0408163265306, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221500365, Length=196, Percent_Identity=27.0408163265306, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24659289, Length=192, Percent_Identity=28.125, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 52318; Mature: 52187

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MGLELRAIQSPIFSEPFDFTFHAQAFTLLVGSNGSGKSSLFQMIAQVSSLPYSGQVLIDG
CCCCHHHHHCCCCCCCCCCEEECEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECC
SEVSQLSIIARVQKVGILLQNPNHQFTMENLFEELIFTLENIGYHLQEIDSKIAEVVQQC
CCHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
RCEAILHRPIHHLSGGEKQKAALAVLFAMNPRVYLLDEPFASIDRKSRIEILEILKELAL
HHHHHHHHHHHHCCCCCCHHHHEEEEEECCCEEEEECCCHHHCCCHHHHHHHHHHHHHHC
DGKTVILCDHDLSDYKAYIDYMVELRDGKLREVFQIPSYEMTQVASKEVAASPELFHMNR
CCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCEEHHH
VTGELGNRPLFSIADFTFYQGISCILGDNGVGKSTLFRSILQFQKYKGRIAWKGTVLKKK
HHHHHCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECHHHHHH
KSLYRDLTGVVQEAEKQFIRVSLREELQLDGPDSERNQRIFQALRYFDLEQAVDKSPYQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
SGGQQKILQLLTILTSKASVILLDEPFAGLDDRACHYFCKWIVEERNQGRSFLLISHRLD
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHH
PLISVVDYWIEMTSQGLRHVKEVTITKPLTSQSSNTQGEVR
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
GLELRAIQSPIFSEPFDFTFHAQAFTLLVGSNGSGKSSLFQMIAQVSSLPYSGQVLIDG
CCCHHHHHCCCCCCCCCCEEECEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECC
SEVSQLSIIARVQKVGILLQNPNHQFTMENLFEELIFTLENIGYHLQEIDSKIAEVVQQC
CCHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
RCEAILHRPIHHLSGGEKQKAALAVLFAMNPRVYLLDEPFASIDRKSRIEILEILKELAL
HHHHHHHHHHHHCCCCCCHHHHEEEEEECCCEEEEECCCHHHCCCHHHHHHHHHHHHHHC
DGKTVILCDHDLSDYKAYIDYMVELRDGKLREVFQIPSYEMTQVASKEVAASPELFHMNR
CCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCEEHHH
VTGELGNRPLFSIADFTFYQGISCILGDNGVGKSTLFRSILQFQKYKGRIAWKGTVLKKK
HHHHHCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECHHHHHH
KSLYRDLTGVVQEAEKQFIRVSLREELQLDGPDSERNQRIFQALRYFDLEQAVDKSPYQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
SGGQQKILQLLTILTSKASVILLDEPFAGLDDRACHYFCKWIVEERNQGRSFLLISHRLD
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHH
PLISVVDYWIEMTSQGLRHVKEVTITKPLTSQSSNTQGEVR
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]