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The map label for this gene is trx [H]

Identifier: 169832424

GI number: 169832424

Start: 1761906

End: 1762220

Strand: Direct

Name: trx [H]

Synonym: SPH_1891

Alternate gene names: 169832424

Gene position: 1761906-1762220 (Clockwise)

Preceding gene: 169834237

Following gene: 169833883

Centisome position: 78.46

GC content: 40.32

Gene sequence:

>315_bases
ATGGCAAAAGCAATTACAGATGCAACATTCGAACAAGAAACAAAAGACGGTTTGGTCTTAGTAGACTTCTGGGCAACTTG
GTGTGGTCCATGTCGTATGCAAGGTCCAATCTTGGACAAATTGTCTGAAGAACTTTCAGAAGATGTCTTGAAAATCGTTA
AAATGGACGTTGATGAAAATCCAAACACAGCTCGTGCTTTTGGAATCATGTCTATTCCAACTCTTCTCTTCAAAAAAGAC
GGCCAAGTTGTCAAACAAGTTGCAGGTGTTCACACAGCAGAACAAATCAAGGCCATCATTGCTGAATTGAGCTAA

Upstream 100 bases:

>100_bases
AAGGGTCATAATTTGGACTACCATGGGACTTATGGAGATATCTTCTTCTATCTCATGAAACAAGATTTAAGCCAATATAA
CTAAAAAAAGGAGAAATACA

Downstream 100 bases:

>100_bases
TCAAACGAGAGACCAAGTACTTTCTTTGGTCTCTTTTTTCTTGCCCTTTGCCATTTTTCAAAAAATATGCTAGACTATAG
TATATTGAAACTAGAATAGT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MAKAITDATFEQETKDGLVLVDFWATWCGPCRMQGPILDKLSEELSEDVLKIVKMDVDENPNTARAFGIMSIPTLLFKKD
GQVVKQVAGVHTAEQIKAIIAELS

Sequences:

>Translated_104_residues
MAKAITDATFEQETKDGLVLVDFWATWCGPCRMQGPILDKLSEELSEDVLKIVKMDVDENPNTARAFGIMSIPTLLFKKD
GQVVKQVAGVHTAEQIKAIIAELS
>Mature_103_residues
AKAITDATFEQETKDGLVLVDFWATWCGPCRMQGPILDKLSEELSEDVLKIVKMDVDENPNTARAFGIMSIPTLLFKKDG
QVVKQVAGVHTAEQIKAIIAELS

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI50592994, Length=107, Percent_Identity=39.2523364485981, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI21361403, Length=85, Percent_Identity=35.2941176470588, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082331, Length=98, Percent_Identity=42.8571428571429, Blast_Score=92, Evalue=9e-21,
Organism=Escherichia coli, GI1788936, Length=85, Percent_Identity=42.3529411764706, Blast_Score=70, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=90, Percent_Identity=41.1111111111111, Blast_Score=78, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323072, Length=89, Percent_Identity=41.5730337078652, Blast_Score=75, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=81, Percent_Identity=38.2716049382716, Blast_Score=70, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17648013, Length=83, Percent_Identity=42.1686746987952, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24583090, Length=83, Percent_Identity=42.1686746987952, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24639826, Length=78, Percent_Identity=38.4615384615385, Blast_Score=72, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24664269, Length=88, Percent_Identity=37.5, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28573567, Length=94, Percent_Identity=32.9787234042553, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11449; Mature: 11318

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKAITDATFEQETKDGLVLVDFWATWCGPCRMQGPILDKLSEELSEDVLKIVKMDVDEN
CCCCCCCCHHHHCCCCCEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
PNTARAFGIMSIPTLLFKKDGQVVKQVAGVHTAEQIKAIIAELS
CCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AKAITDATFEQETKDGLVLVDFWATWCGPCRMQGPILDKLSEELSEDVLKIVKMDVDEN
CCCCCCCHHHHCCCCCEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
PNTARAFGIMSIPTLLFKKDGQVVKQVAGVHTAEQIKAIIAELS
CCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]