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The map label for this gene is mepA [H]

Identifier: 169825154

GI number: 169825154

Start: 1608827

End: 1610128

Strand: Direct

Name: mepA [H]

Synonym: FMG_1457

Alternate gene names: 169825154

Gene position: 1608827-1610128 (Clockwise)

Preceding gene: 169825151

Following gene: 169825158

Centisome position: 89.5

GC content: 36.56

Gene sequence:

>1302_bases
ATGTTGGTTCAAGCTTTGTACAATGTTGTAGATAGAATTTTCCTTGGTGCCGGTGTAAATCAAATGTCCATTGGTGGCGT
TTATTTGATTTTCCCGATTTTTTTATTTTTGATGGCATTCGGAATGTTGATTGGTGTGGGTGGCAATTCACTTTCTTCAA
TTAAATTCGGTGAAGGCAAGAAAACAGAATCAGAAATAATCCTCGGCACGTCTATGGTTTTATCTATTATTTTTGGGGTT
TTGATATCAGGGATTTTTCTTTTAAATTTAAAATGGTTTTTGAAGATTTTCGGCGCAAGTGACACTTTGATGCCTTACGC
TTACGATTATGGAAAAATTATTTTGTATGGTGCGCCTTTTCAAATGGTTGGTTTTGCGATGAACAATTTCATTCGTGGAG
AAGGCAATCCTAGAGCTGCGATGGTAACGATGTTTATCGGTGCGATTTCCAATATTATTTTGGATTATATATTCATCTTC
CCAATGCAAATGGGAGTTAAAGGTGCTGCTTGGGCGACAATTATCGGTCAAGTTTTATCTAGTATTTGGGTTGTGAGATA
TTTCCTTTCAGATCGTGCGTTATTGCGTTTGACTAAGGAAACTTTCAGACTCGATTTTCATTTTTGCAAGCAAATTTTCG
CACTAGGAGTGTCACCATTTGCGATGCAACTTGTAGCTAGTGGTATTAATATTATTTTCAACAATTCCCTTAAAATTTAC
GGTGGAGATTTGGCGACATCATCTATGAGTGTTATCTACAGTGTCTCACAAATTGCATTCATGCCGATTTTCGGTATTAA
CCAAGGTATCCAACCAATTTTAGGATTTAATTTTGGAGCGCACAAATACAGACGTGTTCAGCACACTCTAAGAATTGCAG
TTGTTGCAGGAACTGTGTACATGGTTTTGAATTGGGCATTCACAATGATTAGACCAGATTTGTTGGTGAAAATTTTTATT
TCAAGACCTGAAGATTATGCAGTCATCAAGGACATCGCAATTCCTGGACTTAGAATTTACAATTCGATGATTTTCATGCT
TGGATATTCCATAATTGGATCGTCATTGTTCCAAGCAATCGGCAAACCAAAAATTGGTTTCATATTGACAATGACAAGAC
AACTTATTTATTTGTTGCCGTTGATGTTGATTTTCCCAAAACTTTTCGGACTAACAGGCGTGTGGTCAGCGATGCCAGTG
TCTGATGTTTTATCCACATTAACTACGACTTATTTCTTGGTTAAATCTGGATTTTTGGTTAAAACAATTCACAACGACGA
CGAATTTGTTCTCGGAATTTAA

Upstream 100 bases:

>100_bases
GATTATTATAGAAAATTTAAACGAACAACGATCAAATCTTCTCGGCAATGAATCCATTCCAAAATTAATCTGGAAATTTT
CAGTTCCAGCGACTGTAGGA

Downstream 100 bases:

>100_bases
AAAAGGTTTGAATATTGGGTTTCCAATGTTCAAACCTTTGTTTTTTTAGAATATAAATACTGAAACAAGAATAGACACTA
CAGCCGTTATCATTATCATA

Product: Na+driven multidrug efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLVQALYNVVDRIFLGAGVNQMSIGGVYLIFPIFLFLMAFGMLIGVGGNSLSSIKFGEGKKTESEIILGTSMVLSIIFGV
LISGIFLLNLKWFLKIFGASDTLMPYAYDYGKIILYGAPFQMVGFAMNNFIRGEGNPRAAMVTMFIGAISNIILDYIFIF
PMQMGVKGAAWATIIGQVLSSIWVVRYFLSDRALLRLTKETFRLDFHFCKQIFALGVSPFAMQLVASGINIIFNNSLKIY
GGDLATSSMSVIYSVSQIAFMPIFGINQGIQPILGFNFGAHKYRRVQHTLRIAVVAGTVYMVLNWAFTMIRPDLLVKIFI
SRPEDYAVIKDIAIPGLRIYNSMIFMLGYSIIGSSLFQAIGKPKIGFILTMTRQLIYLLPLMLIFPKLFGLTGVWSAMPV
SDVLSTLTTTYFLVKSGFLVKTIHNDDEFVLGI

Sequences:

>Translated_433_residues
MLVQALYNVVDRIFLGAGVNQMSIGGVYLIFPIFLFLMAFGMLIGVGGNSLSSIKFGEGKKTESEIILGTSMVLSIIFGV
LISGIFLLNLKWFLKIFGASDTLMPYAYDYGKIILYGAPFQMVGFAMNNFIRGEGNPRAAMVTMFIGAISNIILDYIFIF
PMQMGVKGAAWATIIGQVLSSIWVVRYFLSDRALLRLTKETFRLDFHFCKQIFALGVSPFAMQLVASGINIIFNNSLKIY
GGDLATSSMSVIYSVSQIAFMPIFGINQGIQPILGFNFGAHKYRRVQHTLRIAVVAGTVYMVLNWAFTMIRPDLLVKIFI
SRPEDYAVIKDIAIPGLRIYNSMIFMLGYSIIGSSLFQAIGKPKIGFILTMTRQLIYLLPLMLIFPKLFGLTGVWSAMPV
SDVLSTLTTTYFLVKSGFLVKTIHNDDEFVLGI
>Mature_433_residues
MLVQALYNVVDRIFLGAGVNQMSIGGVYLIFPIFLFLMAFGMLIGVGGNSLSSIKFGEGKKTESEIILGTSMVLSIIFGV
LISGIFLLNLKWFLKIFGASDTLMPYAYDYGKIILYGAPFQMVGFAMNNFIRGEGNPRAAMVTMFIGAISNIILDYIFIF
PMQMGVKGAAWATIIGQVLSSIWVVRYFLSDRALLRLTKETFRLDFHFCKQIFALGVSPFAMQLVASGINIIFNNSLKIY
GGDLATSSMSVIYSVSQIAFMPIFGINQGIQPILGFNFGAHKYRRVQHTLRIAVVAGTVYMVLNWAFTMIRPDLLVKIFI
SRPEDYAVIKDIAIPGLRIYNSMIFMLGYSIIGSSLFQAIGKPKIGFILTMTRQLIYLLPLMLIFPKLFGLTGVWSAMPV
SDVLSTLTTTYFLVKSGFLVKTIHNDDEFVLGI

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48069; Mature: 48069

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVQALYNVVDRIFLGAGVNQMSIGGVYLIFPIFLFLMAFGMLIGVGGNSLSSIKFGEGK
CHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCC
KTESEIILGTSMVLSIIFGVLISGIFLLNLKWFLKIFGASDTLMPYAYDYGKIILYGAPF
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCEEEECCCH
QMVGFAMNNFIRGEGNPRAAMVTMFIGAISNIILDYIFIFPMQMGVKGAAWATIIGQVLS
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SIWVVRYFLSDRALLRLTKETFRLDFHFCKQIFALGVSPFAMQLVASGINIIFNNSLKIY
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEECCCEEEE
GGDLATSSMSVIYSVSQIAFMPIFGINQGIQPILGFNFGAHKYRRVQHTLRIAVVAGTVY
ECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
MVLNWAFTMIRPDLLVKIFISRPEDYAVIKDIAIPGLRIYNSMIFMLGYSIIGSSLFQAI
HHHHHHHHHHCHHHHHHEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GKPKIGFILTMTRQLIYLLPLMLIFPKLFGLTGVWSAMPVSDVLSTLTTTYFLVKSGFLV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEE
KTIHNDDEFVLGI
EEEECCCCEEEEC
>Mature Secondary Structure
MLVQALYNVVDRIFLGAGVNQMSIGGVYLIFPIFLFLMAFGMLIGVGGNSLSSIKFGEGK
CHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCC
KTESEIILGTSMVLSIIFGVLISGIFLLNLKWFLKIFGASDTLMPYAYDYGKIILYGAPF
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCEEEECCCH
QMVGFAMNNFIRGEGNPRAAMVTMFIGAISNIILDYIFIFPMQMGVKGAAWATIIGQVLS
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SIWVVRYFLSDRALLRLTKETFRLDFHFCKQIFALGVSPFAMQLVASGINIIFNNSLKIY
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEECCCEEEE
GGDLATSSMSVIYSVSQIAFMPIFGINQGIQPILGFNFGAHKYRRVQHTLRIAVVAGTVY
ECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
MVLNWAFTMIRPDLLVKIFISRPEDYAVIKDIAIPGLRIYNSMIFMLGYSIIGSSLFQAI
HHHHHHHHHHCHHHHHHEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GKPKIGFILTMTRQLIYLLPLMLIFPKLFGLTGVWSAMPVSDVLSTLTTTYFLVKSGFLV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEE
KTIHNDDEFVLGI
EEEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA