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The map label for this gene is tyrS [H]

Identifier: 169825148

GI number: 169825148

Start: 1598814

End: 1600061

Strand: Direct

Name: tyrS [H]

Synonym: FMG_1451

Alternate gene names: 169825148

Gene position: 1598814-1600061 (Clockwise)

Preceding gene: 169825147

Following gene: 169825149

Centisome position: 88.94

GC content: 35.82

Gene sequence:

>1248_bases
ATGATTAATTACAAATTTGAACACGAAAATGTGTTCGACGAATTAGTAGCGCGTGGATATTTTGAACAAGCTACTTATGA
GGATGAATTGAGAGATTTACTTGGAAAAGAAAGAGTTCCATTTTATATCGGATTCGATGCGACTGCAGATAGTTTGACTA
TTGGCCATTTTATTCAACTTATGGTTATGATGAGAATGCAAGCTCACGGTCACATTCCGATTTGTCTTTTGGGTGGTGGA
ACAACTATGATTGGTGATCCTTCCGGTCGTAACGATATGAGAAGTATCATGACTAAGGAAGTTATCGACGAAAATGCCAG
AAGATTTTATTCCCAAATGACAAGATTCATCGATTTTGGTGATGACAAGGCTTACATTGAAAACAACAAGGATTGGTTGT
TGAATTTGAATTTCTTGGATTTCATGAGAGAAATCGGCGTTCATTTTTCTGTAAATCAAATGTTGACTTTGGAAAGTTAC
AAGAACAGAATGAAACAAGGTCTAACATTTTTCGAATTTAGTTACATGTTGATGCAATCATACGATTATTTGGTATTGTA
CAGAAAATACGGTTGTAAATTACAAATGGGCGGCTCTGATCAATGGTCAAATATTTTGGGCGGATACGATTTGGTTAGAA
AATTGGAAAACGACAAAGTTTATGCGATGACTTTCAAGCTTTTAACAACTGCTGACGGAGTGAAAATGGGTAAATCACAA
AAAGGTGCTGTGTGGTTGGACGAAAACAAGACAACTCCTTACGATTTATTCCAATACATGAGAAATGTTGACGACAGAGA
TGTGGAAAAATTCTTGTTGATGTTGACATTCTTGCCAACTGATGAATGCAAGAGACTTGGTAGCTTAGAAGGAAGCGAAA
TCAACAAAGCTAAGGAAGTTTTGGCTTTTGAGGTGTGCAAATTAGTTCACGGCGAAGAAAAAGCAGAAGAAGCTCGCCAA
ACAGCAAATGCGTTGTTCAATTCAAATGTTGTTGATGAAAATATGCCAACAACTGAAATGAAAGCTTTGGATTTTGAAAA
TGGAATTGGTTTGTTGAATTTGTTGACAATGACAGGCCTTACTCAATCAAACAGCGAAGCACGTAGACTTGTAACTCAAA
ACGGTATTTCTGTTAATGACAACAAGGAAGCTGATCCTAAAAGAGTTATCACAATTCACGATTTTAACGACGATGAACTT
ATTATCAAAAAAGGTAAGAAAGTATATCACAGAGTAAAATTAGTATAA

Upstream 100 bases:

>100_bases
TTCATACTTTGCATGGAACATGAGCTTTTGATGAGAAAGGTGGTACCGCGTAGATTCGCCCTTTCGTGTCAAGAGTTTTT
TTATTTTATAGGAGGAGTTT

Downstream 100 bases:

>100_bases
TATAATAATATAAAAGAAGAAAACCTCGGCGATTTTGAATTGATTTTCAAAGTCTGCTGAGGTTTTGTGTTATAATTAAG
TAAATTTAAAAATATTTGTG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MINYKFEHENVFDELVARGYFEQATYEDELRDLLGKERVPFYIGFDATADSLTIGHFIQLMVMMRMQAHGHIPICLLGGG
TTMIGDPSGRNDMRSIMTKEVIDENARRFYSQMTRFIDFGDDKAYIENNKDWLLNLNFLDFMREIGVHFSVNQMLTLESY
KNRMKQGLTFFEFSYMLMQSYDYLVLYRKYGCKLQMGGSDQWSNILGGYDLVRKLENDKVYAMTFKLLTTADGVKMGKSQ
KGAVWLDENKTTPYDLFQYMRNVDDRDVEKFLLMLTFLPTDECKRLGSLEGSEINKAKEVLAFEVCKLVHGEEKAEEARQ
TANALFNSNVVDENMPTTEMKALDFENGIGLLNLLTMTGLTQSNSEARRLVTQNGISVNDNKEADPKRVITIHDFNDDEL
IIKKGKKVYHRVKLV

Sequences:

>Translated_415_residues
MINYKFEHENVFDELVARGYFEQATYEDELRDLLGKERVPFYIGFDATADSLTIGHFIQLMVMMRMQAHGHIPICLLGGG
TTMIGDPSGRNDMRSIMTKEVIDENARRFYSQMTRFIDFGDDKAYIENNKDWLLNLNFLDFMREIGVHFSVNQMLTLESY
KNRMKQGLTFFEFSYMLMQSYDYLVLYRKYGCKLQMGGSDQWSNILGGYDLVRKLENDKVYAMTFKLLTTADGVKMGKSQ
KGAVWLDENKTTPYDLFQYMRNVDDRDVEKFLLMLTFLPTDECKRLGSLEGSEINKAKEVLAFEVCKLVHGEEKAEEARQ
TANALFNSNVVDENMPTTEMKALDFENGIGLLNLLTMTGLTQSNSEARRLVTQNGISVNDNKEADPKRVITIHDFNDDEL
IIKKGKKVYHRVKLV
>Mature_415_residues
MINYKFEHENVFDELVARGYFEQATYEDELRDLLGKERVPFYIGFDATADSLTIGHFIQLMVMMRMQAHGHIPICLLGGG
TTMIGDPSGRNDMRSIMTKEVIDENARRFYSQMTRFIDFGDDKAYIENNKDWLLNLNFLDFMREIGVHFSVNQMLTLESY
KNRMKQGLTFFEFSYMLMQSYDYLVLYRKYGCKLQMGGSDQWSNILGGYDLVRKLENDKVYAMTFKLLTTADGVKMGKSQ
KGAVWLDENKTTPYDLFQYMRNVDDRDVEKFLLMLTFLPTDECKRLGSLEGSEINKAKEVLAFEVCKLVHGEEKAEEARQ
TANALFNSNVVDENMPTTEMKALDFENGIGLLNLLTMTGLTQSNSEARRLVTQNGISVNDNKEADPKRVITIHDFNDDEL
IIKKGKKVYHRVKLV

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=430, Percent_Identity=32.093023255814, Blast_Score=229, Evalue=3e-60,
Organism=Escherichia coli, GI1787925, Length=421, Percent_Identity=38.9548693586698, Blast_Score=307, Evalue=8e-85,
Organism=Caenorhabditis elegans, GI25145802, Length=407, Percent_Identity=32.9238329238329, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI25145805, Length=327, Percent_Identity=30.8868501529052, Blast_Score=151, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6325160, Length=434, Percent_Identity=31.5668202764977, Blast_Score=212, Evalue=7e-56,
Organism=Drosophila melanogaster, GI20130383, Length=433, Percent_Identity=32.7944572748268, Blast_Score=249, Evalue=3e-66,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 47901; Mature: 47901

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINYKFEHENVFDELVARGYFEQATYEDELRDLLGKERVPFYIGFDATADSLTIGHFIQL
CCCEEECCHHHHHHHHHCCHHHHCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHH
MVMMRMQAHGHIPICLLGGGTTMIGDPSGRNDMRSIMTKEVIDENARRFYSQMTRFIDFG
HHHHHHHHCCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DDKAYIENNKDWLLNLNFLDFMREIGVHFSVNQMLTLESYKNRMKQGLTFFEFSYMLMQS
CCCEEEECCCCEEEECHHHHHHHHHCCEEEHHHHEEHHHHHHHHHHCCHHHHHHHHHHHC
YDYLVLYRKYGCKLQMGGSDQWSNILGGYDLVRKLENDKVYAMTFKLLTTADGVKMGKSQ
CCEEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEHHCCCCHHCCCCC
KGAVWLDENKTTPYDLFQYMRNVDDRDVEKFLLMLTFLPTDECKRLGSLEGSEINKAKEV
CCCEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHH
LAFEVCKLVHGEEKAEEARQTANALFNSNVVDENMPTTEMKALDFENGIGLLNLLTMTGL
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHCC
TQSNSEARRLVTQNGISVNDNKEADPKRVITIHDFNDDELIIKKGKKVYHRVKLV
CCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCEEECCCHHHHHHEECC
>Mature Secondary Structure
MINYKFEHENVFDELVARGYFEQATYEDELRDLLGKERVPFYIGFDATADSLTIGHFIQL
CCCEEECCHHHHHHHHHCCHHHHCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHH
MVMMRMQAHGHIPICLLGGGTTMIGDPSGRNDMRSIMTKEVIDENARRFYSQMTRFIDFG
HHHHHHHHCCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DDKAYIENNKDWLLNLNFLDFMREIGVHFSVNQMLTLESYKNRMKQGLTFFEFSYMLMQS
CCCEEEECCCCEEEECHHHHHHHHHCCEEEHHHHEEHHHHHHHHHHCCHHHHHHHHHHHC
YDYLVLYRKYGCKLQMGGSDQWSNILGGYDLVRKLENDKVYAMTFKLLTTADGVKMGKSQ
CCEEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEHHCCCCHHCCCCC
KGAVWLDENKTTPYDLFQYMRNVDDRDVEKFLLMLTFLPTDECKRLGSLEGSEINKAKEV
CCCEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHH
LAFEVCKLVHGEEKAEEARQTANALFNSNVVDENMPTTEMKALDFENGIGLLNLLTMTGL
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHCC
TQSNSEARRLVTQNGISVNDNKEADPKRVITIHDFNDDELIIKKGKKVYHRVKLV
CCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCEEECCCHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA