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The map label for this gene is gmk

Identifier: 169824354

GI number: 169824354

Start: 721260

End: 721847

Strand: Direct

Name: gmk

Synonym: FMG_0657

Alternate gene names: 169824354

Gene position: 721260-721847 (Clockwise)

Preceding gene: 169824353

Following gene: 169824355

Centisome position: 40.12

GC content: 28.23

Gene sequence:

>588_bases
ATGAGAGACGGATTTTTATTAGTTGTTTCTGGTCCATCGGGAGTTGGCAAAGGAACTGTTTGTGAAAAATTAATATCACA
GAAAAAAGATATTGTATATTCTGTATCCGCTACGACAAGAAAAAAGAGACCTTATGAAGTAGACGGAGAAAATTATTATT
TTTTGAGTTTAGATGAGTTTAAGAAAAAAATTGATCAAGGAGATTTCATTGAATATGCTAATGTACACAATAATTATTAT
GGAACTCCAAAATCATTTGTCTTCGACCAAATCAATAAAGGAGAGATAGTTATTTTAGAAATTGATGTTCAAGGAGCATT
AAAAGTAAAAGAAAACTATCCAGAAGCTGTTTTTGTATTCATTCTTCCACCAGATTTAATTGAACTTAGAAGAAGAATTG
AAGGAAGAAACACTGAAGATGAGGAAACAATTAATATTAGAATGCAAAACGCTAAAAAAGAATTGAGTTTTATTGATGAA
TATGATTATGCAGTTATTAATGAAGATGTTGATGAAACTGTAAAAAATATTGAAACTATAATTGATGCAGAAAAATTTAG
AGTTGTAAAAGGAGAAAAATATGATTAA

Upstream 100 bases:

>100_bases
AGTGTAATAATTATGGATTCAAGTCACGTTGTGTTGAGTTGTCTTCAACCAGAGACTTTACAAATGAGATTGGATAAATC
AAATAATAAGGAAGATTAAA

Downstream 100 bases:

>100_bases
TCCATCATTTAAAAAATTATCAGAAATAAATAATAGTAGATATGCACTTTGTGTAATGGTAAGTAAAAGAGCAAGAATGC
TAATAGACGGAAAAGAAACT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MRDGFLLVVSGPSGVGKGTVCEKLISQKKDIVYSVSATTRKKRPYEVDGENYYFLSLDEFKKKIDQGDFIEYANVHNNYY
GTPKSFVFDQINKGEIVILEIDVQGALKVKENYPEAVFVFILPPDLIELRRRIEGRNTEDEETINIRMQNAKKELSFIDE
YDYAVINEDVDETVKNIETIIDAEKFRVVKGEKYD

Sequences:

>Translated_195_residues
MRDGFLLVVSGPSGVGKGTVCEKLISQKKDIVYSVSATTRKKRPYEVDGENYYFLSLDEFKKKIDQGDFIEYANVHNNYY
GTPKSFVFDQINKGEIVILEIDVQGALKVKENYPEAVFVFILPPDLIELRRRIEGRNTEDEETINIRMQNAKKELSFIDE
YDYAVINEDVDETVKNIETIIDAEKFRVVKGEKYD
>Mature_195_residues
MRDGFLLVVSGPSGVGKGTVCEKLISQKKDIVYSVSATTRKKRPYEVDGENYYFLSLDEFKKKIDQGDFIEYANVHNNYY
GTPKSFVFDQINKGEIVILEIDVQGALKVKENYPEAVFVFILPPDLIELRRRIEGRNTEDEETINIRMQNAKKELSFIDE
YDYAVINEDVDETVKNIETIIDAEKFRVVKGEKYD

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=182, Percent_Identity=34.0659340659341, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI226874833, Length=182, Percent_Identity=34.0659340659341, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI4504221, Length=182, Percent_Identity=34.0659340659341, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI38570142, Length=179, Percent_Identity=29.608938547486, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4505237, Length=177, Percent_Identity=29.9435028248588, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI262118259, Length=177, Percent_Identity=29.9435028248588, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI262118263, Length=177, Percent_Identity=29.9435028248588, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI262118255, Length=177, Percent_Identity=29.9435028248588, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI186972120, Length=178, Percent_Identity=30.3370786516854, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI186700627, Length=178, Percent_Identity=30.3370786516854, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI186700629, Length=178, Percent_Identity=30.3370786516854, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI21361598, Length=193, Percent_Identity=26.9430051813472, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=43.2291666666667, Blast_Score=167, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17508835, Length=174, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI193203132, Length=174, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71988048, Length=178, Percent_Identity=28.0898876404494, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71988041, Length=178, Percent_Identity=28.0898876404494, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17557440, Length=179, Percent_Identity=24.5810055865922, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=43.4782608695652, Blast_Score=145, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=33.5164835164835, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI85816106, Length=211, Percent_Identity=28.436018957346, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI85816281, Length=211, Percent_Identity=28.436018957346, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI45551002, Length=211, Percent_Identity=28.436018957346, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI281362232, Length=184, Percent_Identity=29.3478260869565, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161078485, Length=184, Percent_Identity=29.3478260869565, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648810, Length=184, Percent_Identity=29.3478260869565, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281362230, Length=184, Percent_Identity=29.3478260869565, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24648808, Length=184, Percent_Identity=29.3478260869565, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI161078487, Length=181, Percent_Identity=29.8342541436464, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45554481, Length=168, Percent_Identity=25.5952380952381, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI85724806, Length=168, Percent_Identity=25.5952380952381, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24640542, Length=168, Percent_Identity=25.5952380952381, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI116007136, Length=168, Percent_Identity=25.5952380952381, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI45554489, Length=168, Percent_Identity=25.5952380952381, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI161077626, Length=168, Percent_Identity=25.5952380952381, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 22513; Mature: 22513

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDGFLLVVSGPSGVGKGTVCEKLISQKKDIVYSVSATTRKKRPYEVDGENYYFLSLDEF
CCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCCEEEEEEHHHH
KKKIDQGDFIEYANVHNNYYGTPKSFVFDQINKGEIVILEIDVQGALKVKENYPEAVFVF
HHHCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCEEEEEEECCCEEEEECCCCCEEEEE
ILPPDLIELRRRIEGRNTEDEETINIRMQNAKKELSFIDEYDYAVINEDVDETVKNIETI
EECCHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHHHHCCCEEEECCCHHHHHHHHHHH
IDAEKFRVVKGEKYD
HCHHHEEEECCCCCC
>Mature Secondary Structure
MRDGFLLVVSGPSGVGKGTVCEKLISQKKDIVYSVSATTRKKRPYEVDGENYYFLSLDEF
CCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCCEEEEEEHHHH
KKKIDQGDFIEYANVHNNYYGTPKSFVFDQINKGEIVILEIDVQGALKVKENYPEAVFVF
HHHCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCEEEEEEECCCEEEEECCCCCEEEEE
ILPPDLIELRRRIEGRNTEDEETINIRMQNAKKELSFIDEYDYAVINEDVDETVKNIETI
EECCHHHHHHHHHCCCCCCCCEEEEEEEECCHHHHHHHHCCCEEEECCCHHHHHHHHHHH
IDAEKFRVVKGEKYD
HCHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]